Article
Health Care Sciences & Services
Gurkiran Birdi, Michael Larkin, Rebecca C. Knibb
Summary: This study found a bidirectional relationship between stress, anxiety, and depression, and the severity of atopic dermatitis in women. It is important to identify high levels of distress in order to implement optimal management strategies and reduce the risk of increased severity of atopic dermatitis and its impact on psychological well-being.
Article
Medicine, General & Internal
Hidehisa Saeki, Yukihiro Ohya, Hisakatsu Nawata, Kazuhiko Arima, Miho Inukai, Ana B. Rossi, Gaelle Bego-Le-Bagousse
Summary: This study investigated the impact of pediatric atopic dermatitis (AD) on family quality of life in Japanese patients. The results showed that the severity of AD was negatively correlated with family quality of life, especially in families with children under the age of 6, where sleep and tiredness were the most affected aspects. The study also found that family and household environments, such as family history of allergic conditions, residency, second-hand smoke exposure, and household pets, can influence AD prevalence and severity.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Aleksandra K. K. Kobusiewicz, Bartlomiej Tarkowski, Andrzej Kaszuba, Aleksandra Lesiak, Joanna Narbutt, Anna Zalewska-Janowska
Summary: This cross-sectional study investigated the relationship between atopic dermatitis in children, especially concomitant itch, and the quality of life, stress, sleep quality, anxiety, and depression of their mothers. The severity of atopic dermatitis and itch significantly correlated with the quality of life, insomnia, and perceived stress of the mothers. Mothers whose children had had atopic dermatitis for more than 6 months had significantly higher scores of anxiety and depression. These results highlight the importance of screening mothers for functional impairment to provide adequate support.
FRONTIERS IN MEDICINE
(2023)
Article
Dermatology
Michaela Gabes, Aviel Ragamin, Arabella Baker, Gesina Kann, Theresa Donhauser, Daniela Gabes, Laura Howells, Kim S. Thomas, Jart A. F. Oosterhaven, Suzanne G. M. A. Pasmans, Marie L. Schuttelaar, Christian Apfelbacher
Summary: This study evaluated the content validity of the self-reported version of RECAP among young people with atopic eczema in the UK, Germany, and the Netherlands, confirming adequate content validity for self-completion in young people aged 12 years and above.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Medicine, General & Internal
Szabolcs Bozsanyi, Natalia Czurko, Melinda Becske, Roland Kasek, Botond Keve Lazar, Mehdi Boostani, Fanni Adel Meznerics, Klara Farkas, Noemi Nora Varga, Lili Gulyas, Andras Banvolgyi, Bence Agoston Feher, Emese Fejes, Kende Lorincz, Aniko Kovacs, Hunor Gergely, Szabolcs Takacs, Peter Hollo, Norbert Kiss, Norbert Wikonkal, Imre Lazar
Summary: This study aims to analyze the hemispherical lateralization, neurovegetative responses, and psychometric characteristics of patients with plaque psoriasis (Pso) and atopic dermatitis (AD). The results show a significant right-lateralized prefrontal activity in both AD and Pso patients, with distinct psychodermatological mechanisms in AD and Pso.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dermatology
Laurent Misery, Julien Seneschal, Florence Corgibet, Bruno Halioua, Adrien Marquie, Stephanie Merhand, Gaelle Lefur, Delphine Staumont-Salle, Christina Bergqvist, Charles Taieb, Khaled Ezzedine, Marie-Aleth Richard
Summary: This study evaluates the impact of atopic dermatitis on the daily lives of adult patients and their partners. The results show that atopic dermatitis has significant negative effects on both patients and their partners, including sleep disturbance and impaired sexual health. Therefore, the burden of atopic dermatitis on partners should be considered in future patient-centered care.
ACTA DERMATO-VENEREOLOGICA
(2023)
Review
Biology
Anna Balato, Alexander Zink, Graziella Babino, Dario Buononato, Charlotte Kiani, Kilian Eyerich, Stefanie Ziehfreund, Emanuele Scala
Summary: This review examined candidate biomarkers and indicators associated with impaired quality of life in psoriasis and atopic dermatitis patients. Most of the included studies identified genomic or proteomic biomarkers associated with disease activity and quality of life outcomes. Sociodemographic, clinical, and therapeutic factors were also found to be related to reduced quality of life. Considering these factors in drug development programs can enhance the value of biomarkers and improve their future clinical utility as stratification tools.
Article
Dermatology
Silvia Mariel Ferrucci, Simona Tavecchio, Luisa Angileri, Teresa Surace, Emilio Berti, Massimiliano Buoli
Summary: This study aimed to investigate the relationship between affective symptoms, quality of life, and clinical factors in patients with severe atopic dermatitis. The results showed a significant association between more severe anxiety symptoms and poorer quality of life with more severe depressive symptoms. Female sex and disturbed sleep were also linked to increased anxiety levels. Additionally, factors such as previous treatment with cyclosporine or methotrexate, more severe depressive symptoms, itch, impaired sleep, and perceived severity of dermatological illness were predictors of low quality of life. These findings suggest a complex interplay between disease severity, psychological symptoms, and quality of life in atopic dermatitis patients.
ACTA DERMATO-VENEREOLOGICA
(2021)
Review
Medicine, General & Internal
Yu Ri Woo, Hei Sung Kim
Summary: Atopic dermatitis (AD) is highly prevalent in Korea, causing physical discomfort, psychological distress, and social isolation. There are unmet needs in diagnosing and managing AD in Korea, including the lack of a definitive biomarker and the need for more effective, safe, and cost-effective treatments. Understanding the epidemiology, burden, and current diagnostic and management options in Korea can help address these issues and improve outcomes for AD patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dermatology
Ken-ichi Yasuda, Yozo Ishiuji, Toshiya Ebata, Takamasa Kogure, Eitaro Kondo, Arihito Ota, Toshihiro Ito, Koki Endoh, Akihiko Asahina
Summary: Atopic dermatitis itch can affect sleep and quality of life. This study developed algorithms and devices to measure sleep and scratching, and used smartphone applications to improve therapy adherence. The results showed that using the device and application led to improved treatment effectiveness and quality of life in patients with atopic dermatitis.
ACTA DERMATO-VENEREOLOGICA
(2023)
Article
Chemistry, Medicinal
Luca Mastorino, Francois Rosset, Federica Gelato, Michela Ortoncelli, Giovanni Cavaliere, Pietro Quaglino, Simone Ribero
Summary: Chronic pruritus is a major symptom of atopic dermatitis and is effectively treated by targeting and blocking interleukin-4 (IL-4) and interleukin-13 (IL-13) molecules using dupilumab. Questionnaires such as DLQI and POEM are useful for assessing the impact of itching on patients' lives. Monitoring of IgE, eosinophils, and LDH may not be clinically valid or correlated with disease severity and should be gradually abandoned.
Article
Medicine, General & Internal
Mwenya Mubanga, Cecilia Lundholm, Brian M. D'Onofrio, Marlene Stratmann, Anna Hedman, Catarina Almqvist
Summary: This study in Sweden found an association between exposure to antibiotics and an increased risk of atopic dermatitis, particularly in prenatal and early childhood exposures. However, the risk was partially confounded by familial factors, suggesting further research on the impact of antibiotic use and shared familial factors on atopic diseases may be warranted.
Article
Medicine, General & Internal
Bing -Jun Hsieh, Dereck Shen, Chia-Jung Hsu, Tom C. Chan, Yung-Tsu Cho, Chao-Hsiun Tang, Chia-Yu Chu
Summary: This study investigated the relationship between AD severity and HRQoL in Taiwanese patients. Results showed that patients with severe AD had poorer HRQoL compared to those with mild AD, with symptoms, feelings, and work/school being the most troublesome aspects. Demographic characteristics did not significantly affect HRQoL.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Dermatology
Brian T. Cheng, Jonathan Silverberg
Summary: The study found a significant association between childhood atopic dermatitis (AD) and chronic school absenteeism in the United States, while there was no statistical difference in chronic absenteeism for children with psoriasis. Parents of children with AD were more likely to miss work for caregiving compared to those without AD, whereas parents of children with psoriasis had similar rates of work absenteeism compared to those without psoriasis.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Review
Medicine, General & Internal
Andrea Chiricozzi, Martina Maurelli, Laura Calabrese, Ketty Peris, Giampiero Girolomoni
Summary: Atopic dermatitis (AD) is a prevalent chronic inflammatory skin disease that displays heterogeneity across different ethnicities. Genetic factors, such as Filaggrin (FLG) mutations, and immunological pathways, including Th2 hyperactivation and Th17-mediated signals, contribute to the differences in AD among racial groups. This heterogeneity has important therapeutic implications, as a tailored treatment strategy targeting specific immunologic pathways in each ethnic subgroup may be necessary.
JOURNAL OF CLINICAL MEDICINE
(2023)