Review
Endocrinology & Metabolism
Rosa Wartena, Mushi Matjila
Summary: The relationship between polycystic ovarian syndrome (PCOS) and recurrent pregnancy loss (RPL) is still poorly understood and requires further research. Factors that should be further investigated include the contribution of PCOS phenotypes, BMI, obesity, insulin resistance, hyperandrogenemia, SHBG, hs-CRP, CTRP6, adiponectin, plasma leptin, homocysteine, AMH, and thrombophilia to the risk of miscarriage. Other factors that need to be explored in relation to the risk of miscarriage in PCOS patients with RPL include sOB-R, PAI-Fx, and Factor-V-Leiden mutations.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Editorial Material
Obstetrics & Gynecology
Dominique de Ziegler, Rene F. Frydman
Summary: Recurrent pregnancy loss (RPL) is defined as two to three spontaneous pregnancy terminations before 12 weeks of gestation, potentially caused by factors like gamete quality, uterine issues, endometrial receptivity alterations, immunologic factors, and thrombophilia.
FERTILITY AND STERILITY
(2021)
Review
Medicine, General & Internal
Julia Tomkiewicz, Dorota Darmochwal-Kolarz
Summary: Recurrent pregnancy loss is a common problem among reproductive age women and can be caused by various conditions. International guidelines, including those from RCOG, ASRM, and ESHRE, provide different approaches to its diagnosis and treatment. This review highlights the changing approach to miscarriages and the need for further exploration and refinement. It also addresses the challenge of unexplained pregnancy loss for clinicians.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Diana Alecsandru, Amber M. Klimczak, Juan A. Garcia Velasco, Paul Pirtea, Jason M. Franasiak
Summary: Immunologic factors may contribute to miscarriages and recurrent pregnancy loss, with disruption of maternal-fetal immune homeostasis being a potential cause. Remodeling of maternal uterine spiral arteries is crucial for fetal development, ensuring adequate oxygen supply for proper placentation. Development of fetal tissues can lead to immunologic challenges, as the fetus may express paternal and gamete donor antigens, triggering a response from the maternal immune system.
FERTILITY AND STERILITY
(2021)
Review
Medicine, General & Internal
Akbayan Turesheva, Gulzhanat Aimagambetova, Talshyn Ukybassova, Aizada Marat, Perizat Kanabekova, Lyazzat Kaldygulova, Ainur Amanzholkyzy, Svetlana Ryzhkova, Anastassiya Nogay, Zaituna Khamidullina, Aktoty Ilmaliyeva, Wassim Y. Almawi, Kuralay Atageldiyeva
Summary: Recurrent pregnancy loss is a complex health challenge with no universally accepted definition. The true incidence is difficult to estimate due to inconsistency in definitions and criteria applied by international guidelines. The exact etiology remains questionable and up to 75% of cases are unexplained. This review aimed to summarize accumulated knowledge on etiology, risk factors, diagnostic options, and management approach to recurrent pregnancy loss.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Magdalena Peeva, Ahmad Badeghiesh, Haitham Baghlaf, Michael H. Dahan
Summary: The study demonstrates that obesity in women with PCOS increases the risk of specific pregnancy and delivery complications.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
Katherine VanHise, Erica T. Wang, Keith Norris, Ricardo Azziz, Margareta D. Pisarska, Jessica L. Chan
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects women worldwide. There are racial and ethnic differences in PCOS phenotypes and metabolic dysfunction. This review summarizes the current literature on disparities in PCOS diagnosis and outcomes in the United States. Future studies should focus on racial and ethnic-specific differences in PCOS and include a diverse population in PCOS research.
FERTILITY AND STERILITY
(2023)
Article
Endocrinology & Metabolism
Anju E. Joham, Nadira S. Kakoly, Helena J. Teede, Arul Earnest
Summary: This study found a significantly higher incidence of hypertension among women with PCOS compared to those without, especially among obese women. PCOS was independently associated with an increased risk of hypertension, further exacerbated by obesity. Including PCOS in hypertension risk assessments may help in early identification and management of the disorder.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Jia Zhu, Anders U. Eliasen, Izzuddin M. Aris, Sara E. Stinson, Jens-Christian Holm, Torben Hansen, Marie-France Hivert, Klaus Bonnelykke, Rany M. Salem, Joel N. Hirschhorn, Yee-Ming Chan
Summary: Genetic risk factors for PCOS are associated with alterations in metabolic, growth, and developmental traits in childhood.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
D. Abdulkhalikova, A. Sustarsic, E. Vrtacnik Bokal, N. Jancar, M. Jensterle, T. Burnik Papler
Summary: This study aimed to investigate the effects of weight loss on the endometrium specific proteome, endocrine-metabolic characteristics, and motor capabilities of obese women with PCOS and infertility. The results showed increased protein abundance in certain proteins and decreased abundance in others in the endometrium after weight loss, as well as significant reductions in fasting blood glucose and free testosterone levels, and improvements in body composition and physical capacity.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tansel Sapmaz, Kubra Sevgin, Sude Topkaraoglu, Muhammetnur Tekayev, Fatma Gumuskaya, Fatima Efendic, Mahmud Esad Pence, Selman Aktas, Gulam Hekimoglu, Oktay Irkorucu
Summary: This study examined the effects of propolis on ovarian folliculogenesis, p53 expression, and serum LH and P levels in PCOS modeled rats. Treatment with 50 mg/kg of propolis ameliorated cystic and primary follicles, while 150 mg/kg increased LH levels. Low concentrations of propolis cannot completely improve the hormone profile and p53 expression associated with PCOS.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Endocrinology & Metabolism
Yiming Gao, Caihong Xin, Huaying Fan, Xin Sun, Hongli Wang
Summary: In this meta-analysis, it was found that the levels of chemerin, a newly identified adipokine, were significantly higher in patients with PCOS compared to healthy controls. However, there was no significant difference in the levels of apelin, another adipokine, between the two groups.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Genetics & Heredity
Alessio Ardizzone, Anna Paola Capra, Stefania Mondello, Silvana Briuglia, Maria Angela La Rosa, Michela Campolo, Emanuela Esposito
Summary: Recurrent pregnancy loss (RPL) is the loss of two or more pregnancies, affecting approximately 1 to 3% of women worldwide. There is a possible correlation between thrombophilic genetic variants and RPL, but the data are often conflicting. Further investigations evaluating genotype-phenotype correlations can improve clinical management and genetic counseling.
Article
Endocrinology & Metabolism
Jia Zhu, Natalia Pujol-Gualdo, Laura B. L. Wittemans, Cecilia M. Lindgren, Triin Laisk, Joel N. Hirschhorn, Yee-Ming Chan
Summary: Genetic risk factors for PCOS have phenotypic consequences in men, indicating that they can act independently of ovarian function. Thus, PCOS in women may not always be a primary disorder of the ovaries.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Anuradhaa Subramanian, Siang Ing Lee, Katherine Phillips, Konstantinos A. Toulis, Punith Kempegowda, Michael W. O'Reilly, Nicola J. Adderley, Shakila Thangaratinam, Wiebke Arlt, Krishnarajah Nirantharakumar
Summary: The study found that pregnant women with PCOS have a higher risk of preterm birth and cesarean delivery compared to those without PCOS, but there is no significant association with low birthweight, high birthweight, or stillbirth.
Article
Obstetrics & Gynecology
Jon Hyett, Nasrin Asadi, Maryam Zare Khafri, Homeira Vafaei, Maryam Kasraeian, Alireza Salehi, Najmieh Saadati, Khadije Bazrafshan
Summary: This study found that daily administration of 400 mg vaginal progesterone after successful parenteral tocolysis can increase the latency period preceding delivery, improve cervical shortening, and improve neonatal outcomes.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Review
Obstetrics & Gynecology
Maryam Kasraeian, Marjan Zare, Homeira Vafaei, Nasrin Asadi, Azam Faraji, Khadijeh Bazrafshan, Shohreh Roozmeh
Summary: This study conducted a meta-analysis on 87 SARS-CoV-2 positive pregnant women and found that almost 65% of the patients had a history of exposure to an infected person, 78% suffered from mild or moderate COVID-19 pneumonia, and 99.9% had successful termination. No evidence of vertical transmission was found. Despite the immunosuppressive state during pregnancy, most patients had mild or moderate COVID-19 pneumonia with no pregnancy loss.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Homeira Vafaei, Samaneh Karimi, Mojgan Akbarzadeh Jahromi, Nasrin Asadi, Maryam Kasraeian
Summary: This study compared the placental histology and neonatal outcomes among pregnant women with and without beta-thalassemia. The results showed that women with beta-thalassemia had a higher frequency of low birth weight and placental abnormalities.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Review
Obstetrics & Gynecology
Kamran Hessami, Nahid Homayoon, Atefe Hashemi, Homeira Vafaei, Maryam Kasraeian, Nasrin Asadi
Summary: This comprehensive review examines the available evidence on maternal, fetal, and neonatal mortality associated with COVID-19 infection. The results suggest that maternal mortality is more common in women with pre-existing conditions, while fetal and neonatal mortality may be a result of maternal infection severity or prematurity. However, further research is needed to determine the exact magnitude of these mortality rates.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Maryam Kasraeian, Nasrin Asadi, Homeira Vafaei, Mahin Tazang, Azam Faraji, Neda Rahimirad, Sedighe Yousofi, Seyedeh Fatemeh Khaleghi, Marjan Zare
Summary: This study demonstrates that compared with 80 mg of aspirin, taking 150 mg of aspirin every night can reduce the rate of preterm birth and perinatal complications in high-risk pregnant women.
JOURNAL OF PERINATAL MEDICINE
(2022)
Letter
Clinical Neurology
Fariborz Ghaffarpasand, Sirus Sarhadi, Mohammad Hesam Alavi, Ali Rajabpour-Sanati, Maryam Dehghankhalili
WORLD NEUROSURGERY
(2022)
Article
Obstetrics & Gynecology
Azam Faraji, Lida Tahamtani, Najmeh Maharlouei, Nasrin Asadi
Summary: The study compared the efficacy and safety of oral glibenclamide and subcutaneous insulin in patients with gestational diabetes mellitus. The results showed that oral glibenclamide was as effective and safe as subcutaneous insulin in glycemic control and maternal and neonatal outcomes. Therefore, it could be used as a first-line treatment for gestational diabetes mellitus.
OBSTETRIC MEDICINE
(2023)
Review
Medicine, Research & Experimental
Seyed Reza Mousavi, Majid Reza Farrokhi, Keyvan Eghbal, Amirreza Dehghanian, Alireza Rezvani, Fariborz Ghaffarpasand
Summary: Ewing sarcoma is a highly aggressive tumor that mainly affects young children and adolescents, with rare intramedullary metastasis. In this case, a 46-year-old woman with prior clavicular ES developed intramedullary thoracic and lumbar extradural masses, which were managed with surgery and chemotherapy. Management of ES spinal cord metastasis remains challenging, with surgical decompression and adjuvant chemotherapy as main treatments.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Article
Surgery
Alimohammad Bananzade, Maryam Dehghankhalili, Faranak Bahrami, Seyed Mohammad Kazem Tadayon, Fariborz Ghaffarpasand
Summary: This study compared the effects of early versus late closure of the stoma in patients with rectal cancer undergoing low anterior resection. The results showed that early closure was associated with shorter operation duration and lower intra-operative bleeding. There was no difference in complications between the two groups. Therefore, early closure of the stoma is a safe and feasible technique.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Clinical Neurology
Amin Niakan, Hosseinali Khalili, Mohammadhossein Vosoughi, Elnaz Azizi, Fariborz Ghaffarpasand
Summary: The effectiveness of correcting serum fibrinogen level in severe traumatic brain injury patients undergoing traumatic cranial surgery was evaluated in this study. Early delivery of fibrinogen concentrate (FC) was found to decrease intraoperative bleeding, but had no significant effect on other parameters. Further multicenter studies are recommended to investigate the role of early FC administration in the management of post traumatic coagulopathy.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Article
Genetics & Heredity
Fariborz Ghaffarpasand, Sirous Sarhadi, Mohammad Hesam Alavi, Ali Rajabpour Sanati, Maryam Dehghankhalili
Summary: Intervertebral disc degeneration (IDD) is a major cause of low back pain and has significant social and economic impact. Current medical and surgical therapies are ineffective, but miRNA-based therapies show promise in regulating the pathogenesis of IDD. Overcoming obstacles associated with these therapies will allow for their translation from bench to bedside in the near future.
Review
Medicine, General & Internal
Keyvan Eghbal, Majid Reza Farrokhi, Seyed Reza Mousavi, Mohammadhadi Amir Shahpari Motlagh, Ali Kazeminezhad, Fariborz Ghaffarpasand
Summary: Patients with SAA should avoid rapid CSF drainage during durotomy by using cotton pads and keeping the head level low to prevent catastrophic complications.
CLINICAL CASE REPORTS
(2023)
Article
Clinical Neurology
Hosseinali Khalili, Amin Niakan, Ali Rajabpour-Sanati, Elaheh Shaghaghian, Mohammad Hesam Alavi, Maryam Dehghankhalili, Fariborz Ghaffarpasand
Summary: This study examined the effects of Dexmedotomdine hydrochloride (Percedex(R), DEX) on functional outcome of patients with moderate and severe traumatic brain injury (TBI). The results showed that DEX administration was associated with decreased hospital stay and improved functional outcome at 6-months.
JOURNAL OF CLINICAL NEUROSCIENCE
(2023)
Article
Obstetrics & Gynecology
Nasrin Asadi, Shohreh Roozmeh, Homeira Vafaei, Naeimehossadat Asmarian, Akram Jamshidzadeh, Khadije Bazrafshan, Maryam Kasraeian, Azam Faraji, Zahra Shiravani, Ali Mokhtar Pour, Shaghayegh Moradi Alamdarloo, Nazanin Abdi, Fereshte Gharibpour, Sedigheh Izze
Summary: This study evaluated the effects of Pentoxifylline on severe early-onset fetal growth restriction (FGR). It was found that Pentoxifylline improved fetal-placental perfusion, neonatal outcome, and increased fetal weight gain. Additionally, it reduced neonatal mortality by decreasing oxidative stress markers and inflammatory cascade.
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
(2022)
