Article
Gastroenterology & Hepatology
James E. Squires, Alexander G. Miethke, C. Alexander Valencia, Kieran Hawthorne, Lisa Henn, Johan L. K. H. Van Hove, Robert Squires, Kevin Bove, Simon Horslen, Rohit Kohli, Jean P. Molleston, Rene Romero, Estella M. Alonso, Jorge A. Bezerra, Stephen L. Guthery, Evelyn Hsu, Saul J. Karpen, Kathleen M. Loomes, Vicky L. Ng, Philip Rosenthal, Krupa Mysore, Kasper S. Wang, Marisa W. Friederich, John C. Magee, Ronald J. Sokol
Summary: This study aims to enhance the understanding of pathogenesis and natural history of mitochondrial hepatopathies (MH), a range of liver-based conditions caused by alterations in mitochondrial DNA and nuclear DNA genes. The study found differences in clinical presentation, genetic etiology, and survival between acute liver failure (ALF) and chronic liver disease (Chronic) phenotypes of MH. In addition, a subset of patients could not be identified with a specific genetic or enzymatic diagnosis, highlighting the need for further research.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Adrian Truszkiewicz, Dorota Bartusik-Aebisher, Jolanta Zalejska-Fiolka, Aleksandra Kawczyk-Krupka, David Aebisher
Summary: Cellular lactate is a crucial metabolite involved in cellular energy and glycolysis. This study successfully detected lactate in cell cultures using a clinical MR apparatus and identified other metabolites.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Marta Zampino, Richard G. Spencer, Kenneth W. Fishbein, Eleanor M. Simonsick, Luigi Ferrucci
Summary: This study found that decreased mitochondrial oxidative capacity is associated with cardiovascular risk and a history of cardiovascular disease, possibly due to excessive production of oxidative species by dysfunctional mitochondria. Lower energy production may impair the function of the heart and vessels, leading to a vicious cycle in cardiovascular health.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Oncology
Ruikun Liao, Zhuoyue Tang, Xiaojiao Li, Liang Lv, Chao Yang, Hua Xiong, Bi Zhou, Jiayi Yu, Dan Zhang
Summary: This study investigated the diagnostic performance of Cho peak area, Cho peak amplitude, and the combined approach in detecting early-stage liver cancer using hydrogen-1 proton magnetic resonance spectroscopy. The results showed that these approaches were effective in diagnosing VX2 liver cancer. Additionally, a positive correlation was observed between Cho peak area and amplitude with tumor diameter and volume.
FRONTIERS IN ONCOLOGY
(2022)
Editorial Material
Biology
Polytimi Frangou, William T. Clarke
Summary: By combining methods that monitor blood oxygenation and biochemicals, researchers have discovered how the brain processes both perceived and unperceived stimuli.
Review
Biochemistry & Molecular Biology
Benjamin Matis Pizarro-Galleguillos, Liesa Kunert, Norbert Brueggemann, Jannik Prasuhn
Summary: This review emphasizes the biological rationale for studying the pathways of Parkinson's disease and discusses the application of various neuroimaging methods in patients, as well as the limitations and challenges that need to be overcome for successful implementation in clinical studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Thomas Payne, Toby Burgess, Stephen Bradley, Sarah Roscoe, Matilde Sassani, Mark J. Dunning, Dena Hernandez, Sonja Scholz, Alisdair McNeill, Rosie Taylor, Li Su, Iain Wilkinson, Thomas Jenkins, Heather Mortiboys, Oliver Bandmann
Summary: This study characterized bioenergetic dysfunction in Parkinson's disease using a multimodal approach, and found impaired mitophagy and mitochondrial uncoupling in patient-derived fibroblasts. The study also revealed abnormal phosphocreatine levels and implicated a link between impaired mitophagy and impaired striatal energy homeostasis in early Parkinson's disease.
Article
Cardiac & Cardiovascular Systems
Liza Chacko, Michele Boldrini, Raffaele Martone, Steven Law, Ana Martinez-Naharrro, David F. Hutt, Tushar Kotecha, Rishi K. Patel, Yousuf Razvi, Tamer Rezk, Oliver C. Cohen, James T. Brown, Mukunthan Srikantharajah, Sharmananthan Ganesananthan, Thirusha Lane, Helen J. Lachmann, Ashutosh D. Wechalekar, Sajitha Sachchithanantham, Shameem Mahmood, Carol J. Whelan, Daniel S. Knight, James C. Moon, Peter Kellman, Julian D. Gillmore, Philip N. Hawkins, Marianna Fontana
Summary: This study demonstrates that ECV measurements obtained during routine cardiac magnetic resonance scans in patients with suspected amyloidosis can identify and measure the magnitude of amyloid infiltration in the liver and spleen, offering important clues to amyloid type and providing a noninvasive measure of visceral amyloid burden that can assist in guiding and monitoring treatment.
CIRCULATION-CARDIOVASCULAR IMAGING
(2021)
Article
Multidisciplinary Sciences
Haidong Li, Xiuchao Zhao, Yujin Wang, Xin Lou, Shizhen Chen, He Deng, Lei Shi, Junshuai Xie, Dazhong Tang, Jianping Zhao, Louis-S Bouchard, Liming Xia, Xin Zhou
Summary: The recovery process of COVID-19 patients remains unclear, with some experiencing ongoing respiratory issues. Xe-129 MRI analysis reveals higher ventilation defects and longer gas-blood exchange time in COVID-19 patients, indicating lung function impairment during recovery.
Article
Oncology
Irina Heid, Corinna Muench, Sinan Karakaya, Smiths S. Lueong, Alina M. Winkelkotte, Sven T. Liffers, Laura Godfrey, Phyllis F. Y. Cheung, Konstantinos Savvatakis, Geoffrey J. Topping, Florian Englert, Lukas Kritzner, Martin Grashei, Andrea Tannapfel, Richard Viebahn, Heiner Wolters, Waldemar Uhl, Deepak Vangala, Esther M. M. Smeets, Erik H. J. G. Aarntzen, Daniel Rauh, Wilko Weichert, Joerg D. Hoheisel, Stephan A. Hahn, Franz Schilling, Rickmer Braren, Marija Trajkovic-Arsic, Jens T. Siveke
Summary: This study adds functional metabolic phenotyping to transcriptome-based analysis and proposes a functional approach to identify highly glycolytic PDACs as candidates for antimetabolic therapeutic avenues.
CANCER & METABOLISM
(2022)
Review
Oncology
David O. Kamson, Viveka Chinnasamy, Stuart A. Grossman, Chetan Bettegowda, Peter B. Barker, Peter W. Stacpoole, Georg Oeltzschner
Summary: The adverse effects of lactic acidosis in the cancer microenvironment have been recognized. Dichloroacetate (DCA) is a drug that has been studied to reduce lactate production. Magnetic resonance spectroscopy (MRS) is a non-invasive technique that allows detection of metabolic changes. This review gathered evidence on the use of MRS techniques to track metabolic changes after DCA administration in neurologic and oncologic disorders.
FRONTIERS IN ONCOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Florence Franconi, Laurent Lemaire, Jean-Christophe Gimel, Samuel Bonnet, Patrick Saulnier
Summary: NMR-based diffusion methods are valuable tools for nanomedicine characterization and understanding interactions with the biological environment. They provide insights into diffusion phenomena and measurement of self-diffusion and mutual diffusion coefficients. NMR diffusometry spectroscopic and imaging methods have broad applications in nanomedicine, aiding in elucidating important issues.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Biochemistry & Molecular Biology
Benjamin Matis Pizarro-Galleguillos, Liesa Kunert, Norbert Brueggemann, Jannik Prasuhn
Summary: There is a need for disease-modifying therapies for neurodegenerative diseases such as Parkinson's disease (PD). However, clinical trial designs for these disorders face challenges in assessing the neuroprotective properties of potential drugs due to unknown individual disease mechanisms. Neuroimaging methods can provide insights into disease mechanisms, help with patient stratification, and map treatment responses. This review highlights the role of neuroinflammation and mitochondrial dysfunction in PD, discusses different neuroimaging modalities and their challenges, and explores opportunities for future clinical trials.
Article
Physics, Multidisciplinary
C. Munuera-Javaloy, A. Tobalina, J. Casanova
Summary: Ensembles of nitrogen-vacancy centers are used to detect nuclear magnetic resonance signals from micron-sized samples. The large magnetic field regime is of particular interest due to the high thermal polarization and accessibility of chemical shifts and J couplings. However, coupling NV-based sensors with high-frequency nuclear signals has been challenging. This Letter presents a method that overcomes this obstacle and achieves high spectral resolutions, limited only by the coherence of the nuclear spin signal.
PHYSICAL REVIEW LETTERS
(2023)
Article
Physics, Multidisciplinary
A. J. Healey, S. C. Scholten, T. Yang, J. A. Scott, G. J. Abrahams, I. O. Robertson, X. F. Hou, Y. F. Guo, S. Rahman, Y. Lu, M. Kianinia, I Aharonovich, J-P Tetienne
Summary: A versatile quantum microscope is demonstrated using point defects embedded in a thin layer of hexagonal boron nitride, allowing for real-time observation of temperature and magnetic field near the Curie temperature of a van der Waals ferromagnet, as well as mapping of charge currents and Joule heating in a graphene device. The integration of hexagonal boron nitride quantum sensor with other van der Waals materials will have significant practical benefits for the design and measurement of 2D devices.