4.3 Article

Efficient One-Pot Solvent-Free Synthesis of 1H-Pyrazolo[1,2-b]phthalazine-5,10-diones Catalyzed by Sulfonic Acid Functionalized Nanoporous Silica (SBA-Pr-SO3H)

Journal

JOURNAL OF THE CHINESE CHEMICAL SOCIETY
Volume 61, Issue 9, Pages 990-994

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/jccs.201300538

Keywords

Multicomponent reaction; Phthalhydrazide; Functionalized SBA-15; One-pot synthesis; Heterogeneous catalysis

Funding

  1. Research Council of Alzahra University
  2. University of Tehran

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A green protocol has been developed for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones by one-pot cyclocondensation reaction of phthalhydrazide, aromatic aldehydes, and malononitrile or ethyl cyanoacetate using sulfonic acid functionalized SBA-15 (SBA-Pr-SO3H) as a heterogeneous solid acid catalyst under solvent-free conditions.

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