Journal
POLYMER
Volume 66, Issue -, Pages 135-147Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.polymer.2015.04.030
Keywords
Hydrogels; Calibration; Validation
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Funding
- NIAMS NIH HHS [R01 AR065441] Funding Source: Medline
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Concentrating on the case of poly(ethylene glycol) hydrogels, this paper introduces a methodology that enables a natural integration between the development of a so-called mechanistic model and experimental data relating material's processing to response. In a nutshell, we develop a data-driven modeling component that is able to learn and indirectly infer its own parameters and structure by observing experimental data. Using this method, we investigate the relationship between processing conditions, microstructure and chemistry (cross-link density and polymer-solvent interactions) and response (swelling and elasticity) of non-degradable and degradable PEG hydrogels. We show that the method not only enables the determination of the polymer-solvent interaction parameter, but also it predicts that this parameter, among others, varies with processing conditions and degradation. The proposed methodology therefore offers a new approach that accounts for subtle changes in the hydrogel processing. (C) 2015 Elsevier Ltd. All rights reserved.
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