Journal
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
Volume 21, Issue 8, Pages 1537-1542Publisher
SOC BRASILEIRA QUIMICA
DOI: 10.1590/S0103-50532010000800019
Keywords
superparamagnetic nanoparticles; lipase; transesterification catalysis; enantiomeric resolution
Categories
Funding
- FAPESP
- CNPq
- PETROBRAS
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Lipase from Burkholderia cepacia immobilized on superparamagnetic nanoparticles using adsorption and chemisorption methodologies was efficiently applied as recyclable biocatalyst in the enzymatic kinetic resolution of (RS)-1-(phenyl)ethanols via transesterification reactions. (R)-Esters and the remaining (S)-alcohols were obtained with excellent enantiomeric excess (> 99%), which corresponds to a perfect process of enzymatic kinetic resolution (conversion 50%, E > 200). The transesterification reactions catalysed with B. cepacia lipase immobilized by the glutaraldehyde method showed the best results in terms of reusability, preserving the enzyme activity (conversion 50%, E > 200) for at least 8 successive cycles.
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