Journal
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
Volume 21, Issue 12, Pages 2226-2237Publisher
SOC BRASILEIRA QUIMICA
DOI: 10.1590/S0103-50532010001200009
Keywords
triazenes; DNA cleavage; antibacterial activity; cytotoxicity
Categories
Funding
- CNPq [proc. 305254/2009-0]
- CNPq/PIBIC
- CAPES
- Financiadora de Estudos e Projetos (FINEP) [CT-INFRA 03/2001]
Ask authors/readers for more resources
The asymmetric diazoamines 1-(2-chlorophenyl)-3-(4-carboxyphenyl) triazene (1), 1-(2-fluorophenyl)-3-(4-carboxyphenyl) triazene (2) and 1-(2-fluorophenyl)-3-(4-amidophenyl) triazene (3) were evaluated for their ability to cleave pUC18 and pBSKII plasmid DNA, antibacterial activity and in vitro cytotoxicity against acute myeloid leukemia cells and normal leukocytes using the bioassay of reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). The triazenes showed ability to cleave the two types of plasmid DNA: triazene 1 at pH 8.0 and 50 degrees C; triazene 2 at pH 6.5 and 37 and 50 degrees C; triazene 3 at pH 6.5 and 37 degrees C. The compounds presented cytotoxic activity against myeloid leukemia cells. Compound 1 showed high activity against B. cereus (MIC = 32 mu g mL(-1)). The observation of intermolecular hydrogen bonding in the solid state of compound 3, based on the structural analysis by X-ray crystallography, as well as the results of IR and UV-Vis spectroscopic analyses of compounds 1, 2 and 3 are discussed in the present work.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available