Article
Biochemistry & Molecular Biology
Lucie Horackova, Kristyna Chmelickova, Martina Hermannova, Tomas Pitucha, Hana Vagnerova, Ondrej Zidek, Vladimir Velebny, Josef Chmelar
Summary: Water-insoluble fibres prepared from lauroyl-modified HA using a wet spinning process were developed. The properties of these fibres, such as swelling and degradation rate, can be adjusted by modifying the degree of HA. The fibres can be easily processed into various sizes, shapes, and porosities. In addition, they were found to be non-cytotoxic in vitro. Overall, lauroyl HA fibres are a promising material for developing medical devices.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Marcel Krzan, Ewelina Jarek, Hristina Petkova, Eva Santini, Lilianna Szyk-Warszynska, Francesca Ravera, Libero Liggieri, Elena Mileva, Piotr Warszynski
Summary: This study demonstrates the efficiency of using chitosan-LAE mixtures to remove silica nanoparticles from aqueous phase through foaming and flotation, which prolongs the life of the foam and effectively prevents liquid leakage.
Article
Biotechnology & Applied Microbiology
Gerrit Haeger, Jessika Wirges, Nicole Tanzmann, Sven Oyen, Tristan Jolmes, Karl-Erich Jaeger, Ulrich Schoerken, Johannes Bongaerts, Petra Siegert
Summary: This study successfully cloned and expressed a novel aminoacylase gene, and found that co-expression of chaperones can enhance its expression and activity. The recombinant enzyme exhibited high stability and activity at high temperature and neutral pH, and showed good hydrolytic ability towards short-chain and some long-chain acyl-amino acids, suggesting its potential application.
MICROBIAL CELL FACTORIES
(2023)
Review
Biochemistry & Molecular Biology
Sylwia Szrok-Jurga, Aleksandra Czumaj, Jacek Turyn, Areta Hebanowska, Julian Swierczynski, Tomasz Sledzinski, Ewa Stelmanska
Summary: Fatty acid metabolism, especially beta-oxidation, plays a crucial role in human physiology and pathology. Beta-oxidation is not only involved in energy metabolism but also contributes to the synthesis of various important compounds. This review provides an overview of the importance of mitochondrial and peroxisomal beta-oxidation in different organs and cells and discusses the diseases associated with fatty acid oxidation disturbances. The review also highlights the abnormalities of fatty acid oxidation in cancer cells and diseases caused by mutations in enzymes involved in fatty acid oxidation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Cristina Ardean, Corneliu Mircea Davidescu, Nicoleta Sorina Nemes, Adina Negrea, Mihaela Ciopec, Narcis Duteanu, Petru Negrea, Daniel Duda-Seiman, Delia Muntean
Summary: Research shows that new molecules and materials with specific properties against drug-resistant microorganisms, such as chitosan, can be synthesized to enhance antimicrobial activities. Testing revealed that materials functionalized with chitosan and quaternary ammonium salts exhibited the best antimicrobial activity.
Article
Biochemistry & Molecular Biology
Cyrielle Garreau, Corinne Gablin, Didier Leonard, Thierry Delair, Guillaume Sudre, Stephane Trombotto
Summary: This study describes an innovative method for regiospecific chemical grafting of chitosan oligomers onto silicon wafers. The grafting conditions were optimized to achieve functionalized surfaces, which were fully characterized. The study also showed that the addition of a reducing agent could improve grafting density and stability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Xuanhao Zhang, Yi Liu, Asma Ayaz, Huayan Zhao, Shiyou Lu
Summary: This review provides a comprehensive overview of the structural, functional, and regulatory aspects of the fatty acyl reductase (FAR) enzyme family, which plays a crucial role in lipid synthesis in plants. The review also poses several unanswered questions, which serve as directions for future research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Diana R. Fonseca, Ana Moura, Victoria Leiro, Ricardo Silva-Carvalho, Berta N. Estevinho, Catarina L. Seabra, Patricia C. Henriques, Monica Lucena, Catia Teixeira, Paula Gomes, Paula Parreira, M. Cristina L. Martins
Summary: The bioengineered approach of grafting MSI-78A onto chitosan microspheres enhances its bactericidal performance against Helicobacter pylori. The conjugation does not compromise the antimicrobial activity of MSI-78A and even boosts its effectiveness against H. pylori, making it a potential alternative for antibiotic therapy.
ACTA BIOMATERIALIA
(2022)
Article
Biotechnology & Applied Microbiology
Qintao Wang, Yanbin Feng, Yandu Lu, Yi Xin, Chen Shen, Li Wei, Yuxue Liu, Nana Lv, Xuefeng Du, Wenqiang Zhu, Byeong-ryool Jeong, Song Xue, Jian Xu
Summary: This study identified methods to customize the chain length of fatty acids in Nannochloropsis, enabling the production of designer lipids with tailored properties. A mechanistic model was proposed to manipulate carbon distribution among fatty acids, laying the foundation for scalable production of designer lipids via industrial oleaginous microalgae.
METABOLIC ENGINEERING
(2021)
Article
Biochemical Research Methods
Karolis Petkevicius, Eleni Koutsoumpeli, Petri Christina Betsi, Bao-Jian Ding, Kanchana Rueksomtawin Kildegaard, Hilbert Jensen, Nora Mezo, Andrea Mazziotta, Anders Gabrielsson, Christina Sinkwitz, Bettina Lorantfy, Carina Holkenbrink, Christer Lofstedt, Dimitris Raptopoulos, Maria Konstantopoulou, Irina Borodina
Summary: This study developed a biotechnological method to produce the sex pheromone of the European corn borer using engineered yeast, achieving high titers of the pheromone component. The research opens up possibilities for fermentation-based production of ECB pheromones for pest management.
BIOTECHNOLOGY JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Dan Chen, Ruyu Bai, Huimin Yong, Shuai Zong, Changhai Jin, Jun Liu
Summary: In this study, gallic acid was grafted with carboxymethyl chitosan to produce GA-g-CMCS, which showed improved digestive stability and prebiotic effect compared to CMCS.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Microbiology
Ruigang Yang, Hui Wang, Lingyun Zhu, Lvyun Zhu, Tianzhong Liu, Dongyi Zhang
Summary: This study identified a novel candidate gene encoding the chloroplast stromal acyl-acyl carrier protein Delta(9) desaturase in the oleaginous marine microalga Nannochloropsis oceanica. RT-qPCR results showed upregulated transcriptional abundance of this gene under nitrogen starvation condition. The expressed protein displayed desaturated capacity for palmitoyl-ACP (C16:0-ACP) and stearoyl-ACP (C18:0-ACP), and functional complementation assay confirmed its role in oleic acid biosynthesis.
JOURNAL OF MICROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ting Hu, Yuan Sun, Zhuoling An
Summary: This study investigated the dose- and time-dependent manner of liver injury induced by moxifloxacin using a targeted metabolomics method. The results showed that moxifloxacin caused transient hepatotoxicity, with the most severe liver injury occurring after 7 days of continuous administration. Serum concentrations of fatty acyl carnitines, fatty acids, and dehydroepiandrosterone changed dynamically with the severity of moxifloxacin-related liver injury, suggesting their potential as biomarkers for predicting hepatotoxicity.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Woo Cheol Lee, Sungjae Choi, Ahjin Jang, Jiwon Yeon, Eunha Hwang, Yangmee Kim
Summary: In Acinetobacter baumannii, the two ketosynthases (KS), ApeO-ApeC and ApeR, in the Aryl polyenes (APE) biosynthesis gene cluster function complementarily to enhance the production of APE. Mutagenesis at Tyr135 in ApeR significantly reduces its activity, indicating the importance of the stacking of the aryl group between Tyr135 and Phe202 for substrate recognition.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Michelle Tran, Kevin Yang, Alisa Glukhova, Michael Holinstat, Theodore Holman
Summary: Lipid metabolism is crucial for energy production, resulting in high levels of acyl-CoA molecules in the cell. Acyl-CoAs have been implicated in inflammation, and a study found that C18 acyl-CoA derivatives were the most potent against certain lipoxygenase isozymes. Oleoyl-CoA was found to be the most potent inhibitor against h12-LOX and h15-LOX-2, while other acyl-CoAs showed inhibition against different lipoxygenases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Multidisciplinary
Emerson C. G. Campos, Denis A. Turchetti, Alisson J. Santana, Raquel A. Domingues, Luis G. T. A. Duarte, Teresa D. Z. Atvars, Leni Akcelrud
Summary: The study presents a hybrid structure polymer complexed with europium ions, exhibiting luminescence sensitive to viscous chemical environments. The material shows dual-emission profile with red luminescence in DMF and DMSO, and blue emission in chloroform and toluene. DMSO and DMF are suggested to restrict intramolecular motion/rotation, minimizing non-radioactive energy losses and promoting europium luminescence.
Article
Chemistry, Physical
Luis O. de Araujo, Alfredo L. Neto, Lucas Scalon, Paula C. Rodrigues, Joao B. Floriano, C. Moyses Araujo, Cleber F. N. Marchiori, Rafael C. Barreto
Summary: The proposed CBD-CC-E scale optimizes computer-simulated UV-vis spectra by statistically comparing them with experimental spectra, enabling systematic and automated selection of the theory level that best reproduces the experimental UV-vis spectrum.
COMPUTATIONAL AND THEORETICAL CHEMISTRY
(2021)
Article
Polymer Science
Ana Paula Glislere, Denis Turchetti, Bruno Nowacki, Cristiano Zanlorenzi, Leni Akcelrud
Summary: Study on two copolymers, one with a chiral center and another without any asymmetric site, showed that pure polymers did not exhibit any chiro-optical activity. However, blends containing the achiral component displayed significant chiro-optical activity, attributed to stable supramolecular structures unaffected by blend composition. This suggests that utilizing supramolecular morphology can be a key strategy in achieving chiro-optical active polymers.
MACROMOLECULAR RAPID COMMUNICATIONS
(2021)
Article
Polymer Science
Andre Ferreira, Denis Turchetti, Alisson Santana, Leni Akcelrud, Yvonne Mascarenhas
Summary: This research analyzed the crystallites of poly(9,9'-dihexylfluorene) (PHF) and found orthorhombic unit cells with average crystallite sizes of 43.86 angstrom, spherical nanoparticles morphology with average diameters of 69.20 nm, and a possible relationship between the fluorescent properties and the parallel alignment of the chains in the crystallites.
INTERNATIONAL JOURNAL OF POLYMER ANALYSIS AND CHARACTERIZATION
(2021)
Article
Polymer Science
Emerson C. G. Campos, Denis A. Turchetti, Cristiano Zanlorenzi, Raquel A. Domingues, Luis G. T. A. Duarte, Teresa D. Z. Atvars, Leni Akcelrud
Summary: The work explores the solvent effects on the photophysical properties of a terbium copolymer, indicating that the terbium emission is sensitive to the chemical environment and that an aggregation-induced emission phenomenon may occur in certain solvents. Theoretical studies suggest that the DMSO environment may optimize the energy transfer to the terbium ion.
Article
Chemistry, Analytical
Fabio Seiti Hadano, Anderson Emanuel Ximim Gavim, Josiani Cristina Stefanelo, Sara Luiza Gusso, Andreia Gerniski Macedo, Paula Cristina Rodrigues, Abd Rashid bin Mohd Yusoff, Fabio Kurt Schneider, Jeferson Ferreira de Deus, Wilson Jose da Silva
Summary: This study reports on a composite of reduced graphene oxide and poly(aniline), with rGO clusters inserted between PANI chains. The composite exhibited high sensitivity, fast response time, and low detection limit to ammonia gas, attributed to the plasticizing effect of NMP solvent and the improved sensitivity from rGO's higher surface area and presence of carboxylic acids.
Article
Materials Science, Multidisciplinary
Lucas Scalon, Alfredo Leithold Neto, Luis O. Araujo, Soraia Zaioncz, Joao B. Floriano, Andreia G. Macedo, C. Moyses Araujo, Cleber F. N. Marchiori, Paula C. Rodrigues
Summary: Organic dyes have been studied for use in large-area, flexible, cheap, and efficient organic electronic devices, with DPP gaining attention for its planar structure, stability, and processability. The copolymer PFDPP2T, based on DPP, thiophene, and fluorene, shows excellent photophysical and electrochemical properties, especially remarkable electrochemical stability enabling over 400 p-doping cycles. This research unveils fundamental aspects of these copolymers, reinforcing their suitability for photo-electrochemical and optoelectronic applications.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Polymer Science
Alisson J. Santana, Denis A. Turchetti, Cristiano Zanlorenzi, Jose C. R. dos Santos, Adilson J. A. de Oliveira, Leni Akcelrud
Summary: This study investigates the magnetic properties of a polyfluorene derivative and its complexes with neodymium ions, showing that the introduction of Nd atoms leads to paramagnetic behavior in the polymer. The research also demonstrates the significant role of morphology, with polymer forms containing smaller salt ligands exhibiting enhanced magnetic properties compared to those with bulky beta-diketone groups.
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2022)
Article
Materials Science, Multidisciplinary
Sara Luiza Gusso, Leticia Barros Prado, Anderson Emanuel Ximim Gavim, Jeferson Ferreira de Deus, Leonardo Foti, Abd. Rashid Bin Mohd Yusoff, Wilson Jose da Silva, Paula Cristina Rodrigues, Andreia Gerniski Macedo
Summary: In this study, N,N'-di(decyl)-3,4,9,10-perylenebis(dicarboximide) (PDIC10) was functionalized using the hydrothermal synthesis method and applied to single-walled carbon nanotube (SWCN) electrodes and paper substrate. The developed PDC10/SWCN/paper device serves as a noncontact breathalyzer for detecting and quantifying ethanol alcohol, allowing the determination of equivalent blood alcohol concentration (BAC).
PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE
(2022)
Article
Polymer Science
Andre A. Ferreira, Denis A. Turchetti, Alisson J. Santana, Leni C. Akcelrud, Karina de Paula, Yvonne P. Mascarenhas
Summary: This research synthesized a new PHF/n-Eu2O3 nanocomposite and characterized its crystalline structures and morphologies. The results showed that the unit cells and crystallite size of the nanocomposite could be obtained through XRD analysis. The optical properties of the nanocomposite were found to be correlated with the ordering of the polymer chains, crystallinity, and morphology of the mixed nanoparticles.
INTERNATIONAL JOURNAL OF POLYMER ANALYSIS AND CHARACTERIZATION
(2022)
Article
Energy & Fuels
Anderson E. X. Gavim, Eduardo H. dos S. Rosa, Emilson R. Viana, Douglas Jose Coutinho, Paula Cristina Rodrigues, Juan C. Gonzalez, Roberto Mendonca Faria, Wilson Jose da Silva, Andreia Gerniski Macedo
Summary: In this study, a perylene derivative was used as an electron acceptor in organic solar cells. The morphology was optimized using an additive called 1-chlronaphthalene (CN). The power dissipation and electric field distribution were simulated using the transfer matrix method to understand the behavior of the electromagnetic wave inside the device. Monitoring through ellipsometry and TMM modeling provided valuable insights for optimizing the G(x) rate and Jsc parameter.
Article
Chemistry, Physical
Samylla Boazegevski, Jeferson Ferreira de Deus, Denis Augusto Turchetti, Leni Campus Akcelrud, Samim Sardar, Cosimo D'Andrea, Franco V. A. Camargo, Giulio Cerullo, Giovanni Bressan, Stephen R. Meech, Ismael A. Heisler
Summary: A detailed photophysical study was conducted on a polymer based on a fluorene derivative using ultrafast nonlinear spectroscopy. The study found significant differences in the photophysical behavior of the polymer in solution and as a film, suggesting a near absence of self-collapsed chain conformations in solution. In the film, interchain interactions promote efficient energy transfer, resulting in faster excited state relaxation compared to solution. The time scales of exciton dynamics revealed in this study are useful for designing blends for optoelectronic and electro-optical devices.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Polymer Science
Myllena S. Pereira, Luis O. Araujo, Mikaela Daros, Bruno B. M. Torres, Douglas J. Coutinho, Andreia G. Macedo, Roberto M. Faria, Paula C. Rodrigues
Summary: This study explored two methods for fine-tuning the energy levels of conjugated copolymers by manipulating their chemical structures: incorporating heterocyclic moieties and substituting a chalcogen atom. The inclusion of thiophene significantly altered the HOMO level, resulting in enhanced planarization and increased conjugation length.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Chemistry, Physical
Taina Reges Casagrande, Juscelino Valter Barbosas Junior, Jaqueline Cristine Desordi, Mariana Richelle Pereira da Cunha, Anderson Emanuel Ximim Gavim, Luciano Nassif Vidal, Paula Cristina Rodrigues, Indrani Coondoo, Douglas J. Coutinho, Roberto Mendonca Faria, Andreia Gerniski Macedo
Summary: This study investigates the use of SVA treatment to improve the power conversion efficiency in polymer solar cells, and analyzes the effects of SVA treatment on the materials through theoretical simulation and microscopy observation.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Engineering, Chemical
R. A. Konzen, P. R. Batista, L. C. Ducati, T. E. A. Souza, L. C. Cavalcante, C. E. Santos, F. J. Bassetti, P. C. Rodrigues, L. A. Coral
Summary: This study focused on the efficiency of powdered activated carbon in removing BPA, analyzing the impact of adsorption conditions on removal efficiency, and using computational simulation to explain the adsorption mechanism. The experimental results demonstrated that under specific conditions, powdered activated carbon can effectively remove BPA from water.
DESALINATION AND WATER TREATMENT
(2021)
