Journal
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
Volume 19, Issue 7, Pages 1355-1360Publisher
SOC BRASILEIRA QUIMICA
DOI: 10.1590/S0103-50532008000700018
Keywords
palladium complexes; polypyridyl; Leishmania (L.) mexicana
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This paper describes the search for new potential chemotherapeutic agents based on transition metal complexes with planar ligands. In this study, palladium polypyridyl complexes were synthesized and characterized by elemental analysis, NMR, UV-VIS and IR spectroscopies. The interaction of the complexes with DNA was also investigated by spectroscopic methods. All metal-to-ligand charge transfer (MLCT) bands of the palladium polypyridyl complexes exhibited hypochromism and red shift in the presence of DNA. The binding constant and viscosity data suggested that the complexes [PdCl2(phen)] and [PdCl2(phendiamine)] interact with DNA by electrostatic forces. Additionally, these complexes induced an important leishmanistatic effect on L. (L.) mexicana promastigotes at the final concentration of 10 mu mol L-1 in 48 h.
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