Article
Surgery
Willemijn Van der Plas, Schelto Kruijff, Stan B. Sidhu, Leigh W. Delbridge, Mark S. Sywak, Anton F. Engelsman
Summary: This study compared the outcomes of limited, subtotal, and total parathyroidectomy for end-stage renal disease-related hyperparathyroidism, and found that subtotal parathyroidectomy is the optimal strategy. It suggests a shift towards a less aggressive and patient-tailored approach in parathyroid surgery in the changing landscape of kidney transplantation availability and improved dialysis regimens.
Article
Public, Environmental & Occupational Health
Zhuolin Zhang, Lele Cai, Hong Wu, Xinglu Xu, Wenqing Fang, Xuan He, Xiao Wang, Xin Li
Summary: The study investigated the cost-effectiveness analysis of paricalcitol vs. calcitriol + cinacalcet for CKD patients with SHPT in China in 2020, showing that paricalcitol may be more dominant than the latter.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Endocrinology & Metabolism
Matteo Franchi, Joel Gunnarsson, Emilio Gonzales-Parra, Anibal Ferreira, Oskar Stroem, Giovanni Corrao
Summary: This study compared the efficacy of ERC and PCT in treating non-dialysis CKD patients and found no significant differences in reducing PTH levels. PCT was associated with a significant increase in serum calcium compared to ERC. Therefore, ERC is an effective and well-tolerated treatment option for managing SHPT in patients with ND-CKD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Xiu Chen, Feng Zhao, Wei-Juan Pan, Jia-Mei Di, Wei-Nan Xie, Ling Yuan, Zhi Liu
Summary: The results of this study demonstrate that 24 weeks of paricalcitol injection treatment in hemodialysis patients significantly decreased serum levels of iPTH, ALP, and phosphate, while maintaining stability of serum calcium levels. No serious adverse events were observed.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Endocrinology & Metabolism
Cristian Iorga, Cristina Raluca Iorga, Iuliana Andreiana, Iustinian Bengulescu, Traian Constantin, Victor Strambu
Summary: After analyzing the obtained results, it was concluded that total parathyroidectomy is the preferred intervention for patients with secondary hyperparathyroidism when pharmacotherapy fails, in order to prevent disease recurrence and correct metabolic parameters.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Shuqin Xie, Yuan Yu, Yi Liu, Siliang Zhang, Shiyi Yuan, Kui Fan, Bin Tang, Qin Zhou, Yuqing Sun, Rui Liu, Dan Cao, Yong Chen, Yelei Wang, Guangjun Liu, Huan Ma, Chenghui Tao, Li Zeng, Ling Zhong
Summary: This study compared the safety and efficacy of percutaneous paricalcitol injection and intravenously administered paricalcitol in treating secondary hyperparathyroidism. The results showed that the percutaneous injection group had significantly decreased levels of iPTH, phosphate, and volume of the parathyroid gland after 6 months, with relief from ostealgia within 48-72 hours. In the intravenously administered group, the levels of iPTH decreased, but there was no significant change. No severe complications were observed in both groups.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Surgery
Caitlin E. Egan, Murtaza Qazi, Joyce Lee, Yeon J. Lee-Saxton, Jacques A. Greenberg, Toni Beninato, Rasa Zarnegar, Thomas J. Fahey Iii, Brendan M. Finnerty
Summary: This study aimed to assess the impact of pretransplant secondary hyperparathyroidism (sHPT) treatment on posttransplant outcomes. Kidney transplant patients treated with parathyroidectomy or cinacalcet for sHPT were reviewed and their biochemical and clinical parameters, as well as treatment outcomes, were compared. The study found that patients who underwent parathyroidectomy had higher rates of sHPT control at the time of transplantation, fewer cases of tertiary hyperparathyroidism development, and less need for posttransplant cinacalcet treatment.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Oncology
Wenwen Yue, Tingting Jiang, Erya Deng, Huihui Chai, Ning Weng, Hongfeng He, Zhengxian Zhang, Dong Xu, Chengzhong Peng
Summary: This study aimed to investigate the effectiveness of radiofrequency ablation (RFA) for secondary hyperparathyroidism (SHPT) in end-stage renal disease (ESRD) patients and evaluate post-transplantation outcomes. The results showed that RFA can effectively destroy parathyroid tissues in SHPT patients, leading to PTH values within the guideline-oriented range both pre-and post-transplantation.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2023)
Article
Surgery
Zachary Walkenhorst, Alexander Maskin, Scott Westphal, Abbey L. Fingeret
Summary: This study aimed to determine the frequency and factors associated with the incidence of persistent post-transplant hyperparathyroidism (PTHP) following renal transplantation (RT). The results showed that higher pre-RT calcium and PTH levels, as well as pre-RT calcimimetic therapy, were risk factors for PTHP. Further research is needed to determine the optimal PTH cutoff for transplant candidacy and the recommendation for parathyroidectomy in SHP patients requiring calcimimetic therapy.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Surgery
Rongzhi Wang, Griffin Price, Mitchell Disharoon, Gabe Stidham, M. Chandler McLeod, Jessica Liu McMullin, Andrea Gillis, Jessica Fazendin, Brenessa Lindeman, Song Ong, Herbert Chen
Summary: Persistent HPT is common after kidney transplantation and is associated with an increased risk of allograft failure. PTH levels should be closely monitored after transplantation to ensure appropriate treatment.
Review
Endocrinology & Metabolism
Li-Xi Zhang, Ben Zhang, Xu-Yao Liu, Zi-Ming Wang, Peng Qi, Tong-Yue Zhang, Qiang Zhang
Summary: Secondary and tertiary hyperparathyroidism are common and complicated endocrine diseases, and their hyperactivity disorder can cause structural alterations in multiple organs and systems. The current treatment for these diseases remains unclear.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Urology & Nephrology
Gabrielle K. Steinl, Jennifer H. Kuo
Summary: Secondary hyperparathyroidism (SHPT) is common in patients with chronic kidney disease, and those who fail medical treatment should be referred to a parathyroid surgeon. Surgical indications, preoperative planning, intraoperative strategies, and postoperative management are crucial.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Oncology
Boyang Yu, Jiawu Li, Chunyan Lu, Qiang Lu, Yaxin Zhou, Yan Luo
Summary: Ultrasound-guided microwave ablation (MWA) shows potential as a viable treatment for tertiary hyperparathyroidism (THPT) in patients with renal transplantation (RT), but further studies are needed to confirm its safety and effectiveness.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2023)
Article
Endocrinology & Metabolism
Dafu Yu, Lin Zou, Yao Jin, Mingxiang Wei, Xiaoqun Wu, Lingjing Zuo, Mingkang Wu, Yong Jiang
Summary: This study investigates the influential factors of diagnostic accuracy and efficiency of Tc-99m-MIBI uptake in parathyroids of secondary hyperparathyroidism patients with chronic renal failure. The study concludes that patient age, CRF course, hemodialysis vintage, serum PTH, AKP, UA, phosphorus, Ca x P, oral administration of calcitriol and calcium, and parathyroids themselves can significantly influence MIBI uptake.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Transplantation
Laura Martinez-Arias, Sara Panizo, Cristina Alonso-Montes, Julia Martin-Virgala, Beatriz Martin-Carro, Sara Fernandez-Villabrille, Carmen Garcia Gil-Albert, Carmen Palomo-Antequera, Jose Luis Fernandez-Martin, Maria Piedad Ruiz-Torres, Adriana S. Dusso, Natalia Carrillo-Lopez, Jorge B. Cannata-Andia, Manuel Naves-Diaz
Summary: In this study, it was found that the use of VDRAs paricalcitol and calcitriol effectively attenuated renal interstitial fibrosis induced by chronic kidney disease. Paricalcitol was more effective in regulating RAAS activation, inhibiting inflammation, and epithelial/mesenchymal transition compared to calcitriol.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Peripheral Vascular Disease
Michela Bozzetto, Luca Soliveri, Sofia Poloni, Paolo Brambilla, Diego Curto, Giuseppina Carmela Condemi, Pietro Cefali, Irene Spina, Alessandro Villa, Anna Caroli, Andrea Remuzzi
Summary: This study aimed to investigate the impact of an external support device VasQTM on the hemodynamics of arteriovenous fistula (AVF). The results showed that the VasQ device can maintain the angle between the artery and the vein almost unchanged and provide a more stable flow in AVFs.
JOURNAL OF VASCULAR ACCESS
(2022)
Review
Infectious Diseases
Norberto Perico, Monica Cortinovis, Fredy Suter, Giuseppe Remuzzi
Summary: COVID-19 exhibits varying degrees of symptom severity, requiring different levels of care at different stages of the disease. Intervening early with anti-inflammatory drugs, especially NSAIDs, in the outpatient setting could prevent disease progression and long-term complications. Observational studies have shown promising results regarding the use of NSAIDs for early outpatient treatment of COVID-19.
LANCET INFECTIOUS DISEASES
(2023)
Review
Immunology
Erica Daina, Monica Cortinovis, Giuseppe Remuzzi
Summary: Dysregulation and accelerated activation of the alternative pathway of complement play important roles in kidney diseases, and complement-directed therapies have shown potential for treatment. Although there have been successful cases, incorporating these therapies into clinical practice still faces challenges.
IMMUNOLOGICAL REVIEWS
(2023)
Article
Endocrinology & Metabolism
Aneliya Parvanova, Manuela Abbate, Aina Maria Yanez, Miquel Bennasar-Veny, Angel Arturo Lopez-Gonzalez, Jose Ignacio Ramirez-Manent, Ilian Petrov Iliev, Sergio Fresneda, Maria Arias-Fernandez, Giuseppe Remuzzi, Piero Ruggenenti
Summary: This study investigated the prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) in prediabetes, visceral obesity, and preserved kidney function, and explored the association between MAFLD and hyperfiltration. It was found that MAFLD was more frequent in hyperfiltering subjects and was independently associated with hyperfiltration, as well as potentiated the age-related decline in estimated glomerular filtration rate (eGFR).
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Biochemistry & Molecular Biology
Piera Trionfini, Elena Romano, Marco Varinelli, Lorena Longaretti, Paola Rizzo, Roberta Giampietro, Annalina Caroli, Sistiana Aiello, Marta Todeschini, Federica Casiraghi, Giuseppe Remuzzi, Ariela Benigni, Susanna Tomasoni
Summary: Induced pluripotent stem cells (iPSC) have the potential for cell therapy due to their self-renewal and differentiation capabilities. However, the high production costs and limited use for acute conditions hinder their applications. An allogeneic iPSC-based strategy may overcome these issues, but immune rejection is a concern. In this study, CRISPR/Cas9 was used to create hypoimmunogenic iPSCs that can differentiate into liver cells, providing a cost-effective and off-the-shelf opportunity for liver disease cell therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Norberto Perico, Giuseppe Remuzzi, Matthew D. Griffin, Paul Cockwell, Alexander P. Maxwell, Federica Casiraghi, Nadia Rubis, Tobia Peracchi, Alessandro Villa, Marta Todeschini, Fabiola Carrara, Bernadette A. Magee, Piero L. Ruggenenti, Stefano Rota, Laura Cappelletti, Veronica Mcinerney, Tomas P. Griffin, Md Nahidul Islam, Martino Introna, Olga Pedrini, Josee Golay, Andrew A. Finnerty, Jon Smythe, Willem E. Fibbe, Stephen J. Elliman, Timothy O'Brien, NEPHSTROM Trial Consortium
Summary: The NEPHSTROM study evaluates the safety, tolerability, and preliminary efficacy of ORBCEL-M cell therapy in adults with type 2 diabetes and progressive diabetic kidney disease. The results show that ORBCEL-M cell therapy is safe and well-tolerated in the lowest dose cohort, and significantly reduces the decline rate of eGFR over 18 months.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Medicine, General & Internal
Damiano Baldassarre, Licia Iacoviello, Roberta Baetta, Maria Carla Roncaglioni, Gianluigi Condorelli, Giuseppe Remuzzi, Gianfranco Gensini, Luigi Frati, Walter Ricciardi, Pier Giulio Conaldi, Antonio Uccelli, Fabio Blandini, Silvano Bosari, Giovanni Scambia, Massimo Fini, Antonio Di Malta, Mauro Amato, Fabrizio Veglia, Alice Bonomi, Catherine Klersy, Francesca Colazzo, Martino Pengo, Francesca Gorini, Luciana Auteri, Giuseppe Ferrante, Marta Baviera, Giuseppe Ambrosio, Alberico Catapano, Alessandro Gialluisi, Alexis Elias Malavazos, Serenella Castelvecchio, Massimiliano Marco Corsi-Romanelli, Rosanna Cardani, Maria Teresa La Rovere, Valentina Agnese, Bianca Pane, Daniele Prati, Laura Spinardi, Giovanna Liuzzo, Eloisa Arbustini, Maurizio Volterrani, Marco Visconti, Jose Pablo Werba, Stefano Genovese, Grzegorz Bilo, Cecilia Invitti, Anna Di Blasio, Carolina Lombardi, Andrea Faini, Debora Rosa, Luisa Ojeda-Fernandez, Andreana Foresta, Amalia De Curtis, Augusto Di Castelnuovo, Simonetta Scalvini, Antonia Pierobon, Alessandra Gorini, Luca Valenti, Livio Luzi, Annarosa Racca, Manuela Bandi, Elena Tremoli, Lorenzo Menicanti, Gianfranco Parati, Giulio Pompilio
Summary: The CV-PREVITAL study is a multicentre, prospective, randomised, controlled, open-label interventional trial aiming to compare the effectiveness of an educational and motivational mobile health intervention with usual care in reducing cardiovascular risk. The trial plans to enrol approximately 80,000 subjects without overt cardiovascular diseases and evaluate the short-term endpoints, as well as conduct a long-term follow-up to assess the incidence of major adverse cardiovascular events.
Editorial Material
Surgery
Giuseppe Remuzzi
UPDATES IN SURGERY
(2023)
Article
Multidisciplinary Sciences
Angelo M. Lavecchia, Polyxeni Mantzouratou, Domenico Cerullo, Monica Locatelli, Sara Conti, Matteo Tironi, Fabio Sangalli, Daniela Corna, Carlamaria Zoja, Giuseppe Remuzzi, Christodoulos Xinaris
Summary: Research shows that activation of thyroid hormone (TH) signaling can counteract cellular remodeling and pathological alterations caused by diabetes, providing a potential approach for the treatment of diabetes and its complications.
Article
Medicine, General & Internal
Karen Courville, Efrain Castillo, Norman Bustamante, Rolando Millord
Summary: Mesoamerican nephropathy (MeN) is a growing endemic renal disorder in Central America with multiple proposed risk factors. Diagnosis is confirmed by renal biopsy or suspected based on reduced estimated glomerular filtration rate (eGFR) in hotspot regions. Early diagnosis and intervention on risk factors are crucial for prognosis improvement as there is no specific treatment available. This case report highlights a young male with agricultural labor exposure who presented with acute abdominal pain, back pain, and renal dysfunction progressing to chronic kidney disease (CKD) due to MeN, which is a rare occurrence.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anna Caroli, Giulia Villa, Paolo Brambilla, Matias Trillini, Kanishka Sharma, Sandro Sironi, Giuseppe Remuzzi, Norberto Perico, Andrea Remuzzi
Summary: This study presents and validates a diffusion MRI (DWI)-based method for quantifying total kidney and cyst volume (TCV) and characterizing non-cystic tissue microstructure in autosomal dominant polycystic kidney disease (ADPKD). DWI shows potential in ADPKD to assess and predict disease progression, evaluate the impact of novel therapies, and identify microcysts and peritubular interstitial fibrosis in non-cystic kidney tissue.
EUROPEAN RADIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Federica Casiraghi, Marta Todeschini, Manuel Alfredo Podesta, Marilena Mister, Barbara Ruggiero, Matias Trillini, Camillo Carrara, Olimpia Diadei, Alessandro Villa, Ariela Benigni, Giuseppe Remuzzi
Summary: Immune dysregulation plays a key role in the pathogenesis of steroid-dependent/frequently relapsing nephrotic syndrome (SDNS/FRNS). However, no major B- or T-cell alterations have been described for adults, unlike in pediatric cases. This study found that patients with SDNS/FRNS have expansion of memory B cells and reduced memory Tregs. The levels of CD45RO(+) Tregs at baseline may help predict which patients will achieve sustained remission following rituximab infusion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Monica Locatelli, Daniela Rottoli, Rayan Mahmoud, Mauro Abbate, Daniela Corna, Domenico Cerullo, Susanna Tomasoni, Giuseppe Remuzzi, Carlamaria Zoja, Ariela Benigni, Daniela Macconi
Summary: In BTBR ob/ob mice with type 2 diabetic nephropathy, peritubular capillaries show endothelial cell abnormalities and basement membrane thickening. Remodeling and focal loss of the endothelial glycocalyx were observed in diabetic kidneys, and ACEi treatment preserved the glycocalyx and attenuated the ultrastructural abnormalities of peritubular capillaries.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)