Review
Biochemistry & Molecular Biology
Wei-Yang Kong, Siew Ching Ngai, Bey-Hing Goh, Learn-Han Lee, Thet-Thet Htar, Lay-Hong Chuah
Summary: The rise in cancer cases is alarming globally, with challenges in treatment resistance and toxicities. Curcumin combination therapy shows promise in enhancing anticancer effects through multitarget intervention, warranting further research on its future directions.
Article
Nutrition & Dietetics
Zahra Ilyas, Simone Perna, Tariq A. Alalwan, Muhammad Nauman Zahid, Daniele Spadaccini, Clara Gasparri, Gabriella Peroni, Alessandro Faragli, Alessio Alogna, Edoardo La Porta, Ali Ali Redha, Massimo Negro, Giuseppe Cerullo, Giuseppe D'Antona, Mariangela Rondanelli
Summary: This review evaluates the effectiveness of the ketogenic diet for the management of sarcopenic obesity. The results indicate that the ketogenic diet improves metabolic health and helps control glycaemia during obesity. It also has positive effects on visceral adipose tissue, gut microbiota, and body composition, making it a potential therapeutic option for individuals with sarcopenic obesity. However, more research is needed to understand its long-term effects.
Article
Immunology
Nadia H. Khan, Nadine G. Rouphael, Lindsey R. Baden, Daniel S. Graciaa
Summary: While the development of SARS-CoV-2 vaccines was rapid, challenges in development and implementation remain. Trained immunity through BCG vaccination offers a potential intervention to protect vulnerable populations and preserve health system capacity before targeted vaccines are available.
Review
Biotechnology & Applied Microbiology
Emilie Velot, Henning Madry, Jagadeesh K. Venkatesan, Arnaud Bianchi, Magali Cucchiarini
Summary: Extracellular vesicles (EVs) are biological particles released from cells that act as messengers for cell-to-cell communication. They have a membrane with a lipid bilayer, but lack a nucleus and consequently are unable to replicate. Researchers focus on their biological effects rather than their specific origins.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Editorial Material
Hematology
Rory McCulloch
Summary: In a large retrospective analysis, outcomes of post-BTKi mantle cell lymphoma patients were described, providing a benchmark for future studies and highlighting the challenges in managing this patient cohort.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Zhen Liu, Xinyan Zhang, Yanrong Wang, Yifan Tai, Xiaolin Yao, Adam C. Midgley
Summary: This review summarizes emergent antifibrotic peptides and their utilization for targeted prevention of myofibroblasts, highlighting recent studies on peptide inhibitors of upstream pathogenic processes driving the formation of profibrotic cell phenotypes. Peptides from non-mammalian origins that show promise as antifibrotic therapeutics are also briefly discussed. Future perspectives of peptide design and development in targeting myofibroblasts to mitigate fibrosis are also addressed.
Editorial Material
Computer Science, Hardware & Architecture
Scott Davidson
Summary: Over 40 years ago, when I first started in electronic testing, it was a straightforward process. Testing involved applying a functional test to a chip and obtaining a result. The expected values, generated through simulation, consisted of simple vectors of ones and zeroes, which could be easily compared with the circuit output. If the simulation and test program were reliable, the outputs would match unless there was a circuit fault.
IEEE DESIGN & TEST
(2023)
Article
Environmental Sciences
Congyu Zhao, Kangyin Dong, Zhengguang Liu, Xiaoyue Ma
Summary: The digital economy has a significant inhibitory effect on the energy trilemma and can effectively eliminate it by promoting its development. The impact of the digital economy on the energy trilemma is more prominent at lower levels, and diminishes as the level of the energy trilemma increases. The digital economy has a direct and indirect negative impact on energy insecurity, inequity, and unsustainability, the three pillars of the energy trilemma.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2024)
Editorial Material
Hematology
David R. Gibb, Krystalyn E. Hudson
Summary: In patients with sickle cell disease, the release of free hemoglobin S (HbS) from intravascular hemolysis leads to monocyte activation and production of inflammatory cytokines, which is significantly and profoundly greater than the effects of hemoglobin A (HbA) despite their difference of only one amino acid.
Article
Hematology
Barbara Simon, Andrea Cegledi, Janos Dolgos, Peter Farkas, Manila Gaddh, Laszlo Hanko, Robert Horvath, Ambrus Kaposi, Laszlone Magyar, Tamas Masszi, Attila Szederjesi, Nikolett Wohner, Imre Bodo
Summary: Acquired hemophilia A (AHA) is a rare and severe autoimmune bleeding disorder. This study analyzed the data of 32 AHA patients treated with the CyDRi regimen and found that it significantly increased complete remission rates and overall survival compared to current sequential regimens.
Article
Medicine, General & Internal
Ling Bai, Yanfen Wang, Xindi Liu, Yuping Zheng, Wenjing Wang, Na He, Farheen Tariq, Feng Wang, Shu Zhang
Summary: This study investigates the safety and efficacy of conbercept injection for neovascular glaucoma treatment. The results show that conbercept injection can improve visual acuity, control intraocular pressure, and promote regression of neovascularization. The choice of injection route has different effects on patients at different stages of NVG. Therefore, different injection methods can be used for the treatment of patients at different stages.
FRONTIERS IN MEDICINE
(2022)
Article
Infectious Diseases
Stefanie Sammet, Veronique Touzeau-Roemer, Eva Wolf, Pia Schenk-Westkamp, Birgit Romano, Elke Gersbacher, Ulrich Kastenbauer, Christoph Boesecke, Juergen Rockstroh, Stefan Scholten, Stephan Schneeweiss, Julia Roider, Ulrich Seybold
Summary: This study shows that a combination therapy of doravirine and dolutegravir is a durable treatment option for HIV patients, even in those with extensive treatment history and resistance-associated mutations.
Review
Psychology, Clinical
John Read, Joanna Moncrieff
Summary: This article critically evaluates the effectiveness and value of antidepressant drugs and electroconvulsive therapy (ECT), and proposes an alternative understanding of depression as an emotional and meaningful response to unwanted life events and circumstances.
PSYCHOLOGICAL MEDICINE
(2022)
Editorial Material
Immunology
Aaron Yang, Amanda C. Poholek
Summary: In this study, a distal silencer element that disrupts promoter-enhancer looping was identified, which plays a critical role in regulating IFN-gamma expression and preventing inappropriate inflammation.
Article
Mathematics
Jianbo Cui, Shu Liu, Haomin Zhou
Summary: This article presents a definition of stochastic Hamiltonian process on finite graphs via density dynamics in Wasserstein manifold, demonstrating its existence in classical discrete problems such as the optimal transport problem, Schrodinger equation, and Schrodinger bridge problem. The stationary and periodic properties of Hamiltonian processes are also investigated within the framework of the Schrodinger bridge problem.
JOURNAL OF DIFFERENTIAL EQUATIONS
(2021)
