Article
Immunology
Su Woong Jung, Won-Hee Cho, Jung-Woo Seo, Yang-Gyun Kim, Ju-Young Moon, Jin Sug Kim, Chan-Duck Kim, Byung Ha Chung, Jae Berm Park, Yeong Hoon Kim, Sang-Ho Lee
Summary: Urine exosomal bkv-miR-B1-5p is associated with BK virus nephropathy and may serve as a predictive marker during the early posttransplant period.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Surgery
Zachary A. Yetmar, Yogish C. Kudva, Maria Teresa Seville, Wendelyn Bosch, Patrick G. Dean, Janna L. Huskey, Pooja Budhiraja, Tambi Jarmi, Aleksandra Kukla, Elena Beam
Summary: This retrospective cohort study aims to investigate the epidemiology and outcomes of BK polyomavirus (BKV) infection in pancreas transplant recipients. The results showed that BKV DNAemia was common among pancreas transplant recipients, but lower than pancreas-kidney recipients. However, BKV DNAemia was not associated with adverse native kidney outcomes, but was associated with pancreas allograft failure.
CLINICAL TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Isaac E. Hall, Peter Philip Reese, Sherry G. Mansour, Sumit Mohan, Yaqi Jia, Heather R. Thiessen-Philbrook, Daniel C. Brennan, Mona D. Doshi, Thangamani Muthukumar, Enver Akalin, Meera Nair Harhay, Bernd Schroeppel, Pooja Singh, Francis L. Weng, Jonathan S. Bromberg, Chirag R. Parikh
Summary: A study on kidney transplant recipients found that deceased-donor AKI was independently associated with lower risk for BKV infection, contrary to the initial hypothesis. Data from the OPTN database also showed that donor AKI was linked to lower risk for graft failure attributed to BKV.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Review
Genetics & Heredity
Margherita Borriello, Diego Ingrosso, Alessandra Fortunata Perna, Angela Lombardi, Paolo Maggi, Lucia Altucci, Michele Caraglia
Summary: Poliomavirus BK virus (BKV) is a highly infective virus that can cause asymptomatic infections. In renal transplanted recipients, BKV can lead to severe complications. Current treatments and prophylaxis options are limited, but increasing surveillance and early diagnosis show promise in improving outcomes.
Article
Immunology
Jiayu Guo, Bo Yu, Jilin Zou, Long Zhang, Tianyu Wang, Jiangqiao Zhou, Tao Qiu
Summary: An analysis of CYP3A5 gene polymorphism in 134 renal transplant recipients revealed a higher incidence of BKV infection in the fast metabolism genotype group compared to the slow metabolism genotype group, suggesting a potential relationship between CYP3A5 gene polymorphism and BKV infection.
TRANSPLANT IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Maria Grazia Tarsitano, Gabriele Porchetti, Rossana Caldara, Antonio Secchi, Caterina Conte
Summary: Obesity negatively impacts clinical outcomes in kidney transplant recipients. Limited information is available on the prevalence of obesity in this population and the associated lifestyle habits. This study found that the burden of obesity among kidney transplant recipients is similar to that of the general population. Adherence to the Mediterranean diet is generally low, and a significant portion of recipients have a low level of physical activity.
Article
Oncology
Pierluca Piselli, Diego Serraino, Claudia Cimaglia, Lucrezia Furian, Luigi Biancone, Ghil Busnach, Nicola Bossini, Paola Todeschini, Maurizio Iaria, Franco Citterio, Mariarosaria Campise, Massimiliano Veroux, Giuseppe Tisone, Vincenzo Cantaluppi, Margherita Mangino, Simona Simone, Davide Argiolas, Andrea Ambrosini, Francesco Pisani, Flavia Caputo, Martina Taborelli
Summary: This cohort study examined cancer incidence among 11,418 Italian recipients of kidney transplantation over a 25-year period. The study found a decreased risk of Kaposi's sarcoma, but no significant changes in the incidence of other cancers over time. It highlights the need for continued cancer prevention efforts in kidney transplant recipients.
Article
Medicine, General & Internal
Natsuki Eguchi, Ekamol Tantisattamo, Dean Chung, Uttam G. Reddy, Antoney Ferrey, Donald Dafoe, Hirohito Ichii
Summary: This study aims to investigate the kidney transplant outcomes of undocumented immigrants at an academic medical center in California. The retrospective cohort study found that the kidney transplant outcomes of undocumented immigrants were not inferior to those of US residents.
Article
Virology
Baptiste Demey, Veronique Descamps, Claire Presne, Francois Helle, Catherine Francois, Gilles Duverlie, Sandrine Castelain, Etienne Brochot
Summary: In this study, the levels of bkv-miR-B1-3p and bkv-miR-B1-5p in urine were found to be potentially valuable markers for monitoring viral replication in kidney transplant recipients (KTRs), which could help prevent excessive reduction in immunosuppressive therapy. The study also observed a progressive reduction in BKPyV DNA load and subsequent disappearance of microRNAs in some KTRs with sustained BKPyV infection, while stability was seen in others over the first year post-transplantation.
Article
Medicine, General & Internal
Yiting Liu, Chenyang Kong, Haochong Hu, Yalong Zhang, Tianyu Wang, Tao Qiu, Jiangqiao Zhou
Summary: This study aims to analyze the risk factors associated with BK viruria and BK viruria progressing to BK viremia in recipients of donation after cardiac death (DCD), with the goal of facilitating early intervention. Donor age and donor procalcitonin (PCT) levels were identified as independent risk factors for BK viruria. High BK viruria, recipient age, and immunoinduction regimen (ATG) were identified as independent risk factors for BK viruria progressing to BK viremia. Machine learning analysis confirmed the importance of high BK viruria, recipient age, and immunoinduction regimen (ATG) in predicting the progression of BK viruria to BK viremia.
FRONTIERS IN MEDICINE
(2023)
Article
Immunology
Christophe Masset, Simon Ville, Franck Halary, Benjamin Gaborit, Celine Bressolette-Bodin, Clement Deltombe, Amaury Dujardin, Lola Jacquemont, Sabine Lebot, Delphine Kervella, Lucille Figueres, Diego Cantarovich, Magali Giral, Maryvonne Hourmant, Gilles Blancho, Claire Garandeau, Aurelie Meurette, Jacques Dantal
Summary: This study reported two cases of BKV replication in kidney transplant recipients after non-severe SARS-CoV-2 infection. Even without severe symptoms, SARS-CoV-2 infection may disrupt the immune system leading to increased viral replication, highlighting the need for monitoring in kidney transplant recipients post-infection.
TRANSPLANT INFECTIOUS DISEASE
(2021)
Article
Medicine, General & Internal
Kenza Zoubir, Veronique Descamps, Aurelien Aubry, Francois Helle, Catherine Francois, Sandrine Castelain, Etienne Brochot, Baptiste Demey
Summary: Overall, TaqMan MicroRNA Assays appeared to be a more sensitive and accurate RT-qPCR method than TaqMan Advanced MicroRNA Assays to quantify bkv-miR-B1-3p and bkv-miR-B1-5p BKPyV miRNAs in patients' urine samples.
FRONTIERS IN MEDICINE
(2023)
Article
Food Science & Technology
Piotr K. Krajewski, Kinga Tyczynska, Klaudia Bardowska, Piotr Olczyk, Magdalena Krajewska, Jacek C. Szepietowski
Summary: Itch is a common symptom of chronic dermatoses and can be associated with systemic disorders. This study found that itch is a significant burden in renal transplant recipients (RTR), with higher prevalence of anxiety and depression among those experiencing itch. The severity of itch was positively correlated with anxiety, depression, and stigmatization. The results highlight the importance of addressing itch relief in a holistic approach to RTR patients.
Article
Urology & Nephrology
Ryan Gately, Elasma Milanzi, Wai Lim, Armando Teixeira-Pinto, Phil Clayton, Nicole Isbel, David W. Johnson, Carmel Hawley, Scott Campbell, Germaine Wong
Summary: BK polyomavirus-associated nephropathy (BKPyVAN) is associated with an increased risk of graft dysfunction and loss in kidney transplant recipients. This cohort study in Australia and New Zealand found that BKPyVAN occurred in 3% of recipients and was linked to higher rates of graft loss, rejection, and death. Changes in immunosuppression, such as reducing tacrolimus and mycophenolate doses, were commonly made after BKPyVAN. Several factors, including gender, age, blood group, donor characteristics, transplantation era, immunosuppression use, and transplant center volume, were associated with the development of BKPyVAN. The study also found that BKPyVAN increased the risk of graft loss but not mortality. It highlights the need for interventional trials to evaluate strategies for reducing immunosuppression and minimizing adverse outcomes associated with BKPyVAN.
KIDNEY INTERNATIONAL REPORTS
(2023)
Review
Cell Biology
Ramin Yaghobi, Afsoon Afshari, Jamshid Roozbeh
Summary: Early detection of BK polyomavirus (BKPyV) infection is crucial for kidney transplant recipients (KTRs) to improve their quality of life and preserve the transplanted kidney. This study explores the detection of BKPyV microRNAs (miRNAs) during viral infection in KTRs. It also examines the impact of BKPyV-associated nephropathy (BKVAN) on the expression of host genes and miRNAs. However, further research is necessary to determine the potential value of these miRNAs as viral infection markers and understand the regulatory network during viral-host interactions.
WILEY INTERDISCIPLINARY REVIEWS-RNA
(2023)
Article
Surgery
Daniel J. Watford, Xingxing S. Cheng, Jialin Han, Margaret R. Stedman, Glenn M. Chertow, Jane C. Tan
Summary: This study found that self-reported SF-36 physical functioning subscale score can predict the risk faced by kidney transplant candidates, especially the risk of waitlist removal or death. These metrics can be obtained remotely and help identify patients with poor physical functioning.
CLINICAL TRANSPLANTATION
(2021)
Review
Cardiac & Cardiovascular Systems
Xingxing S. Cheng, Suman Mohanty, Valery Turner, Domenico Mastrodicasa, Simon Winther, Dominik Fleischmann, Jane C. Tan, William F. Fearon
Summary: This study conducted a systematic review and meta-analysis on the sensitivity and specificity of CCTA in patients with advanced kidney disease, showing that CCTA has high sensitivity but lower specificity compared to non-kidney disease population.
CARDIORENAL MEDICINE
(2021)
Article
Surgery
Jon Kobashigawa, Darshana M. Dadhania, Maryjane Farr, W. H. Wilson Tang, Arvind Bhimaraj, Lawrence Czer, Shelley Hall, Abdolreza Haririan, Richard N. Formica, Jignesh Patel, Rafael Skorka, Savitri Fedson, Titte Srinivas, Jeffrey Testani, Julie M. Yabu, Xingxing S. Cheng
Summary: Simultaneous heart-kidney transplant has achieved successful outcomes for patients with end-stage heart disease and concomitant kidney disease, but decision-making for this procedure presents challenges. A consensus conference in 2019 aimed to develop interdisciplinary criteria, evaluate kidney allocation, and recommend standardized care for sHK recipients.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Letter
Surgery
Xingxing S. Cheng, Peter P. Reese
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Xingxing S. Cheng, Philip J. Held, Avi Dor, Jennifer L. Bragg-Gresham, Jane C. Tan, John D. Scandling, Glenn M. Chertow, John P. Roberts
Summary: Expanding donor acceptability criteria to include nonstandard donors could be a potential solution to the organ shortage issue. Despite higher costs per organ, kidney transplantation from nonstandard donors remained cost-effective based on contemporary US data, with economies of scale observed in high OPO volume leading to lower costs.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Gastroenterology & Hepatology
Allison Kwong, W. Ray Kim, Paul Y. Kwo, Uerica Wang, Xingxing Cheng
Summary: In non-ICU settings where terlipressin is not available, a sequential vasoconstrictor regimen of midodrine-octreotide followed by norepinephrine can be effective in improving transplant-free survival and achieving responses for patients with hepatorenal syndrome (HRS).
LIVER TRANSPLANTATION
(2021)
Article
Surgery
Brian Wayda, Xingxing S. Cheng, Jeremy D. Goldhaber-Fiebert, Kiran K. Khush
Summary: The increasing rates of simultaneous heart-kidney (SHK) transplant in the United States exacerbate the shortage of deceased donor kidneys (DDK). The current allocation policy does not impose constraints on SHK eligibility. By applying a decision-analytic model, this study compares SHK with a Safety Net strategy and identifies patient subsets for whom SHK is efficient. The findings favor the implementation of a Safety Net provision and the establishment of objective criteria for SHK transplant eligibility.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Brian Shaw, Marya L. Samoylova, Andrew S. Barbas, Xingxing S. Cheng, Yee Lu, Lisa M. McElroy, Scott Sanoff
Summary: There are no established regulations governing patient selection for simultaneous heart-kidney transplantation, leading to significant variations in clinical practice among different centers. National guidelines are needed to standardize the selection of patients for SHK.
CLINICAL TRANSPLANTATION
(2022)
Article
Medicine, General & Internal
Xingxing S. Cheng, Jialin Han, Jennifer L. Braggs-Gresham, Philip J. Held, Stephan Busque, John P. Roberts, Jane C. Tan, John D. Scandling, Glenn M. Chertow, Avi Dor
Summary: This study aims to describe the temporal trends in Organ Acquisition Cost Center (OACC) costs per kidney transplantation and identify the factors associated with cost. The study found that OACC costs increased by 4% per year from 2012 to 2017 and were not solely attributable to the cost of organ procurement. Expanding the waiting list is likely to contribute to further increases in OACC costs and substantially increase Medicare liability.
Article
Cardiac & Cardiovascular Systems
Xingxing S. Cheng, Lisa B. VanWagner, Salvatore P. Costa, David A. Axelrod, Sripal Bangalore, Silas P. Norman, Charles A. Herzog, Krista L. Lentine
Summary: Coronary heart disease is a significant cause of mortality and morbidity in kidney and liver transplantation candidates and recipients. Screening for asymptomatic candidates has not shown to improve outcomes but is common in practice. New approaches and multidisciplinary involvement are suggested for pretransplant evaluation.
Article
Medicine, General & Internal
Xingxing S. Cheng, Sai Liu, Jialin Han, Margaret R. Stedman, Michael Baiocchi, Jane C. Tan, Glenn M. Chertow, William F. Fearon
Summary: Testing for coronary heart disease (CHD) before kidney transplant is common, but its association with perioperative outcomes is unclear. This cohort study found that pretransplant CHD testing was not associated with a reduction in early posttransplant death or acute MI.
JAMA INTERNAL MEDICINE
(2023)
Article
Urology & Nephrology
Calyani Ganesan, Malorie Holmes, Sai Liu, Maria Montez-Rath, Simon Conti, Timothy C. C. Chang, Colin R. Lenihan, Xingxing S. S. Cheng, Glenn M. Chertow, John T. Leppert, Alan C. C. Pao
Summary: Background: Kidney stone disease is common and can lead to complications in kidney transplant recipients. This study found that approximately 2% of kidney transplant recipients were diagnosed with a kidney stone in the first 3 years after transplantation. Risk factors for kidney stone events included a history of kidney stones and longer dialysis vintage.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Gastroenterology & Hepatology
Xingxing S. Cheng, Lisa M. Mcelroy, Scott L. Sanoff, Allison J. Kwong
Summary: Standard eligibility criteria for simultaneous liver-kidney transplantation (SLK) are established in the US. This study examines the mortality benefit of SLK compared to liver transplant alone, based on the specific SLK eligibility criteria met by the patients. The analysis of a retrospective cohort of liver transplant or SLK recipients indicates that SLK is associated with a survival benefit, particularly for patients with end-stage kidney disease.
LIVER TRANSPLANTATION
(2023)
Letter
Medicine, General & Internal
Xingxing S. S. Cheng
JAMA INTERNAL MEDICINE
(2023)
Article
Urology & Nephrology
Xingxing S. Cheng, Sai Liu, Jialin Han, Margaret R. Stedman, Glenn M. Chertow, Jane C. Tan, William F. Fearon
Summary: Coronary artery disease (CAD) screening rates before kidney transplantation in the United States remained constant from 2000 through 2015, despite widespread changes in cardiology guidelines and practice.