Review
Immunology
Guoping Huang, Fei Liu, Ling Yu, Jingjing Wang, Junyi Chen, Jianhua Mao
Summary: Membranous nephropathy (MN) is a glomerular disease characterized by immune complex deposition and capillary wall thickening. MN in pediatric population has a lower incidence and more secondary factors compared to adult patients. Novel antigens have been identified in recent years, representing different clinical and pathologic findings. In-depth research is needed to understand the outcomes and pathophysiology of novel antigen-associated MN, and targeted treatment options are being developed for patients of different ages.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Francesco Scolari, Federico Alberici, Federica Mescia, Elisa Delbarba, Hernando Trujillo, Manuel Praga, Claudio Ponticelli
Summary: Primary Membranous Nephropathy (PMN) is the most common cause of nephrotic syndrome in adults and can lead to end-stage renal disease if left untreated. This review discusses the evidence for different immunosuppressive regimens used for PMN and provides recommendations based on current evidence. The association of PMN with HLA-DQA1 and the presence of autoantibodies support the autoimmune nature of the disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Urology & Nephrology
Tiffany N. Caza, Aaron J. Storey, Samar I. Hassen, Christian Herzog, Rick D. Edmondson, John M. Arthur, Daniel J. Kenan, Christopher P. Larsen
Summary: Multiple new antigenic targets have been identified in PLA2R-/THSD7A-/EXT-/NELL1-quadruple negative MN biopsies through mass spectrometry of immune complexes. These discoveries expand our understanding of the disease and may contribute to the development of new diagnostic approaches.
KIDNEY INTERNATIONAL
(2023)
Review
Urology & Nephrology
Sanjeev Sethi
Summary: Membranous nephropathy is a disease caused by immune complex deposition along the glomerular basement membrane, with PLA2R and THSD7A being the main antigens. New mass spectrometry techniques have led to the discovery of four novel types of MN, each with distinct clinical and pathologic features. Additional studies are needed to understand the pathophysiology, treatment response, and outcomes of these new MN subtypes.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Review
Immunology
Vladimir Tesar, Zdenka Hruskova
Summary: The discovery of anti-podocyte antibodies in primary membranous nephropathy has significantly impacted the diagnosis, treatment, and prognosis of this disease. Evaluation of serum levels of these antibodies allows for non-invasive diagnosis, prediction of renal outcomes, and personalized treatment. However, further research is needed to understand the relationship between anti-podocyte antibodies and cancer, the risk of MN recurrence before renal transplantation, and the implications of antibodies against minor antigens.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Sarah M. S. Koellner, Larissa Seifert, Gunther Zahner, Nicola M. Tomas
Summary: Membranous nephropathy (MN) is a rare but potentially severe autoimmune disease, and the traditional treatments have undesirable side effects. Recent research has shown that eliminating pathogenic antibodies and clearing pathogenic B cells can provide more targeted and effective treatment for MN.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Shane A. Bobart, Shahrzad Tehranian, Sanjeev Sethi, Mariam P. Alexander, Samih H. Nasr, Casal Moura Marta, Julie A. Vrana, Samar Said, Callen D. Giesen, John C. Lieske, Fernando C. Fervenza, An S. De Vriese
Summary: This study described the clinical and pathological phenotype of membranous nephropathy associated with different target antigens. The distinction between primary and secondary MN was found to have limitations, and a refined terminology combining target antigen and associated disease was proposed for better classification.
MAYO CLINIC PROCEEDINGS
(2021)
Review
Immunology
Maxime Teisseyre, Marion Cremoni, Sonia Boyer-Suavet, Caroline Ruetsch, Daisy Graca, Vincent L. M. Esnault, Vesna Brglez, Barbara Seitz-Polski
Summary: Primary membranous nephropathy (pMN) is an autoimmune disease characterized by damage to the glomerular basement membrane due to auto-antibodies. The conventional treatment approach for pMN involves uniform management, regardless of disease severity. However, recent advances have led to a more personalized management based on prognostic markers. Rituximab, an immunosuppressive drug, has shown to be effective in achieving remission in a majority of patients with pMN. However, there are cases of rituximab resistance, which pose challenges to treatment. Immunomonitoring may aid in overcoming treatment resistance by identifying possible causes and adjusting the treatment accordingly.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Meng-Ru Hua, Yan-Long Zhao, Jun-Zheng Yang, Liang Zou, Ying-Yong Zhao, Xia Li
Summary: This article summarizes the etiology, pathogenesis, and treatment of membranous nephropathy (MN), focusing on the role of autoimmune reaction, autoantigens, immunoglobulin G4, and immunosuppressive drugs in the diagnosis and treatment of MN.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Pingna Zhang, Yunling Geng, Jingyi Tang, Zijing Cao, Xiaojun Xiang, Kezhen Yang, Hongbo Chen
Summary: Our study identified CSF1 and CYBB as immune-related hub genes that potentially influence the expression of CCRs and pro-inflammatory cytokines (CCR1, CX3CR1, IL1B, CCL4, TNF, and CCR2). CSF1 and CYBB may be potential biomarkers for MN progression, providing a perspective for diagnostic and immunotherapeutic targets of MN.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Tiffany N. Caza, Laith F. Al-Rabadi, Laurence H. Beck
Summary: The identification of main and minor antigens in MN has led to the recognition of distinctive disease forms, challenging the traditional paradigm of podocyte injury. An antigen-based classification system may be more useful in distinguishing primary and secondary MN.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Le Deng, Qipeng Huang, Jiang Wang, Kaiping Luo, Jiarong Liu, Wenjun Yan, Fang Jiang, Gaosi Xu
Summary: This study evaluated clinical features and prognosis of patients with seropositive M-type phospholipase-A2-receptor (PLA2R)-associated membranous nephropathy (MN) based on different risk ranks. The results showed that patients with high titer PLA2Rab had more severe proteinuria and hypoalbuminemia, lower remission rates, and longer time to remission compared to those with non-high titer antibody. The study also found that PLA2Rab level at baseline was an independent predictive factor for remission.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oceanography
John Malito, Emily Eidam, Jaap Nienhuis
Summary: This study investigates the morphologic response of the Alaskan Beaufort Shelf (ABS) to increasing wave energy and suggests that coastal changes in response to the growing Arctic wave climate may be dependent on shelf morphology and even mitigated in some regions by morphologic adjustment.
JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS
(2022)
Article
Multidisciplinary Sciences
Jiqin Zhang, Yongxian Hu, Jiaxuan Yang, Wei Li, Mingming Zhang, Qingcan Wang, Linjie Zhang, Guoqing Wei, Yue Tian, Kui Zhao, Ang Chen, Binghe Tan, Jiazhen Cui, Deqi Li, Yi Li, Yalei Qi, Dongrui Wang, Yuxuan Wu, Dali Li, Bing Du, Mingyao Liu, He Huang
Summary: A two-in-one approach to generate non-viral, gene-specific targeted CAR-T cells through CRISPR-Cas9 was successfully developed, demonstrating feasibility and efficacy in a preclinical study. An innovative type of anti-CD19 CAR-T cell with PD1 integration showed superior ability to eradicate tumor cells.
Review
Immunology
Wenbin Liu, Guangrui Huang, Hongliang Rui, Jie Geng, Haikun Hu, Yujiao Huang, Guiyang Huo, Baoli Liu, Anlong Xu
Summary: Membranous nephropathy (MN) is a common pattern of glomerular injury in multiple autoimmune responses. Detecting autoantibodies can lead to personalized precision medicine. Further identification of autoantibodies and biomarkers is needed to accurately predict disease prognosis and therapeutic response.
AUTOIMMUNITY REVIEWS
(2022)
Article
Urology & Nephrology
Sanjeev Sethi, Hanna Debiec, Benjamin Madden, M. Cristine Charlesworth, Johann Morelle, LouAnn Gross, Aishwarya Ravindran, David Buob, Michel Jadoul, Fernando C. Fervenza, Pierre Ronco
KIDNEY INTERNATIONAL
(2020)
Review
Pathology
Pierre Ronco, Hanna Debiec
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 15, 2020
(2020)
Article
Multidisciplinary Sciences
Jingyuan Xie, Lili Liu, Nikol Mladkova, Yifu Li, Hong Ren, Weiming Wang, Zhao Cui, Li Lin, Xiaofan Hu, Xialian Yu, Jing Xu, Gang Liu, Yasar Caliskan, Carlo Sidore, Olivia Balderes, Raphael J. Rosen, Monica Bodria, Francesca Zanoni, Jun Y. Zhang, Priya Krithivasan, Karla Mehl, Maddalena Marasa, Atlas Khan, Fatih Ozay, Pietro A. Canetta, Andrew S. Bomback, Gerald B. Appel, Simone Sanna-Cherchi, Matthew G. Sampson, Laura H. Mariani, Agnieszka Perkowska-Ptasinska, Magdalena Durlik, Krzysztof Mucha, Barbara Moszczuk, Bartosz Foroncewicz, Leszek Paczek, Ireneusz Habura, Elisabet Ars, Jose Ballarin, Laila-Yasmin Mani, Bruno Vogt, Savas Ozturk, Abdulmecit Yildiz, Nurhan Seyahi, Hakki Arikan, Mehmet Koc, Taner Basturk, Gonca Karahan, Sebahat Usta Akgul, Mehmet Sukru Sever, Dan Zhang, Domenico Santoro, Mario Bonomini, Francesco Londrino, Loreto Gesualdo, Jana Reiterova, Vladimir Tesar, Claudia Izzi, Silvana Savoldi, Donatella Spotti, Carmelita Marcantoni, Piergiorgio Messa, Marco Galliani, Dario Roccatello, Simona Granata, Gianluigi Zaza, Francesca Lugani, GianMarco Ghiggeri, Isabella Pisani, Landino Allegri, Ben Sprangers, Jin-Ho Park, BeLong Cho, Yon Su Kim, Dong Ki Kim, Hitoshi Suzuki, Antonio Amoroso, Daniel C. Cattran, Fernando C. Fervenza, Antonello Pani, Patrick Hamilton, Shelly Harris, Sanjana Gupta, Chris Cheshire, Stephanie Dufek, Naomi Issler, Ruth J. Pepper, John Connolly, Stephen Powis, Detlef Bockenhauer, Horia C. Stanescu, Neil Ashman, Ruth J. F. Loos, Eimear E. Kenny, Matthias Wuttke, Kai-Uwe Eckardt, Anna Koettgen, Julia M. Hofstra, Marieke J. H. Coenen, Lambertus A. Kiemeney, Shreeram Akilesh, Matthias Kretzler, Lawrence H. Beck, Benedicte Stengel, Hanna Debiec, Pierre Ronco, Jack F. M. Wetzels, Magdalena Zoledziewska, Francesco Cucca, Iuliana Ionita-Laza, Hajeong Lee, Elion Hoxha, Rolf A. K. Stahl, Paul Brenchley, Francesco Scolari, Ming-hui Zhao, Ali G. Gharavi, Robert Kleta, Nan Chen, Krzysztof Kiryluk
NATURE COMMUNICATIONS
(2020)
Article
Urology & Nephrology
Nicolas Hanset, Selda Aydin, Nathalie Demoulin, Jean-Pierre Cosyns, Diego Castanares-Zapatero, Ralph Crott, Jean-Francois Cambier, Jean-Michel Pochet, Gaelle Gillerot, Francois Reginster, Frederic Houssiau, Hanna Debiec, Pierre Ronco, Michel Jadoul, Johann Morelle
AMERICAN JOURNAL OF KIDNEY DISEASES
(2020)
Article
Urology & Nephrology
Xiaoyuan Jia, Tomohiko Yamamura, Rasheed Gbadegesin, Michelle T. McNulty, Kyuyong Song, China Nagano, Yuki Hitomi, Dongwon Lee, Yoshihiro Aiba, Seik-Soon Khor, Kazuko Ueno, Yosuke Kawai, Masao Nagasaki, Eisei Noiri, Tomoko Horinouchi, Hiroshi Kaito, Riku Hamada, Takayuki Okamoto, Koichi Kamei, Yoshitsugu Kaku, Rika Fujimaru, Ryojiro Tanaka, Yuko Shima, Jiwon Baek, Hee Gyung Kang, Il-Soo Ha, Kyoung Hee Han, Eun Mi Yang, Asiri Abeyagunawardena, Brandon Lane, Megan Chryst-Stangl, Christopher Esezobor, Adaobi Solarin, Claire Dossier, Georges Deschenes, Marina Vivarelli, Hanna Debiec, Kenji Ishikura, Masafumi Matsuo, Kandai Nozu, Pierre Ronco, Hae Il Cheong, Matthew G. Sampson, Katsushi Tokunaga, Kazumoto Iijima
KIDNEY INTERNATIONAL
(2020)
Article
Urology & Nephrology
Sanjeev Sethi, Hanna Debiec, Benjamin Madden, Marina Vivarelli, M. Cristine Charlesworth, Aishwarya Ravindran, LouAnn Gross, Tim Ulinski, David Buob, Cheryl L. Tran, Francesco Emma, Francesca Diomedi-Camassei, Fernando C. Fervenza, Pierre Ronco
KIDNEY INTERNATIONAL
(2020)
Article
Urology & Nephrology
Satoru Kudose, Dominick Santoriello, Hanna Debiec, Pietro A. Canetta, Andrew S. Bomback, M. Barry Stokes, Ibrahim Batal, Pierre Ronco, Vivette D. D'Agati, Glen S. Markowitz
Summary: Segmental membranous glomerulopathy (sMGN) is a rare PLA2R-negative variant of MGN with favorable prognosis, even in the absence of immunosuppressive treatment. During follow-up, most patients had stable/improved kidney function.
KIDNEY INTERNATIONAL
(2021)
Article
Urology & Nephrology
Aishwarya Ravindran, Benjamin Madden, M. Cristine Charlesworth, Rishi Sharma, Amit Sethi, Hanna Debiec, Daniel Cattran, Fernando C. Fervenza, Richard J. Smith, Pierre Ronco, Sanjeev Sethi
KIDNEY INTERNATIONAL REPORTS
(2020)
Article
Urology & Nephrology
Lena Berchtold, Eric Letouze, Mariam Priya Alexander, Guillaume Canaud, Anne-Els Van de Logt, Patrick Hamilton, Christiane Mousson, Vincent Vuiblet, Ann M. Moyer, Sylvain Guibert, Petra Mrazova, Charlene Levi, Valerie Dubois, Josep Maria Cruzado, Armando Torres, Manish J. Gandhi, Nadhir Yousfi, Vladimir Tesar, Ondrej Viklicky, Maryvonne Hourmant, Bruno Moulin, Philippe Rieu, Gabriel Choukroun, Christophe Legendre, Jack Wetzels, Paul Brenchley, Jose Aurelio Ballarin Castan, Hanna Debiec, Pierre Ronco
Summary: The study identified genetic variants in HLA-D and PLA2R1 genes associated with recurrence of primary membranous nephropathy. Specifically, donor expression of certain SNPs in these genes was predictive of recurrence, while recipient expression was not. A genetic risk score based on these SNPs can help identify patients at high risk of recurrence.
KIDNEY INTERNATIONAL
(2021)
Review
Urology & Nephrology
Pierre Ronco, Hanna Debiec
Summary: Membranous nephropathy is an autoimmune disease caused by antibodies mostly directed to podocyte antigens. Recent advancements in technology have led to the discovery of new antigens and biomarkers associated with the disease, which may result in a new classification system based on serology and tissue antigen identification. The identification of these antigens also has significant implications for patient care, as they provide valuable markers for treatment monitoring and etiological investigations.
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2021)
Review
Medicine, General & Internal
Pierre Ronco, Emmanuelle Plaisier, Hanna Debiec
Summary: Recent advances in the treatment and pathophysiology of membranous nephropathy have shed light on the competition between traditional cyclophosphamide therapy and rituximab, with substantial progress made in the last two years. This has led to a more personalized approach to medicine in the diagnosis and treatment of the disease.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, Research & Experimental
Mahamadou Dembele, Marion Delafosse, Nadhir Yousfi, Hanna Debiec, Kieu Ngo, Emmanuelle Plaisier, Pierre Ronco, Guillaume Perry
Summary: This article presents the latest innovations in generating in vitro models of the glomerular filtration barrier, with a focus on enhancing physiological relevance through the use of stem cells and bioengineering techniques. It introduces various methods for obtaining podocytes, the key cells in the glomerulus, while emphasizing the significance of the glomerular microenvironment in maintaining cell phenotype.
M S-MEDECINE SCIENCES
(2021)
Article
Urology & Nephrology
Cornelia Daehnrich, Sandra Saschenbrecker, Iva Gunnarsson, Wolfgang Schlumberger, Pierre Ronco, Hanna Debiec
KIDNEY INTERNATIONAL REPORTS
(2020)
Meeting Abstract
Transplantation
Joana Justino, Vesna Brglez, Guillaume Dolla, Alexandra Rousseau, Christelle Zaghrini, Christine Payre, Barbara Seitz-Polski, Vincent L. M. Esnault, Christophe Mariat, Karine Dahan, Hanna Debiec, Pierre Ronco, Gerard Lambeau
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2019)
Meeting Abstract
Transplantation
Christelle Zaghrini, Barbara Seitz-Polski, Joana Justino, Guillaume Dolla, Christine Payre, Noemie Jourde, Anne-Els Van de Logt, Jennie Lonnbro-Widgren, Jenny C. Nystrom, Zhao Cui, Jack F. Wetzels, Gian Marco Ghiggeri, Laurence H. Beck, Pierre Ronco, Hanna Debiec, Gerard Lambeau
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2019)