Article
Urology & Nephrology
Ziyi Zhao, Xuantong Dai, Gengru Jiang, Fujun Lin
Summary: This study investigates the role of Ash2l gene in renal development and its impact on H3K4 methylation and UB morphogenesis. The results suggest that Ash2l inactivation disrupts H3K4 trimethylation, impairs UB branching morphogenesis, and leads to CAKUT.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Midori Awazu, Yoshifumi Yamaguchi, Michio Nagata, Masayuki Miura, Mariko Hida
Summary: Inhibition of Casp3 reduces ureteric branching by promoting UB cell migration. Maternal nutrient restriction affects ureteric branching through a mechanism possibly mediated by Casp3.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell & Tissue Engineering
Sara E. Howden, Sean B. Wilson, Ella Groenewegen, Lakshi Starks, Thomas A. Forbes, Ker Sin Tan, Jessica M. Vanslambrouck, Emily M. Holloway, Yi-Hsien Chen, Sanjay Jain, Jason R. Spence, Melissa H. Little
Summary: Distinct progenitors contribute to the nephrons versus the ureteric epithelium during kidney development. The distal nephron segment alone displays significant in vitro plasticity and can adopt a ureteric epithelial tip identity when isolated and cultured in defined conditions. Cultures harboring loss-of-function mutations in PKHD1 recapitulate the cystic phenotype associated with autosomal recessive polycystic kidney disease.
Review
Cell Biology
Sophie M. Travis, Brian P. Mahon, Sabine Petry
Summary: The microtubule cytoskeleton is crucial for intracellular organization and regulated motion. Branching microtubule nucleation is a key pathway for generating microtubules, and recent research has focused on characterizing the factors and regulation involved in this process, as well as its implications in human disease.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Plant Sciences
Monika Czaja, Anna Kolton
Summary: It has been found that artificial light at night (ALAN) affects the spring phenology and physiology of deciduous species. Street lamps emit light that disrupts the natural photoperiod of plants, accelerating bud development in some species. Different species are affected at different stages of bud development and show varying responses in terms of soluble sugar content. These findings highlight the impact of light pollution on the spring phenology and physiology of plants.
URBAN FORESTRY & URBAN GREENING
(2022)
Article
Multidisciplinary Sciences
Zhenwei Zhang, Norbert Rigo, Olexandr Dybkov, Jean-Baptiste Fourmann, Cindy L. Will, Vinay Kumar, Henning Urlaub, Holger Stark, Reinhard Luehrmann
Summary: During the splicing process, the integration of U2 small nuclear ribonucleoprotein into the spliceosomal A complex is facilitated by the DEAD-box helicase Prp5. Research reveals that the RNA duplex formed by U2 small nuclear RNA is proofread by Prp5, and the U2-BS helix is formed in the pre-A complex. The study further shows a large-scale remodelling of U1 and U2 snRNPs and how the binding of Hsh155(HEAT) triggers closure, disrupting Prp5 binding.
Article
Pathology
Beatrix Sarkany, Levente Kuthi, Gyula Kovacs
Summary: This study aimed to investigate the involvement of ureteric bud (UB) derivatives in nephrogenic rest and Wilms' tumor. Immunohistochemistry analysis revealed that tubules surrounded by tumorous blastemal cells resembling UB tip were positive for RET, ROBO1, and SLIT2 in Wilms' tumor. Furthermore, CA2-positive tubular structures and ATP6V1B1-and ATP6V0D2-positive immature non-cc- and non-13-intercalated cells were detected in nephrogenic rest and Wilms' tumor. This study suggests that Wilms' tumor is a malignant embryonal neoplasm derived from pluripotential cells of nephrogenic blastema and of ureteric bud tip.
Article
Business, Finance
Annick Pamen Nyola, Alain Sauviat, Amine Tarazi
Summary: This paper investigates how host country and home country regulations affect the decision-making process of European Union banks and their foreign affiliates in different countries. The findings suggest that banks prefer to invest in high-income countries with numerous activity restrictions and weaker supervision, while they choose less developed countries with less restrictions and stronger supervision for investment. The study also reveals that banks tend to operate subsidiaries in high and middle-income countries with stringent entry requirements, but opt for branches in developing countries with stricter capital requirements and greater supervisory power.
INTERNATIONAL JOURNAL OF FINANCE & ECONOMICS
(2022)
Article
Medicine, Research & Experimental
Beatrix Sarkany, Gyula Kovacs, Daniel Banyai
Summary: Recent research suggests that not only the nephrogenic blastema but also the ureteric bud may be involved in the oncogenesis of Wilms' tumor. The study found KRT17-positive tubular structures resembling ureteric bud derivatives in both nephrogenic rests and Wilms' tumors, indicating a potential role of the ureteric bud in the histogenesis of these tumors.
Article
Business, Finance
Paula Cruz-Garcia, Jesus Peiro-Palomino
Summary: This paper examines the impact of bank branch density on income inequality in the Spanish provinces during the post-crisis years (2015-2019). The study finds that bank branch density has no significant effect on income inequality during this period, which contradicts previous literature suggesting that bank branches reduce inequality. The emergence of digitalization and new forms of banking are potential explanations for these results.
FINANCE RESEARCH LETTERS
(2023)
Editorial Material
Plant Sciences
Jack H. Kelly, Philip B. Brewer
Summary: Short stature crops have advantages such as lodging resistance, easy management, and high yield. However, changes in the gibberellin pathway may have negative effects on other important traits. Efforts are currently being made to address the side effects of gibberellin or explore alternative dwarfing pathways.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Review
Gastroenterology & Hepatology
Amanda E. Hird, Andra Nica, Natalie G. Coburn, Girish S. Kulkarni, Robert K. Nam, Lilian T. Gien
Summary: Prophylactic ureteric stent insertion did not reduce the risk of ureteric injury, but significantly prolonged operating time. There was no significant impact on AKI, UTI, sepsis, LOS, and mortality rates.
COLORECTAL DISEASE
(2021)
Review
Immunology
Josephine A. Mapunda, Houyam Tibar, Wafa Regragui, Britta Engelhardt
Summary: Multiple Sclerosis (MS) is the most common inflammatory demyelinating disease of the central nervous system (CNS), with varying prevalence worldwide. Understanding how immune cells enter the CNS and the effects of immunomodulatory treatments on neuroinflammation is crucial. The brain barriers play a key role in regulating immune cell entry into the CNS.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Jian-geng Chiou, Kyle D. Moran, Daniel J. Lew
Summary: The diversity of cell morphologies is partly regulated by Rho-family GTPases. Understanding how cells generate different numbers of polarity sites is a fundamental question. Theoretical analyses predicted that as GTPase concentrations increase at different polarity sites, competition would slow down, allowing polarity sites to coexist.
Article
Horticulture
Giuseppe Ferrara, Carlo Porfido, Roberto Terzano, Ali Sarkhosh, Andrea Mazzeo
Summary: This research found that there are different types of buds in pomegranate plants and the flowers vary among cultivars. These observations suggest that pomegranate is more suitable for warm sub-tropical and tropical areas.