Article
Pharmacology & Pharmacy
Ivan Cavero-Redondo, Alicia Saz-Lara, Cristina Lugones-Sanchez, Diana P. Pozuelo-Carrascosa, Leticia Gomez-Sanchez, Jose Francisco Lopez-Gil, Luis Garcia-Ortiz, Rosa Maria Bruno, Manuel Angel Gomez-Marcos
Summary: This study synthesized and evaluated scientific evidence on the efficacy of antihypertensive drugs on arterial stiffness in patients with hypertension. The findings suggest that thiazide diuretics, ACE inhibitors, ARBs, and their combinations can effectively reduce pulse wave velocity, while ACE inhibitors and ARBs can reduce augmentation index.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Gabriele Brosolo, Andrea Da Porto, Luca Bulfone, Antonio Vacca, Nicole Bertin, Gianluca Colussi, Alessandro Cavarape, Leonardo A. Sechi, Cristiana Catena
Summary: The study found a significant association between plasma lipoprotein(a) (Lp(a)) levels and markers of vascular stiffening in hypertensive patients. This association may help predict cardiovascular risk and suggests that reducing Lp(a) levels could be beneficial for cardiovascular protection in hypertensive patients.
Article
Medicine, General & Internal
Konstantinos Markakis, Nikolaos Pagonas, Eleni Georgianou, Panagiota Zgoura, Benjamin J. Rohn, Sebastian Bertram, Maximilian Seidel, Sebastian Bettag, Hans-Joachim Trappe, Nina Babel, Timm H. Westhoff, Felix S. Seibert
Summary: The study found that in patients with shock, both oscillometric blood pressure monitoring devices were successful in completing hemodynamic assessments, but there were significant differences between invasive and non-invasive techniques. There were discrepancies in pulse wave velocity measurements between the two devices. Non-invasive peripheral blood pressure measurement may not always be successful in certain circumstances.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cardiac & Cardiovascular Systems
Lucas Busch, Yvonne Heinen, Manuel Stern, Georg Wolff, Goksen Ozaslan, Konstantina Tzetou, Roberto Sansone, Christian Heiss, Malte Kelm
Summary: Angioplasty of flow-limiting stenoses in patients with peripheral artery disease can lower aortic and brachial blood pressure, especially in patients with more severe lesions and higher baseline systolic blood pressure.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Chemistry, Multidisciplinary
Minyoung Kim, Ruda Lee, Nyeonju Kang, Moon-Hyon Hwang
Summary: This study investigated the impact of limb-specific resistance training on arterial stiffness in young adults. Results showed that upper-limb resistance training could decrease central artery wave reflection and potentially improve local peripheral artery stiffness in healthy young adults.
APPLIED SCIENCES-BASEL
(2021)
Article
Cardiac & Cardiovascular Systems
Xianjin Hu, Xin Zhang, Zhipeng Zhang, Xinran Li, Qiling Gou, Runyu Ye, Xiaoping Chen
Summary: This study found that total cholesterol and non-HDL cholesterol were associated with vascular compliance alterations in normotensive men. In pre-menopausal women, LDL cholesterol, non-HDL cholesterol, TC/HDL cholesterol, and LDL cholesterol/HDL cholesterol were associated with vascular compliance alterations. However, lipid parameters did not appear to be linked to vascular function in post-menopausal women.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Endocrinology & Metabolism
Andrew M. South, Joseph Rigdon, Saroja Voruganti, Jeanette M. Stafford, Dana Dabelea, Santica Marcovina, Amy K. Mottl, Cate Pihoker, Elaine M. Urbina, Elizabeth T. Jensen
Summary: This study investigated the association between uric acid levels and blood pressure and arterial stiffness in adolescents and young adults with type 1 diabetes. The results showed no significant relationship between uric acid and blood pressure or arterial stiffness in these patients. These findings support the results of clinical trials in older adults with diabetes, which show that lowering uric acid levels does not improve cardiovascular health.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Lucia Salvi, Jacopo Alfonsi, Andrea Grillo, Alessandro Pini, Davide Soranna, Antonella Zambon, Davide Pacini, Roberto Di Bartolomeo, Paolo Salvi, Gianfranco Parati
Summary: This study evaluated aortic distensibility and pulse waveform patterns associated with ascending aortic aneurysm, and analyzed the hemodynamic changes induced by prosthetic replacement of the ascending aorta. The results showed that replacing the ascending aorta with a noncompliant vascular prosthesis did not worsen global aortic distensibility.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Peripheral Vascular Disease
Haojia Chen, Weiqiang Wu, Wei Fang, Zhichao Chen, Xiuzhu Yan, Youren Chen, Shouling Wu
Summary: This study evaluated the association between estimated pulse wave velocity (ePWV) and the incidence of hypertension, finding a positive correlation with both systolic and diastolic blood pressure. An increase in ePWV was associated with an increase in the incidence of hypertension.
JOURNAL OF HYPERTENSION
(2021)
Article
Physiology
Norsuhana Omar, Boon Seng Yeoh, Kalaivani Chellappan, Sara Zijiun Chui, Norizam Salamt, Amilia Aminuddin
Summary: Cardiovascular diseases (CVDs) are the leading cause of mortality and morbidity in Malaysia and worldwide. The prevalence of risk factors such as hypertension, dyslipidemia, smoking, and obesity has contributed to this trend. Increased physical activity, as assessed by pulse wave velocity (PWVCF), augmentation index (AI), and finger photoplethysmography fitness (PPGF) index, has been associated with improved CVD risk factors. However, the effects of long-term exercise on PPGF index are still unclear.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Peripheral Vascular Disease
Lazaros K. Yofoglu, Fotios Karachalias, Marios K. Georgakis, Christos Tountas, Antonios A. Argyris, Yi Zhang, Theodoros G. Papaioannou, Jacques Blacher, Thomas Weber, Charalampos Vlachopoulos, Michel Safar, Athanase D. Protogerou
Summary: This study aimed to examine the relationship between pressure wave reflections (PWRs) and left ventricular mass. Through a meta-analysis of 19 studies, it was found that there is a significant association between PWRs and left ventricular mass, except for the aortic augmentation index as estimated by generalized transfer functions. The association between carotid augmentation index and left ventricular mass was higher among populations with higher heart rate.
Article
Physiology
Matthew P. Harber, Allison McCurry, Nicholas Carlini, Brandon Kistler, Bradley S. Fleenor
Summary: The study found that in healthy middle-aged men, pre-exercise caffeine ingestion led to higher central and peripheral systolic blood pressures, PWV, and AIx at 30 minutes post-exercise, indicating an increased left ventricular workload which may have implications for cardiovascular event risk.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Alessandro Scalia, Chadi Ghafari, Wivine Navarre, Philippe Delmotte, Rob Phillips, Stephane Carlier
Summary: This study demonstrates the advantages of non-invasive central blood pressure monitoring and validates the accuracy of different devices through comparison with invasive measurements. It also provides a novel method of validation using recognized gold standard transducers and highlights the potential for easily measuring pulse wave velocity during coronary angiography.
Article
Medicine, General & Internal
Paolo Salvi, Filippo Valbusa, Anna Kearney-Schwartz, Carlos Labat, Andrea Grillo, Gianfranco Parati, Athanase Benetos
Summary: This study found a significant inverse correlation between carotid-femoral pulse wave velocity and carotid distensibility, indicating a close relationship between aortic stiffness evaluated by the propagative method and local carotid cross-sectional distensibility.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Fabio Anastasio, Marzia Testa, Cinzia Ferreri, Arianna Rossi, Gaetano Ruocco, Mauro Feola
Summary: This study aimed to evaluate the prognostic role of arterial stiffness in heart failure patients. The results showed that arterial stiffness was inversely correlated with patient survival and could serve as a prognostic predictor. This study is important for understanding the pathogenesis and clinical outcome of heart failure patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Erifili Venieri, Constantina Aggeli, Aris Anastasakis, Helen Sambatakou, Christodoulos Stefanadis, Dimitrios Tousoulis
Summary: This study assessed the mitral valve in HCM patients and found that patients with and without obstruction share some common anatomic features, but those with obstruction have unique characteristics that may contribute to LVOT obstruction.
HELLENIC JOURNAL OF CARDIOLOGY
(2021)
Article
Dermatology
Theodosios Bisdas, Nikolaos Patelis, Georgia Argyrakopoulou, Dimitrios Tsiachris, Aristotelis Kurtis, Panagiotis Gargalianos-Kakoliris, Christodoulos Stefanadis
Summary: The complexity of critical limb ischemia (CLI) requires a dedicated multidisciplinary team for treatment. This study aimed to assess the effectiveness of referring CLI patients scheduled for major amputation elsewhere to a dedicated CLI center. The analysis showed that patients in severe stages of CLI who received a second opinion from a dedicated multidisciplinary team had high limb salvage and survival rates after major amputation.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2022)
Review
Pharmacology & Pharmacy
Hassan Yousefi, Ladan Mashouri, Samuel C. Okpechi, Nikhilesh Alahari, Suresh K. Alahari
Summary: The outbreak of the novel coronavirus has caused a major global public health concern, with over 31 million cases confirmed and efforts being made to repurpose existing cancer drugs to treat COVID-19. These drugs target the viral replication cycle and immune response, offering a potential novel approach to combat the virus.
BIOCHEMICAL PHARMACOLOGY
(2021)
Letter
Cardiac & Cardiovascular Systems
Georgios Zakynthinos, Gerasimos Siasos, Evangelos Oikonomou, Maria Gazouli, Konstantinos Mourouzis, Marina Zaromitidou, Vasiliki Tsigkou, Evanthia Bletsa, Panagiota Stampouloglou, Stamatis Tsouroulas, Georgios Marinos, Konstantinos Vlasis, Manolis Vavuranakis, Christodoulos Stefanadis, Dimitris Tousoulis
HELLENIC JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Erika Rimondi, Annalisa Marcuzzi, Fabio Casciano, Gianluca Tornese, Agnese Pellati, Barbara Toffoli, Paola Secchiero, Elisabetta Melloni
Summary: This study demonstrates that vitamin D deficiency may contribute to the formation and instability of atheromatous plaques in mice, suggesting a potential role for vitamin D in preventing or delaying atheromatous disease in cardiovascular disorders. Further research is needed to fully understand the impact of vitamin D in cardiovascular diseases.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Nutrition & Dietetics
Alexandra Foscolou, Christina Chrysohoou, Kyriakos Dimitriadis, Konstantina Masoura, Georgia Vogiatzi, Viktor Gkotzamanis, George Lazaros, Costas Tsioufis, Christodoulos Stefanadis
Summary: This study aimed to evaluate the sociodemographic, lifestyle, and clinical characteristics of Ikarian islanders and identify healthy aging trajectories of multimorbidity. The results showed that multimorbidity was negatively correlated with a healthy aging index (HAI), with a 20% lower odds of multimorbidity for every 10-unit increase in HAI. Multimorbidity trends in relation to HAI varied between men and women at different ages, converging only in the seventh decade of life.
Letter
Medicine, General & Internal
Ioannis Doundoulakis, Dimitris Tsiachris, Konstantinos A. Gatzoulis, Christodoulos Stefanadis, Konstantinos Tsioufis
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Dimitris Tsiachris, Ioannis Doundoulakis, Panagiotis Tsioufis, Eirini Pagkalidou, Christos-Konstantinos Antoniou, Stefanos M. Zafeiropoulos, Konstantinos A. Gatzoulis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: This systematic review compares the effectiveness and safety of class Ic agents for cardioversion of paroxysmal AF and finds that intravenous flecainide is the most effective option. Class Ic agents appear to be safe for pharmacologic cardioversion of AF regardless of the presence of SHD.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Economics
Jay Pil Choi, Christodoulos Stefanadis
Summary: This article examines tippy network markets that allow price discrimination and finds that under certain conditions, network competition may lead to a unique subgame-perfect equilibrium where the winner's identity is fully determined by its product features. The concept of the dominant value margin is introduced as a metric for the effectiveness of divide-and-conquer strategies. However, the outcome of a market where suppliers with larger dominant value margins can sell to all customers does not necessarily result in social efficiency.
INTERNATIONAL ECONOMIC REVIEW
(2022)
Letter
Cardiac & Cardiovascular Systems
Christodoulos Stefanadis, Christina Chrysohoou, Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Panagiota Manolakou, Gerasimos Siasos, Konstantinos Tsioufis, George Panagiotakopoulos, Theoklis Zaoutis, Demosthenes Panagiotakos
HELLENIC JOURNAL OF CARDIOLOGY
(2022)
Letter
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Grigorios Chatzantonis, Christos-Konstantinos Antoniou, Haris Lalos, Gregory C. Bogdanis, Pantelis Nikolaou, Anastasios Spanos, Stefanos Karagiannis, Costas Tsiou, Ali Yilmaz, Christodoulos Stefanadis
HELLENIC JOURNAL OF CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Dimitris Tsiachris, Ioannis Doundoulakis, Christos-Konstantinos Antoniou, Eirini Pagkalidou, Stefanos Zafeiropoulos, Athanasios Kordalis, Konstantinos A. Gatzoulis, Gian-Battista Chierchia, Carlo de Asmundis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: This study conducted a systematic review and meta-analysis to evaluate the effectiveness and safety of a time to isolation (TTI)-based strategy of cryoballoon ablation (CBA) in the treatment of atrial fibrillation. The results suggest that an individualized CBA dosing strategy based on TTI and extended duration of CBA can reduce recurrence post-AF ablation and decrease procedure time and incidence of phrenic nerve palsy.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Ioannis Doundoulakis, Panagiota Manolakou, Athanasios Kordalis, Dimitrios Konstantinou, Konstantinos Gatzoulis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: This study compared the clinical outcomes of a three-dimensional electroanatomical mapping (3D-EAM)-based strategy targeting slow pathway (SP) elimination with the conventional fluoroscopic approach in atrioventricular node reentrant tachycardia (AVNRT) ablation. The results showed that 3D-EAM improved procedural parameters, reduced fluoroscopy time and dose, and increased SP elimination frequency. Follow-up results demonstrated lower recurrence rates and redo procedure rates in the 3D-EAM-based group.
JOURNAL OF ARRHYTHMIA
(2022)
Review
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Ioannis Doundoulakis, Panagiota Manolakou, Demetrios Sougiannis, Athanasios Kordalis, Konstantinos A. Gatzoulis, Gian-Battista Chierchia, Carlo de Asmundis, Christodoulos Stefanadis, Konstantinos Tsioufis
Summary: Nowadays, cryoballoon (CB) has become an established alternative to radio frequency (RF) ablation for pulmonary vein isolation (PVI), with the ability to isolate PVs in a single application. In a study on over 1000 consecutive patients, our center optimized the CB PVI procedure. It is expected that future guidelines will recommend CB as the first-line PVI for patients with paroxysmal AF and a class I indication. In a long-term follow-up of the EARLY-AF trial, CB showed a lower incidence of persistent atrial fibrillation compared to anti-arrhythmic drugs.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Review
Peripheral Vascular Disease
Shane A. Phillips, Kendra Osborn, Chueh-Lung Hwang, Ahmad Sabbahi, Mariann R. Piano
Summary: Oxidative stress is implicated in the development of many ethanol-induced pathologies, contributing to endothelial dysfunction and cardiovascular diseases such as hypertension. Ethanol consumption may alter vascular cell function and microvascular function, increasing the risk for hypertension. Data from human investigations have shown an association between alcohol consumption, changes in blood pressure, and hypertension risk.
CURRENT HYPERTENSION REVIEWS
(2021)