Article
Cardiac & Cardiovascular Systems
Hyun-Jung Lee, Hyung-Kwan Kim, Tae-Min Rhee, You-J Ung Choi, In-Chang Hwang, Yeonyee E. Yoon, Jun-Bean Park, Seung-Pyo Lee, Yong-Jin Kim, Goo-Yeong Cho
Summary: LARS can be used to categorize LV diastolic function and predict HF events in patients with hypertrophic cardiomyopathy.
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Mirae Lee, Alon Shechter, Donghee Han, Long-Co Nguyen, Min Sun Kim, Daniel S. Berman, Florian Rader, Robert J. Siegel
Summary: This study evaluated the morphologic progression of the left ventricle (LV) in apical hypertrophic cardiomyopathy (AHC) patients using serial echocardiograms. The results showed that about half of the patients had changes in LV morphology, with some patients experiencing further hypertrophic involvement and the development of apical pouches or aneurysms. The study also found that patients with more severe LV hypertrophy and apical involvement had higher rates of adverse clinical events.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Marianne Forsa, Marit K. Smedsrud, Kristina H. Haugaa, Anders W. Bjerring, Andreas Fruh, Sebastian Sarvari, Hege W. Landgraff, Jostein Hallen, Thor Edvardsen
Summary: This study compared left ventricular (LV) hypertrophy in early adolescent athletes and hypertrophic cardiomyopathy (HCM) genotype positive patients. The results showed that LV hypertrophy was found in a similar proportion in both groups, but only HCM genotype positive patients showed progression of hypertrophy. The study also identified a potential grey zone of LV hypertrophy with septum thickness Z-scores ranging from 2.0 to 3.3. LV volumes remained larger in athletes. These findings can help clinicians distinguish physiological LV hypertrophy from early HCM.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Vivek Jani, Filip Konecny, Aaron Shelby, Aparna Kulkarni, James Hammel, Andreas Schuster, John Lof, David Danford, Shelby Kutty
Summary: This study investigated the effects of pulmonary stenosis and pulmonary insufficiency on ventricular interactions using a porcine model. The results showed that pulmonary stenosis was associated with preserved LV systolic function and evidence of some LV diastolic dysfunction, while pulmonary insufficiency was associated with LV systolic dysfunction and noncompliance.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Hyun-Jung Lee, Hyung-Kwan Kim, Sang Chol Lee, Jihoon Kim, Jun-Bean Park, In-Chang Hwang, You-Jung Choi, Seung-Pyo Lee, Sung-A Chang, Whal Lee, Eun-Ah Park, Goo-Yeong Cho, Yong-Jin Kim
Summary: This study investigated the prognostic role of LV-GLS and its incremental value in predicting SCD in patients with HCM. The results showed that lower LV-GLS values were associated with higher rates of SCD events. LV-GLS provided additional information to established risk models and improved their predictive performance for SCD.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Chemistry, Multidisciplinary
Krzysztof Sadowski, Ryszard Piotrowicz, Mariusz Klopotowski, Jadwiga Wolszakiewicz, Agnieszka Lech, Adam Witkowski, Edyta Smolis-Bak, Ilona Kowalik, Anna Mierzynska, Dorota Piotrowska, Piotr Dobrowolski, Maciej Dobrowski, Ewa Sadowy, Ewa Piotrowicz
Summary: The study aims to assess the effectiveness and safety of hybrid cardiac rehabilitation in HCM patients without LV outflow tract obstruction and preserved systolic function, providing innovative data for this population.
APPLIED SCIENCES-BASEL
(2022)
Article
Multidisciplinary Sciences
Zheina Cherneva, Dinko Valev, Vania Youroukova, Radostina Cherneva
Summary: This study aimed to evaluate the predictive value of inflammatory, oxidative stress, cardio-pulmonary, and echocardiographic parameters at rest for the diagnosis of stress LVDD in non-severe COPD patients. Results showed a high prevalence of masked HFpEF in COPD patients, with parameters like RV E/A >0.75 being the best independent predictors for stress LVDD.
Article
Acoustics
Xin Hu, Yuwei Bao, Ying Zhu, Kangchao Zheng, Jun Zhang, Wei Zhou, Youbin Deng, Yani Liu
Summary: This study aimed to investigate the predictive value of multiple strain parameters for myocardial fibrosis in patients with hypertrophic cardiomyopathy (HCM) using speckle tracking automated functional imaging (AFI). The results showed that GLS could predict significant myocardial fibrosis.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2023)
Review
Medicine, General & Internal
Beatrice Musumeci, Giacomo Tini, Domitilla Russo, Matteo Sclafani, Francesco Cava, Alessandro Tropea, Carmen Adduci, Francesca Palano, Pietro Francia, Camillo Autore
Summary: While most patients with hypertrophic cardiomyopathy (HCM) exhibit a stable phenotype, certain patients may experience progressive changes in left ventricular (LV) wall thickness, cavity size, and function, overall defined as LV remodeling. Various pathophysiologic mechanisms, from genetic factors to myocardial ischemia and fibrosis, contribute to this process. Different patterns of LV remodeling have specific impacts on the clinical course and management of the disease, underscoring the importance of serial multimodal evaluations to identify and characterize LV remodeling. A more comprehensive definition of disease stages may offer opportunities to improve management of HCM patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Mark Sherrid, Samuel Bernard, Nidhi Tripathi, Yash Patel, Vivek Modi, Leon Axel, Soheila Talebi, Brian B. Ghoshhajra, Danita Y. Sanborn, Muhamed Saric, Elizabeth Adlestein, Isabel Castro Alvarez, Yuhe Xia, Daniel G. Swistel, Daniele Massera, Michael A. Fifer, Bette Kim
Summary: This study investigated the frequency of mid-LV obstruction in apical aneurysms of hypertrophic cardiomyopathy (HCM). The results showed that 95% of patients with aneurysms had mid-LV obstruction. Further research is needed to explore the relationship between mid-LV obstruction and aneurysms.
JACC-CARDIOVASCULAR IMAGING
(2023)
Review
Medicine, General & Internal
Errico Federico Perillo, Grazia Canciello, Felice Borrelli, Gaetano Todde, Massimo Imbriaco, Leopoldo Ordine, Salvatore Di Napoli, Raffaella Lombardi, Giovanni Esposito, Maria-Angela Losi
Summary: Hypertrophic cardiomyopathy (HCM) is a genetic disease with a varied clinical presentation and prognosis. A subgroup of patients with HCM may develop a left ventricular (LV) apical aneurysm, which is characterized by dysfunctional movement in the apex area of the heart. The main mechanism of this complication is believed to be the high pressure inside the aneurysm, combined with reduced blood perfusion, leading to ischemia and myocardial injury. However, the effectiveness of preventative treatment options such as anticoagulation and intracardiac defibrillator is still uncertain.
Article
Cardiac & Cardiovascular Systems
Kristine Andreassen, Lars A. Dejgaard, Oyvind Lie, Trine S. Fink, Ida G. Lunde, Thor Edvardsen, Kristina H. Haugaa, Mathis K. Stokke
Summary: This study found that more exercise training during childhood and adolescence was associated with favorable left ventricular (LV) diastolic function in patients with hypertrophic cardiomyopathy (HCM) and individuals with an HCM-causative genotype. The results indicate that exercise training initiated during childhood and adolescence has positive effects on cardiac function later in life for individuals with HCM or an HCM-causative genotype.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Silvia Aguiar Rosa, Luis Rocha Lopes, Luisa Branco, Ana Galrinho, Antonio Fiarresga, Boban Thomas, Pedro Bras, Antonio Goncalves, Isabel Cardoso, Ana Papoila, Marta Alves, Pedro Rio, Ines Cruz, Mafalda Selas, Filipa Silva, Ana Silva, Rui Cruz Ferreira, Miguel Mota Carmo
Summary: Lower CFVR is associated with impairment in biventricular systolic function parameters and functional capacity in patients with hypertrophic cardiomyopathy (HCM).
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Masliza Mahmod, Betty Raman, Kenneth Chan, Sanjay Sivalokanathan, Robert W. Smillie, Azlan H. Abd Samat, Rina Ariga, Sairia Dass, Elizabeth Ormondroyd, Hugh Watkins, Stefan Neubauer
Summary: This study found that right ventricular (RV) function and left ventricular (LV) function decrease over time in hypertrophic cardiomyopathy (HCM), while left ventricular ejection fraction (LVEF) remains preserved. Reduced RV function is associated with adverse cardiovascular outcomes, and assessing RV function in early HCM disease may help prevent future cardiovascular events.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2022)
Article
Medicine, General & Internal
Ji-won Hwang, Sang-Chol Lee, Darae Kim, Jihoon Kim, Eun Kyoung Kim, Sung-A Chang, Sung-Ji Park, Sung Mok Kim, Yeon Hyeon Choe, Joong Hyun Ahn, Seung Woo Park
Summary: The present study aimed to identify factors that may affect exercise capacity in patients with hypertrophic cardiomyopathy (HCM). The results showed that age, female sex, increased NT-proBNP level, and E/e' ratio on echocardiography were significantly associated with decreased exercise capacity. Monitoring hemodynamic changes and increased filling pressure on echocardiography is important for improved outcomes in this population.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Chi Young Shim, Jiwon Seo, Young Jin Kim, Seung Hyun Lee, Raffaele De Caterina, Sak Lee, Geu-Ru Hong
Summary: This study compared the efficacy and safety of edoxaban with warfarin in patients early after surgical bioprosthetic valve implantation or valve repair. The results showed that edoxaban is noninferior to warfarin for preventing thromboembolism and is potentially comparable for risk of major bleeding.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Seo-Yeon Gwak, Kyu-Yong Ko, Iksung Cho, Geu-Ru Hong, Jong-Won Ha, Chi Young Shim
Summary: This study found that young age at operation, chronic kidney disease, elevated pressure gradient across the bioprosthetic mitral valve early after surgery, and postsurgical anemia are associated with bioprosthetic mitral valve dysfunction (MVD). Bioprosthetic MVD is associated with poor clinical outcomes.
Letter
Cardiac & Cardiovascular Systems
Dae-Young Kim, Iksung Cho, Geu-Ru Hong, Jong-Won Ha, Chi Young Shim
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Letter
Cardiac & Cardiovascular Systems
Darae Kim, Minjeong Kim, Jae Berm Park, Juhan Lee, Kyu Ha Huh, Geu-Ru Hong, Jong-Won Ha, Jin-Oh Choi, Chi Young Shim
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Kyu Kim, Dae-Young Kim, Jiwon Seo, Iksung Cho, Chi Young Shim, Geu-Ru Hong, Jong-Won Ha
Summary: This study evaluated the efficacy of the measured effective orifice area (EOA)/reference EOA ratio in discriminating mechanical prosthetic aortic valve (PAV) obstruction. The results showed that the measured/reference EOA ratio had better discriminative ability in identifying obstruction compared to conventional parameters.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Jae-Sun Uhm, Kyu-Yong Ko, Chi Young Shim, Je-Wook Park, Minkwan Kim, Sung A. Bae, In Hyun Jung, In-Soo Kim, Jong Youn Kim, Eui-Young Choi, Won Jeong Son, Yun Ho Roh, Hee Tae Yu, Tae-Hoon Kim, Geu-Ru Hong, Boyoung Joung, Hui-Nam Pak, Moon-Hyoung Lee
Summary: This study aimed to investigate the relationship between premature ventricular complexes (PVCs) and right ventricular (RV) dysfunction, and the impact of radiofrequency catheter ablation (RFCA) on RV function. The results showed that frequent PVCs are associated with RV dysfunction and successful RFCA can reverse RV dysfunction.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Minkwan Kim, Chan Joo Lee, Hye-Jin Kang, Nak-Hoon Son, SungA Bae, Jiwon Seo, Jaewon Oh, Se-Joong Rim, In Hyun Jung, Eui-Young Choi, Seok-Min Kang
Summary: This study aimed to evaluate the impact of red cell distribution width (RDW) on the prognosis of patients with heart failure. The results showed that elevated RDW at the time of diagnosis was associated with poor prognosis in patients with heart failure, independent of clinical risk factors and echocardiographic parameters. RDW may have important implications in the management of patients with heart failure.
Article
Cardiac & Cardiovascular Systems
Eun Kyoung Kim, Hong-Mi Choi, Jong-Hwan Lee, Dong Woo Han, Hye Sun Lee, Eui-Young Choi
Summary: Preoperative echocardiography can predict the risk of postoperative adverse cardiovascular events in low-risk non-cardiac surgery patients, which is of great significance in clinical practice.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Medicine, General & Internal
Hyemoon Chung, Eui-Young Choi
Summary: This article reviews the role of multimodal imaging in patients with hypertrophic cardiomyopathy (HCM) and atrial fibrillation (AF), emphasizing the importance of evaluating the morphology and physiology of the atrium and ventricle for treatment and prognosis determination.