Journal
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
Volume 25, Issue 6, Pages 1079-1082Publisher
SPRINGER
DOI: 10.1007/s13361-014-0872-5
Keywords
Gaussian laser beam profile; Aspheric laser optics; MALDI; SmartBeam; High spatial resolution
Funding
- National Institutes of Health [5P41GM103391-03]
- NIH/NIGMS [5R01 GM058008-14]
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We have investigated the use of a Gaussian beam laser for MALDI Imaging Mass Spectrometry to provide a precisely defined laser spot of 5 mu m diameter on target using a commercial MALDI TOF instrument originally designed to produce a 20 mu m diameter laser beam spot at its smallest setting. A Gaussian beam laser was installed in the instrument in combination with an aspheric focusing lens. This ion source produced sharp ion images at 5 mu m spatial resolution with signals of high intensity as shown for images from thin tissue sections of mouse brain.
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