Journal
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
Volume 24, Issue 8, Pages 1161-1166Publisher
SPRINGER
DOI: 10.1007/s13361-013-0660-7
Keywords
Microorganisms; Proteomics; Detect-to-protect; Detect-to-treat
Funding
- DARPA
- HSARPA
- DHS
- DOD
- NIHGMS
- German Science Foundation
- ARCS Foundation
- NATIONAL CENTER FOR RESEARCH RESOURCES [S10RR023383] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM021248] Funding Source: NIH RePORTER
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Strategies for the rapid and reliable analysis of microorganisms have been sought to meet national needs in defense, homeland security, space exploration, food and water safety, and clinical diagnosis. Mass spectrometry has long been a candidate technique because it is extremely rapid and can provide highly specific information. It has excellent sensitivity. Molecular and fragment ion masses provide detailed fingerprints, which can also be interpreted. Mass spectrometry is also a broad band method-everything has a mass-and it is automatable. Mass spectrometry is a physiochemical method that is orthogonal and complementary to biochemical and morphological methods used to characterize microorganisms.
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