Journal
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
Volume 22, Issue 10, Pages 1885-1890Publisher
SPRINGER
DOI: 10.1007/s13361-011-0203-z
Keywords
Imaging Mass Spectrometry; Washing; Peptides and Proteins; MALDI; SIMS
Funding
- Nederlandse organisatie voor Wetenschappelijk Onderzoek (NWO)
- National Institutes of Health (NIH) [R01 CA134695]
- Netherlands Proteomics Centre
Ask authors/readers for more resources
Surface treatment of biological tissue sections improves detection of peptides and proteins for mass spectrometry imaging. However, liquid surface treatments can result in diffusion of surface analytes and fragile tissue sections can be easily damaged by typical washing solvents. Here, we present a new surface washing procedure for mass spectrometry imaging. This procedure uses solvent wetted fiber-free paper to enable local washing of tissue sections for mass spectrometry imaging and tissue profiling experiments. In addition, the method allows fragile tissues that cannot be treated by conventional washing techniques to be analyzed by mass spectrometry imaging.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available