Conformation and dynamics of biopharmaceuticals: Transition of mass spectrometry-based tools from academe to industry

Two recombinant human interferon-beta 1a pharmaceutical preparations produce a similar transcriptional response determined using whole genome microarray analysis

(2011) A.E. Sterin Prync et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

Homology model of human interferon-α8 and its receptor complex

(2010) Marian H. Seto et al.   PROTEIN SCIENCE

H/D Exchange and Mass Spectrometry in the Studies of Protein Conformation and Dynamics: Is There a Need for a Top-Down Approach?

(2009) Igor A. Kaltashov et al.   ANALYTICAL CHEMISTRY

Characterization of IgG1 Conformation and Conformational Dynamics by Hydrogen/Deuterium Exchange Mass Spectrometry

(2009) Damian Houde et al.   ANALYTICAL CHEMISTRY

Extending Mass Spectrometry Contribution to Therapeutic Monoclonal Antibody Lead Optimization: Characterization of Immune Complexes Using Noncovalent ESI-MS

(2009) Cédric Atmanene et al.   ANALYTICAL CHEMISTRY

Recommendations regarding technical standards for follow-on biologics: comparability, similarity, interchangeability

(2009) Gregory C. Davis et al.   CURRENT MEDICAL RESEARCH AND OPINION

Existence of a Noncanonical State of Iron-Bound Transferrin at Endosomal pH Revealed by Hydrogen Exchange and Mass Spectrometry

(2009) Cedric E. Bobst et al.   JOURNAL OF MOLECULAR BIOLOGY

Discrimination among IgG1-κ monoclonal antibodies produced by two cell lines using charge state distributions in nanoESI-TOF mass spectra

(2009) Leila Zamani et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Whatever Happened to Immunotoxins? Research, and Hope, Are Still Alive

(2009) D. C. Holzman   JNCI-Journal of the National Cancer Institute

Gearing up for follow-on biologics

(2009) Bethan Hughes   NATURE REVIEWS DRUG DISCOVERY

Gas-Phase Proton-Transfer Chemistry Coupled with TOF Mass Spectrometry and Ion Mobility-MS for the Facile Analysis of Poly(ethylene glycols) and PEGylated Polypeptide Conjugates

(2008) Dhanashri Bagal et al.   ANALYTICAL CHEMISTRY

Detection and Characterization of Altered Conformations of Protein Pharmaceuticals Using Complementary Mass Spectrometry-Based Approaches

(2008) Cedric E. Bobst et al.   ANALYTICAL CHEMISTRY

The Impact of PEGylation on Biological Therapies

(2008) Francesco M Veronese et al.   BIODRUGS

Formulations for delivery of therapeutic proteins

(2008) Snjezana Stolnik et al.   BIOTECHNOLOGY LETTERS

Nucleic Acids as Therapeutic Agents

(2008) Luis Alvarez-Salas   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The Stability of the Ternary Interferon-Receptor Complex Rather than the Affinity to the Individual Subunits Dictates Differential Biological Activities

(2008) Eyal Kalie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein structure and dynamics studied by mass spectrometry: H/D exchange, hydroxyl radical labeling, and related approaches

(2008) Lars Konermann et al.   JOURNAL OF MASS SPECTROMETRY

Ligand Binding Induces a Conformational Change in ifnar1 that Is Propagated to Its Membrane-Proximal Domain

(2008) Jennifer Julia Strunk et al.   JOURNAL OF MOLECULAR BIOLOGY

Effects of glycosylation on the stability of protein pharmaceuticals

(2008) Ricardo J. Solá et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Do Ionic Charges in ESI MS Provide Useful Information on Macromolecular Structure?

(2008) I KALTASHOV et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Mass spectrometry for structural characterization of therapeutic antibodies

(2008) Zhongqi Zhang et al.   MASS SPECTROMETRY REVIEWS

Native mass spectrometry: a bridge between interactomics and structural biology

(2008) Albert J R Heck   NATURE METHODS

Scientific and Legal Viability of Follow-on Protein Drugs

(2008) David M. Dudzinski et al.   NEW ENGLAND JOURNAL OF MEDICINE

The EM Structure of a Type I Interferon–Receptor Complex Reveals a Novel Mechanism for Cytokine Signaling

(2007) Zongli Li et al.   JOURNAL OF MOLECULAR BIOLOGY

Protein therapeutics: a summary and pharmacological classification

(2007) Benjamin Leader et al.   NATURE REVIEWS DRUG DISCOVERY