Article
Infectious Diseases
Kawisara Krasaewes, Saowaluck Yasri, Phadungkiat Khamnoi, Romanee Chaiwarith
Summary: The study shows that implementing a management protocol for patients with Staphylococcus aureus bloodstream infection can improve quality of care, but the mortality rate did not decrease.
Article
Infectious Diseases
Emanuele Pivetta, Silvia Corcione, Paolo Peasso, Irene Cara, Alberto Capodanno, Andrea Brussino, Paolo Petitti, Eleonora Galli, Maddalena Galmozzi, Valeria Ghisetti, Rossana Cavallo, Franco Apra, Enrico Lupia, Francesco Giuseppe De Rosa, Giuseppe Montrucchio
Summary: Bloodstream infections (BSI) are increasingly common reasons for hospital admissions. Differentiating between community-acquired and healthcare-associated (HCA) BSI is important due to varying risks of multidrug resistance (MDR). A retrospective study was conducted in three cohorts to develop and validate a prognostic model for identifying MDR non-hospital-acquired (non-HA) BSI. The model includes various factors such as age, gender, and recent medical procedures, and shows acceptable performance with a C-index of 70%.
Article
Critical Care Medicine
Alexis Tabah, Niccolo Buetti, Quentin Staiquly, Stephane Ruckly, Murat Akova, Abdullah Tarik Aslan, Marc Leone, Andrew Conway Morris, Matteo Bassetti, Kostoula Arvaniti, Jeffrey Lipman, Ricard Ferrer, Haibo Qiu, Jose-Artur Paiva, Pedro Povoa, Liesbet De Bus, Jan De Waele, Farid Zand, Mohan Gurjar, Adel Alsisi, Khalid Abidi, Hendrik Bracht, Yoshiro Hayashi, Kyeongman Jeon, Muhammed Elhadi, Francois Barbier, Jean-Francois Timsit
Summary: This study investigated hospital-acquired bloodstream infections (HA-BSI) in 2600 adult patients from 333 ICUs in 52 countries. HA-BSI were frequently caused by Gram-negative, carbapenem-resistant, and difficult-to-treat pathogens. Antimicrobial resistance led to delays in adequate antimicrobial therapy, resulting in high mortality rates.
INTENSIVE CARE MEDICINE
(2023)
Article
Immunology
Andrew Bock, Blake M. Hanson, Felicia Ruffin, Joshua B. Parsons, Lawrence P. Park, Batu Sharma-Kuinkel, Michael Mohnasky, Cesar A. Arias, Vance G. Fowler, Joshua T. Thaden
Summary: Recurrent gram-negative bacterial bloodstream infections (GNB-BSI) are mainly caused by relapse, and pulsed-field gel electrophoresis accurately differentiates relapse from reinfection. Having a cardiac device is a risk factor for relapse.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Luciana Rodrigues Pires de Campos, Marina Farrel Cortes, Beatriz Deo, Camila Rizek, Sania Santos, Lauro Perdigao, Silvia Figueiredo Costa
Summary: Mechanical ventilation, surgery, and hemodialysis are independent risk factors for multidrug-resistant bloodstream infections in critically ill trauma patients. Carbapenemase (KPC) is the main mechanism of resistance, and cross-transmission may contribute to its spread.
AMERICAN JOURNAL OF INFECTION CONTROL
(2022)
Article
Public, Environmental & Occupational Health
Sheena Mukkada, Mario Melgar, Craig Bullington, Alicia Chang, Maysam R. Homsi, Miriam L. Gonzalez, Federico Antillon, Yin Su, Li Tang, Miguela A. Caniza
Summary: Infectious complications remain major contributors to adverse outcomes in patients treated for non-communicable disease, particularly in resource limited settings. Investments in laboratory and clinical data collection are critical to understanding the contributors to poor outcomes and therefore to improving the quality of bloodstream infection management in resource limited settings.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Microbiology
Mark T. Anderson, Aric N. Brown, Ali Pirani, Sara N. Smith, Amanda L. Photenhauer, Yuang Sun, Evan S. Snitkin, Michael A. Bachman, Harry L. T. Mobley
Summary: Bloodstream infections, caused by Gram-negative species, are a significant public health burden due to high mortality rates and treatment costs. A study characterizing infection kinetics and bacterial replication rates of six common pathogens in a murine model revealed different colonization abilities in major organs. While some species replicated rapidly in the liver or kidney, others were steadily cleared from targeted organs during infection, highlighting the complex dynamics of bacterial replication and immune-mediated clearance. Insights from this study may aid in developing strategies to combat bloodstream infections in the future.
Article
Microbiology
Mark Verway, Kevin A. Brown, Alex Marchand-Austin, Christina Diong, Samantha Lee, Bradley Langford, Kevin L. Schwartz, Derek R. MacFadden, Samir N. Patel, Beate Sander, Jennie Johnstone, Gary Garber, Nick Daneman
Summary: This study aimed to describe the population-wide prevalence of BSIs and examine the associated mortality risk for the responsible microorganisms. The results showed that BSIs are associated with increased mortality risk, which varies across different organisms.
JOURNAL OF CLINICAL MICROBIOLOGY
(2022)
Article
Critical Care Medicine
Jordy P. Pijl, Mark Londema, Thomas C. Kwee, Maarten W. N. Nijsten, Riemer H. J. A. Slart, Rudi A. J. O. Dierckx, Peter H. J. van der Voort, Andor W. J. M. Glaudemans, Janesh Pillay
Summary: This study evaluated the diagnostic yield of FDG-PET/CT in intensive care patients with BSI, showing a high sensitivity and specificity for identifying infection foci. Poor image quality was significantly associated with decreased likelihood of finding infection foci.
Review
Infectious Diseases
Jessica Waters, Andrew F. F. Shorr
Summary: Newer antibiotics have been developed and proven effective in treating various types of multidrug-resistant infections, but there is limited information on their efficacy specifically for bloodstream infections.
Article
Emergency Medicine
Leon Hsueh, Janine Molino, Leonard Mermel
Summary: This study retrospectively analyzed the relationship between percentage of bands on an initial CBC and bloodstream infections and in-hospital mortality, finding a positive correlation between elevated bands and the risk of these adverse events. Particularly, clinical suspicion for bloodstream infections due to Gram-negative bacilli should rise if bands are elevated, prompting consideration of obtaining blood cultures.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Infectious Diseases
Kevin B. Laupland, David L. Paterson, Adam G. Stewart, Felicity Edwards, Patrick N. A. Harris
Summary: This study describes the epidemiology and outcome of Sphingomonas species bloodstream infections (BSI) in an Australian population. The findings suggest that this infection primarily occurs in the community and is associated with a significant risk of death.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Geriatrics & Gerontology
Yaara Leibovici-Weissman, Noam Tau, Dafna Yahav
Summary: Bloodstream infections (BSI) in older patients have higher incidence and mortality rates compared to younger patients, with potential differences in disease presentation. Old patients with BSI commonly have sources from urinary and respiratory tracts, with gram-negative bacteria being the most common isolates and long-term care facilities serving as reservoirs for multidrug-resistant bacteria. Mortality rates for BSI in older patients are higher, associated with factors such as appropriateness of antibiotic therapy and nosocomial acquisition of infection, while health-related quality of life issues for elderly patients with BSI are not well addressed in the literature.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Health Care Sciences & Services
Brett N. Hryciw, Stefan Rodic, Shehab Selim, Chuqi Wang, Melissa-Fay Lepage, Long Hoai Nguyen, Vineet Goyal, Carl van Walraven
Summary: This study derived and validated the Ottawa BSI Model, which uses commonly available data to predict the probability of bloodstream infection in acutely ill patients. The model showed good discrimination and calibration, and slight improvement in discrimination was observed when patients with acute SARS-CoV-2 infection were excluded from validation.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Melkam Birru, Melat Woldemariam, Aseer Manilal, Addis Aklilu, Tsegaye Tsalla, Asaye Mitiku, Tigist Gezmu
Summary: This study investigated bacterial bloodstream infections in a hospital in southern Ethiopia and found that the majority of infections were caused by Gram-positive cocci, with a high prevalence of multidrug resistance.
SCIENTIFIC REPORTS
(2021)