Article
Endocrinology & Metabolism
Giovanni Barassi, Raffaello Pellegrino, Celeste Di Matteo, Loris Prosperi, Edoardo Di Simone, Celeste Marinucci, Noemi Pepe, Federico Papa, Marta Odorisio, Valentina Zincani, Ilaria Gabriella Micolucci, Ali Younes, Angelo Di Iorio
Summary: This study considered data from 10 patients with non-specific chronic low back pain. The patients underwent six sessions of electrical neuromodulation applied to the areas of the skin with the most perturbed electrical conduction. The study observed improvements in the balance of electrical activity, temperature, disability caused by chronic low back pain, and pressure-pain threshold.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Medicine, General & Internal
Vanesa Canton-Habas, Maria Del Pilar Carrera-Gonzalez, Maria Teresa Moreno-Casbas, Manuel Rich-Ruiz
Summary: This study validated the adaptation of the PAINAD scale in Spanish, showing excellent content validity and internal consistency. The scale can effectively assess pain in patients with dementia who are unable to communicate verbally.
Review
Nursing
Yvette I-Pei Tsai, Graeme Browne, Kerry Jill Inder
Summary: Comprehensive pain models improve nurses' assessment and management of pain, while balance between pharmacological and non-pharmacological pain management is crucial in dementia care. The involvement of multidisciplinary health professionals is essential for the design of effective pain management interventions in dementia.
JOURNAL OF ADVANCED NURSING
(2021)
Article
Nursing
Yvette I-Pei Tsai, Graeme Browne, Kerry Jill Inder
Summary: This study evaluated nurses' documented practice when communicating about pain for people with dementia in hospital. The results showed that pain frequently occurs in people with dementia during hospitalization, but there are gaps in nurses' pain assessment and management, suggesting a potential knowledge gap and practice gap in dementia care. Further improvement is needed in nursing practice of pain assessment and management in dementia care in hospitals.
JOURNAL OF ADVANCED NURSING
(2022)
Article
Health Care Sciences & Services
Netta Bentur, Jiska Cohen-Mansfield, Zorian Radomyslsky
Summary: This study demonstrates the feasibility of improving pain assessment and identification among OPAD by using validated tools by family members and paid care workers. The correlations between family members and paid care workers ratings were statistically significant, especially when family members lived with the OPAD. The moderate and significant correlations between PAINE and PAINAD scores suggest potential for improving quality of care and life for OPAD.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2021)
Article
Geriatrics & Gerontology
Emma Dunford, Emily West, Elizabeth L. Sampson
Summary: This study evaluated the psychometric properties of the PAINAD scale in people with dementia. The results showed good inter-rater reliability and internal consistency, but modest test-retest reliability. The concurrent validity was weak, and there was no evidence of convergent validity. PAINAD scores were higher during movement, indicating discriminant validity.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Vanesa Canton-Habas, Manuel Rich-Ruiz, Maria Teresa Moreno-Casbas, Maria Jesus Ramirez-Exposito, Jose Manuel Martinez-Martos, Maria Del Pilar Carrera-Gonzalez
Summary: The study found a correlation between the PAINAD scale and salivary levels of sTNF-RII and sIgA, indicating the usefulness of the scale and confirming sTNF-RII and sIgA as biomarkers of pain.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Hugo Ribeiro, Raquel Alves, Joana Jorge, Ana Cristina Goncalves, Ana Bela Sarmento-Ribeiro, Manuel Teixeira-Verissimo, Jose Paulo Andrade, Marilia Dourado
Summary: This study aimed to investigate the potential non-invasive peripheral biomarkers for identifying and characterizing pain in severe dementia patients. The levels of monocytes and their phenotype markers CD11c, CD163, and CD206 were evaluated. The findings suggest that monocyte levels, particularly the classic subtype, and the expression levels of CD11c, CD163, and CD206 could serve as pain biomarkers in severe dementia patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Catherine Riffin, Lilla Brody, Priya Mukhi, Keela Herr, Karl Pillemer, Madeline Rogers, Charles R. Henderson Jr, M. Cary Reid
Summary: Despite the prevalence of pain in persons with dementia, it is often underdetected and undermanaged. This study evaluates a multicomponent intervention called the Pain Identification and Communication Toolkit (PICT) which provides training in observational pain assessment and coaching in pain communication techniques for family caregivers. The results show that PICT is feasible to implement, acceptable to caregivers, and has the potential to improve confidence in recognizing and communicating about pain.
INNOVATION IN AGING
(2023)
Article
Geriatrics & Gerontology
Jeffrey T. Boon, Keela Herr, Lori Schirle, Mary S. Dietrich, Cathy A. Maxwell
Summary: This study investigated the frequency of different elements of pain assessment used by family caregivers of people living with dementia (PLWD), as well as the correlations between caregivers' characteristics and their use of these elements. Participants reported frequent use of many pain assessment elements. Statistically significant correlations were found for caregiving self-efficacy and obtaining respite, as well as for responding to disruptive patient behaviors and multiple pain assessment elements. Further efforts are needed to describe pain assessments by family caregivers of PLWD.
Article
Medicine, General & Internal
Jing Tian, Graeme Jones, Xin Lin, Yuan Zhou, Anna King, James Vickers, Feng Pan
Summary: This study investigates the association between the number of chronic pain sites and the risk of dementia and its subtypes. The findings suggest that a greater number of chronic pain sites is associated with an increased risk of all-cause dementia and Alzheimer's disease, but not vascular and frontotemporal dementia.
Article
Nursing
Alicia Minaya-Freire, Mireia Subirana-Casacuberta, Emma Puigoriol-Juvanteny, Anna Ramon-Aribau
Summary: The study assessed pain management nursing practice in older adults with dementia through EHR and found variability in practices. Admission diagnosis correlated with analgesic administration schedule, number of drugs administered, and number of pain nursing annotations.
Review
Nursing
Wm. Larkin Iversen, Ronald L. Cowan, Sebastian Atalla, Sydney S. Englehart, Tanya R. Gure, Karen O. Moss, Claire M. Ryan, Douglas W. Scharre, Kathy D. Wright, Todd B. Monroe
Summary: The manuscript summarizes research on how experimental pain is experienced by adults with Alzheimer's disease and translates results into implications for nurses through discussing clinical vignettes and introducing research-related psychophysics. It emphasizes the importance of exploring pain characteristics in AD that differ from cognitively intact controls to provide high quality care to this population. Nurses are encouraged to consider research methodology and address pain issues in adults with AD.
Article
Cardiac & Cardiovascular Systems
Suvi Linna-Kuosmanen, Vanesa Tomas Bosch, Pierre R. Moreau, Maria Bouvy-Liivrand, Henri Niskanen, Emilia Kansanen, Annukka Kivela, Juha Hartikainen, Mikko Hippelainen, Hannu Kokki, Pasi Tavi, Anna-Liisa Levonen, Minna U. Kaikkonen
Summary: This study investigated the genome-wide effects of oxidized phospholipids on transcriptional gene regulation in endothelial cells, focusing on the role of miRNAs and NRF2 transcription factor. The results showed that NRF2 plays a key role in up-regulated transcripts and transcriptional initiation in response to oxidized phospholipids. Furthermore, NRF2 was identified as a novel regulator of over 100 endothelial pri-miRNAs, with miR-21-5p and miR-100-5p demonstrating opposing roles in gene expressions and potential correlation with the severity of coronary artery disease.
CARDIOVASCULAR RESEARCH
(2021)
Article
Clinical Neurology
Kathryn Gauthreaux, Walter A. Kukull, Karin B. Nelson, Charles Mock, Yen-Chi Chen, Kwun C. G. Chan, David W. Fardo, Yuriko Katsumata, Erin L. Abner, Peter T. Nelson
Summary: Research-oriented autopsy cohorts provide valuable insights into dementia pathobiology, but each study may have its own recruitment biases leading to disparate findings. This study suggests that the percentage of participants recruited while cognitively normal can predict differences in findings among autopsy research cohorts.
ALZHEIMERS & DEMENTIA
(2023)