Review
Cell Biology
Wei Zheng So, Natalie Shi Qi Wong, Hong Chang Tan, Molly Tzu Yu Lin, Isabelle Xin Yu Lee, Jodhbir S. Mehta, Yu-Chi Liu
Summary: This article reviews the relationship between diabetic corneal neuropathy and diabetic peripheral neuropathy, including their pathogenesis, clinical presentation, evaluation, and management. It emphasizes the importance of diabetic corneal neuropathy as a surrogate marker for detecting diabetic peripheral neuropathy.
NEURAL REGENERATION RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Xi Chen, Wanchun Wu, Wenwen Wei, Liqun Zou
Summary: Peripheral T-cell lymphomas (PTCLs) are highly heterogeneous and immune checkpoint therapies, particularly PD-1/PD-L1 blockers, show promise as a treatment option for this disease. The clinical trials of these blockers have demonstrated good efficacy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Kimo Bachiashvili, Liton Francisco, Yanjun Chen, Alysia Bosworth, Stephen J. Forman, Ravi Bhatia, Smita Bhatia
Summary: Therapy-related myeloid neoplasms (t-MN) are a major cause of nonrelapse mortality after autologous peripheral blood stem cell transplantation (aPBSCT) in patients with Hodgkin lymphoma (HL) and non-Hodgkin lymphomas (NHL). This study found that abnormalities in peripheral blood parameters (such as hemoglobin, hematocrit, white blood cell, and platelet counts) can help identify patients at high risk for t-MN, allowing for personalized close surveillance and potential interventions.
Article
Hematology
Mwanasha H. Merrill, Parastoo B. Dahi, Robert A. Redd, Mikaela M. Mcdonough, Yi-Bin Chen, Zachariah Defilipp, Alex F. Herrera, David C. Fisher, Ann S. Lacasce, Oreofe O. Odejide, Samuel Y. Ng, Caron A. Jacobson, Reid W. Merryman, Austin I. Kim, Yago L. Nieto, Craig S. Sauter, Gunjan L. Shah, Jasmine M. Zain, Philippe Armand, Eric D. Jacobsen
Summary: Autologous stem cell transplantation (ASCT) is commonly used as consolidation therapy for PTCL, but relapse is common with a poor prognosis. This study evaluated the efficacy of pembrolizumab, an anti-PD-1 monoclonal antibody, after ASCT in PTCL patients. The results showed promising activity, with a high percentage of patients achieving progression-free survival at 18 months after ASCT.
Article
Multidisciplinary Sciences
Ji Yun Lee, Joo Hyun Kim, Heejin Bang, Junhun Cho, Young Hyeh Ko, Seok Jin Kim, Won Seog Kim
Summary: ENKTL is an aggressive malignancy with a dismal prognosis. The study found EGR1 upregulation is associated with localized stage with low risk based on PINK index. High expression levels of CD59, GAS1, CXCR7, and RAMP3 genes are associated with a good survival prognosis. EGR1 may be a candidate for prognostic markers in ENKTL.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Ye Jin Lee, Young Sik Park, Hyun Woo Lee, Tae Yoen Park, Jung Kyu Lee, Eun Young Heo
Summary: The study investigated the predictive value of serum peripheral lymphocyte count (PLC) as a peripheral blood biomarker for Immune check point inhibitors (ICIs) response in NSCLC patients. Results showed that higher post-treatment PLC levels were significantly associated with improved progression-free survival (PFS) and overall survival (OS) in NSCLC patients. This suggests that PLC could be a helpful marker for predicting ICI responses in NSCLC patients.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Yi-Ying Xiong, Jing Wang, Li Wang, Jian-Bin Chen, Lin Liu, Xiao-Qiong Tang, Xin Wang, Hong-Bin Zhang
Summary: CEAC and IEAC regimens can be used as alternative conditioning regimens for autologous stem cell transplantation (ASCT) in peripheral T-cell lymphoma (PTCL) patients, and their efficacy and safety are comparable to the BEAM regimen. Patients with high PIT score and failure to reach complete response early after ASCT have worse outcomes.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Xia Feng, Xiangyi Luo, Yingmei Yang, Yuchen Fan, Qing Ye
Summary: The difference in PD-1 and PD-L1 levels between classical Hodgkin's lymphoma (cHL) and peripheral T-cell lymphoma (PTCL) has clinical implications, with potential for predicting patient prognosis and disease stage.
Article
Oncology
Hongye Gao, Meng Wu, Shaoxuan Hu, Ning Ding, Xinqiang Ji, Lan Mi, Xiaopei Wang, Yuqin Song, Jun Zhu, Weiping Liu
Summary: Consolidation therapy with ASCT may improve the long-term survival of PTCL patients in first CR or PR, especially for those with angioimmunoblastic T-cell lymphoma.
FRONTIERS IN ONCOLOGY
(2022)
Review
Medicine, General & Internal
Jun Du, Dandan Yu, Xinle Han, Lijun Zhu, Zoufang Huang
Summary: This study compared the efficacy and safety of allogeneic HSCT and autologous HSCT in treating refractory or relapsed peripheral T-cell lymphoma, and found that both had similar overall survival and progression-free survival outcomes, with allogeneic HSCT potentially offering specific survival benefits in certain patient populations.
Article
Oncology
Seok Jin Kim, Jae-Cheol Jo, Dok Hyun Yoon, Deok-Hwan Yang, Sang Eun Yoon, Gyeong-Won Lee, Jee Hyun Kong, Yong Park, Ka-Won Kang, Ho-Sup Lee, Sung Yong Oh, Ho-Jin Shin, Won Sik Lee, Yoon Seok Choi, Seong Hyun Jeong, Min Kyoung Kim, Hye Jin Kang, Jun Ho Yi, Sung-Nam Lim, Ho-Young Yhim, Young Rok Do, Hwan Jung Yun, Hyeon-Seok Eom, Mark Hong Lee, Cheolwon Suh, Won Seog Kim
Summary: For patients newly diagnosed with peripheral T-cell lymphoma (PTCL), upfront autologous stem cell transplantation (ASCT) is recommended, and CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone), an anthracycline-based chemotherapy, is the frontline treatment for PTCL. However, it is uncertain whether anthracycline-based chemotherapies, such as CHOP, can be the standard induction therapy for PTCL.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Jing Zhou, Jin Huang, Min Xiao, Ying Wang, Wei Zhang, Jie Wan, Yi Xiao, Jianfeng Zhou
Summary: High EBV-CN was associated with male and elderly patients, and patients in the high EBV-CN group had significantly worse survival rates. Additionally, peripheral blood EBV-CN can predict outcomes of patients with DLBCL, and 10(4) copies/ml may be a more suitable boundary value than the traditional normal value for predicting prognosis.
LEUKEMIA & LYMPHOMA
(2022)
Article
Medicine, General & Internal
Zhen-Yang Gu, Yu-Jun Dong, Xiao-Rui Fu, Nai-Nong Li, Yao Liu, Xiao-Xiong Wu, Yi-Ni Wang, Yu-Hang Li, Han-Yun Ren, Ming-Zhi Zhang, Xiao-Fan Li, Mai-Hong Wang, Ya-Mei Wu, Dai-Hong Liu, Zhao Wang, Liang-Ding Hu, Wen-Rong Huang
Summary: This study analyzed the clinical outcomes of autologous and allogeneic hematopoietic stem cell transplantation in China, finding that autologous transplantation may be associated with better survival for patients in good condition, while for those with unfavorable characteristics, the survival of allogeneic transplantation was similar to autologous transplantation.
CHINESE MEDICAL JOURNAL
(2021)
Article
Immunology
Fabio Guolo, Paola Minetto, Silvia Pesce, Filippo Ballerini, Marino Clavio, Michele Cea, Michela Frello, Matteo Garibotto, Marco Greppi, Matteo Bozzo, Maurizio Miglino, Monica Passannante, Riccardo Marcolin, Elisabetta Tedone, Nicoletta Colombo, Rosa Mangerini, Alessandra Bo, Maria Rosaria Ruzzenenti, Paolo Carlier, Alberto Serio, Silvia Luchetti, Alida Dominietto, Riccardo Varaldo, Simona Candiani, Vanessa Agostini, Jean Louis Ravetti, Genny Del Zotto, Emanuela Marcenaro, Roberto Massimo Lemoli
Summary: This study aimed to investigate a novel therapeutic approach for Hodgkin Lymphoma patients, using a combination of autologous lymphocytes and immune checkpoint inhibitors, which proved to have anti-tumor efficacy and accelerated the development of specific immune cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Integrative & Complementary Medicine
Zhiqiang Peng, Jianping Xiong, Hanzhi Dong
Summary: Valproic acid (VPA) can inhibit the proliferation of Hut 78 cells and promote cell apoptosis and mitochondrial structure and dysfunction by regulating the activity of the PI3K/AKT pathway.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Obstetrics & Gynecology
Francesco D'Ambrosi, Enrico Iurlaro, Beatrice Tassis, Matteo Di Maso, Roberta Erra, Giulia E. Cetera, Nicola Cesano, Daniela Di Martino, Manuela W. Ossola, Enrico Maria Ferrazzi
Summary: The study found that pregnant women aged 35 and older had a significantly lower risk of developing COVID-19, while foreign women, unemployed women, and women with unemployed partners had a higher risk. Ethnicity was also positively associated with COVID-19 risk, with foreign women more likely to have lower education levels, be unemployed, and live in larger families compared to Italian pregnant women.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2021)
Review
Nutrition & Dietetics
Matteo Di Maso, Paolo Boffetta, Eva Negri, Carlo La Vecchia, Francesca Bravi
Summary: The study confirms the beneficial health effects of caffeinated coffee consumption on outcomes such as cardiovascular disease, diabetes, and cancer among the US population, quantifying their potential magnitude.
ADVANCES IN NUTRITION
(2021)
Editorial Material
Hematology
Emanuela Vaccher, Antonino Carbone
Article
Nutrition & Dietetics
Valeria Edefonti, Matteo Di Maso, Laura Tomaino, Maria Parpinel, Werner Garavello, Diego Serraino, Monica Ferraroni, Anna Crispo, Carlo La Vecchia, Francesca Bravi
Summary: This study analyzed the relationship between diet and oral and pharyngeal cancer risk, and estimated the number of preventable cases under different levels of adherence to the dietary guidelines. The findings showed that a higher adherence to the guidelines was associated with a lower risk of oral and pharyngeal cancer, and a significant proportion of cases could be prevented by improving adherence to the guidelines.
JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS
(2022)
Article
Obstetrics & Gynecology
Francesco D'Ambrosi, Gabriele Rossi, Matteo Di Maso, Cecilia Marino, Chiara M. Soldavini, Agnese Caneschi, Giulia E. Cetera, Roberta Erra, Enrico Ferrazzi
Summary: The study revealed significant variations in fetal Doppler velocimetry in patients with gestational diabetes, particularly in the brain, even with minimal metabolic derangements.
FETAL DIAGNOSIS AND THERAPY
(2022)
Article
Multidisciplinary Sciences
Francesco D'Ambrosi, Nicola Cesano, Enrico Iurlaro, Alice Ronchi, Ilaria Giuditta Ramezzana, Matteo Di Maso, Carlo Pietrasanta, Andrea Ronchi, Lorenza Pugni, Enrico Ferrazzi
Summary: This study aimed to identify low-risk and high-risk patients with term prelabor rupture of membranes (PROM) and investigate the effects of immediate induction and expectant management on maternal and perinatal outcomes. The results showed that immediate induction in high-risk patients reduced the risks of maternal fever and meconium-stained amniotic fluid without increasing the rate of cesarean sections.
Article
Nutrition & Dietetics
Matteo Di Maso, Francesca Bravi, Monica Ferraroni, Carlo Agostoni, Simone R. B. M. Eussen, Tamas Decsi, Pasqua A. Quitadamo, Paola Tonetto, Chiara Peila, Claudio Profeti, Guglielmo Salvatori, Iwona Kazmierska, Adriano Decarli, Elisabetta Vacca, Enrico Bertino, Bernd Stahl, Guido E. Moro
Summary: A high adherence to the Mediterranean diet was associated with lower content of SFA and higher content of MUFA and omega-3 FA in human milk. This suggests that the Mediterranean diet may play a role in regulating the fatty acid content in breast milk.
FRONTIERS IN NUTRITION
(2022)
Article
Obstetrics & Gynecology
Francesco D'Ambrosi, Matteo Di Maso, Anna Viscardi, Manuela W. Ossola, Chiara M. Soldavini, Giulia E. Cetera, Roberta Erra, Enrico Ferrazzi
Summary: The aim of this study was to evaluate the association between SARS-CoV-2 infection and serum hepatic biomarker levels in women with obstetric cholestasis. The results showed that SARS-CoV-2 infected women had higher levels of liver enzymes compared to noninfected patients, suggesting possible hepatic involvement in patients with SARS-CoV-2 infection.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Article
Nutrition & Dietetics
Daniela Denis Di Martino, Laura Avagliano, Enrico Ferrazzi, Federica Fuse, Vittoria Sterpi, Marco Parasiliti, Tamara Stampalija, Sara Zullino, Antonio Farina, Gaetano Pietro Bulfamante, Matteo Di Maso, Francesco D'Ambrosi
Summary: This study found a higher prevalence of placental maternal vascular malperfusion in HDP-FGR and early FGR groups, which were associated with abnormal feto-placental Doppler parameters. In contrast, HDP-AGA fetus and late FGR presented more heterogeneous placental lesions not severe enough to cause feto-placental Doppler anomalies. These findings suggest potential preventive nutritional approaches for pregnant women with predisposing factors for HDP-AGA fetuses and late FGR.
Article
Biology
Annalisa Cappella, Barbara Bertoglio, Matteo Di Maso, Debora Mazzarelli, Luciana Affatato, Alessandra Stacchiotti, Chiarella Sforza, Cristina Cattaneo
Summary: Despite the popularity of sex estimation methods from crania in forensic anthropology, few studies have validated their accuracy and reliability in different populations. This study analyzes the accuracy of regression models for predicting sex from cranial morphological traits in an Italian population and proposes new models specific to the population. The results highlight the significant effects of population variability on sexual dimorphism and provide important guidance for forensic anthropologists.
Article
Hematology
Antonino Carbone, Annunziata Gloghini, Carmelo Carlo-Stella
Summary: Classic Hodgkin lymphoma (cHL) and B-cell lymphomas have different tumor microenvironments (TMEs) containing inflammatory/immune cells. PD-1-PD ligand 1 pathway blockade drugs have varying effectiveness among refractory/relapsed patients with cHL and B-cell lymphomas. Further research is needed to identify molecules influencing sensitivity or resistance to therapy in individual patients.
Article
Cell Biology
Francesco Da Ros, Kinga Kowal, Carla Vicinanza, Elisabetta Lombardi, Francesco Agostini, Rosanna Ciancia, Maurizio Rupolo, Cristina Durante, Mariagrazia Michieli, Mario Mazzucato
Summary: Multiple myeloma (MM) is an aggressive malignancy that alters the microenvironment and gene expression of mesenchymal stem cells (MSCs). MSCs from MM patients show increased cell mobility and activation of FilaminA (FLNA). The IRE1a-FLNA axis may play a role in controlling MSC migration and could be a potential target for MM therapy.
Article
Biochemistry & Molecular Biology
Matteo Di Maso, Livia S. A. Augustin, David J. A. Jenkins, Greta Carioli, Federica Turati, Benedetta Grisoni, Anna Crispo, Carlo La Vecchia, Diego Serraino, Jerry Polesel
Summary: Evidence suggests that adhering to a cholesterol-lowering diet can reduce the risk of prostate cancer (PCa). Men who fulfill 5 to 7 dietary indicators associated with cholesterol reduction have a 43% lower risk of PCa compared to those who fulfill 0 to 2 indicators.
Review
Hematology
Antonino Carbone, Emanuela Vaccher, Annunziata Gloghini
Summary: HIV infection increases the risk of cancer, especially lymphomas. The treatment for HIV-associated lymphomas has improved with the introduction of modern therapies, but there is still a need for the development of new treatment strategies.