Article
Oncology
Alexia Roux, Valentin David, Sylvia M. Bardet, Emilie Auditeau, Sylvaine Durand Fontanier, Abdelkader Taibi
Summary: This study investigated the predictive value of C-reactive protein (CRP) in postoperative complications after cytoreduction surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). The findings demonstrated that monitoring CRP levels can be useful in predicting the occurrence of infectious and non-infectious complications after surgery, which has clinical significance.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yaseen Al Lawati, Aroub Alkaaki, Jose Luis Ramirez Garcia Luna, Elena Skothos, Carmen Mueller, Jonathan Spicer, David Mulder, Lorenzo Ferri, Jonathan Cools-Lartigue
Summary: The study found that patients who developed anastomotic leak after esophagectomy for esophageal adenocarcinoma had higher neutrophil-to-lymphocyte ratios in the early postoperative period with rising trends, while a low ratio was associated with a high negative predictive value.
ANNALS OF THORACIC SURGERY
(2021)
Article
Pediatrics
Fengming Ji, Haoyu Tang, Chengchuang Wu, Li Chen, Huake Wang, Bing Yan
Summary: This study demonstrated that postoperative C-reactive protein (CRP) level is associated with postoperative complications in children with hypospadias, serving as a reliable marker for predicting patient prognosis. Attention should be paid to the length of urethral defect and CRP level as independent risk factors for hypospadias prognosis.
FRONTIERS IN PEDIATRICS
(2021)
Article
Surgery
Jonathan Golledge, Ramesh Velu, Frank Quigley, Jason Jenkins, Tejas P. Singh
Summary: This study aimed to identify the biomarkers that can independently predict major adverse cardiovascular events (MACE) in patients with small abdominal aortic aneurysm (AAA), and found that C-reactive protein (CRP) can assist in classifying the risk of MACE.
JOURNAL OF VASCULAR SURGERY
(2023)
Review
Oncology
Ognjen Barcot, Matija Boric, Marija Cavar, Goran Poropat, Livia Puljak
Summary: The study found that measuring abdominal drain amylase level (d-AMY) on postoperative day 1 can accurately predict the development of postoperative pancreatic fistula (POPF) after gastric surgery, with high sensitivity and specificity.
Review
Surgery
Martin Wagner, Pascal Probst, Michael Haselbeck-Koebler, Johanna M. Brandenburg, Eva Kalkum, Dominic Stoerzinger, Jens Kessler, Joe J. Simon, Hans-Christoph Friederich, Michaela Angelescu, Adrian T. Billeter, Thilo Hackert, Beat P. Mueller-Stich, Markus W. Buechler
Summary: Appetite loss is a common problem after major abdominal surgery, and it is associated with decreased quality of life. This review examines the etiology and treatment options for appetite loss. The findings suggest that reduced gastric volume and ghrelin secretion, as well as increased satiety hormone secretion, influence appetite loss. Treatment options include gum chewing.
Review
Medicine, Research & Experimental
Lihong Chi, Shuai Wang, Xiaoyu Wang, Chengwu Yang, Jianghong Luo
Summary: This study summarizes the predictive value of C-reactive protein (CRP) in COVID-19 patients, showing that CRP levels are associated with disease severity and survival. These findings can contribute to disease treatment and reducing the risk of death.
CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Review
Surgery
Gabby T. J. A. Reijnders-Boerboom, Kim I. Albers, Lotte M. C. Jacobs, Esmee van Helden, Camiel Rosman, Oscar Diaz-Cambronero, Guido Mazzinari, Gert-Jan Scheffer, Christiaan Keijzer, Michiel C. Warle
Summary: A meta-analysis of previous studies found that low intra-abdominal pressure (IAP) in laparoscopic surgery is safe and can reduce the incidence of postoperative complications, alleviate postoperative pain, decrease the occurrence of postoperative nausea and vomiting (PONV), and shorten the length of hospital stay.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Medicine, General & Internal
Kartik Gupta, Rajat Kalra, Mike Pate, Shivaraj Nagalli, Sameer Ather, Indranee Rajapreyar, Pankaj Arora, Ankur Gupta, Wunan Zhou, Raul San Jose Estepar, Marcelo Di Carli, Sumanth D. Prabhu, Navkaranbir S. Bajaj
Summary: This study investigated the predictive value of circulating immune cell markers for cardiovascular mortality in ambulatory adults without cardiovascular disease, finding that MLR had the best predictive value. Adding MLR to the 10-year ASCVD risk score significantly improved risk classification for participants.
MAYO CLINIC PROCEEDINGS
(2021)
Article
Oncology
Jakub Kenig, Kinga Szabat, Jerzy Mitus, Tomasz Rogula, Jerzy Krzeszowiak
Summary: The study found that preoperative geriatric assessment in older cancer patients undergoing high-risk abdominal surgery can effectively predict short-term and long-term postoperative outcomes. The research indicates that biological age and frailty are significant predictors of postoperative outcomes and 12-month mortality.
Article
Surgery
J. Meyerov, M. Louis, D. K. Lee, L. Fletcher, D. Banyasz, L. F. Miles, R. Ma, S. Tosif, A. N. Koshy, D. A. Story, R. Bellomo, L. Weinberg
Summary: This retrospective cohort study found that patients with lower preoperative Hb concentrations incurred higher hospital costs during major abdominal surgery, with packed red blood cell transfusions being a principal cost driver.
Article
Multidisciplinary Sciences
Koki Maeda, Naohisa Kuriyama, Yuki Nakagawa, Takahiro Ito, Aoi Hayasaki, Kazuyuki Gyoten, Takehiro Fujii, Yusuke Iizawa, Yasuhiro Murata, Akihiro Tanemura, Masashi Kishiwada, Hiroyuki Sakurai, Shugo Mizuno
Summary: This study aimed to evaluate the management and outcomes of patients with postoperative pancreatic fistula after distal pancreatectomy. The results showed that patients with grade B postoperative pancreatic fistulas who received therapeutic antibiotics only had better outcomes. Computed tomography values may be useful in predicting peripancreatic fluid collection infection.
Review
Anesthesiology
Kwame Wiredu, Edmund Aduse-Poku, Shahzad Shaefi, Scott A. Gerber
Summary: Delirium is a significant health care burden, particularly in the elderly population, and is associated with various negative outcomes. The pathomechanism of the disease is not well understood, and current diagnostic approaches are subjective. There is a lack of definitive diagnostic biomarkers for delirium.
ANESTHESIA AND ANALGESIA
(2023)
Article
Surgery
Victor D. Plat, Daan M. Voeten, Freek Daams, Donald L. van der Peet, Jennifer Straatman
Summary: This study addressed the predictive value of routine assessment of C-reactive protein levels as an early marker for infectious complications after major abdominal surgery. It found that C-reactive protein levels can serve as an important indicator for predicting major infectious complications, with specific cut-off values calculated for each postoperative day. These cut-off values can be used as discharge criteria or to identify patients who may require further intervention due to infectious complications, facilitating clinical decision-making in surgical practice.
Article
Nutrition & Dietetics
Alba Fernandez-Candela, Alicia Calero, Luis Sanchez-Guillen, Javier Escrig-Sos, Jose A. Barreras, Francisco Lopez-Rodriguez-Arias, Laura Armananzas, Ana Murcia, Antonio Arroyo, Francisco Javier Lacueva
Summary: The study assessed the impact of preoperative immunonutrition intake on postoperative major complications in patients undergoing cytoreductive surgery, showing that immunonutrition intake was associated with a decreased risk of postoperative complications.
Review
Surgery
Nadia A. G. Hakkenbrak, Elise P. Jansma, N. van der Wielen, Donald L. van der Peet, Jennifer Straatman
Summary: This meta-analysis aims to compare laparoscopic distal gastrectomy (LDG) and open distal gastrectomy (ODG) in terms of short-term and long-term surgical outcomes, recovery, and oncological results. The results show that LDG leads to less intraoperative blood loss, faster patient recovery, and fewer complications. Moreover, LDG meets the clinical requirements in terms of lymph node yield, adequacy of resection, and survival.
Review
Medicine, General & Internal
Dennis Visser, Elizabeth M. Wattel, Karin H. L. Gerrits, Johannes C. van der Wouden, Franka J. M. Meiland, Aafke J. de Groot, Elise P. Jansma, Cees M. P. M. Hertogh, Ewout B. Smit
Summary: Physical fitness training can be effective for adults aged over 65 years, with current existing guidelines widely applicable. However, adjustments may be necessary based on individual health conditions.
Article
Virology
Federica Inturrisi, Johannes A. Bogaards, Albert G. Siebers, Chris J. L. M. Meijer, Danielle A. M. Heideman, Johannes Berkhof
Summary: Little is known about the long-term association between high-risk human papillomavirus (hrHPV) test results in women participating in a hrHPV-based cervical cancer screening program. This study found that women who tested hrHPV-positive had a higher risk of testing positive again in the future, as well as an increased risk of CIN3. These findings support the concept of risk-stratification in hrHPV-based cervical cancer screening.
TUMOUR VIRUS RESEARCH
(2022)
Article
Clinical Neurology
Daniele Altomare, Lyduine Collij, Camilla Caprioglio, Philip Scheltens, Bart N. M. van Berckel, Isadora Lopes Alves, Johannes Berkhof, Yvonne de Gier, Valentina Garibotto, Christian Moro, Lea Poitrine, Julien Delrieu, Pierre Payoux, Laure Saint-Aubert, Jose Luis Molinuevo, Oriol Grau-Rivera, Juan-Domingo Gispert, Carolina Minguillon, Karine Fauria, Marta Felez Sanchez, Andreea Radoi, Alexander Drzezga, Frank Jessen, Claus Escher, Philip Zeyen, Agneta Nordberg, Irina Savitcheva, Vesna Jelic, Zuzana Walker, Ho-Yun Lee, Lean Lee, Jean-Francois Demonet, Sonia Plaza Wuthrich, Rossella Gismondi, Gill Farrar, Frederik Barkhof, Andrew W. Stephens, Giovanni B. Frisoni
Summary: The AMYPAD Diagnostic and Patient Management Study aims to investigate the clinical utility and cost-effectiveness of amyloid-PET in Europe. Participants with subjective cognitive decline, mild cognitive impairment, or dementia were recruited in eight European memory clinics and randomized into three study arms. The baseline features of the participants were representative of a memory clinic population, ensuring the generalizability of the study results.
ALZHEIMERS & DEMENTIA
(2023)
Review
Surgery
Simone Augustinus, Iris W. J. M. van Goor, Johannes Berkhof, Lois A. Daamen, Bas Groot Koerkamp, Tara M. Mackay, I. Q. Molenaar, Hjalmar C. van Santvoort, Helena M. Verkooijen, Peter M. van de Ven, Marc G. Besselink
Summary: This review examines the use of alternative randomized controlled trial designs in surgical research, with a focus on their increasing popularity in Europe and within gastrointestinal/oncological surgery. When appropriately utilized, these alternative designs have the potential to address some of the challenges associated with traditional surgical RCTs.
Article
Health Care Sciences & Services
Eddymurphy U. Akwiwu, Thomas Klausch, Henriette C. Jodal, Beatriz Carvalho, Magnus Loberg, Mette Kalager, Johannes Berkhof, Veerle M. H. Coupe
Summary: This study proposes a method to indirectly estimate the time it takes for advanced adenomas (AA) to develop into colorectal cancer (CRC). By applying this method to a Norwegian adenoma cohort, the average time and cumulative incidence of developing CRC from AA were estimated.
BMC MEDICAL RESEARCH METHODOLOGY
(2022)
Review
Oncology
Marc Arbyn, Marie Simon, Silvia de Sanjose, Megan A. Clarke, Mario Poljak, Remila Rezhake, Johannes Berkhof, Victoria Nyaga, Murat Gultekin, Karen Canfell, Nicolas Wentzensen
Summary: The cross-sectional accuracy of hrHPV mRNA testing is similar to DNA testing in detecting cervical intraepithelial neoplasia, but it is less sensitive for self-collected samples. Longitudinal follow-up studies show that hrHPV mRNA testing is comparable to DNA testing in preventing cervical intraepithelial neoplasia.
Article
Clinical Neurology
Arenda Mank, Ingrid S. van Maurik, Judith J. M. Rijnhart, Els D. Bakker, Vincent Bouteloup, Lisa Le Scouarnec, Charlotte E. Teunissen, Frederik Barkhof, Philip Scheltens, Johannes Berkhof, Wiesje M. van der Flier
Summary: This study developed prediction models for institutionalization and mortality along the Alzheimer's disease cognitive continuum with good accuracy for SCD/MCI patients and moderate accuracy for patients with AD dementia.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Oncology
Clare A. Aitken, Federica Inturrisi, Sylvia Kaljouw, Daan Nieboer, Albert G. Siebers, Willem J. G. Melchers, Adriaan J. C. van den Brule, Anco Molijn, John W. J. Hinrichs, Hubert G. M. Niesters, Folkert J. van Kemenade, Johannes Berkhof, Inge M. C. M. de Kok
Summary: In the Netherlands, self-collected samples have lower high-risk human papillomavirus (hrHPV) positivity but higher cervical intraepithelial neoplasia (CIN) 2+ detection compared to clinician-collected samples. The differences between the two sampling methods are likely related to sociodemographic factors as well as differences in screening test accuracy and background risk. Self-sampling can be used as a more convenient screening tool for underscreened women.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Letter
Oncology
Johannes Berkhof, Stefanie Dick, Wieke Kremer, Maaike Bleeker, Chris Meijer
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Irene Man, Damien Georges, Tiago M. de Carvalho, Lopamudra Ray Saraswati, Prince Bhandari, Ishu Kataria, Mariam Siddiqui, Richard Muwonge, Eric Lucas, Johannes Berkhof, Rengaswamy Sankaranarayanan, Johannes A. Bogaards, Partha Basu, Iacopo Baussano
Summary: The use of single-dose HPV vaccination could significantly reduce the burden of cervical cancer in India.
Article
Clinical Neurology
Arenda Mank, Judith J. M. Rijnhart, Ingrid S. van Maurik, Linus Jonsson, Ron Handels, Els D. Bakker, Charlotte E. Teunissen, Bart N. M. van Berckel, Argonde C. van Harten, Johannes Berkhof, Wiesje M. van der Flier
Summary: This study compared the trajectories of quality of life (QoL) between amyloid-positive and amyloid-negative patients with subjective cognitive decline (SCD) or mild cognitive impairment (MCI). The results showed that amyloid-positive patients had a faster decline in QoL over time compared to amyloid-negative patients. QoL decreased along the Alzheimer's disease continuum, with the steepest decrease in dementia patients.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Immunology
Joske Hoes, Audrey J. King, Johannes Berkhof, Hester E. de Melker
Summary: The long-term effectiveness of three-dose HPV16/18 vaccination among Dutch women who were eligible for vaccination during a catch-up campaign was evaluated. The vaccine showed high effectiveness of 95.8% against persistent infections with HPV16/18 and 64.6% against cross protective type persistent infections (HPV31/33/45). There was no evidence of waning of protection over time, indicating promising long-term protection and future clinical impact.
Article
Oncology
Feline O. Voss, Nikki B. Thuijs, Sylvia Duin, Mujde Ozer, Marc van Beurden, Johannes Berkhof, Renske D. M. Steenbergen, Maaike C. G. Bleeker
Summary: This study aimed to validate the accuracy of previously identified DNA methylation markers for detection of high-grade vulvar intraepithelial neoplasia (VIN). The best-performing individual marker was found to be SST, detecting 80% of high-grade VIN cases, with excellent detection of HPV-independent VIN, known to have the highest cancer risk. Selection of a marker panel including ZNF582, SST, and miR124-2 also yielded high accuracy for detection of high-grade VIN.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Dermatology
B. Rook, M. J. E. van Rijn, E. P. Jansma, C. van Montfrans
Summary: Physical exercise after DVT has positive effects on patients' quality of life, pain reduction, and severity of PTS. Lifestyle interventions, such as guided individualized training programs, can be a useful supplementary therapy for both DVT patients and PTS patients.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)