Article
Surgery
Diamantis I. Tsilimigras, Kota Sahara, J. Madison Hyer, Adrian Diaz, Dimitrios Moris, Fabio Bagante, Alfredo Guglielmi, Andrea Ruzzenente, Sorin Alexandrescu, George Poultsides, Kazunari Sasaki, Federico Aucejo, Aslam Ejaz, Jordan M. Cloyd, Timothy M. Pawlik
Summary: The study found that the proportion of patients undergoing simultaneous resection for synchronous colorectal liver metastases increased over time, while the incidence of severe complications decreased over time. Survival rates were comparable between simultaneous and staged resection in the long term.
Article
Oncology
Shengyong Zhai, Xiaojing Sun, Longfeng Du, Kai Chen, Shanshan Zhang, Yiran Shi, Fei Yuan
Summary: This retrospective analysis of 953 patients with SCLM found that liver resection significantly improved survival outcomes compared to nonoperative treatment. Simultaneous resection of the primary tumor and liver metastases was recommended for patients with resectable SCLM.
CANCER MANAGEMENT AND RESEARCH
(2021)
Review
Medicine, General & Internal
Emmanouil Georgilis, Maria Gavriatopoulou, Diamantis I. Tsilimigras, Panagiotis Malandrakis, Theodosios Theodosopoulos, Ioannis Ntanasis-Stathopoulos
Summary: Although surgical resection is the gold standard for resectable colorectal cancer liver metastases (CRLMs), the management after surgery remains controversial. This systematic review aimed to evaluate the efficacy, tolerability, and safety profile of different chemotherapeutic agents used as adjuvant treatment after surgical resection of CRLMs. The results showed that adjuvant therapy improved regression-free survival (RFS) and disease-free survival (DFS), but did not significantly prolong overall survival (OS), and the choice of therapeutic strategy did not have a differential impact on patient outcomes. More high-quality clinical trials are needed to determine which patients would benefit the most from adjuvant therapy after surgery for CRLMs.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Pablo E. Serrano, Sameer Parpia, Paul Karanicolas, Steven Gallinger, Alice C. Wei, Marko Simunovic, Mohit Bhandari, Mark Levine
Summary: The study tested the feasibility of a simultaneous resection clinical trial in patients with synchronous colorectal cancer liver metastases, showing a high feasibility but higher than anticipated postoperative complication rate.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Surgery
Kosuke Kobayashi, Yosuke Inoue, Yuki Kitano, Shoki Sato, Atsushi Oba, Yoshihiro Ono, Takafumi Sato, Hiromichi Ito, Yoshihiro Mise, Akio Saiura, Yu Takahashi
Summary: A predictive model for conversion surgery was developed and the long-term outcomes of patients with technically unresectable colorectal liver metastases were evaluated. Patients who underwent conversion surgery had significantly higher median overall survival compared to those who did not. The predictive model for conversion surgery was constructed using several predictive factors. Patients were graded according to their scores, and those in Grade A had significantly better overall survival than Grade B and C patients.
Article
Gastroenterology & Hepatology
Michael R. Driedger, Thomas S. Yamashita, Patrick Starlinger, Kellie L. Mathis, Rory L. Smoot, Sean P. Cleary, David M. Nagorney
Summary: The concurrent resection of primary cancer and synchronous colorectal cancer liver metastases (CRCLM) may lead to increased morbidity and mortality, especially in patients undergoing major liver/major colorectal resections. Postoperative complications may result in the inability to receive adjuvant chemotherapy, which could impact survival outcomes.
Article
Medicine, General & Internal
Noemi Reboux, Valerie Jooste, Juste Goungounga, Michel Robaszkiewicz, Jean-Baptiste Nousbaum, Anne-Marie Bouvier
Summary: This study analyzed the temporal patterns and outcomes of synchronous and metachronous liver metastases from colorectal cancer using a population-based cohort study in France. The incidence of synchronous liver metastases remained relatively stable over time, while the probability of developing metachronous liver metastases decreased. Survival rates were significantly higher for patients with metachronous liver metastases compared to synchronous metastases. The differences in the epidemiological features of synchronous and metachronous liver metastases may have implications for future clinical trials.
Review
Oncology
Gabriel D. Ivey, Fabian M. Johnston, Nilofer S. Azad, Eric S. Christenson, Kelly J. Lafaro, Christopher R. Shubert
Summary: Colorectal cancer is one of the most common types of cancer, and at least half of patients diagnosed with it will develop metastatic liver disease. Surgical resection of colorectal liver metastases is considered potentially curative, but it is underutilized despite the availability of various operative strategies. Differing views on resectability may contribute to this underutilization.
Article
Oncology
Vincenza Granata, Roberta Fusco, Federica De Muzio, Carmen Cutolo, Sergio Venanzio Setola, Federica Dell'Aversana, Alessandro Ottaiano, Guglielmo Nasti, Roberta Grassi, Vincenzo Pilone, Vittorio Miele, Maria Chiara Brunese, Fabiana Tatangelo, Francesco Izzo, Antonella Petrillo
Summary: This study aimed to evaluate the effectiveness of radiomics features obtained by EOB-MRI phase in predicting clinical outcomes and assessing various factors in patients with colorectal liver metastases. The results showed that radiomics can serve as biomarkers to identify prognostic features that may influence treatment choices in these patients.
Article
Surgery
Elliott J. Yee, Mohammed H. Al-Temimi, Katelyn F. Flick, E. Molly Kilbane, Trang K. Nguyen, Nicholas J. Zyromski, C. Max Schmidt, Attila Nakeeb, Michael G. House, Eugene P. Ceppa
Summary: This study found that a substantial percentage of patients undergoing combined resection for sCRLM had primary surgical drains placed. The case-matched analysis suggested that surgical drains are associated with an increase in postoperative morbidity. Postoperative drain maintenance past 13 days is associated with worse outcomes compared to earlier removal.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Surgery
Omeed Moaven, Thomas E. Tavolara, Cristian D. Valenzuela, Tan To Cheung, Carlos U. Corvera, Charles H. Cha, John A. Stauffer, Muhammad Khalid Khan Niazi, Metin N. Gurcan, Perry Shen
Summary: Machine learning models have been developed to predict survival and recurrence after surgery for colorectal liver metastases. The models showed good predictive power, with the gradient-boosted trees model performing better. These models have the potential to be adopted in clinical practice.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2023)
Article
Oncology
Anthony K. C. Chan, James M. Mason, Minas Baltatzis, Ajith K. Siriwardena
Summary: The study recruited 125 patients with colorectal cancer and synchronous liver metastases, showing equivalent perioperative complications and healthcare occupancy outcomes between patients completing staged and synchronous pathways. Future research should focus on optimizing pathway selection criteria, integrating cancer genomics data, and considering patient preferences.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Surgery
Jasper Paul Sijberden, Antonino Spinelli, Alessandro Ferrero, Manish Chand, Steven Wexner, Marc G. Besselink, Ibrahim Dagher, Giuseppe Zimmitti, Burak Gorgec, Antonio de Lacy, Mayank Roy, Pieter Tanis, Carlo Tonti, Mohammed Abu Hilal
Summary: This study aimed to assess the attitudes of surgeons involved in the treatment of synchronous colorectal liver metastases (sCRLM). The study found that there were differences in clinical practices and viewpoints on the management of sCRLM among surgeons from different specialties and continents. However, there was consensus on a growing role for minimally invasive surgery (MIS) and a need for evidence-based input.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Medicine, General & Internal
Yaron Rudnicki, Ron Pery, Sherief Shawki, Susanne Warner, Sean Patrick Cleary, Kevin T. Behm
Summary: This case series describes the initial institutional experience of synchronous robotic colorectal and liver resections for metastatic colorectal cancer. Eight patients underwent the surgeries without any intra-operative complications or conversions. There were two post-operative complications, but overall short-term outcomes and oncologic resection quality were acceptable.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Vincenza Granata, Roberta Fusco, Federica De Muzio, Carmen Cutolo, Sergio Venanzio Setola, Roberta Grassi, Francesca Grassi, Alessandro Ottaiano, Guglielmo Nasti, Fabiana Tatangelo, Vincenzo Pilone, Vittorio Miele, Maria Chiara Brunese, Francesco Izzo, Antonella Petrillo
Summary: The study evaluated the efficacy of radiomics features obtained by T2-weighted sequences in predicting clinical outcomes following liver resection in colorectal liver metastases patients. The results confirmed the capacity of radiomics to identify prognostic features that could affect treatment choice, leading to a more personalized approach in patients with liver metastases.
Article
Psychology, Clinical
Scott B. Cantor, Ashish A. Deshmukh, Nancy Stancic Luca, Graciela M. Nogueras-Gonzalez, Tanya Rajan, Alexander V. Prokhorov
ADDICTIVE BEHAVIORS
(2015)
Article
Economics
Ariel Chen, Kathryn H. Jacobsen, Ashish A. Deshmukh, Scott B. Cantor
SOCIO-ECONOMIC PLANNING SCIENCES
(2015)
Article
Public, Environmental & Occupational Health
Van T. Nghiem, Kalatu R. Davies, Wenyaw Chan, Zuber D. Mulla, Scott B. Cantor
ANNALS OF EPIDEMIOLOGY
(2016)
Article
Oncology
Uma R. Phatak, Lillian S. Kao, Y. Nancy You, Miguel A. Rodriguez-Bigas, John M. Skibber, Barry W. Feig, Sa Nguyen, Scott B. Cantor, George J. Chang
ANNALS OF SURGICAL ONCOLOGY
(2014)
Article
Oncology
Ashish A. Deshmukh, Scott B. Cantor, Melissa A. Crosby, Wenli Dong, Yu Shen, Isabelle Bedrosian, Susan K. Peterson, Patricia A. Parker, Abenaa M. Brewster
ANNALS OF SURGICAL ONCOLOGY
(2014)
Article
Critical Care Medicine
David E. Ost, Carlos A. Jimenez, Xiudong Lei, Scott B. Cantor, Horiana B. Grosu, Donald R. Lazarus, Saadia A. Faiz, Lara Bashoura, Vickie R. Shannon, Dave Balachandran, Lailla Noor, Yousra B. Hashmi, Roberto F. Casal, Rodolfo C. Morice, George A. Eapen
Article
Otorhinolaryngology
Ronald S. Walters, Heidi W. Albright, Randal S. Weber, Thomas W. Feeley, Ehab Y. Hanna, Scott B. Cantor, Carol M. Lewis, Thomas W. Burke
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2014)
Article
Health Care Sciences & Services
Stephanie L. McFall, Patricia D. Mullen, Theresa L. Byrd, Scott B. Cantor, Yen-Chi Le, Isabel Torres-Vigil, Curtis Pettaway, Robert J. Volk
HEALTH EXPECTATIONS
(2015)
Article
Oncology
Nader N. Massarweh, Chung-Yuan Hu, Y. Nancy You, Brian K. Bednarski, Miguel A. Rodriguez-Bigas, John M. Skibber, Scott B. Cantor, Janice N. Cormier, Barry W. Feig, George J. Chang
JOURNAL OF CLINICAL ONCOLOGY
(2014)
Editorial Material
Pediatrics
Robert C. Orth, Scott B. Cantor
PEDIATRIC RADIOLOGY
(2014)
Article
Oncology
Robert J. Volk, Stephanie L. McFall, Scott B. Cantor, Theresa L. Byrd, Yen-Chi L. Le, Deborah A. Kuban, Patricia Dolan Mullen
Article
Immunology
Ashish A. Deshmukh, Elizabeth Y. Chiao, Prajnan Das, Scott B. Cantor
Article
Rheumatology
Christian A. Waimann, Rodrigo J. Fernandez-Mazarambroz, Scott B. Cantor, Maria A. Lopez-Olivo, Hong Zhang, Glenn C. Landon, Sherwin J. Siff, Maria E. Suarez-Almazor
ARTHRITIS CARE & RESEARCH
(2014)
Review
Rheumatology
Aliza R. Karpes Matusevich, Maria E. Suarez-Almazor, Scott B. Cantor, Lincy S. Lal, J. Michael Swint, Maria A. Lopez-Olivo
ARTHRITIS CARE & RESEARCH
(2020)
Article
Surgery
Clement S. Sun, Scott B. Cantor, Gregory P. Reece, Melissa A. Crosby, Michelle C. Fingeret, Mia K. Markey
PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN
(2014)