Article
Cardiac & Cardiovascular Systems
Samina Park, Hak Jae Kim, In Kyu Park, Young Tae Kim, Chang Hyun Kang
Summary: The study compared the long-term survival rates of surgical resection and stereotactic ablative radiotherapy (SABR) for the treatment of early-stage lung cancer in older patients. The results showed that surgical resection provides better overall survival, while SABR remains an alternative treatment for those who are not suitable for surgery.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Review
Oncology
Benjamin E. Lee, Nasser Altorki
Summary: The Lung Cancer Study Group has established lobectomy as the standard treatment for clinical T1N0 NSCLC. Recent studies, JCOG 0802 and CALGB 140503, reviewed in the context of LCSG 0821, confirm the non-inferiority of sub-lobar resection compared to lobectomy for peripheral T1N0 NSCLC ≤2 cm. Sub-lobar resection should now be considered as the new standard of care in this patient subset with NSCLC.
Article
Cardiac & Cardiovascular Systems
Julianne Cynthia de Ruiter, Judi Nani Annet van Diessen, Egbert Frederik Smit, Vincent van der Noort, Ronald Alphons Maria Damhuis, Koen Johan Hartemink
Summary: This study aimed to compare outcomes between minimally invasive lobectomy (MIL) and stereotactic ablative radiotherapy (SABR) for stage I non-small cell lung cancer (NSCLC) patients. The results showed differences in survival rates and progression-free survival rates between MIL and SABR.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yang Ni, Guanghui Huang, Xia Yang, Xin Ye, Xiaoguang Li, Qingliang Feng, Yongjie Li, Wenhong Li, Jiao Wang, Xiaoying Han, Min Meng, Zhigeng Zou, Zhigang Wei
Summary: This study demonstrates that microwave ablation is a safe, effective, and potentially curative therapy for medically inoperable stage I non-small cell lung cancer patients. The five-year follow-up shows high disease-free survival and overall survival rates.
EUROPEAN RADIOLOGY
(2022)
Article
Oncology
Zhexue Hao, Hengrui Liang, Yichi Zhang, Wei Wei, Yuting Lan, Shuxian Qiu, Guo Lin, Runchen Wang, Yulin Liu, Yingying Chen, Jun Huang, Wei Wang, Fei Cui, Taichiro Goto, Jin Yong Jeong, Giulia Veronesi, Alberto Lopez-Pastorini, Hitoshi Igai, Wenhua Liang, Jianxing He, Jun Liu
Summary: Lobectomy has been independently correlated with longer cancer-specific survival time in metastatic NSCLC patients, while wedge resection and segmentectomy did not show significant survival differences. Lymph node dissection was associated with better CSS and OS, providing additional survival benefits for stage IV NSCLC patients.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Oncology
Sunyi Zheng, Jiapan Guo, Johannes A. Langendijk, Stefan Both, Raymond N. J. Veldhuis, Matthijs Oudkerk, Peter M. A. van Ooijen, Robin Wijsman, Nanna M. Sijtsema
Summary: This study aimed to develop and evaluate a prediction model for 2-year overall survival (OS) in stage I-IIIA non-small cell lung cancer (NSCLC) patients who received definitive radiotherapy. The hybrid model, which integrated clinical variables and image features from pre-treatment CT scans, achieved reasonable performance and has the potential to identify high mortality risk patients and guide clinical decision making.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Arta M. Monjazeb, Megan E. Daly, Guillaume Luxardi, Emanual Maverakis, Alexander A. Merleev, Alina I. Marusina, Alexander Borowsky, Amin Mirhadi, Stephen L. Shiao, Laurel Beckett, Shuai Chen, David Eastham, Tianhong Li, Logan V. Vick, Heather M. Mcgee, Frances Lara, Leslie Garcia, Leigh Anne Morris, Robert J. Canter, Jonathan W. Riess, Kurt A. Schalper, William J. Murphy, Karen Kelly
Summary: Stereotactic ablative radiotherapy (SABR) is a standard-of-care for medically-inoperable-early-stage non-small cell lung cancer (NSCLC). A phase I study tested the addition of atezolizumab to SABR in high risk, medically inoperable, early-stage NSCLC, and found that it was well tolerated and showed efficacy signals.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Brendan T. Heiden, Daniel B. Eaton, Kathryn E. Engelhardt, Su-Hsin Chang, Yan Yan, Mayank R. Patel, Daniel Kreisel, Ruben G. Nava, Bryan F. Meyers, Benjamin D. Kozower, Varun Puri
Summary: This study found that surgical procedures delayed more than 12 weeks were associated with increased risk of recurrence and worse survival in patients with clinical stage I NSCLC, suggesting that timely treatment is crucial for better outcomes.
Article
Oncology
Corbin D. Jacobs, Kurren Mehta, Junheng Gao, Xiaofei Wang, Joseph K. Salama, Chris R. Kelsey, Jordan A. Torok
Summary: An online nomogram was developed to predict overall survival (OS) for patients with early-stage non-small cell lung cancer (NSCLC) treated with stereotactic ablative radiotherapy (SABR) or observation. The study found that SABR treatment significantly narrowed the baseline prognostic gap between squamous cell carcinoma and adenocarcinoma patients.
CLINICAL LUNG CANCER
(2022)
Article
Respiratory System
Fabian Doerr, Sebastian Stange, Maximilian Michel, Georg Schlachtenberger, Hruy Menghesha, Thorsten Wahlers, Khosro Hekmat, Matthias B. Heldwein
Summary: This article presents a meta-analysis on the mean-survival of patients with small-cell lung cancer (SCLC) in stage I and II who underwent surgery compared to those who did not. The results show a significant survival benefit after surgery in both stage I and II SCLC.
Review
Oncology
Megan E. Daly
Summary: Stereotactic ablative radiotherapy (SABR) is the standard treatment for medically inoperable, early-stage non-small-cell lung cancer. However, regional and distant failures remain a challenge, especially in larger and more biologically aggressive tumors. Use of cytotoxic chemotherapy is limited in this patient population, prompting the investigation of alternative systemic therapy options with fewer side effects, such as immune checkpoint inhibitors.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Xiaoli Zheng, Yanan Sun, Ke Ye, Chengcheng Fan, Xiaohui Wang, Yang Yang, Ruidi Jiao, Hong Ge
Summary: The study evaluated the survival outcomes and recurrence patterns after Stereotactic Ablative Radiotherapy (SABR) for inoperable early stage non-small cell lung cancer. Results showed high survival rates with SABR but emphasized the necessity for prolonged surveillance and adjuvant therapy.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hyewon Choi, Young Sik Park, Kwon Joong Na, Samina Park, In Kyu Park, Chang Hyun Kang, Young Tae Kim, Jin Mo Goo, Soon Ho Yoon
Summary: This study investigated the association between baseline adipopenia and outcomes in patients with early-stage NSCLC. The results showed that adipopenia was associated with a reduced 5-year overall survival rate, indicating a potential risk for non-cancer-related death.
Article
Oncology
Meghann Wheeler, Shama D. D. Karanth, Hiren J. J. Mehta, Danting Yang, Livingstone Aduse-Poku, Caretia Washington, Young-Rock Hong, Dongyu Zhang, Michael K. K. Gould, Dejana Braithwaite
Summary: This study compared the relationship between comorbidity burden and survival among stage I/II non-small-cell lung cancer patients who received thoracoscopic surgery as their primary treatment. It found that increasing comorbidity burden was associated with a higher risk of all-cause mortality, and this impact was stronger in female patients with NSCLC. These findings highlight the importance of considering comorbidities in candidate selection for thoracoscopic resection.
Article
Oncology
Kazuhiko Hayashi, Osamu Suzuki, Hiroya Shiomi, Masataka Nakai, Kei Fujiwara, Erina Nakanishi, Shotaro Tatekawa, Takero Hirata, Keisuke Tamari, Haruhiko Hirata, Soichiro Funaki, Yuji Seo, Yoshito Takeda, Fumiaki Isohashi, Yasushi Shintani, Kazuhiko Ogawa
Summary: A retrospective study evaluated the effectiveness and safety of Cyberknife in treating stage I non-small cell lung cancer. The results showed high rates of local control and overall survival, with acceptable toxicity.
ANTICANCER RESEARCH
(2022)
Article
Surgery
Brody Wiles, Matthew Comito, Nicos Labropoulos, Lee Ann Santore, Thomas Bilfinger
Summary: The study found a high prevalence of abdominal aortic aneurysms among patients with lung cancer, with smoking, male sex, increasing age, and hypertension being identified as independent risk factors for AAA.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Toby Rogers, Christian Shults, Rebecca Torguson, Corey Shea, Puja Parikh, Thomas Bilfinger, Thomas Cocke, Mariano E. Brizzio, Robert Levitt, Chiwon Hahn, Nicholas Hanna, George Comas, Paul Mahoney, Joseph Newton, Maurice Buchbinder, Ricardo Moreno, Cheng Zhang, Paige Craig, Federico M. Asch, Gaby Weissman, Hector M. Garcia-Garcia, Itsik Ben-Dor, Lowell F. Satler, Ron Waksman
Summary: In low-risk transcatheter aortic valve replacement patients, anticoagulation with warfarin may prevent transcatheter heart valve dysfunction in the short term without excess bleeding, as revealed by a randomized open-label study.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Ron Waksman, Rebecca Torguson, Giorgio A. Medranda, Corey Shea, Cheng Zhang, Paul Gordon, Afshin Ehsan, Sean R. Wilson, Robert Levitt, Chiwon Hahn, Puja Parikh, Thomas Bilfinger, David Butzel, Scott Buchanan, Nicholas Hanna, Maurice Buchbinder, Federico Asch, Gaby Weissman, Itsik Ben-Dor, Christian Shults, Hector M. Garcia-Garcia, Lowell F. Satler, Toby Rogers
Summary: The study showed that TAVR is safe and feasible in low-risk patients with severe tricuspid AS, with low mortality and minimal impact of HALT on valve durability at 2 years follow-up.
AMERICAN HEART JOURNAL
(2021)
Article
Multidisciplinary Sciences
David R. Busch, Wei Lin, Chia Chieh Goh, Feng Gao, Nicholas Larson, Joseph Wahl, Thomas V. Bilfinger, Arjun G. Yodh, Thomas F. Floyd
Summary: The researchers developed an epidural device using diffuse correlation spectroscopy to continuously monitor spinal cord ischemia at multiple positions, demonstrating high sensitivity and specificity in detecting changes in blood flow, which may allow for early identification and localization of spinal cord ischemia.
Article
Critical Care Medicine
James W. Schurr, Mohammad Noubani, Lee Ann Santore, Andrew P. Rabenstein, Kathleen Dhundale, Jillian Fitzgerald, Jan Cahill, Thomas Bilfinger, Frank C. Seifert, Allison J. McLarty
Summary: This study evaluated the use of ECMO in cardiac arrest patients, finding that BMI, RRT, and tracheostomy are predictors of in-hospital survival, and that mSAVE score and BMI are predictors of favorable neurologic outcomes.
Article
Cardiac & Cardiovascular Systems
Giorgio A. Medranda, Toby Rogers, Syed W. Ali, Cheng Zhang, Corey Shea, Kathryn A. Sciandra, Brian C. Case, Brian J. Forrestal, Joseph A. Sutton, Eugene P. McFadden, Prerna Malla, Paul Gordon, Afshin Ehsan, Sean R. Wilson, Robert Levitt, Puja Parikh, Thomas Bilfinger, Rebecca Torguson, Federico M. Asch, Gaby Weissman, Itsik Ben-Dor, Christian C. Shults, Hector M. Garcia-Garcia, Lowell F. Satler, Ron Waksman
Summary: Prosthetic valve endocarditis (PVE) following transcatheter aortic valve replacement (TAVR) in low-risk patients is rare but associated with significant morbidity and mortality. The majority of PVE cases were complicated by embolic stroke, leading to worse outcomes in these patients. Efforts should be made to minimize PVE in TAVR.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2022)
Review
Neurosciences
George B. Stefano, Pascal Buttiker, Simon Weissenberger, Radek Ptacek, Fuzhou Wang, Tobias Esch, Thomas Bilfinger, Jiri Raboch, Richard M. Kream
Summary: The long-term sequelae of COVID-19, including cognitive dysfunction such as brain fog, are becoming increasingly recognized. The mechanisms underlying these neuropsychiatric manifestations are complex, but mitochondrial dysregulation is a key factor. These manifestations are not dissimilar from those observed in other pandemics, suggesting potential common mechanisms of CNS dysfunction subsequent to viral infection. COVID-19 may also worsen neurological deficits in patients with neurodegenerative disorders. Preventing, diagnosing, and managing sustained neuropsychiatric manifestations of COVID-19 is crucial.
CURRENT NEUROPHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Puja B. Parikh, Jamie L. Romeiser, Britney Dhautel, Duran Mitchell, William Holecek, Thomas Bilfinger, Jeremy Poppers, Elliott Bennett-Guerrero
Summary: This study aimed to evaluate the prevalence, predictors, and impact of post-operative diastolic blood pressure (DBP) and pulse pressure (PP) on aortic insufficiency (AI) and mortality in patients undergoing transcatheter aortic valve replacement (TAVR). The results showed an association between low DBP and increased 1-year mortality, but no association with post-procedural AI.
CARDIOVASCULAR REVASCULARIZATION MEDICINE
(2022)
Article
Surgery
Edvard Skripochnik, Thomas Bilfinger, Shang A. Loh
Summary: The study analyzed patients with blunt thoracic aortic injury (BTAI) who underwent successful thoracic aortic endografting (TEVAR) and found that TEVAR promotes rapid aortic healing in BTAI with no evidence of residual aortic injury, suggesting long-term seal may not be necessary. The healthy aorta dilates to accommodate the stent graft size, while the injured aortic segment heals around the stent graft and assumes its diameter as well.
ANNALS OF VASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Sukhdeep Bhogal, Ron Waksman, Paul Gordon, Afshin Ehsan, Sean R. Wilson, Robert Levitt, Puja Parikh, Thomas Bilfinger, Nicholas Hanna, Maurice Buchbinder, Federico M. Asch, Gaby Weissman, Itsik Ben-Dor, Christian C. Shults, Syed Ali, Corey Shea, Cheng Zhang, Hector M. Garcia-Garcia, Lowell F. Satler, Toby Rogers
Summary: This study evaluated the impact of antithrombotic regimens on subclinical leaflet thrombosis (SLT) in low-risk patients who underwent transcatheter aortic valve implantation (TAVI). The results showed that oral anticoagulation was associated with significantly lower rates of SLT at 30 days compared to dual antiplatelet therapy (DAPT) or single antiplatelet therapy (SAPT), and there was no apparent benefit of DAPT over SAPT. Additionally, short-term oral anticoagulation did not increase bleeding risk compared to SAPT or DAPT.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Samantha Novotny, Smadar Kort, Henry Tannous, Robert Pyo, Ely Gracia, Ting-Yu Wang, Susan Callahan, Hal Skopicki, Thomas Bilfinger, Puja B. Parikh
Summary: Gender-related disparities in mortality and predictors of mortality were investigated in patients who underwent transcatheter aortic valve implantation (TAVI). The study found that risk-adjusted 1-year mortality was significantly higher in men compared to women, and there were disparate predictors of mortality between the two genders.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Oncology
Lee Ann Santore, Samantha Novotny, Robert Tseng, Mit Patel, Denise Albano, Ankit Dhamija, Henry Tannous, Barbara Nemesure, Kenneth R. Shroyer, Thomas Bilfinger
Summary: This study investigated the correlation between atypia severity and diagnosis of lung cancer or benign respiratory processes. Atypia severity, smoking pack years, and modified Herder score were found to independently predict cancer diagnosis. Patients with severe atypia may benefit from repeat sampling for cytologic confirmation, while those with milder atypia may be followed clinically.
Article
Cardiac & Cardiovascular Systems
Ron Waksman, Sukhdeep Bhogal, Paul Gordon, Afshin Ehsan, Sean R. Wilson, Robert Levitt, Puja Parikh, Thomas Bilfinger, Nicholas Hanna, Maurice Buchbinder, Federico M. Asch, Francis Y. Kim, Gaby Weissman, Itsik Ben-Dor, Christian C. Shults, Syed Ali, Joseph A. Sutton, Corey Shea, Cheng Zhang, Hector M. Garcia-Garcia, Lowell F. Satler, Toby Rogers
Summary: The study showed that TAVR is safe and durable at 4 years in low-risk patients with symptomatic severe tricuspid aortic stenosis. The presence of HALT at 30 days did not affect structural valve deterioration, transcatheter valve hemodynamics, and stroke rate at 4 years.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2023)
Letter
Medicine, Research & Experimental
Natalie K. Kolba, Byungho Lee, Henry J. Tannous, Thomas V. Bilfinger, Annie L. Shroyer
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Giorgio A. Medranda, Cesar E. Soria Jimenez, Rebecca Torguson, Brian C. Case, Brian J. Forrestal, Syed W. Ali, Corey Shea, Cheng Zhang, John C. Wang, Paul Gordon, Afshin Ehsan, Sean R. Wilson, Robert Levitt, Puja Parikh, Thomas Bilfinger, Nicholas Hanna, Maurice Buchbinder, Federico M. Asch, Gaby Weissman, Christian C. Shults, Hector M. Garcia-Garcia, Itsik Ben-Dor, Lowell F. Satler, Ron Waksman, Toby Rogers
Summary: By using CT simulation, it is possible to predict how many TAVI procedures a patient can undergo in their lifetime, as well as estimate the risk of coronary obstruction and the need for leaflet modification.