Review
Biochemistry & Molecular Biology
Yan Li, Lungen Lu, Xiaobo Cai
Summary: Liver transplantation is the only curative option for end-stage liver disease, but limitations exist, prompting the need for research into alternative options. Liver regeneration, divided into hepatocyte-driven and liver progenitor cell-driven categories, shows promise as a therapeutic strategy for end-stage liver disease.
Article
Gastroenterology & Hepatology
Branden D. Tarlow, W. Ray Kim, Ajitha Mannalithara, Paul Y. Kwo, C. Andrew Bonham, Allison Kwong
Summary: This study found that MELD 3.0 scores beyond 40 are associated with increasing waitlist mortality without adversely affecting posttransplant outcomes. Uncapping the MELD score for waitlist candidates may lead to greater survival benefits from liver transplantation.
Article
Gastroenterology & Hepatology
W. Ray Kim, Ajitha Mannalithara, Julie K. Heimbach, Patrick S. Kamath, Sumeet K. Asrani, Scott W. Biggins, Nicholas L. Wood, Sommer E. Gentry, Allison J. Kwong
Summary: The final MELD 3.0 model had better discrimination than MELDNa and accurately predicted mortality, particularly in female patients. It addresses determinants of wait list outcomes, including sex disparity, resulting in fewer wait list deaths compared to MELDNa.
Article
Oncology
Wei Li, Haitao Xiao, Hong Wu, Xuewen Xu, Yange Zhang
Summary: This study compared the long-term outcomes of liver transplantation (LT) and liver resection (LR) for patients with stage I and II hepatocellular carcinoma (HCC). The results showed that LT provided significant prognostic advantages in overall survival and disease-free survival compared to LR. Increasing the LT rate may lead to better long-term survival, but caution is needed when selecting LT for special populations like elderly patients due to similar outcomes with LR.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell & Tissue Engineering
Xin-Hao Hu, Lan Chen, Hao Wu, Yang-Bo Tang, Qiu-Min Zheng, Xu-Yong Wei, Qiang Wei, Qi Huang, Jian Chen, Xiao Xu
Summary: This article discusses the application of cell therapy in the treatment of end-stage liver disease, with a focus on various cell types used for cell transplantation and the processes involved. Furthermore, the practical obstacles of cell therapy are summarized, and potential solutions are offered.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Oncology
Jingrui Wang, Jiaqi Bao, Rui Wang, Jiachen Hong, Lincheng Zhang, Qingyang Que, Shengjun Xu, Yongfeng Wu, Qifan Zhan, Yuchen Liu, Jimin Liu, Shusen Zheng, Sunbin Ling, Xiao Xu
Summary: This study aims to establish a model to effectively predict overall survival in Chinese HCC patients with multiple tumors (> 3 tumors) who undergo LT. The AFP model is superior in predicting tumor recurrence in HCC patients with > 3 tumors prior to LT.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Review
Biology
Silvia Cesario, Virginia Genovesi, Francesca Salani, Enrico Vasile, Lorenzo Fornaro, Caterina Vivaldi, Gianluca Masi
Summary: Liver transplantation is a primary treatment for HCC, but not always possible. Immune checkpoint inhibitors have shown promising results in down-staging tumors, but more research is needed to determine their optimal use and safety.
Article
Gastroenterology & Hepatology
Zhiyong Guo, Qiang Zhao, Zehua Jia, Changjun Huang, Dongping Wang, Weiqiang Ju, Jian Zhang, Lu Yang, Shanzhou Huang, Maogen Chen, Xiaofeng Zhu, Anbin Hu, Yi Ma, Linwei Wu, Yinghua Chen, Ming Han, Yunhua Tang, Guodong Wang, Linhe Wang, Lifen Li, Wei Xiong, Zhiheng Zhang, Yuekun Shen, Zhaoxia Tang, Caihui Zhu, Xiaoxiang Chen, Xiaoguang Hu, Yiwen Guo, Honghui Chen, Yihao Ma, Tao Zhang, Shunwei Huang, Ping Zeng, Simei Lai, Tielong Wang, Zhitao Chen, Jinlong Gong, Jia Yu, Canhui Sun, Chang Li, Haiyi Tan, Yao Liu, Yuqi Dong, Chengjun Sun, Bing Liao, Jun Ren, Zhenhai Zhou, Schlegel Andrea, Nashan Bjorn, Changjie Cai, Fengqiu Gong, Jian Rong, Wenqi Huang, Xiangdong Guan, Pierre-Alain Clavien, Tullius G. Stefan, Jiefu Huang, Xiaoshun He
Summary: Ischemia-reperfusion injury (IRI) is a significant concern in organ transplantation, but ischemia-free organ transplantation may provide a solution by avoiding IRI and improving outcomes.
JOURNAL OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Ming Chao Tsai, Chee-Chien Yong, Chih-Che Lin, Wei-Chen Lee, Chih-Chi Wang, Chao-Hung Hung, I-Hsuan Chen, Yu-Fan Cheng, Chang-Chun Hsiao, Tsung-Hui Hu, Chao-Long Chen
Summary: The study found that LDLT may be a valuable therapeutic option for selected patients with BCLC stage B HCC, as patients treated with LDLT achieved better overall survival compared to the non-LDLT group. Age, NLR, and LRT before LDLT were identified as independent risk factors for HCC recurrence and overall survival.
HEPATOBILIARY SURGERY AND NUTRITION
(2021)
Article
Surgery
Hans-Christian Pommergaard, Thomas Rojkjaer Daugaard, Andreas Arendtsen Rostved, Nicolai Aagaard Schultz, Jens Hillingso, Paul Suno Krohn, Allan Rasmussen
Summary: An increased MELD score in the early postoperative period is associated with a higher risk of subsequent complications, which highlights the importance of clinician awareness to potential complications.
LANGENBECKS ARCHIVES OF SURGERY
(2021)
Article
Immunology
Therese Bittermann, Nadim Mahmud, Ethan M. Weinberg, K. Rajender Reddy
Summary: The number of patients with alcoholic hepatitis (AH) in the liver transplant waitlist has been increasing in recent years. AH patients have a shorter waiting time and higher survival and transplant rates compared to other patients with high Model for End-stage Liver Disease (MELD) scores.
Review
Radiology, Nuclear Medicine & Medical Imaging
Giuseppe Mamone, Settimo Caruso, Mariapina Milazzo, Giorgia Porrello, Ambra Di Piazza, Giovanni Gentile, Vincenzo Carollo, Francesca Crino, Gianluca Marrone, Gianvincenzo Sparacia, Luigi Maruzzelli, Roberto Miraglia, Salvatore Gruttadauria
Summary: Liver transplantation provides the best survival benefit for hepatocellular carcinoma (HCC) patients who cannot undergo resection. The Milan criteria have been developed to select suitable candidates for transplantation, aiming to improve survival and reduce the risk of HCC recurrence. However, up to 20% of cases experience HCC recurrence after transplantation, posing a significant challenge due to poor prognosis. Various extended criteria have been proposed to accommodate the increasing demand for organs and the associated higher risk of recurrence. Radiologists need to be aware of the possibility of HCC recurrence involving multiple organs after transplantation. Understanding the location and radiologic appearance of recurrent HCC is crucial for choosing the most appropriate therapy.
INSIGHTS INTO IMAGING
(2023)
Article
Medicine, General & Internal
Indah Jamtani, Kwang-Woong Lee, Yunhee Choi, YoungRok Choi, Jeong-Moo Lee, Eui-Soo Han, Kwangpyo Hong, Gyu-Seong Choi, Jong Man Kim, Nam-Joon Yi, Suk Kyun Hong, Jeik Byun, Su Young Hong, Sanggyeun Suh, Jae-Won Joh, Kyung-Suk Suh
Summary: This study aimed to develop a tailored prediction model of HCC-specific survival after transplantation, validated internally and externally. By combining multiple risk factors, the model showed good accuracy in predicting HCC-specific survival tailored for patients undergoing transplantation. The calculated SALT predictor provided accurate information on expected survival rates based on risk scores and specific characteristics.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Suguru Nakashiki, Satoshi Miuma, Hiroyuki Mishima, Hiroshi Masumoto, Masaaki Hidaka, Akihiko Soyama, Yasuko Kanda, Masanori Fukushima, Masafumi Haraguchi, Ryu Sasaki, Hisamitsu Miyaaki, Tatsuki Ichikawa, Mitsuhisa Takatsuki, Susumu Eguchi, Koh-ichiro Yoshiura, Kazuhiko Nakao
Summary: EVs, particularly bile EVs, show potential as novel biomarkers for liver diseases, with higher concentrations observed in recipients with liver failure, particularly those with hepatocellular carcinoma. The miRNA content in bile EVs increases in the ESLD state, and these miRNA levels are not correlated with those in serum EVs, indicating their promise as diagnostic tools.
HEPATOLOGY INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Mengfan Yang, Abdul Rehman Khan, Di Lu, Xuyong Wei, Wenzhi Shu, Chuanshen Xu, Binhua Pan, Zhisheng Zhou, Rui Wang, Qiang Wei, Beini Cen, Jinzhen Cai, Shusen Zheng, Xiao Xu
Summary: Avoiding ABO blood type incompatibility and cold ischemia time (CIT) >= 6 hours can greatly improve the long-term prognosis of recipients with MELD scores >30.
FRONTIERS IN MEDICINE
(2022)
Article
Pediatrics
Inbal Samuk, Akin Tekin, Panagiotis Tryphonopoulos, Ignacio G. Pinto, Jennifer Garcia, Debbie Weppler, David M. Levi, Seigo Nishida, Gennaro Selvaggi, Phillip Ruiz, Andreas G. Tzakis, Rodrigo Vianna
PEDIATRIC SURGERY INTERNATIONAL
(2016)
Article
Gastroenterology & Hepatology
Joshua Weiner, Adam Griesemer, Eddie Island, Steven Lobritto, Mercedes Martinez, Gennaro Selvaggi, Jay Lefkowitch, Monica Velasco, Panagiotis Tryphonopoulos, Jean Emond, Andreas Tzakis, Tomoaki Kato
LIVER TRANSPLANTATION
(2016)
Article
Oncology
Juan Pablo Alderuccio, Alexandra Stefanovic, Daniel Dammrich, Jennifer R. Chapman, Francisco Vega, Gennaro Selvaggi, Andreas Tzakis, Izidore S. Lossos
LEUKEMIA & LYMPHOMA
(2018)
Article
Gastroenterology & Hepatology
Zhobin Moghadamyeghaneh, Mahmoud Alameddine, Joshua S. Jue, Giselle Guerra, Gennaro Selvaggi, Seigo Nishida, J. Fan, Thiago Beduschi, Rodrigo Vianna
Letter
Surgery
Jacques Simkins, Ana Coro, Michele Morris, Jose Fernando Camargo, Shweta Anjan, Rodrigo Vianna, Gennaro Selvaggi, Thiago Beduschi, Akin Tekin, Mahmoud Morsi, Lilian Abbo
CLINICAL TRANSPLANTATION
(2019)
Article
Immunology
Jacques Simkins, Jose A. Morillas-Rodriguez, Michele I. Morris, Lilian M. Abbo, Jose F. Camargo, Gennaro Selvaggi, Thiago Beduschi, Akin Tekin, Rodrigo Vianna
TRANSPLANT INFECTIOUS DISEASE
(2019)
Article
Surgery
Ramona Nicolau-Raducu, Joshua Livingstone, Jason Salsamendi, Thiago Beduschi, Rodrigo Vianna, Akin Tekin, Gennaro Selvaggi, Yehuda Raveh
CLINICAL TRANSPLANTATION
(2019)
Article
Nutrition & Dietetics
Yehuda Raveh, Joshua Livingstone, Jared Mahan, Akin Tekin, Gennaro Selvaggi, Molly Bowdon-Romero, Ramona Nicolau-Raducu
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2020)
Article
Pediatrics
Filipe Kunzler de Oliveira Maia, Akin Tekin, Ramona Nicolau-Raducu, Thiago Beduschi, Gennaro Selvaggi, Rodrigo Vianna, Mohamad Ammar Al Nuss, Javier Gonzalez, Jeffrey J. Gaynor, Gaetano Ciancio
PEDIATRIC TRANSPLANTATION
(2020)
Article
Pediatrics
Donna Ann Cheung, Thiago Beduschi, Akin Tekin, Gennaro Selvaggi, Phillip Ruiz, Rodrigo M. Vianna, Jennifer Garcia
PEDIATRIC TRANSPLANTATION
(2020)
Article
Immunology
Rodrigo Vianna, Ahmed Farag, Jeffrey J. Gaynor, Gennaro Selvaggi, Akin Tekin, Jennifer Garcia, Thiago Beduschi
Article
Immunology
Rodrigo Vianna, Ahmed Farag, Jeffrey J. Gaynor, Gennaro Selvaggi, Akin Tekin, Jennifer Garcia, Conlan Pierce, Thiago Beduschi
Review
Immunology
Yumeng M. Li, Clara Milikowski, Gennaro Selvaggi, Lillian M. Abbo, Dimitra Skiada, Fabrizio Galimberti
TRANSPLANT INFECTIOUS DISEASE
(2020)
Review
Transplantation
Jennifer Garcia, Gennaro Selvaggi, Akin Tekin, Rodrigo Vianna
Summary: Recent practices in intestinal transplantation have shown improvement in overall results, making it a viable option for patients requiring permanent home parenteral nutrition. Timing for referral and preoperative and postoperative management are crucial factors in optimizing long-term outcomes.
CURRENT OPINION IN ORGAN TRANSPLANTATION
(2021)
Article
Surgery
Jeffrey J. Gaynor, Marina M. Tabbara, Gaetano Ciancio, Gennaro Selvaggi, Jennifer Garcia, Akin Tekin, Rodrigo Vianna
Summary: In testing the prognostic value of an intervening event, three statistical methods exist, but many clinical reports show time-dependent bias, leading to severe underestimation of the true hazard ratio.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)