Article
Gastroenterology & Hepatology
Jan Bednarsch, Zoltan Czigany, Isabella Lurje, Christian Trautwein, Tom Luedde, Pavel Strnad, Nadine Therese Gaisa, Alexandra Barabasch, Philipp Bruners, Tom Ulmer, Sven Arke Lang, Ulf Peter Neumann, Georg Lurje
Summary: In a European cohort of patients undergoing surgical resection for HCC, Child-Pugh Score, operative time, and intraoperatively administered fresh frozen plasma were identified as independent prognostic markers of major surgical complications. Intraoperative administration of FFP was found to be an important independent predictor of perioperative morbidity in these patients.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Gastroenterology & Hepatology
Jordyn Silverstein, Francis Y. Yao, Joshua D. Grab, Hillary J. Braun, John Roberts, Jennifer L. Dodge, Neil Mehta
Summary: Living donor liver transplantation (LDLT) is an attractive option for hepatocellular carcinoma (HCC) patients, but its utilization has remained low in recent years. LDLT is an underutilized but valuable option for high-risk patients at risk of waitlist dropout.
LIVER TRANSPLANTATION
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ningbin Luo, Xiangyang Huang, Yinan Ji, Guanqiao Jin, Yunying Qin, Bangde Xiang, Danke Su, Weizhong Tang
Summary: This study found that the functional liver imaging score (FLIS) based on preoperative gadoxetic acid-enhanced MRI can predict posthepatectomy liver failure (PHLF) in hepatocellular carcinoma (HCC) patients. FLIS has a higher predictive power than the MELD score, ALBI score, and ICG-R15 clearance.
EUROPEAN RADIOLOGY
(2022)
Article
Surgery
Maria Conticchio, Antonella Delvecchio, Valentina Ferraro, Matteo Stasi, Annachiara Casella, Nicola Chetta, Emma De Marinis, Andrea Madaro, Margherita Raele, Rosalinda Filippo, Michele Ammendola, Michele Tedeschi, Nicola deAngelis, Riccardo Memeo
Summary: Spontaneous rupture of hepatocellular carcinoma (HCC) is a rare complication, and its management requires considering the clinical conditions of the patient and the best curative treatment. We reported a case of an emergency robotic liver resection for a ruptured HCC in an elderly patient. Minimally invasive liver resection is currently recognized as a safe and feasible approach for the treatment of HCC in elderly patients.
INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY
(2023)
Article
Oncology
Feng Tian, Songyao Leng, Jian Chen, Yong Cao, Li Cao, Xiaojun Wang, Xuesong Li, Juan Wang, Shuguo Zheng, Jianwei Li
Summary: LLR has shown better short-term outcomes and comparable long-term outcomes with OLR in treating HCCs. LMLR-DS and LMH can also be effective in the treatment of HCCs.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Zhancheng Qiu, Weili Qi, Youwei Wu, Lingling Li, Chuan Li
Summary: This study examines the impact of public insurance status on the survival outcomes of HCC patients after liver resection in China. The results show that underinsured HCC patients have worse survival outcomes after liver resection. This may be due to the limited access to care for underinsured patients, but further exploration is needed for conclusive evidence.
Article
Oncology
Emrullah Birgin, Sarah R. Kaslow, Svetlana Hetjens, Camilo Correa-Gallego, Nuh N. Rahbari
Summary: In patients with HCC, minimally invasive liver resection is associated with similar overall survival but improved short-term postoperative outcomes compared to traditional open liver resection. However, there is a higher rate of positive margins after MILR, which requires further investigation, and surgical procedures at academic institutions may help prevent these adverse outcomes.
Article
Multidisciplinary Sciences
Anisa Nutu, Iago Justo, Alberto Marcacuzco, Oscar Caso, Alejandro Manrique, Jorge Calvo, Alvaro Garcia-Sesma, Maria Garcia-Conde, Maria Santos Gallego, Carlos Jimenez-Romero
Summary: The recurrence of HCC was similar between patients receiving DBD and uDCD livers, but graft survival was lower in the uDCD group. Patient survival was found to be associated with recipient age, pre-OLT bridging therapy, and HCC recurrence, while HCC recurrence was primarily linked to pre-OLT transarterial chemoembolization.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Ioannis Angelopoulos, Cesar Trigo, Maria-Ignacia Ortuzar, Jimena Cuenca, Claudia Brizuela, Maroun Khoury
Summary: This study evaluated the potential of Platelet Poor Plasma (PPP) as a biomaterial for regenerative endodontics procedures (REPs). The study found that PPP scaffold was compatible with dental pulp stem cells (DPSC) and umbilical cord mesenchymal stem cells (UC-MSC), with differences in proliferation and angiogenic properties. Histological analysis showed the formation of dentin-like structure with MSC-PPP implants. This study provides evidence of a cost-effective scaffold for dental pulp regeneration.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Zhiyong Guo, Liqiang Zhan, Ningxin Gao, Zhiheng Zhang, Shanzhou Huang, Linhe Wang, Caihui Zhu, Zehua Jia, Meixian Yin, Fangcong Li, Shirui Chen, Tao Luo, Yao Liu, Yu Jia, Tielong Wang, Jinghong Xu, Yuexin Li, Yifan Zhu, Yichao Chen, Chuhan Yu, Yunhua Tang, Qiang Zhao, Dongping Wang, Xiaoshun He
Summary: This study compared the metabolism activities of donor livers between in situ and ex situ conditions during ischemia-free liver transplantation. Common and distinct metabolites were identified, indicating suppressed urea cycle pathway and more active metabolism in standard criteria donor group. These findings provide insights for improving perfusion device design, perfusate components, and graft viability criteria.
Article
Oncology
Shogo Tanaka, Shoji Kubo, Takeaki Ishizawa
Summary: Laparoscopic liver resection (LLR) is widely accepted in the surgical treatment of hepatocellular carcinoma (HCC) due to its advantages such as earlier recovery and fewer complications compared to open liver resection (OLR). LLR is technically feasible for selected patients with HCC even in challenging situations. Robot-assisted liver resection (RALR) has also gained popularity and is expected to become the main approach for minimally invasive surgery in the future.
Article
Oncology
Masateru Yamamoto, Tsuyoshi Kobayashi, Masakazu Hashimoto, Shintaro Kuroda, Tomokazu Kawaoka, Hiroshi Aikata, Kazuaki Chayama, Hideki Ohdan
Summary: The study validated the prognostic significance of Kinki criteria subclassifications in patients with intermediate stage HCC and analyzed the role of liver resection in patients of different substage. The results showed that liver resection provides a better prognosis than other treatment modalities for B1 substage patients, while alternative approaches are needed for B2 and B3 substage patients.
Article
Geriatrics & Gerontology
Jinhuan Yang, Kaiwen Chen, Chongming Zheng, Kaiyu Chen, Jian Lin, Qishan Meng, Ziyan Chen, Liming Deng, Haitao Yu, Tuo Deng, Zhiyuan Bo, Qikuan He, Yi Wang, Gang Chen
Summary: This study found that sarcopenia is associated with adverse outcomes after liver resection for HCC, with higher rates of major complications, blood transfusion, hospitalization expenses, and longer hospital stay. Evaluating sarcopenia upon admission can help classify high-risk patients and reduce the risk of major complications.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Medicine, General & Internal
Lea Penzkofer, Jens Mittler, Stefan Heinrich, Nicolas Wachter, Beate K. Straub, Roman Kloeckner, Fabian Stoehr, Simon Johannes Gairing, Fabian Bartsch, Hauke Lang
Summary: Liver cirrhosis is a common risk factor for hepatocellular carcinoma (HCC), but a small percentage of HCC cases occur in non-cirrhotic livers. This study found that liver resection for non-cirrhotic HCC is an acceptable treatment approach with relatively good outcomes, even for extensive tumors.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Xinye Qian, Wang Hu, Lu Gao, Jingyi Xu, Bo Wang, Jiyong Song, Shizhong Yang, Qian Lu, Lin Zhang, Jun Yan, Jiahong Dong
Summary: In this study, the possibility of positive liver watershed staining via trans-arterial ICG injection under DSA examination for navigating laparoscopic watershed-oriented hepatic resection was explored.
FRONTIERS IN ONCOLOGY
(2022)