Article
Pharmacology & Pharmacy
Gaelle Hugon, Sebastien Goutal, Ambre Dauba, Louise Breuil, Benoit Larrat, Alexandra Winkeler, Anthony Novell, Nicolas Tournier
Summary: Focused ultrasound in combination with microbubbles enhances therapeutics delivery to the brain by increasing blood-brain barrier permeability. PET imaging using [F-18]FDS is evaluated as a marker for BBB integrity, showing significantly increased distribution in the brain after FUS. These findings demonstrate the potential of [F-18]FDS PET as a sensitive and reproducible marker for noninvasive monitoring of BBB disruption induced by FUS in vivo.
Article
Oncology
Maxwell W. G. Miner, Heidi Liljenback, Jenni Virta, Semi Helin, Olli Eskola, Petri Elo, Jarmo Teuho, Kerttu Seppala, Vesa Oikonen, Guangli Yang, Andrea Kindler-Roehrborn, Heikki Minn, Xiang-Guo Li, Anne Roivainen
Summary: This study investigated the imaging capabilities of three PET imaging compounds in orthotopic BT4C gliomas in BDIX rats and compared two imaging systems. Results indicated that [F-18]FGln may offer improved imaging compared to [C-11]Met and [F-18]FDG, with similar end-result ratios between Inveon and Molecubes camera systems. Pharmacokinetic modeling suggested both reversible and irreversible uptake play an important role in the uptake of [F-18]FGln in BDIX rat pharmacokinetics.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemical Research Methods
Filipa Mota, Patricia De Jesus, Sanjay K. Jain
Summary: Researchers developed a method to synthesize F-18-FDS for positron emission tomography imaging to visualize infections. Clinical study in 26 patients showed that F-18-FDS PET was safe and could differentiate infections caused by Enterobacterales from other pathologies such as sterile inflammation or cancer.
Article
Biochemistry & Molecular Biology
Xiang Zhang, Falguni Basuli, Sameh Abdelwahed, Tadhg Begley, Rolf Swenson
Summary: A simple and efficient process for fluorine-18-labeled 1,2,3-triazole was reported, achieving successful radiofluorination through iodine-fluorine-18 exchange in an aqueous medium. The methodology was optimized on a model reaction and validated on multiple 1,2,3-triazole substrates, with radiochemical conversions ranging from 18-60%. Using this strategy, a triazole-based thiamin analogue was synthesized with isolated radiochemical yield of 10-16% in 40 minutes, showing potential for positron emission tomography (PET) imaging of thiamin-dependent enzymes.
Article
Veterinary Sciences
Yoonhoi Koo, Taesik Yun, Yeon Chae, Dohee Lee, Mingyun Son, Dayoung Ku, Hakhyun Kim, Mhan-Pyo Yang, Byeong-Teck Kang
Summary: This case report discusses the use of F-18-2-deoxy-2-fluoro-D-glucose positron emission tomography/computed tomography for evaluating the invasiveness and metastasis of inflammatory mammary carcinoma in a dog.
VETERINARY MEDICINE AND SCIENCE
(2022)
Article
Oncology
Peng He, Bing Zhang, Yuan Zou, Yan Zhang, Zhihao Zha, Yali Long, Jia Qiu, Wanqing Shen, Xiaoping Lin, Zhoulei Li, Xiangsong Zhang
Summary: The study aimed to identify AA-sensitive tumor cells using molecular imaging, showing that colorectal cancer cells with high SVCT2 expression uptake more AA. The results demonstrated that the F-18-DFA tracer can visualize tumor accumulation in mice, with SVCT2 potentially being a biomarker in this process.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sangwon Han, Yong-il Kim, Jungsu S. Oh, Seung Yeon Seo, Min-Jae Park, Geun Dong Lee, Sehoon Choi, Hyeong Ryul Kim, Yong-Hee Kim, Dong Kwan Kim, Seung-Il Park, Jin-Sook Ryu
Summary: The study evaluated the diagnostic and prognostic value of pretreatment 2-[F-18]FDG PET/CT in TETs patients. The results showed that SUVmax was excellent in distinguishing thymic carcinoma from other subtypes (low-risk thymoma, high-risk thymoma) and had significant prognostic value for predicting TC.
EUROPEAN RADIOLOGY
(2022)
Article
Otorhinolaryngology
Kuo-Wei Hung, Hsiao-Yun Chen, Jia Joanna Wang, Hsueh-Chien Cheng, Ming-Syuan Wu, Leong-Perng Chan
Summary: This case report presents a rare case of laryngeal rhabdomyoma, which was incidentally found on a chest CT scan. After surgery and histological examination, it was confirmed to be a rhabdomyoma, and the patient had no recurrence after treatment.
ENT-EAR NOSE & THROAT JOURNAL
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Dineo Mpanya, Akinwale Ayeni, Stuart More, Bawinile Hadebe, Mike Sathekge, Nqoba Tsabedze
Summary: Current guidelines recommend timely revascularisation for acute coronary syndromes, but many patients in LMIC or remote areas in HIC do not have immediate access to this treatment, resulting in delayed intervention and potentially worse outcomes.
CLINICAL AND TRANSLATIONAL IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Philip Z. Mannes, Clayton E. Barnes, Joseph D. Latoche, Kathryn E. Day, Jessie R. Nedrow, Janet S. Lee, Sina Tavakoli
Summary: This study aims to use [F-18]FDG PET to image inflammation and monitor therapeutic response to anti-inflammatory intervention in a preclinical model of ALI. The results demonstrate that [F-18]FDG PET can noninvasively detect lung inflammation in ALI and its response to anti-inflammatory therapy.
MOLECULAR IMAGING AND BIOLOGY
(2023)
Article
Medicine, General & Internal
Hou-Ying Cheng, Kai-Wen Huang, Jin-Tung Liang, Been-Ren Lin, John Huang, Ji-Shiang Hung, Chi-Ling Chen
Summary: Multi-RFA and hepatectomy provide similar survival benefits for resectable colorectal cancer liver metastases patients, while systemic treatment has inferior outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
S. Habbous, X. Tai, T. Gill, J. Arias, J. Beca, M. J. Raphael, E. Kennedy, J. J. Biagi, K. K. W. Chan
Summary: The aim of this study was to evaluate the safety and effectiveness of oxaliplatin-based combination chemotherapy for patients with metastatic colorectal cancer (mCRC) to extrahepatic sites. A retrospective study conducted in Ontario, Canada showed that oxaliplatin-based chemotherapy was safe and resulted in similar outcomes in patients with resectable or potentially resectable mCRC with extrahepatic metastases, compared to patients with liver-only metastases.
Article
Oncology
Diego G. Vaz da Silva, Luis C. Bredt, Alessandro L. Diniz, Victor H. R. Vieira, Paulo H. S. Fernandes, Reitan Ribeiro, Heber S. C. Ribeiro, Alexandre F. Oliveira
Summary: The management of colorectal cancer liver metastasis has become complex with the increasing availability of medical, radiological, and surgical treatment options. However, surgical resection remains the only evidence-based curative therapy. These surgical standards by the Brazilian Surgical Oncology Society aim to guide clinicians in making evidence-based decisions regarding the modern surgical management of resectable CRLM within a multidisciplinary team.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Veterinary Sciences
Yeon Chae, Taesik Yun, Yoonhoi Koo, Dohee Lee, Hakhyun Kim, Mhan-Pyo Yang, Byeong-Teck Kang
Summary: This study used FDG-PET/CT to identify physiological FDG uptake in cats and compared it with dogs, revealing differences in brain and digestive system uptake. Understanding these differences can improve cancer diagnosis and glucose metabolism understanding in both cats and dogs.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Amanda J. Boyle, Emily Murrell, Junchao Tong, Christin Schifani, Andrea Narvaez, Melinda Wuest, Frederick West, Frank Wuest, Neil Vasdev
Summary: This study demonstrates the potential of using fluorine-18 labeled 6-fluoro-6-deoxy-D-fructose (6-[F-18]FDF) as a PET radiotracer to image microglial GLUT5 density in the brain following neuroinflammatory insult. The uptake of 6-[F-18]FDF in the ipsilateral striatum of LPS-injected rats was significantly higher compared to the contralateral striatum, while [F-18]FDG showed highest uptake at one week post-LPS injection. Immunohistochemistry confirmed the activation of microglia and astrocytes in the ipsilateral striatum. This proof-of-concept study highlights the early response of 6-[F-18]FDF to neuroinflammatory stimuli and its potential applications in neuroinflammatory and neurodegenerative diseases.
Article
Pharmacology & Pharmacy
Jingxia Liu, Chengjie Xiong, Lei Liu, Guoqiao Wang, Luo Jingqin, Feng Gao, Ling Chen, Yan Li
Summary: This study investigates the impact of equal versus unequal cluster sizes on treatment effects in cluster randomized trials, suggesting that increasing the number of clusters can compensate for efficiency loss due to different cluster sizes.
JOURNAL OF BIOPHARMACEUTICAL STATISTICS
(2021)
Article
Oncology
Jennifer A. Foltz, Brian T. Hess, Veronika Bachanova, Nancy L. Bartlett, Melissa M. Berrien-Elliott, Ethan McClain, Michelle Becker-Hapak, Mark Foster, Timothy Schappe, Brad Kahl, Neha Mehta-Shah, Amanda F. Cashen, Nancy D. Marin, Kristen McDaniels, Chaz Moreno, Matthew Mosior, Feng Gao, Obi L. Griffith, Malachi Griffith, Julia A. Wagner, Narendranath Epperla, Amy D. Rock, John Lee, Allegra A. Petti, Patrick Soon-Shiong, Todd A. Fehniger
Summary: The combination therapy of N-803 with rituximab demonstrated safety and durable clinical responses in patients with indolent non-Hodgkin lymphoma, including rituximab-refractory patients. Analysis using CITE-seq revealed altered molecular programs in NK cells and monocytes post-treatment, suggesting the potential for further investigation of N-803 in combination with immunotherapies.
CLINICAL CANCER RESEARCH
(2021)
Article
Statistics & Probability
Jingqin Luo, Feng Gao, Jingxia Liu, Guoqiao Wang, Ling Chen, Anne M. Fagan, Gregory S. Day, Jonathan Voeglein, Jasmeer P. Chhatwal, Chengjie Xiong
Summary: Bivariate correlation coefficients are commonly used in medical research to assess the relationship between two variables. In a family-type clustered design, BCCs can be defined and estimated at various hierarchical levels. Simulation studies were conducted to evaluate the performance of proposed estimators.
JOURNAL OF APPLIED STATISTICS
(2022)
Article
Oncology
Bita Fakhri, Elif Yilmaz, Feng Gao, Richard F. Ambinder, Richard Jones, Nancy L. Bartlett, Amanda Cashen, Nina Wagner-Johnston
Summary: For relapsed Hodgkin lymphoma, salvage chemotherapy followed by auto-HCT is the standard of care. It is important to identify subpopulations who could benefit from allo-HCT. The choice of transplant (auto-HCT or allo-HCT) did not affect PFS or OS after controlling for risk factors, but in patients with >= 3 high risk features, those who underwent allo-HCT had a slightly better 4-year PFS compared to the auto-HCT cohort.
LEUKEMIA & LYMPHOMA
(2021)
Letter
Oncology
Sena Kim, Kidist Ashami, Sora Lim, Karl Staser, Kiran Vij, Srikanth Santhanam, Julie Ritchey, Sarah Peterson, Feng Gao, Matthew A. Ciorba, Matthew L. Cooper, John F. DiPersio, Jaebok Choi
Article
Hematology
Jingyu Xiang, Min Shi, Mark A. Fiala, Feng Gao, Michael P. Rettig, Geoffrey L. Uy, Mark A. Schroeder, Katherine N. Weilbaecher, Keith E. Stockerl-Goldstein, Shamim Mollah, John F. DiPersio
Summary: Mobilized peripheral blood has become the primary source of hematopoietic stem cells. This study compared different mobilization regimens and developed a machine learning model to predict inadequate stem cell yields in allogeneic donors.
Editorial Material
Theater
Aoife Mcgrath, Marcus Cheng Chye Tan, Prarthana Purkayastha, Tereza Havelkova
THEATRE RESEARCH INTERNATIONAL
(2021)
Article
Theater
Marcus Cheng Chye Tan
Summary: "Dear John" is an experimental choreomusical work that reinterprets Cage's works and explores the relationship between improvised movement and a soundscape of defamiliarized instruments. It considers the interplay of movement and music, as well as the sonic politics of relational possibility, while also investigating experiences of time's indeterminacy and elasticity through the interaction of motion and music.
THEATRE RESEARCH INTERNATIONAL
(2021)
Article
Biology
Horng-Shiuann Wu, F. Gao, L. Yan, C. Given
Summary: The study found that light therapy can significantly improve post-treatment fatigue and subjective sleep quality in female survivors of breast cancer who still experience fatigue and sleep disruption 1-3 years after completing chemotherapy and/or radiation. Additionally, unexpected benefits of dim light on sleep were observed, improving some sleep parameters.
CHRONOBIOLOGY INTERNATIONAL
(2022)
Book Review
Medieval & Renaissance Studies
Marcus Cheng Chye Tan
RENAISSANCE AND REFORMATION
(2021)
Article
Education & Educational Research
Marcus Cheng Chye Tan, Stefanie Yen Leng Chye, Kylin Shu Min Teng
Summary: There is an increasing use of interactive technologies and virtual environments in classrooms, and immersive virtual environments (IVEs) can better facilitate perspective-taking and empathy among students.
EDUCATION AND INFORMATION TECHNOLOGIES
(2022)
Correction
Education & Educational Research
Marcus Cheng Chye Tan, Stefanie Yen Leng Chye, Kylin Shu Min Teng
EDUCATION AND INFORMATION TECHNOLOGIES
(2022)
Article
Theater
Marcus Cheng Chye Tan
Summary: This passage discusses how avantgarde toy pianist Margaret Leng Tan exploits the interplay between theatricality and musicality to demonstrate the importance of theatrimusicality in the creation and reception of her music. It uses Curios (2015) as an example to illustrate how the structure of meaning and the experience of the carnivalesque are evoked through theatrimusical dramaturgy.
TDR-THE DRAMA REVIEW-THE JOURNAL OF PERFORMANCE STUDIES
(2022)
Article
Hematology
Michael Slade, Mark A. Fiala, Marie Kirchmeyer, Jeff King, Feng Gao, Mark A. Schroeder, A. Keith Stewart, Keith Stockerl-Goldstein, Christine Chen, Ravi Vij
Summary: This study investigates the use of elotuzumab, pomalidomide, and dexamethasone (EPd) as salvage therapy prior to and maintenance after second autologous hematopoietic cell transplantation (AHCT2) for relapsed multiple myeloma. The results show that EPd maintenance after AHCT2 is safe and tolerable, with similar 1-year progression-free survival (PFS) and median PFS compared to previous studies.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)
Article
Hematology
Lawrence Wayne Liu, Alicia Yn, Feng Gao, Marissa Olson, Mallory Crain, Ramzi Abboud, Peter Westervelt, Camille Abboud, Ravi Vij, Keith Stockerl-Goldstein, Iskra Pusic, Amanda F. Cashen, Mark A. Schroeder
Summary: Letermovir is effective in preventing CMV infection in CMV seropositive recipients. This study provides data on the incidence of csCMVi and overall survival beyond the initial 24 weeks after alloSCT. It also identifies risk factors for CMV-related mortality and suggests the possible need for extended use of letermovir.
TRANSPLANTATION AND CELLULAR THERAPY
(2022)