Article
Surgery
Xuefei Wang, Guochao Zhang, Zhichao Zuo, Qingli Zhu, Shafei Wu, Yidong Zhou, Feng Mao, Yan Lin, Songjie Shen, Xiaohui Zhang, Xue Qin, Cunli Yan, Xiaoying Ma, Yue Shi, Qiang Sun
Summary: This retrospective study found an association between SLN positive rate and non-SLN metastasis in breast cancer, with SLN-PR > 0.333 being a potential risk factor for non-SLN metastasis. The results provide valuable reference for guiding adjuvant treatment in breast cancer patients.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Medicine, General & Internal
Shuang-long Cai, Ran-mei Wei, Lei Han, Xiao-geng Chen, Guo-xian Gong, Xiu-quan Lin, Jin Zhang, Hong-dan Chen
Summary: By analyzing the risk factors of non-sentinel lymph node (NSLN) metastasis in breast cancer patients with sentinel lymph node (SLN) positive, this study found that primary tumor size, number of positive SLNs, ratio of positive SLNs, and SLN metastasis type were independent risk factors. These factors can effectively predict NSLN metastasis and guide appropriate surgical treatments.
Article
Oncology
Ya Qiu, Xiang Zhang, Zhiyuan Wu, Shiji Wu, Zehong Yang, Dongye Wang, Hongbo Le, Jiaji Mao, Guochao Dai, Xuwei Tian, Renbing Zhou, Jiayi Huang, Lanxin Hu, Jun Shen
Summary: The MRI-clinical-radiomics nomograms developed in this study showed high predictive performance in determining axillary NSLN status in SLN-positive breast cancer patients, reducing overtreatment and optimizing personalized surgical strategies.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Paolo Izzo, Claudia De Intinis, Simone Sibio, Luigi Basso, Andrea Polistena, Raimondo Gabriele, Massimo Codacci-Pisanelli, Luciano Izzo, Sara Izzo
Summary: This study proposed new techniques to prevent complications of sentinel lymph node biopsy and presented initial data from our experience. The identification rates of sentinel lymph node detection using radioactive tracers and the magnetic tracer technology (Sentimag) were 88.9% and 89.5% respectively.
Article
Oncology
Stacy B. Sanders, Tanya L. Hoskin, Arielle P. Stafford, Judy C. Boughey
Summary: This study evaluated the rate of non-sentinel lymph node (NSLN) positivity and factors influencing this in patients with a positive sentinel lymph node (SLN) following neoadjuvant chemotherapy (NAC). The results showed a high rate of nodal positivity on completion axillary lymph node dissection (cALND) in the setting of positive SLN after NAC, supporting the current standard of routine cALND. In patients with cN+ disease, NSLN positivity varied based on tumor biology, multicentricity/multifocality, number of positive SLNs, and SLN metastasis size.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Sean M. Hacking, Kara-Lynne Leonard, Dongling Wu, Mara Banks, Theresa Graves, Lijuan Wang, Evgeny Yakirevich, Yihong Wang
Summary: The use of sentinel lymph node biopsy (SLNB) in patients with microinvasive breast cancer (MIBC) has been debated. This study evaluated clinical and histological features to predict disease free survival (DFS) and factors influencing clinical decision making in MIBC patients. SLNB was found to be associated with mastectomy, high nuclear grade, and negativity for ER and HER-2. However, SLNB did not impact DFS in this study.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Madeleine Hetterich, Michael Gerken, Olaf Ortmann, Elisabeth C. Inwald, Monika Klinkhammer-Schalke, Holm Eggemann, Atanas Ignatov
Summary: The study found that axillary lymph node micrometastases have an impact on the survival and recurrence rates of breast cancer patients, but this effect disappears after adjusting for age, tumor size, and grading. For patients with micrometastases, adjuvant chemotherapy did not significantly improve overall survival or recurrence-free survival compared to those without adjuvant chemotherapy.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Chemistry, Analytical
Fahime Shahsavari, Mohsen Bakhshi Kashi, Saeed Farzanefar, Elisabeth Eppard, Nasim Vahidfar
Summary: Breast cancer is a deadly malignancy, and early and accurate diagnosis is crucial for long-term survival. Nuclear medicine has recently introduced a novel method for evaluating breast cancer at both early and advanced stages. This method is based on sentinel lymph node scintigraphy, which is preferable to axillary lymphadenectomy due to its lower postoperative complications. Radiocolloids have shown superior effectiveness in detecting metastatic lymph nodes. In this short review, we will introduce the important role of radiopharmaceuticals in the clinical application of breast cancer lymphoscintigraphy.
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2023)
Article
Oncology
Xi'E Hu, Jingyi Xue, Shujia Peng, Ping Yang, Zhenyu Yang, Lin Yang, Yanming Dong, Lijuan Yuan, Ting Wang, Guoqiang Bao
Summary: This study developed a nomogram to preoperatively predict the risk of SLN metastasis in breast cancer patients, demonstrating high predictive performance and clinical usefulness.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Stacy B. Sanders, Tanya L. Hoskin, Malvika H. Solanki, Arielle P. Stafford, Judy C. Boughey, Tina J. Hieken
Summary: Immunohistochemistry (IHC) improves the detection of pN0(i+) disease in invasive lobular carcinoma (ILC) patients undergoing sentinel lymph node (SLN) surgery, but does not increase nodal upstaging, the number of positive SLNs detected, or axillary lymph node dissection (ALND) rates.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Francesco Giammarile, Sergi Vidal-Sicart, Diana Paez, Olivier Pellet, Estrada-Lobato Enrique, Miriam Mikhail-Lette, Olga Morozova, Navarro Marulanda Maria Camila, Rodriguez Sanchez Diana Ivonne, Roberto C. Delgado Bolton, Renato A. Valdes Olmos, Giuliano Mariani
Summary: Breast cancer is the most common cancer in women worldwide, and sentinel lymph node biopsy is a highly reliable method for detecting lymph node metastasis. Despite some variations and differences, improved accuracy can be achieved with the accumulation of experience.
SEMINARS IN NUCLEAR MEDICINE
(2022)
Article
Medicine, General & Internal
Piotr Kedzierawski, Artur Bocian, Agnieszka Radowicz-Chil, Anna Huruk-Kuchinka, Ryszard Mezyk
Summary: The purpose of this study was to determine the correlation between the biological subtype of breast cancer and the risk of metastasis to a sentinel lymph node. In the analyzed group of 1018 women with breast cancer, 57% were classified as Luminal A subtype. A positive sentinel lymph node was found in 26.5% of the women.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Review
Surgery
Fulong Chen, Xiaowen Li, Xianjun Lin, Lijia Chen, Zhaoling Lin, Hao Wu, Jishang Chen
Summary: This meta-analysis examined the role of axillary lymph node dissection (ALND) in breast cancer patients with positive sentinel lymph nodes (SLNs) undergoing mastectomy. The results showed that performing ALND in patients with limited SLN metastases was associated with certain clinicopathological factors, but it did not significantly improve survival outcomes. Further randomized clinical trials are needed to confirm these findings.
WORLD JOURNAL OF SURGERY
(2023)
Article
Medicine, General & Internal
Alan Sosa, Xiudong Lei, Wendy A. Woodward, Mariana Chavez Mac Gregor, Anthony Lucci, Sharon H. Giordano, Kevin T. Nead
Summary: This retrospective cohort study using the National Cancer Database found that there is a frequent and increasing use of SLNB in patients with IBC. The study included women diagnosed with nonmetastatic IBC who underwent axillary surgery from 2012 to 2017, and revealed a significant increasing trend in the use of SLNB from 2012 to 2017.
Article
Oncology
Toralf Reimer
Summary: The local treatment of axilla in early breast cancer patients without clinically evident lymph node metastases is a subject of debate. Various prospective randomized surgical trials are currently being conducted to evaluate the safety of omitting sentinel lymph node biopsy in upfront breast-conserving surgery and neoadjuvant setting. These trials aim to determine whether it is possible to make therapeutic decisions without pathologic evaluation of nodal status. Additionally, ongoing trials are investigating the possibility of de-escalating surgery based on the response to neoadjuvant systemic therapy.
Article
Oncology
Brittany J. Mathias, James Sun, Weihong Sun, Jun-Min Zhou, William J. Fulp, Christine Laronga, M. Catherine Lee, John Kiluk
Summary: The study evaluates the factors that led surgeons to forego CALND in cN0 mastectomy patients with positive SLNB. Younger age, larger tumors, increased number of positive sentinel nodes, invasive lobular carcinoma, extranodal extension, and lymphovascular invasion were significantly associated with delayed CALND.
CLINICAL BREAST CANCER
(2021)
Article
Oncology
James Sun, Danielle A. Henry, Michael J. Carr, Adel Yazdankhahkenary, Christine Laronga, M. Catherine Lee, Susan J. Hoover, Weihong Sun, Brian J. Czerniecki, Nazanin Khakpour, John Kiluk
Summary: Radar reflector localization (RRL)-guided targeted axillary dissection (TAD) after neoadjuvant chemotherapy (NAC) is a safe and feasible approach for assessing nodal involvement in breast cancer patients, confirming the excision of positive axillary nodes, and reducing false-negative rates.
CLINICAL BREAST CANCER
(2021)
Article
Oncology
James Sun, Brittany J. Mathias, Christine Laronga, Weihong Sun, Jun-Min Zhou, William J. Fulp, John Kiluk, M. Catherine Lee
Summary: The study found that completion axillary lymph node dissection (CLND) after mastectomy did not significantly reduce recurrence or improve overall survival (OS) in clinically node-negative, sentinel lymph node (SLN)-positive breast cancer patients. However, completion of postmastectomy radiotherapy was associated with improved OS.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Puja Parikh, Zena Jameel, Shannon Falcon, Marilin Rosa, John Kiluk, Susan Hoover, Hatem Soliman, Dana Ataya
Summary: Adenomyoepithelioma of the breast is a rare tumor composed of epithelial and myoepithelial cells, with the potential for malignant transformation. Imaging features, clinical presentation, and management are important aspects to consider in the diagnosis and treatment of this condition.
Meeting Abstract
Oncology
Hatem Hussein Soliman, Hyo S. Han, Deanna Hogue, Blaise Mooney, Ricardo L. Costa, Marie Catherine Lee, Bethany Niell, Angela Williams, Alec Chau, Shannon Falcon, Nazanin Khakpour, Aixa Soyano, Avan J. Armaghani, Robert J. Weinfurtner, Susan Hoover, John Kiluk, Marilin Rosa, Brooke Fridley, Hung T. Khong, Brian J. Czerniecki
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Surgery
Kelly Walton, Kirsti Walker, Megan Riddle, Brent H. Koehn, Jordan Reff, Elizabeth M. Sagatys, Michael A. Linden, Joseph Pidala, Jongphil Kim, Marie C. Lee, John Kiluk, Jane Yuet Ching Hui, Sang Y. Yun, Yan Xing, Heather Stefanski, Harshani R. Lawrence, Nicholas J. Lawrence, Jakub Tolar, Claudio Anasetti, Bruce R. Blazar, Said M. Sebti, Brian C. Betts
Summary: AJI-100, a dual inhibitor of JAK2 and Aurora kinase A, ameliorates skin graft rejection by human T cells and provides durable allo-inactivation. It reduces allograft invasion by limiting skin-homing CLA(+) donor T cells and suppresses pathogenic Th1 and Th17 cells while sparing regulatory T cells. Additionally, AJI-100 enhances human type 2 innate lymphoid cell responses for tissue repair by maintaining pSTAT5 levels and blocking interference by STAT3.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Pathology
Zena Jameel, John Kiluk, Marilin Rosa
Summary: Adenomyoepithelioma is a spectrum of lesions with variable morphology and clinical behavior. It is characterized by proliferation of epithelial and myoepithelial cells and can be benign, atypical or malignant. Malignant cases may require additional treatments such as radiotherapy and lymph node biopsy.
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
(2022)
Article
Oncology
James Sun, Xiaojun Zhong, Junjie Ma, Weihong Sun, Hyo S. Han, Hatem H. Soliman, Loretta S. Loftus, Ricardo L. B. Costa, Avan J. Armaghani, Aixa E. Soyano-Muller, Brian J. Czerniecki, M. Catherine Lee, John Kiluk, Nazanin Khakpour, Susan J. Hoover, Christine Laronga, Hung T. Khong
Summary: The combination of CDK4/6 inhibitor and endocrine therapy shows similar efficacy in real-world settings for the treatment of HR-positive, HER2-negative mBC patients compared to the PALOMA-2 trial. Lower neutrophil count may be associated with a reduced risk of early disease progression.
Article
Nursing
Jong Y. Park, Cecile A. Lengacher, Richard R. Reich, Hyun Y. Park, Junmin Whiting, Anh Thy Nguyen, Carmen Rodriguez, Hongdao Meng, Sara Tinsley, Katterine Chauca, Liliana Gordillo-Casero, Trudy Wittenberg, Anisha Joshi, Katherine Lin, Roohi Ismail-Khan, John Kiluk, Kevin E. Kip
Summary: This preliminary study aims to investigate the relationship between genetic variants and cognitive/cardiac phenotypes in breast cancer survivors treated with chemotherapy. The study found significant relationships between certain genetic variants and cognitive functioning as well as cardiac outcomes, providing initial targets for interventions to improve cognitive and cardiac functioning following chemotherapy.
BIOLOGICAL RESEARCH FOR NURSING
(2022)
Article
Oncology
Julia M. Selfridge, Heather F. Sinner, Junmin Whiting, Weihong Sun, Melissa A. Mallory, Susan J. Hoover, John Kiluk, Nazanin Khakpour, Brian J. Czerniecki, Christine Laronga, Qianxing Mo, Marie C. Lee
Summary: Microporous polysaccharide particles (MPP) were evaluated as a hemostatic agent for post-operative outcomes. The study found no significant difference in infection, seroma, or hematoma between patients treated with and without MPP. However, it was noted that patients undergoing lymphovenous anastomosis (LVA) were more at risk of seroma and less likely to receive MPP. Consideration should be given to utilizing MPP in this LVA population.
CLINICAL BREAST CANCER
(2022)
Correction
Biochemistry & Molecular Biology
Hatem Soliman, Deanna Hogue, Hyo Han, Blaise Mooney, Ricardo Costa, Marie C. C. Lee, Bethany Niell, Angela Williams, Alec Chau, Shannon Falcon, Aixa Soyano, Avan Armaghani, Nazanin Khakpour, Robert J. J. Weinfurtner, Susan Hoover, John Kiluk, Christine Laronga, Marilin Rosa, Hung Khong, Brian Czerniecki
Article
Biochemistry & Molecular Biology
Hatem Soliman, Deanna Hogue, Hyo Han, Blaise Mooney, Ricardo Costa, Marie C. Lee, Bethany Niell, Angela Williams, Alec Chau, Shannon Falcon, Aixa Soyano, Avan Armaghani, Nazanin Khakpour, Robert J. Weinfurtner, Susan Hoover, John Kiluk, Christine Laronga, Marilin Rosa, Hung Khong, Brian Czerniecki
Summary: This article presents the phase 2 trial of T-VEC plus NAC for triple-negative breast cancer (TNBC). The study found that T-VEC plus NAC may increase RCB0-1 rates in TNBC patients, supporting further investigation of this treatment approach.
Meeting Abstract
Surgery
James Sun, Michael Carr, Weihong Sun, Junmin Zhou, Youngchul Kim, Susan J. Hoover, John V. Kiluk, Marie Catherine Lee, Christine Laronga
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2020)
Meeting Abstract
Oncology
Dakota Jenneman, Xiaojun Zhong, Junjie Ma, Weihong Sun, Heather Han, Hatem Soliman, Loretta Loftus, Ricardo Costa, Avan Armaghani, Aixa Soyano, Brian Czerniecki, M. Catherine Lee, John Kiluk, Nazanin Khakpour, Susan Hoover, Christine Laronga, Hung T. Khong
Meeting Abstract
Oncology
Hatem Soliman, Deanna Hogue, Hyo Han, Hung Khong, Ricardo Costa, Avan Armaghani, Axia Soyano Muller, Nazanin Khakpour, Marie C. Lee, John Kiluk, Brian Czerniecki