Enabling Low Cost Biopharmaceuticals: A Systematic Approach to Delete Proteases from a Well-Known Protein Production Host Trichoderma reesei

N-terminal entrance loop of yeast Yps1 and O-glycosylation of substrates are determinant factors controlling the shedding activity of this GPI-anchored endopeptidase

(2015) Alexandre K Dubé et al.   BMC MICROBIOLOGY

A genomic survey of proteases in Aspergilli

(2014) Sebnem Budak et al.   BMC GENOMICS

Enhanced production of heterologous proteins by the filamentous fungus Trichoderma reesei via disruption of the alkaline serine protease SPW combined with a pH control strategy

(2014) Guoxiu Zhang et al.   PLASMID

Unconventional microbial systems for the cost-efficient production of high-quality protein therapeutics

(2012) José Luis Corchero et al.   BIOTECHNOLOGY ADVANCES

Transcriptional and Proteomic Analysis of the Aspergillus fumigatus ΔprtT Protease-Deficient Mutant

(2012) Shelly Hagag et al.   PLoS One

Proteomic Analysis of pH and Strains Dependent Protein Secretion ofTrichoderma reesei

(2011) Sunil S Adav et al.   JOURNAL OF PROTEOME RESEARCH

Transformation System forHypocrea jecorina(Trichoderma reesei) That Favors Homologous Integration and Employs Reusable Bidirectionally Selectable Markers

(2010) Matthias G. Steiger et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Disruption of ten protease genes in the filamentous fungus Aspergillus oryzae highly improves production of heterologous proteins

(2010) Jaewoo Yoon et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Transcription Factor PrtT Controls Expression of Multiple Secreted Proteases in the Human Pathogenic Mold Aspergillus fumigatus

(2009) H. Sharon et al.   INFECTION AND IMMUNITY

The effect of environmental conditions on extracellular protease activity in controlled fermentations of Aspergillus niger

(2009) M. Braaksma et al.   MICROBIOLOGY-SGM

Construction of quintuple protease gene disruptant for heterologous protein production in Aspergillus oryzae

(2008) Jaewoo Yoon et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Monitoring Global Gene Expression of Proteases and Improvement of Human Lysozyme Production in thenptBGene Disruptant ofAspergillus oryzae

(2008) Shinya KIMURA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

The interaction of induction, repression and starvation in the regulation of extracellular proteases in Aspergillus nidulans: evidence for a role for CreA in the response to carbon starvation

(2008) Margaret E. Katz et al.   CURRENT GENETICS

Characterization of the Aspergillus niger prtT, a unique regulator of extracellular protease encoding genes

(2008) Peter J. Punt et al.   FUNGAL GENETICS AND BIOLOGY

Genome sequencing and analysis of the biomass-degrading fungus Trichoderma reesei (syn. Hypocrea jecorina)

(2008) Diego Martinez et al.   NATURE BIOTECHNOLOGY

Isolation of four pepsin-like protease genes from Aspergillus niger and analysis of the effect of disruptions on heterologous laccase expression

(2007) Yongchao Wang et al.   FUNGAL GENETICS AND BIOLOGY