Article
Public, Environmental & Occupational Health
Yizhen Hu, Canqing Yu, Yu Guo, Zheng Bian, Yuting Han, Ling Yang, Yiping Chen, Huaidong Du, Yuanjie Pang, Dianjianyi Sun, Jianrong Jin, Jun Zhang, Jingjia Wang, Chunli Shao, Yi-Da Tang, Junshi Chen, Zhengming Chen, Jun Lv, Liming Li
Summary: A study based on the China Kadoorie Biobank found that pneumonia hospitalization was associated with both short- and long-term increases in ischaemic cardiovascular disease risk among middle-aged and older Chinese adults. Pre-existing cardiovascular risk factors and age above 70 years amplified this association.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Daniel Bos, Banafsheh Arshi, Quirijn J. A. van den Bouwhuijsen, M. Kamran Ikram, Mariana Selwaness, Meike W. Vernooij, Maryam Kavousi, Aad van der Lugt
Summary: This study found that hemorrhage in carotid atherosclerotic plaque is an independent risk factor for stroke and coronary heart disease.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cell Biology
Yizhou Zhu, Seungjin Ryu, Archana Tare, Nir Barzilai, Gil Atzmon, Yousin Suh
Summary: Genome-wide association studies have identified the chromosomal locus 9p21.3 as a genetic hotspot for age-related disorders. In this study, the sequencing of this region in an Ashkenazi Jewish centenarian cohort revealed a significant depletion of risk alleles associated with various diseases. The findings suggest that the extreme longevity cohort may have collectively lower risks of multiple age-related diseases in the 9p21.3 locus.
Article
Medicine, General & Internal
Jaskanwal Deep Singh Sara, Elad Maor, Diana Orbelo, Rajiv Gulati, Lliach O. Lerman, Amir Lerman
Summary: This study found a significant association between a noninvasive voice biomarker and incident CAD events at follow-up, which may have important clinical implications for the remote and noninvasive screening of patients to identify those at risk of coronary disease and its complications.
MAYO CLINIC PROCEEDINGS
(2022)
Article
Cardiac & Cardiovascular Systems
Jun Gu, Zhao-fang Yin, Zuo-jun Xu, Yu-qi Fan, Chang-qian Wang, Jun-feng Zhang
Summary: This study showed that after PCI, the predominant subtype of HF is HFpEF, and higher BNP levels, lower eGFR levels, and atrial fibrillation are independent risk factors for new-onset HF. Being male and being prescribed with ACEI/ARB medications are negative predictors for new-onset HF. Additionally, long-term ACEI/ARB therapy is associated with reduced risks of developing all three subtypes of HF (HFrEF, HFmrEF, and HFpEF), compared to beta-blocker use.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Adebamike A. Oshunbade, Wondwosen Kassahun-Yimer, Karen A. Valle, Arsalan Hamid, Rodney K. Kipchumba, Daisuke Kamimura, Donald Clark, Wendy B. White, Andrew P. DeFilippis, Michael J. Blaha, Emelia J. Benjamin, Emily C. O'Brien, Robert J. Mentz, Carlos J. Rodriguez, Ervin R. Fox, Javed Butler, Rachel J. Keith, Aruni Bhatnagar, Rose Marie Robertson, Adolfo Correa, Michael E. Hall
Summary: In a large prospective cohort of Black adults, current smoking was associated with a more than 2-fold increased risk of CHD over a median follow-up of greater than a decade. The difference in CHD risk between former smokers and never smokers was not statistically significant. There was no observed dose-response effect for CHD risk among current smokers. Furthermore, current smokers had greater odds of coronary artery calcification compared with never smokers.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Mahmoud Al Rifai, Michael J. Blaha, Vijay Nambi, Steven J. C. Shea, Erin D. Michos, Roger S. Blumenthal, Christie M. Ballantyne, Moyses Szklo, Philip Greenland, Michael D. Miedema, Khurram Nasir, Jerome I. Rotter, Xiuqing Guo, Jie Yao, Wendy S. Post, Salim S. Virani
Summary: Current cigarette smoking, diabetes, and hypertension are independently associated with incident ASCVD over a 16-year follow-up among those with CAC=0.
Article
Biology
Flavia Hodel, Zhi Ming Xu, Christian Wandall Thorball, Roxane de la Harpe, Prunelle Letang-Mathieu, Nicole Brenner, Julia Butt, Noemi Bender, Tim Waterboer, Pedro Manuel Marques-Vidal, Peter Vollenweider, Julien Vaucher, Jacques Fellay
Summary: Coronary heart disease (CHD) is a major health problem, with complex interactions between genetic and environmental factors leading to its occurrence. A study using multiplex serological testing and genome-wide analysis on a population cohort revealed that high polygenic risk and infection with Fusobacterium nucleatum are independently associated with incident CHD.
Article
Genetics & Heredity
Muhammad Mobeen Zafar, Muhammad Saqlain, Asad Mehmood Raja, Pakeeza Arzoo Shaiq, Muhammad Javaid Asad, Muhammad Kausar Nawaz Shah, Farah Fatima, Hadi Valadi, Muhammad Nawaz, Ghazala Kaukab Raja
Summary: In Pakistani subjects, the genetic variant in the 9p21 locus is strongly associated with MetS and cardiometabolic risks regardless of cardiovascular diseases. This study provides important insights into genetic prediction of cardiometabolic risks.
Article
Cardiac & Cardiovascular Systems
Chike C. Nwabuo, Duke Appiah, Henrique T. Moreira, Henrique D. Vasconcellos, Yuichiro Yano, Jared P. Reis, Ravi Shah, Venkatesh L. Murthy, Norrina B. Allen, Stephen Sidney, Paul Muntner, Cora E. Lewis, Donald M. Lloyd-Jones, Pamela J. Schreiner, Samuel S. Gidding, Joao A. C. Lima
Summary: The study found that cumulative blood pressure in young adults is associated with the risk of heart failure, coronary heart disease, stroke, and cardiovascular diseases. Cumulative blood pressure provides incremental prognostic value and improves risk reclassification for cardiovascular diseases when compared to single blood pressure assessments or changes in blood pressure.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Feng Xiong, Rui Mao, Ruohan Zhao, Lijuan Zhang, Kunyue Tan, Chunxia Liu, Shuzhen Wang, Min Xu, Yi Li, Tongtong Zhang
Summary: This study identified potential non-invasive biomarkers for coronary heart disease (CHD) screening by analyzing the mRNA expression levels in small extracellular vesicles (sEVs). Upregulated S1PR5 and downregulated CARNS1 in sEVs showed significant differences between CHD patients and non-CHD patients, and were correlated with various clinical parameters. These findings suggest that S1PR5 and CARNS1 have the potential to become non-invasive biomarkers for CHD screening.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Oncology
Yujing Xia, Alison Brewer, Jordana T. Bell
Summary: Coronary heart disease (CHD) is a major global cause of mortality. Recent studies have identified DNA methylation signatures associated with CHD development, suggesting their potential use in predicting future CHD events. New mechanisms involved in CHD progression have been uncovered through DNA methylation studies.
CLINICAL EPIGENETICS
(2021)
Article
Cardiac & Cardiovascular Systems
Raphael S. Peter, Andrea Jaensch, Ute Mons, Ben Schottker, Roman Schmucker, Wolfgang Koenig, Hermann Brenner, Dietrich Rothenbacher
Summary: In patients with stable coronary heart disease, a trajectory of high stable symptoms of depression was associated with an increased risk of incident diabetes mellitus (DM) and subsequent cardiovascular events (CVE). Identifying depressive symptoms and providing relevant treatment may be an important and promising approach to improve outcomes in patients with coronary heart disease, warranting further research and implementation.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Wending Li, Kuai Yu, Ningning Jia, Xuedan Xu, Yu Yuan, Rong Peng, Rundong Niu, Xiaomin You, Handong Yang, Gaokun Qiu, Huan Guo, Meian He, Xiaomin Zhang, An Pan, Lap Ah Tse, Tangchun Wu
Summary: This study showed that longer durations of past shift work were associated with higher risk of coronary heart disease among retired workers, especially those in the service or sales sectors. Physical exercise may help reduce this excess risk.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yuechuan Fu, Mayinuer Yusufu, Yueye Wang, Mingguang He, Danli Shi, Ruobing Wang
Summary: There is a significant association between retinal microvascular parameters and incident coronary heart disease (CHD). The study found that a lower complexity and density of the retinal vascular network may indicate an increased risk of incident CHD, suggesting that quantitative measurements of retinal structure can help predict CHD.
Article
Biotechnology & Applied Microbiology
Marie de Bakker, Jaco Kraan, K. Martijn Akkerhuis, Rohit Oemrawsingh, Folkert W. Asselbergs, Imo Hoefer, Isabella Kardys, Eric Boersma
Summary: Patients who have had acute coronary syndrome (ACS) are at risk of a recurrent event, but their level of risk varies. Longitudinal measurements of circulating endothelial cells (CECs) have the potential to improve individual risk assessment.
Article
Mathematical & Computational Biology
Abdulrahman Alasiri, Konrad J. J. Karczewski, Brian Cole, Bao-Li Loza, Jason H. H. Moore, Sander W. W. van der Laan, Folkert W. W. Asselbergs, Brendan J. J. Keating, Jessica van Setten
Summary: Loss-of-Function (LoF) variants in human genes have a significant impact on clinical phenotypes and are frequently found in healthy individuals' genomes. The Loss-of-Function ToolKit (LoFTK) has been developed to efficiently predict LoF variants from genotyped and sequenced genomes, allowing the identification of inactive genes with 1 or 2 copies and the discovery of potential therapeutic targets.
Review
Cardiac & Cardiovascular Systems
Karen R. Gaar-Humphreys, Alyssa Brink, Mark Wekking, Folkert W. Asselbergs, Frank G. van Steenbeek, Magdalena Harakalova, Jiayi Pei
Summary: Inherited cardiomyopathies, caused by pathological genetic variants, encompass various types of heart diseases. Next-generation sequencing has facilitated the identification of numerous genetic variants as pathological ones, but there is variation in disease penetrance among mutated genes, leading to a complex genotype-phenotype relationship. Previous studies have highlighted disrupted metabolism and metabolic adaptations in inherited cardiomyopathies, particularly in lipid metabolism. This mini-review discusses the metabolic changes associated with dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM), the most common subtypes, and emphasizes the potential of PPARA-targeting drugs as fatty acid oxidation modulators in treating inherited cardiomyopathies.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Megan Schroeder, Yvonne Mei Fong Lim, Gianluigi Savarese, Kiliana Suzart-Woischnik, Claire Baudier, Tomasz Dyszynski, Ilonca Vaartjes, Marinus J. C. Eijkemans, Alicia Uijl, Ronald Herrera, Eleni Vradi, Jasper J. Brugts, Hans-Peter Brunner-La Rocca, Vanessa Blanc-Guillemaud, Sandra Waechter, Fabrice Couvelard, Benoit Tyl, Samuel Fatoba, Arno W. Hoes, Lars H. Lund, Christoph Gerlinger, Folkert W. Asselbergs, Diederick E. Grobbee, Maureen Cronin, Stefan Koudstaal
Summary: To understand the impact of sex differences on the generalizability of randomized clinical trials (RCTs) in heart failure (HF) patients, a comparison was made between RCTs and HF observational registries stratified by sex. The results showed that there were no differences in trial enrollment between males and females, but female trial participants had lower mortality rates while male trial participants had higher cardiovascular mortality rates.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Medicine, General & Internal
Jasper J. Brugts, Sumant P. Radhoe, Pascal R. D. Clephas, Dilan Aydin, Marco W. F. van Gent, Mariusz K. Szymanski, Michiel Rienstra, Mieke H. van den Heuvel, Carlos A. da Fonseca, Gerard C. M. Linssen, C. Jan Willem Borleffs, Eric Boersma, Folkert W. Asselbergs, Arend Mosterd, Hans-Peter Brunner-La Rocca, Rudolf A. de Boer
Summary: The MONITOR-HF trial conducted in the Netherlands examined the impact of haemodynamic monitoring on quality of life and heart failure hospitalization in patients with heart failure. The study found that haemodynamic monitoring significantly improved patients' quality of life and reduced heart failure hospitalizations.
Article
Cardiac & Cardiovascular Systems
Lieke Numan, Daniel Zimpfer, Osnat Itzhaki Ben Zadok, Emmeke Aarts, Michiel Morshuis, Sabina P. W. Guenther, Julia Riebandt, Dominik Wiedemann, Faiz Z. Ramjankhan, Anne-Marie Oppelaar, Tuvia Ben-Gal, Binyamin Ben-Avraham, Folkert W. Asselbergs, Rene Schramm, Linda W. Van Laake
Summary: This study compared the outcomes of patients using HeartWare (HVAD) and HeartMate 3 (HM3), and found that HM3 patients had better survival rates and lower incidence of heart failure. The results suggest that prophylactic exchange to HM3 is necessary for HVAD patients.
Letter
Public, Environmental & Occupational Health
Elsie M. F. Horne, William J. Hulme, Ruth H. Keogh, Tom M. Palmer, Elizabeth J. Williamson, Edward P. K. Parker, Venexia M. Walker, Rochelle Knight, Yinghui Wei, Kurt Taylor, Louis Fisher, Jessica Morley, Amir Mehrkar, Iain Dillingham, Sebastian Bacon, Ben Goldacre, Jonathan A. C. Sterne
Summary: Understanding how the effectiveness of COVID-19 vaccines changes over time and in response to new variants is crucial for scheduling subsequent doses. Previous research has shown that vaccine effectiveness decreases in a log-linear manner over time and remains consistent across different risk-based subgroups. To further investigate the waning effectiveness beyond 26 weeks and in the era of the Omicron variant, the follow-up period was extended to the earliest of 50 weeks after the second dose or March 31, 2022.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Medicine, General & Internal
Wichanon Sae-jie, Suangsuda Supasai, Mika Kivimaki, Jackie F. Price, Andrew Wong, Meena Kumari, Jorgen Engmann, Tina Shah, Amand F. Schmidt, Tom R. Gaunt, Aroon Hingorani, Pimphen Charoen
Summary: This study uses triangulation of evidence from observational and Mendelian randomization studies to investigate the association and causation between ketone bodies and cognitive function. The results suggest that 3-beta-hydroxybutyrate (BOHBUT), the most abundant ketone metabolite, has a beneficial effect on cognitive performance and may delay cognitive impairment and reduce the risk of Alzheimer's disease.
Article
Cardiac & Cardiovascular Systems
Feddo P. Kirkels, Nick van Osta, Christine Rootwelt-Norberg, Monica Chivulescu, Tim van Loon, Eivind W. Aabel, Anna I. Castrini, Oyvind H. Lie, Folkert W. Asselbergs, Tammo Delhaas, Maarten J. Cramer, Arco J. Teske, Kristina H. Haugaa, Joost Lumens
Summary: This study aims to assess the need for age-tailoring of follow-up protocols in early ARVC by evaluating myocardial disease progression in different age groups.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Genetics & Heredity
Maryam Kavousi, Maxime M. Bos, Hanna J. Barnes, Christian L. Lino Cardenas, Doris Wong, Haojie Lu, Chani J. Hodonsky, Lennart P. L. Landsmeer, Adam W. Turner, Minjung Kho, Natalie R. Hasbani, Paul S. de Vries, Donald W. Bowden, Sandesh Chopade, Joris Deelen, Ernest Diez Benavente, Xiuqing Guo, Edith Hofer, Shih-Jen Hwang, Sharon M. Lutz, Leo-Pekka Lyytikaeinen, Lotte Slenders, Albert V. Smith, Maggie A. Stanislawski, Jessica van Setten, Quenna Wong, Lisa R. Yanek, Diane M. Becker, Marian Beekman, Matthew J. Budoff, Mary F. Feitosa, Chris Finan, Austin T. Hilliard, Sharon L. R. Kardia, Jason C. Kovacic, Brian G. Kral, Carl D. Langefeld, Lenore J. Launer, Shaista Malik, Firdaus A. A. Mohamed Hoesein, Michal Mokry, Reinhold Schmidt, Jennifer A. Smith, Kent D. Taylor, James G. Terry, Jeroen van der Grond, Joyce van Meurs, Rozemarijn Vliegenthart, Jianzhao Xu, Kendra A. Young, Nuno R. Zilhao, Robert Zweiker, Themistocles L. Assimes, Lewis C. Becker, Daniel Bos, J. Jeffrey Carr, L. Adrienne Cupples, Dominique P. v. de Kleijn, Menno de Winther, Hester M. den Ruijter, Myriam Fornage, Barry I. Freedman, Vilmundur Gudnason, Aroon D. Hingorani, John E. Hokanson, M. Arfan Ikram, Ivana Isgum, David R. Jacobs, Mika Kaehoenen, Leslie A. Lange, Terho Lehtimaeki, Gerard Pasterkamp, Olli T. Raitakari, Helena Schmidt, P. Eline Slagboom, Andre G. Uitterlinden, Meike W. Vernooij, Joshua C. Bis, Nora Franceschini, Bruce M. Psaty, Wendy S. Post, Jerome I. Rotter, Johan L. M. Bjoerkegren, Christopher J. O'Donnell, Lawrence F. Bielak, Patricia A. Peyser, Rajeev Malhotra, Sander W. van der Laan, Clint L. Miller
Summary: This study conducted a large-scale analysis and identified eleven new risk loci for coronary artery calcification (CAC), a measure of subclinical atherosclerosis. These new loci are related to bone mineralization, phosphate catabolism, and hormone metabolic pathways. The findings contribute to a better understanding of the genetic architecture of CAC and provide potential targets for therapeutic interventions.
Review
Biochemistry & Molecular Biology
Claudia Langenberg, Aroon D. Hingorani, Christopher J. M. Whitty
Summary: Globally, the number of people with multiple co-occurring diseases is expected to rise in the future, which will have significant implications for various stakeholders. To address this challenge, there needs to be a shift in clinical, educational, and scientific thinking, emphasizing the maintenance of generalist skills alongside specialized medical education and research. Multimorbidity is not uniform, but varies across different factors, such as age, ethnicity, gender, socioeconomic status, and geography. Data-driven research can help quantify the impact of disease co-occurrence and identify common clusters, enabling a more comprehensive understanding of multimorbidity and the provision of efficient and integrated healthcare services for patients.
Article
Clinical Neurology
Mona M. Almramhi, Chris Finan, Catherine S. Storm, Amand F. Schmidt, Demis A. Kia, Rachel Coneys, Sandesh Chopade, Aroon D. Hingorani, Nick W. Wood
Summary: The study suggests that RAC2 is a genetic modifier of MS risk and supports a causal effect of HDL-C on MS risk.
Article
Medicine, General & Internal
Teun B. Petersen, Marie de Bakker, Folkert W. Asselbergs, Magdalena Harakalova, K. Martijn Akkerhuis, Jasper J. Brugts, Jan van Ramshorst, R. Thomas Lumbers, Rachel M. Ostroff, Peter D. Katsikis, Peter J. van der Spek, Victor A. Umans, Eric Boersma, Dimitris Rizopoulos, Isabella Kardys
Summary: This study identified four distinct subphenotypes of HFrEF based on circulating protein profiles, which had different prognosis and clinical characteristics. These findings can provide insights into the underlying biological mechanisms and personalized treatment opportunities for patients with HFrEF.
Article
Medical Informatics
Valerie Kuan, Spiros Denaxas, Praveetha Patalay, Dorothea Nitsch, Rohini Mathur, Arturo Gonzalez-Izquierdo, Reecha Sofat, Linda Partridge, Amanda Roberts, Ian C. K. Wong, Melanie Hingorani, Nishi Chaturvedi, Harry Hemingway, Aroon Hingorani, MMTRC
Summary: This study provides important data on multimorbidity and comorbidity in diverse populations, highlighting non-random disease associations and patterns. It offers valuable resources for patients, clinicians, researchers, and policymakers to improve prevention, detection, and management of comorbid conditions. The findings also have implications for biomedical research and the development of clinical trials.
LANCET DIGITAL HEALTH
(2023)