High-Throughput Assay Development for Cystine-Glutamate Antiporter (xc-) Highlights Faster Cystine Uptake than Glutamate Release in Glioma Cells

Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target

(2013) Luika A. Timmerman et al.   CANCER CELL

Metabotropic Glutamate Receptors Inhibit Microglial Glutamate Release

(2012) Stephen M McMullan et al.   ASN Neuro

Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells

(2012) Anne Le et al.   Cell Metabolism

Mechanisms of Oxidative Glutamate Toxicity: The Glutamate/Cystine Antiporter System xc¯ as a Neuroprotective Drug Target

(2012) Philipp Albrecht et al.   CNS & Neurological Disorders-Drug Targets

Cancer metabolism: current perspectives and future directions

(2012) C Muñoz-Pinedo et al.   Cell Death & Disease

Inhibition of transporter-mediated cystine uptake by sulfasalazine analogs

(2011) Krupa Shukla et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

System xc− regulates microglia and macrophage glutamate excitotoxicity in vivo

(2011) Kristina A. Kigerl et al.   EXPERIMENTAL NEUROLOGY

Increased expression of cystine/glutamate antiporter in multiple sclerosis

(2011) Olatz Pampliega et al.   Journal of Neuroinflammation

Loss of System xFormula Does Not Induce Oxidative Stress But Decreases Extracellular Glutamate in Hippocampus and Influences Spatial Working Memory and Limbic Seizure Susceptibility

(2011) D. De Bundel et al.   JOURNAL OF NEUROSCIENCE

Glutaminolysis: Supplying carbon or nitrogen or both for cancer cells?

(2010) Chi V. Dang   CELL CYCLE

Dopaminergic neurons of system xc−-deficient mice are highly protected against 6-hydroxydopamine-induced toxicity

(2010) Ann Massie et al.   FASEB JOURNAL

HIV-Tat elicits microglial glutamate release: Role of NAPDH oxidase and the cystine–glutamate antiporter

(2010) Sunita Gupta et al.   NEUROSCIENCE LETTERS

Isoxazole analogues bind the System xc- transporter: Structure–activity relationship and pharmacophore model

(2009) Sarjubhai A. Patel et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Conformationally-restricted amino acid analogues bearing a distal sulfonic acid show selective inhibition of system over the vesicular glutamate transporter

(2009) Jean-Louis G. Etoga et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Activation of Metabotropic Glutamate Receptor 5 Modulates Microglial Reactivity and Neurotoxicity by Inhibiting NADPH Oxidase

(2009) David J. Loane et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sulfasalazine inhibits the growth of primary brain tumors independent of nuclear factor-κB

(2009) W. Joon Chung et al.   JOURNAL OF NEUROCHEMISTRY

The xc− cystine/glutamate antiporter: A potential target for therapy of cancer and other diseases

(2008) Maisie Lo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Small interfering RNA–mediated xCT silencing in gliomas inhibits neurodegeneration and alleviates brain edema

(2008) Nicolai E Savaskan et al.   NATURE MEDICINE

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols