Article
Medicine, General & Internal
Agnieszka Bartczak-Rutkowska, Lidia Tomkiewicz-Pajak, Katarzyna Kawka-Paciorkowska, Natalia Bajorek, Aleksandra Cieplucha, Mariola Ropacka-Lesiak, Olga Trojnarska
Summary: A study investigated the maternal and fetal outcomes of women who had undergone the Fontan procedure in two Polish medical centers. Among 26 pregnancies, 11 ended in miscarriages and 15 resulted in 16 live births. Fetal complications were observed in 9 live births, with prematurity being the most common. Obstetrical complications occurred in 6 pregnancies, including placental abruption, premature rupture of membranes, and antepartum hemorrhage. Specialized care from experienced cardiologists and obstetricians is necessary for these women.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Emma Payne, Frances Garden, Yves D'Udekem, Zoe McCallum, Helen Wightman, Diana Zannino, Dominica Zentner, Rachael Cordina, Robert Weintraub, Thomas G. Wilson, Julian Ayer
Summary: Poor infant growth in patients with a single ventricle is associated with increased long-term Fontan failure. Establishing BMI trajectory models in these patients helps determine optimal BMI targets for patient outcomes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Review
Cardiac & Cardiovascular Systems
Jianrui Ma, Jimei Chen, Tong Tan, Xiaobing Liu, Rong Liufu, Hailong Qiu, Shuai Zhang, Shusheng Wen, Jian Zhuang, Haiyun Yuan
Summary: Fontan surgery provides a surgical approach for functional single-ventricle patients, but it can lead to non-physiological circulation and various complications. Current understanding of these complications is incomplete and treatment strategies are not well-defined.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Critical Care Medicine
Asaad G. Beshish, Ozzie Jahadi, Ashley Mello, Vamsi V. Yarlagadda, Andrew Y. Shin, David M. Kwiatkowski
Summary: This retrospective study examined the association between hyperoxia during cardiopulmonary bypass and outcomes in infants undergoing cardiac surgery. The results showed that hyperoxia was associated with increased mortality risk, acute kidney injury, and prolonged postoperative length of stay. Further research is needed to validate these findings and understand the mechanisms behind this association.
PEDIATRIC CRITICAL CARE MEDICINE
(2021)
Article
Critical Care Medicine
Jacek Kolcz, Elzbieta Karnas, Zbigniew Madeja, Ewa K. Zuba-Surma
Summary: Inhaled nitric oxide during cardiopulmonary bypass in Fontan surgery can improve short-term clinical outcomes by reducing respiratory support time, intensive care time, inflammatory response, and metabolic stress, and enhancing myocardial and lung protection.
JOURNAL OF INTENSIVE CARE
(2022)
Article
Cardiac & Cardiovascular Systems
David A. Katz, Daniel Peck, Adam M. Lubert, Mathias Possner, Faizeen Zafar, Andrew T. Trout, Joseph J. Palermo, Nadeem Anwar, Jonathan R. Dillman, Adam W. Powell, Stavra A. Xanthakos, Alexander R. Opotowsky, Gruschen Veldtman, Tarek Alsaied
Summary: Hepatic steatosis in patients with Fontan circulation is associated with risk factors such as obesity and dyslipidemia, similar to the general population, while not related to Fontan hemodynamics.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Richard D. Mainwaring, Lou Capecci, R. Thomas Collins, Frank L. Hanley
Summary: This study assessed the midterm fate of unifocalized major aortopulmonary collateral arteries (MAPCAs) in patients with retroesophageal MAPCAs. The majority of unifocalized MAPCAs remained widely patent, but a quarter developed stenoses or occlusion. Close vigilance is necessary for the management of these patients.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Adam M. Lubert, Tarek Alsaied, Joseph J. Palermo, Nadeem Anwar, Elaine M. Urbina, Nicole M. Brown, Craig Alexander, Hassan Almeneisi, Fred Wu, Andrew R. Leventhal, Nael Aldweib, Michael Mendelson, Alexander R. Opotowsky
Summary: Fontan circulation is associated with decreased cholesterol levels, and lower high-density lipoprotein cholesterol is linked to adverse outcomes, possibly driven by inflammation. Further studies are needed to explore the relationship between the severity of Fontan-associated liver disease and lipid metabolism.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Pediatrics
Antonio F. Corno, Tina O. Findley, Jorge D. Salazar
Summary: This article reviews the changes in management strategies and innovations for patients with functionally single ventricle physiology. By analyzing a series of innovations in methods, diagnosis, and treatment from fetal to adult life, it is found that these last 40 years have indeed changed the natural history of patients with congenital single ventricle. However, there is still much left unexplored and room for improvement, which requires collaboration among different institutions and specialties.
TRANSLATIONAL PEDIATRICS
(2023)
Article
Cardiac & Cardiovascular Systems
Makoto Miyake, Jiro Sakamoto, Hirokazu Kondo, Atsushi Iwakura, Hiraku Doi, Toshihiro Tamura
Summary: This study aimed to investigate the long-term outcomes of patients with single-ventricle physiology after the Glenn procedure without the subsequent Fontan procedure. The study found that the 40-year overall survival after the Glenn procedure in patients with single-ventricle physiology was 40.3%. Dominant left ventricular morphology may be associated with better long-term overall survival than dominant right ventricular morphology.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Shinichiro Oda, Satoshi Fujita, Hideki Tatewaki, Akira Shiose
Summary: This article reports a case of coronary artery compression associated with aortic root dilation in a patient with congenital heart disease, and introduces an effective method of treatment using valve-sparing aortic root replacement.
ANNALS OF THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Russell S. Martins, Ronika D. Ukrani, Muhammad K. Memon, Waris Ahmad, Saleem Akhtar
Summary: Prolonged cardiopulmonary bypass time during operations for adult congenital heart disease may lead to worse postoperative outcomes. Risk factors included preoperative left ventricular dysfunction, while obesity was found to be protective. Prolonged CPBT was associated with longer ventilation, cardiac ICU stay, and hospital stay.
JOURNAL OF CARDIOVASCULAR SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Syed Shahyan Bakhtiyar, Sara Sakowitz, Konmal Ali, Nikhil L. Chervu, Arjun Verma, Ming-Sing Si, David D'Alessandro, Peyman Benharash
Summary: The study evaluates the survival rate after heart transplantation in adults with single and biventricular CHD and compares it to that of non-CHD transplant recipients. Single-ventricle physiology is associated with higher short-term mortality, but 10-year conditional survival is similar for biventricular CHD patients and most single-ventricle CHD patients, and notably better for biventricular CHD patients compared to non-CHD heart transplant recipients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Nutrition & Dietetics
Letizia Baldini, Katia Librandi, Chiara D'Eusebio, Antonella Lezo
Summary: This review aims to analyze the role of an adequate form of nutritional support in patients with Fontan circulation throughout different stages of their lives and provide a practical approach to appropriate nutritional management.
Article
Medicine, General & Internal
Ilona Palyga-Bysiecka, Aneta Maria Polewczyk, Maciej Polewczyk, Elzbieta Kolodziej, Henryk Mazurek, Andrzej Pogorzelski
Summary: This study examines the clinical course, therapeutic measures, outcome, and follow-up of plastic bronchitis (PB) in children with congenital heart disease (CHD) and children without cardiac problems. It found that there are differences in the course of the disease in patients without CHD, such as a higher age of first episode of PB, the location of plastic casts, and a stronger role of inflammatory factors and mechanisms.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Sara K. Pasquali, Eric D. Peterson, Jeffrey P. Jacobs, Xia He, Jennifer S. Li, Marshall L. Jacobs, J. William Gaynor, Jennifer C. Hirsch, Samir S. Shah, John E. Mayer
ANNALS OF THORACIC SURGERY
(2013)
Meeting Abstract
Cardiac & Cardiovascular Systems
D. L. Morales, F. Zafar, J. W. Gaynor, J. W. Rossano, J. L. Jefferies, T. D. Ryan, J. A. Towbin, A. Lorts
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2013)
Meeting Abstract
Cardiac & Cardiovascular Systems
D. S. Lefkowitz, R. S. Novosel, Z. Mohamad, A. Scharko, K. Y. Lin, R. E. Shaddy, S. M. Paridon, K. Miller, B. D. Kaufman, J. W. Gaynor, J. W. Rossano
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2013)
Biographical-Item
Cardiac & Cardiovascular Systems
Landi M. Cranstoun, J. William Gaynor
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2013)
Article
Cardiac & Cardiovascular Systems
Erin M. Buckley, Jennifer M. Lynch, Donna A. Goff, Peter J. Schwab, Wesley B. Baker, Turgut Durduran, David R. Busch, Susan C. Nicolson, Lisa M. Montenegro, Maryam Y. Naim, Rui Xiao, Thomas L. Spray, A. G. Yodh, J. William Gaynor, Daniel J. Licht
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2013)
Article
Cardiac & Cardiovascular Systems
William T. Mahle, Minmin Lu, Richard G. Ohye, J. William Gaynor, Caren S. Goldberg, Lynn A. Sleeper, Victoria L. Pemberton, Kathleen A. Mussatto, Ismee A. Williams, Erica Sood, Catherine Dent Krawczeski, Alan Lewis, Nicole Mirarchi, Mark Scheurer, Sara K. Pasquali, Nelangi Pinto, Jeffrey P. Jacobs, Brian W. McCrindle, Jane W. Newburger
PEDIATRIC CARDIOLOGY
(2013)
Article
Pediatrics
Erin M. Buckley, Maryam Y. Naim, Jennifer M. Lynch, Donna A. Goff, Peter J. Schwab, Laura K. Diaz, Susan C. Nicolson, Lisa M. Montenegro, Natasha A. Lavin, Turgut Durduran, Thomas L. Spray, J. William Gaynor, Mary E. Putt, A. G. Yodh, Mark A. Fogel, Daniel J. Licht
PEDIATRIC RESEARCH
(2013)
Article
Clinical Neurology
Celine Thibault, Maryam Y. Naim, Nicholas S. Abend, Daniel J. Licht, J. William Gaynor, Rui Xiao, Shavonne L. Massey
Article
Multidisciplinary Sciences
J. William Gaynor, Nancy B. Burnham, Richard F. Ittenbach, Marsha Gerdes, Judy C. Bernbaum, Elaine Zackai, Daniel J. Licht, William W. Russell, Erin E. Zullo, Thomas Miller, Hakon Hakonarson, Kayan A. Clarke, Gail P. Jarvik, Antonia M. Calafat, Asa Bradman, David C. Bellinger, Frederick M. Henretig, Eric S. Coker
Summary: This study investigated the impact of environmental chemical exposures on neurodevelopmental outcomes in toddlers with congenital heart defects after cardiac surgery. The findings suggest that infants with congenital heart defects, like other children, are exposed to complex mixtures of environmental chemicals in daily life. Higher exposure biomarker concentrations were associated with significantly worse performance for language and motor skills in this population.
Article
Surgery
Jonathan B. Edelson, Xuemei Zhang, Andrew B. Goldstone, Joseph W. Rossano, Matthew J. O'Connor, J. William Gaynor, Jonathan J. Edwards, Carol Wittlieb-Weber, Katsuhide Maeda
Summary: Rejection remains a primary cause of graft loss after heart transplant. Combining heart transplant with kidney or liver transplant reduces the risk of rejection compared to isolated heart transplant.
CLINICAL TRANSPLANTATION
(2023)
Article
Medicine, Research & Experimental
Richard F. Ittenbach, J. William Gaynor, Jenny M. Dorich, Nancy B. Burnham, Guixia Huang, Madisen T. Harvey, Jeremy J. Corsmo
Summary: The purpose of this study was to establish a new measure of understanding of informed consent for use in clinical research. A total of 109 teens/young adults completed the consenting process of a hypothetical biobanking study. The final uConsent scale consisted of 19 items that mapped directly onto the Basic Elements of Informed Consent. The scale showed good reliability and validity.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Article
Genetics & Heredity
Helen M. Stanley, Brian R. White, Christopher J. LaRosa, Mark W. Cocalis, J. William Gaynor, Alanna Strong, Balram Gangaram
Summary: Pathogenic variants in PRDM6 have been found to be etiologically associated with non-syndromic PDA. We present three patients with PDA and CoA found to harbor PRDM6 variants, including a novel, likely-pathogenic variant.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2023)
Article
Biochemistry & Molecular Biology
Emilie J. Benson, Danielle I. Aronowitz, Rodrigo M. Forti, Alec Lafontant, Nicolina R. Ranieri, Jonathan P. Starr, Richard W. Melchior, Alistair Lewis, Jharna Jahnavi, Jake Breimann, Bohyun Yun, Gerard H. Laurent, Jennifer M. Lynch, Brian R. White, J. William Gaynor, Daniel J. Licht, Arjun G. Yodh, Todd J. Kilbaugh, Constantine D. Mavroudis, Wesley B. Baker, Tiffany S. Ko
Summary: The effects of cardiopulmonary bypass on cerebral oxygen supply and metabolic demands during neonatal congenital heart surgery are generally unknown. However, a study using swine models found that following the initiation of cardiopulmonary bypass, oxygen extraction fraction increased while cerebral blood flow and oxygen metabolism decreased, and this persisted for up to 8 hours after cardiopulmonary bypass.
Article
Genetics & Heredity
Alyssa L. Rippert, Sarah Trackman, Danielle Burstein, J. William Gaynor, Heather Griffis, Christine Seymour, Rebecca Ahrens-Nicklas
Summary: This study aimed to assess the association between CB scores and clinical outcomes in pediatric CM patients. The results showed no significant association between CB scores and clinical outcomes in pediatric CM patients. The study highlights the deficits in variant interpretation for pediatric CM and cautions the use of this tool for stratifying clinical outcomes in the pediatric population.
Article
Psychology, Multidisciplinary
Brian J. Piper, Alia L. Yasen, Amy E. Taylor, Jonatan R. Ruiz, J. William Gaynor, Catherine A. Dayger, Marcela Gonzalez-Gross, Oh D. Kwon, Lars-Goran Nilsson, Ian N. M. Day, Jacob Raber, Jeremy K. Miller