Article
Obstetrics & Gynecology
Gaojie Fan, Qing Liu, Jianing Bi, Xiya Qin, Qing Fang, Youjie Wang, Lulu Song
Summary: Early menarche, early menopause, short reproductive lifespan, early age at first birth, multiparity, and use of oral contraceptives (OCs) and hormone replacement therapy (HRT) were associated with shorter leukocyte telomere length (LTL).
HUMAN REPRODUCTION
(2023)
Article
Green & Sustainable Science & Technology
Xianhong Su, Yanmei Li, Kai Fang, Yin Long
Summary: This paper examines the impact of China's direct investment on carbon dioxide emissions in Belt and Road Initiative countries. The results show that Chinese investment has a significant influence on the carbon dioxide emissions of these countries, especially in high-income countries where the reduction effect is more pronounced.
JOURNAL OF CLEANER PRODUCTION
(2022)
Editorial Material
Hematology
Sharon A. Savage
Summary: In this study, novel pathogenic variants in RPA1 were discovered as a new cause of TBDs. The researchers investigated the clinical manifestations in patients from different families, and revealed the role of RPA1 in hematopoiesis and telomeric DNA binding and unfolding. The discovery enhances our understanding of RPA function in telomere biology and provides valuable information for families in understanding the cause of their illness.
Article
Reproductive Biology
Jordi Ribas-Maynou, Marc Llavanera, Yentel Mateo-Otero, Nicolas Ruiz, Rodrigo Muino, Sergi Bonet, Marc Yeste
Summary: This study determined the mean telomere length in bovine sperm for the first time and found a high variability within each sperm cell. While telomere length was found to be correlated to reactive oxygen species generation, it was not related to bull reproductive performance.
Review
Oncology
Peter Lansdorp
Summary: The number of telomere repeats varies greatly between chromosomes, cells, and species. Loss of telomere repeats limits cell proliferation and contributes to aging, but the mechanisms behind these processes are still not fully understood. Further research is needed to investigate the role of factors such as damaged telomeric DNA, replication errors, chromatin structure, and secondary DNA structures in telomere dynamics in different cell types.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Dries S. Martens, Charlotte Van der Stukken, Catherine Derom, Evert Thiery, Esm Ee M. Bijnens, Tim S. Nawrot
Summary: The study found that there is a correlation between telomere length at birth and later in life in both children and adults. The ranking of telomere length tends to be stable over time, indicating the importance of understanding the initial setting of newborn telomere length and its significance for later life. Additionally, longer maternal telomere length is associated with lower telomere attrition in the next generation.
Article
Endocrinology & Metabolism
Helen B. Chin, Andrea Kelly, Margaret A. Adgent, Stacy A. Patchel, Kerry James, Hubert W. Vesper, Julianne C. Botelho, Donald Walt Chandler, Babette S. Zemel, Joan Schall, Eileen G. Ford, Kassa Darge, Virginia A. Stallings, Donna D. Baird, Walter J. Rogan, David M. Umbach
Summary: The study found that reproductive hormone concentrations and anatomical responses in infant boys fed soy formula and cow milk formula followed similar trajectories. The findings suggest that early male reproductive development measures do not respond to phytoestrogen exposure during infancy.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Helen B. Chin, Andrea Kelly, Margaret A. Adgent, Stacy A. Patchel, Kerry James, Hubert W. Vesper, Julianne C. Botelho, Donald Walt Chandler, Babette S. Zemel, Joan Schall, Eileen G. Ford, Kassa Darge, Virginia A. Stallings, Donna D. Baird, Walter J. Rogan, David M. Umbach
Summary: A study on 147 male infants found that reproductive hormone concentrations and anatomical responses in infants fed soy formula were similar to those fed cow milk formula, while compared to breastfed infants, those fed soy formula had a more rapid increase in penile length.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Manuel Gentiluomo, Alice Luddi, Annapaola Cingolani, Marco Fornili, Laura Governini, Ersilia Lucenteforte, Laura Baglietto, Paola Piomboni, Daniele Campa
Summary: The study found no significant association between sperm telomere length (STL) and leukocyte telomere length (LTL) with sperm quality parameters, but identified five single nucleotide polymorphisms (SNPs) that were statistically significantly associated with sperm variables. The results suggest moderate involvement of telomere length in male fertility, while indicating the potential pleiotropic effects of certain SNPs on sperm parameters independent of telomere homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Tina Levstek, Katarina Trebusak Podkrajsek
Summary: Telomeres are dynamic DNA nucleoprotein structures located at the end of chromosomes that maintain genomic stability. Shortened telomeres contribute to cellular senescence and degenerative diseases such as chronic kidney diseases (CKDs). Oxidative stress also accelerates telomere shortening. This review examines the association between telomere length and CKDs, particularly in patients receiving kidney replacement therapy. Understanding the relationship between telomere attrition and kidney disease can contribute to new strategies for managing CKDs.
Review
Reproductive Biology
Betul Tire, Saffet Ozturk
Summary: Telomeres are repetitive DNA sequences that protect the ends of eukaryotic chromosomes and play a crucial role in maintaining the integrity and stability of the genome. Shortening of telomeres can occur due to factors such as aging, DNA replication, oxidative stress, and genotoxic agents. However, telomeres can be lengthened by telomerase and alternative lengthening mechanisms. If telomeres become critically short, it can lead to genomic instability and abnormalities in cell division. The effects of assisted reproductive technologies (ARTs), such as ovarian stimulation, culture conditions, and cryopreservation procedures, on telomere length and telomerase activity in oocytes and embryos have been extensively studied. These parameters could potentially serve as biomarkers for assessing the quality of oocytes and embryos in ART centers.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Medicine, Research & Experimental
Ratan Sadhukhan, Utpal Ghosh
Summary: The study revealed that PARP1 controls SLX4 recruitment at telomeres by poly(ADP-ribosyl)ation reaction, thereby regulating SLX4-mediated telomere sister chromatid exchange (T-SCE) and telomere length (TL) homeostasis.
Article
Cell Biology
Congrong Wang, Tim S. Nawrot, Charlotte Van der Stukken, Dominika Tylus, Hanne Sleurs, Martien Peusens, Rossella Alfano, Sabine A. S. Langie, Michelle Plusquin, Dries S. Martens
Summary: The study found stronger epigenetic regulation in setting newborn TL and more factors influencing telomere dynamics in early life. Functional enrichment analysis of the selected CpGs in the two models revealed potential roles of GLUT4 translocation and immune cell signaling pathways in newborn TL and early telomere dynamics.
Article
Pediatrics
Mohamed E. Suliman, Mohammed G. A. Ansari, Mohamed A. Rayis, Muaawia A. Hamza, Abdullah A. Saeed, Abdul Khader Mohammed, Nasser M. Al-Daghri
Summary: This study investigated telomere length and plasma TRF2 levels in children with sickle cell disease (SCD) in Saudi Arabia. Children with SCD had shorter telomere length compared to healthy controls, with no association between telomere length and TRF2 observed. Hydroxyurea treatment had no impact on telomere length in children with SCD. This study is the first of its kind in children with SCD and may lead to further research with a larger sample size in different populations to validate these findings.
PEDIATRIC RESEARCH
(2022)
Article
Nutrition & Dietetics
Lisa Daneels, Dries S. Martens, Soumia Arredouani, Jaak Billen, Gudrun Koppen, Roland Devlieger, Tim S. Nawrot, Manosij Ghosh, Lode Godderis, Sara Pauwels
Summary: The study found a positive association between maternal vitamin D intake (diet + supplements) and newborn TL, particularly during the first trimester. However, there was no significant association between mean maternal serum 25-OHD concentrations during pregnancy and newborn TL.
