Article
Medicine, General & Internal
Shinhaeng Lee, Taehwan Kim, Seung Chul Han, Haeyong Pak, Han Ho Jeon
Summary: This study evaluated the clinical outcomes and prognostic factors of transcatheter arterial embolization (TAE) for acute gastrointestinal bleeding. The results showed that TAE is an effective, safe, and potentially lifesaving procedure for GI bleeding, with coagulopathy being a prognostic factor for rebleeding and mortality.
Review
Medicine, General & Internal
Ling Yang, Rui Sun, Ning Wei, Hong Chen
Summary: CTP was superior to other risk scores in identifying AVB patients at high risk of death in hospital and low risk within follow-up. GBS, though recommended by the Guidelines, should be cautiously used when assessing AVB patients.
ANNALS OF MEDICINE
(2021)
Article
Surgery
Jun-young Seo, Jin Hee Noh, Ji Yong Ahn, Sang Yong Cho, Seung-pyo Oh, Boram Cha, Hee Kyong Na, Jeong Hoon Lee, Kee Wook Jung, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
Summary: This study compared the clinical outcomes of marginal ulcer bleeding (MUB) with peptic ulcer bleeding (PUB). The results showed that MUB had a higher rebleeding rate and a higher mortality rate compared to PUB. Prophylactic use of proton pump inhibitors (PPIs) may reduce the risk of rebleeding in MUB.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Multidisciplinary Sciences
Ho-Jun Jang, Dongyoung Lee, Tae-Hoon Kim, Je Sang Kim, Hyun-Jong Lee, Ji Bak Kim, Ji-Young Kim
Summary: This study aimed to find an appropriate anticoagulation cessation strategy in cases of gastrointestinal bleeding during oral anticoagulation therapy. The results showed that no single risk factor or drug cessation strategy was attributed to adverse clinical events. Therefore, future treatment should be individualized and controlled based on personalized risk assessment.
Article
Clinical Neurology
Rodrigo Alvarez-Velasco, Gerardo Gutierrez-Gutierrez, Juan Carlos Trujillo, Elisabeth Martinez, Sonia Segovia, Marina Arribas-Velasco, Guillermo Fernandez, Carmen Paradas, Beatriz Velez-Gomez, Carlos Casasnovas, Velina Nedkova, Antonio Guerrero-Sola, Alba Ramos-Fransi, Alicia Martinez-Pineiro, Julio Pardo, Teresa Sevilla, Maria Teresa Gomez-Caravaca, Adolfo Lopez de Munain, Ivonne Jerico, Ana L. Pelayo-Negro, Maria Asuncion Martin, Yolanda Morgado, Maria Dolores Mendoza, Helena Perez-Perez, Ricard Rojas-Garcia, Janina Turon-Sans, Luis Querol, Eduard Gallardo, Isabel Illa, Elena Cortes-Vicente
Summary: The study on myasthenia gravis patients with thymoma found that they had more severe symptoms and worse prognosis compared to non-thymoma patients. Thymoma recurrence may lead to transient worsening, while patients with unresectable thymomas tend to present more severe forms of MG.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Woo Jin Lee, Han Sang Lee, Do Yong Kim, Hye Sung Lee, Jangsup Moon, Kyung Il Park, Sang Kun Lee, Kon Chu, Soon Tae Lee
Summary: This institutional cohort study examines the clinical characteristics, disease course, effectiveness of immunotherapy, and prognostic factors in patients with seronegative autoimmune encephalitis. Combination immunotherapy with steroids, immunoglobulin, rituximab, and tocilizumab was associated with improved outcomes.
Article
Hematology
Thomas Kartika, Rick Mathews, Gina Migneco, Taylor Bundy, Andy J. Kaempf, Michael Pfeffer, Thomas G. Deloughery, Kerry Moore, Rachel Beardshear, Heath J. Oetken, Jonathan Case, Monica T. Hinds, Owen J. T. Mccarty, Joseph J. Shatzel, David Zonies, Bishoy L. Zakhary
Summary: This study evaluated thrombotic and hemorrhagic complications with heparin versus bivalirudin in veno-venous extracorporeal membrane oxygenation (V-V ECMO). Results showed that bivalirudin was associated with a lower risk of thrombotic events and longer circuit membrane lung lifespan, despite higher rates of severe COVID-19 and higher BMI in the bivalirudin group.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2023)
Article
Medicine, General & Internal
Jin Hee Noh, Boram Cha, Ji Yong Ahn, Hee Kyong Na, Jeong Hoon Lee, Kee Wook Jung, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
Summary: This study found that scoring systems such as the Rockall score, Glasgow-Blatchford score, and AIMS65 score can predict clinical outcomes in patients with peptic ulcer bleeding. Among these scores, RS was identified as an independent prognostic factor for rebleeding and overall survival.
Article
Endocrinology & Metabolism
Shan Lin, Dingfeng Lai, Wanmei He
Summary: This study aimed to assess the interaction between admission glucose level and clinical endpoints in critically ill sepsis patients with diabetes admitted in the ICU. The results showed that severe hyperglycemia did not increase the risk of 28-day mortality, while lower blood glucose levels were associated with increased risk of poor prognosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Maria Jose Martinez, Ferran Rueda, Carlos Labata, Teresa Oliveras, Santiago Montero, Marc Ferrer, Nabil El Ouaddi, Jordi Serra, Josep Lupon, Antoni Bayes-Genis, Cosme Garcia-Garcia
Summary: Cardiogenic shock is a severe complication of acute myocardial infarction. This study analyzed the clinical profile, acute-phase prognosis, and long-term outcomes of cardiogenic shock patients based on the ST pattern on admission. It was found that patients with elevated ST segment had higher 30-day mortality, but no differences in long-term outcomes were observed.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Hematology
Sarah Goldman-Mazur, Alissa Visram, Prashant Kapoor, Angela Dispenzieri, Martha Q. Lacy, Morie A. Gertz, Francis K. Buadi, Suzanne R. Hayman, David Dingli, Taxiarchis Kourelis, Wilson Gonsalves, Rahma Warsame, Eli Muchtar, Nelson Leung, Moritz Binder, Amie Fonder, Miriam Hobbs, Yi Lisa Hwa, Robert A. Kyle, S. Vincent Rajkumar, Shaji K. Kumar
Summary: It is unclear whether initiating therapy at the time of biochemical progression (BP) improves outcomes compared with initiating therapy at the clinical progression (CP) stage in patients with relapsed MM. This retrospective study found that patients with BP had longer time from second-line treatment to the next treatment and longer overall survival from first relapse. Male sex, plasma cell labeling index >= 2%, and extramedullary disease at diagnosis were associated with higher risk of CP, while very good partial remission or better decreased the risk of CP.
Article
Multidisciplinary Sciences
Jessica O. Asiedu, Ananda J. Thomas, Nicolas C. Cruz, Ryan Nicholson, Linda M. S. Resar, Mouen Khashab, Steven M. Frank
Summary: This case series explores the management of gastrointestinal bleed patients who declined blood transfusions and suggests that bloodless techniques can be effective in stabilizing patients. Even those with low hemoglobin concentrations can safely undergo anesthesia, endoscopy, and surgery with aggressive anemia treatment. The methods used for bloodless medicine patients have the potential to improve clinical care for all patients.
Article
Critical Care Medicine
Hong Yeul Lee, Jinwoo Lee, Yoon Sun Jung, Woon Yong Kwon, Dong Kyu Oh, Mi Hyeon Park, Chae-Man Lim, Sang-Min Lee
Summary: This study aims to determine the association between preexisting clinical frailty and clinical outcomes in patients with sepsis. The results showed that preexisting clinical frailty is associated with worse clinical outcomes in patients with sepsis, including inhospital mortality and discharge to home.
CRITICAL CARE MEDICINE
(2022)
Article
Immunology
Lauren S. Peetluk, Peter F. Rebeiro, Felipe M. Ridolfi, Bruno B. Andrade, Marcelo Cordeiro-Santos, Afranio Kritski, Betina Durovni, Solange Calvacante, Marina C. Figueiredo, David W. Haas, Dandan Liu, Valeria C. Rolla, Timothy R. Sterling
Summary: Using baseline clinical data, a prediction model for unsuccessful TB treatment outcome was developed. The model performed well in predicting treatment outcomes and may inform resource allocation and targeted interventions.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Cardiac & Cardiovascular Systems
Marcos Garcia-Guimaraes, Monica Masotti, Ricardo Sanz-Ruiz, Fernando Macaya, Gerard Roura, Juan Manuel Nogales, Helena Tizon-Marcos, Maite Velazquez-Martin, Gabriela Veiga, Xacobe Flores-Rios, Omar Abdul-Jawad Altisent, Marcelo Jimenez-Kockar, Santiago Camacho-Freire, Jose Moreu, Soledad Ojeda, Sandra Santos-Martinez, Ancor Sanz-Garcia, David Del Val, Teresa Bastante, Fernando Alfonso
Summary: This study conducted a nationwide follow-up of a cohort of patients with spontaneous coronary artery dissection (SCAD) and found that the prognosis was generally favorable, with reinfarctions and unplanned revascularizations being the main adverse events. History of hypothyroidism, proximal vessel involvement, type 2 intramural hematoma (IMH), and dual antiplatelet therapy (DAPT) at discharge were identified as independent predictors of major adverse cardiovascular and cerebrovascular events (MACCE).
Review
Cardiac & Cardiovascular Systems
Paul Guedeney, Gennaro Giustino, Sabato Sorrentino, Bimmer E. Claessen, Anton Camaj, Deborah N. Kalkman, Birgit Vogel, Samantha Sartori, Salvatore De Rosa, Usman Baber, Ciro Indolfi, Gilles Montalescot, George D. Dangas, Robert S. Rosenson, Stuart J. Pocock, Roxana Mehran
Summary: Treatment with alirocumab or evolocumab is associated with reduced risk of myocardial infarction, stroke, and coronary revascularization, with a favorable safety profile.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Johny Nicolas, Bimmer E. Claessen, Davide Cao, Samantha Sartori, Usman Baber, David Power, Mauro Chiarito, Ridhima Goel, Anastasios Roumeliotis, Rishi Chandiramani, Siyan Chen, Jaya Chandrasekhar, Didier Tchetche, Anna Sonia Petronio, Julinda Mehilli, Thierry Lefevre, Patrizia Presbitero, Piera Capranzano, Alessandro Iadanza, Gennaro Sardella, Nicolas M. Van Mieghem, Emanuele Meliga, Nicolas Dumonteil, Chiara Fraccaro, Daniela Trabattoni, Ghada Mikhail, Maria-Cruz Ferrer-Gracia, Christoph Naber, Samin Sharma, Marie-Claude Morice, George D. Dangas, Alaide Chieffo, Roxana Mehran
Summary: Severe anemia in females undergoing TAVI was independently associated with increased rates of VARC-2 efficacy endpoint and mortality at 1 year.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2021)
Review
Cardiac & Cardiovascular Systems
A. van Veelen, J. Elias, I. M. van Dongen, L. P. C. Hoebers, B. E. P. M. Claessen, J. P. S. Henriques
Summary: This meta-analysis of 1790 CTO patients found that CTO-PCI did not lead to improvements in survival or MACE at up to 4 years of follow-up, nor did it improve left ventricular function. However, CTO-PCI resulted in less angina and fewer target lesion revascularisations compared to OMT.
NETHERLANDS HEART JOURNAL
(2021)
Review
Cardiac & Cardiovascular Systems
Bimmer E. Claessen, Gilbert H. L. Tang, Annapoorna S. Kini, Samin K. Sharma
Summary: Aortic valve stenosis is the most common manifestation of acquired valvular heart disease in developed countries, and transcatheter aortic valve replacement (TAVR) has been established as a safe and effective alternative to surgical aortic valve replacement. Currently, there are only a few TAVR devices commercially available in the US, with several others undergoing clinical trials. Each type of TAVR device has specific strengths and limitations due to differences in engineering features.
Review
Cardiac & Cardiovascular Systems
Davide Cao, Rishi Chandiramani, Mauro Chiarito, Bimmer E. Claessen, Roxana Mehran
Summary: Since its introduction in 1977, percutaneous coronary intervention has become one of the most commonly performed therapeutic procedures worldwide, with antithrombotic agents playing a crucial role in patient management. The past 40 years have seen significant advancements in interventional cardiology in both drug therapies and device technologies.
EUROPEAN HEART JOURNAL
(2021)
Review
Cardiac & Cardiovascular Systems
Mauro Chiarito, Davide Cao, Johny Nicolas, Anastasios Roumeliotis, David Power, Rishi Chandiramani, Samantha Sartori, Anton Camaj, Ridhima Goel, Bimmer E. Claessen, Giulio G. Stefanini, Roxana Mehran, George Dangas
Summary: Radial access for coronary angiography and PCI is associated with a significant reduction in major bleeding, vascular complications, and mortality compared to femoral access, regardless of clinical characteristics. Risk of stroke or MI is comparable between radial and femoral access patients.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Felix Mahfoud, Michael Weber, Roland E. Schmieder, Melvin D. Lobo, Peter J. Blankestijn, Alexandre Persu, Tim A. Fischell, Helen Parise, Atul Pathak, David E. Kandzari
Summary: The TARGET BP trials are large-scale, international, randomized trials aimed at investigating the safety and efficacy of alcohol-mediated RDN for treating uncontrolled hypertension. The trials have completed enrollment for one cohort and will continue to enroll more subjects in another cohort to evaluate the novel RDN method.
AMERICAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Anton Camaj, Gennaro Giustino, Nikola Kocovic, Davide Cao, Bimmer E. Claessen, Samantha Sartori, Zhongjie Zhang, Hanbo Qiu, Johny Nicolas, Tomoya Hinohara, Usman Baber, David A. Power, Nitin Barman, Joseph Sweeny, George Dangas, Annapoorna Kini, Samin K. Sharma, Roxana Mehran
Summary: In patients who underwent percutaneous coronary intervention (PCI), elevated levels of high sensitivity C-reactive protein (hsCRP) are associated with an increased risk of ischemic events, regardless of the complexity of the procedure.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Frans J. Beerkens, Bimmer E. Claessen, Marielle Mahan, Mario F. L. Gaudino, Derrick Y. Tam, Jose P. S. Henriques, Roxana Mehran, George D. Dangas
Summary: In this review, the authors explore changes in CABG surgical techniques, differences in conduit pathophysiology, and the latest evidence regarding PCI in patients with previous CABG surgery, focusing on safety and long-term efficacy. They discuss the complexities of contemporary CABG surgery and subsequent percutaneous revascularization in this unique patient population.
NATURE REVIEWS CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Shqipdona Lahu, Gjin Ndrepepa, Franz-Josef Neumann, Maurizio Menichelli, Isabell Bernlochner, Gert Richardt, Jochen Wohrle, Bernhard Witzenbichler, Rayyan Hemetsberger, Katharina Mayer, Ibrahim Akin, Salvatore Cassese, Senta Gewalt, Erion Xhepa, Sebastian Kufner, Christian Valina, Hendrik B. Sager, Michael Joner, Tareq Ibrahim, Karl-Ludwig Laugwitz, Heribert Schunkert, Stefanie Schupke, Adnan Kastrati
Summary: Pre-admission treatment with aspirin and/or clopidogrel does not affect the efficacy and safety of ticagrelor and prasugrel in patients with acute coronary syndromes.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Yaling Han, Bimmer E. Claessen, Shao-Liang Chen, Qiu Chunguang, Yujie Zhou, Yawei Xu, Lin Hailong, Jiyan Chen, Wu Qiang, Ruiyan Zhang, Suxin Luo, Yongjun Li, Jianhua Zhu, Xianxian Zhao, Xiang Cheng, Jian'an Wang, Xi Su, Jianhong Tao, Yingxian Sun, Geng Wang, Yi Li, Liya Bian, Ridhima Goel, Samantha Sartori, Zhongjie Zhang, Dominick J. Angiolillo, David J. Cohen, C. Michael Gibson, Adnan Kastrati, Mitchell Krucoff, Shamir R. Mehta, E. Magnus Ohman, Philippe Gabriel Steg, Yuqi Liu, George Dangas, Samin Sharma, Usman Baber, Roxana Mehran
Summary: The TWILIGHT trial enrolled 1169 patients from China, showing that ticagrelor monotherapy significantly reduced clinically relevant bleeding without increasing ischemic events compared to ticagrelor plus aspirin in Chinese patients undergoing high-risk percutaneous coronary intervention.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Shqipdona Lahu, Antonia Presch, Gjin Ndrepepa, Maurizio Menichelli, Christian Valina, Rayyan Hemetsberger, Bernhard Witzenbichler, Isabell Bernlochner, Michael Joner, Erion Xhepa, Alexander Hapfelmeier, Sebastian Kufner, Nonglag Rifatov, Hendrik B. Sager, Katharina Mayer, Thorsten Kessler, Karl-Ludwig Laugwitz, Gert Richardt, Heribert Schunkert, Franz-Josef Neumann, Dirk Sibbing, Dominick J. Angiolillo, Adnan Kastrati, Salvatore Cassese
Summary: This study aimed to compare the efficacy and safety of ticagrelor and prasugrel in acute coronary syndrome patients with high bleeding risk undergoing percutaneous coronary intervention. The results showed that HBR status increased the risk of ischemic and bleeding events in these patients, but there was no significant difference in the treatment effect between ticagrelor and prasugrel. Further studies are needed for confirmation.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Shqipdona Lahu, Maria Scalamogna, Gjin Ndrepepa, Maurizio Menichelli, Christian Valina, Rayyan Hemetsberger, Bernhard Witzenbichler, Isabell Bernlochner, Michael Joner, Erion Xhepa, Alexander Hapfelmeier, Sebastian Kufner, Hendrik B. Sager, Katharina Mayer, Thorsten Kessler, Karl-Ludwig Laugwitz, Gert Richardt, Heribert Schunkert, Franz-Josef Neumann, Adnan Kastrati, Salvatore Cassese
Summary: This study compares the efficacy and safety of ticagrelor and prasugrel in patients with acute coronary syndrome and prior myocardial infarction (MI). The results show that prasugrel is superior to ticagrelor in reducing the risk of recurrent ischemic events without increasing the risk of bleeding.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Bahira Shahim, Bjorn Redfors, Thomas D. Stuckey, Mengdan Liu, Zhipeng Zhou, Bernhard Witzenbichler, Giora Weisz, Michael J. Rinaldi, Franz-Josef Neumann, D. Christopher Metzger, Timothy D. Henry, David A. Cox, Peter L. Duffy, Bruce R. Brodie, Iva Srdanovic, Mahesh Madhavan, Ernest L. Mazzaferri, Roxana Mehran, Ori Ben-Yehuda, Ajay J. Kirtane, Gregg W. Stone
Summary: Diabetes mellitus and high platelet reactivity (HPR) are both associated with increased risk of ischemic events after percutaneous coronary intervention. However, it is unknown whether the HPR-related risk of adverse ischemic events differs according to diabetes mellitus status.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Niels M. R. van der Sangen, Bimmer E. P. M. Claessen
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
