Article
Oncology
Mingyao Zhang, Zhiguang Zhao, Sailing Chen, Zongwen Liang, Jiawei Zhu, Manman Zhao, Chaoyi Xu, Jing He, Ping Duan, Anqi Zhang
Summary: The study revealed that specific polymorphisms in the PARPI, hOGGI, and LIG3 genes may impact the risk of ovarian cancer, with certain variants of PARPI and hOGGI decreasing the risk, while a variant of LIG3 increasing the risk of developing ovarian cancer. Further research with larger and diverse populations is needed to confirm these findings.
Review
Medicine, General & Internal
Kunyan Zhou, Jing Zhang, Liangzhi Xu, Chi Eung Danforn Lim
Summary: Overall, there is insufficient evidence to support the use of Chinese herbal medicine (CHM) for subfertile women with PCOS. The effectiveness of CHM on pregnancy rates remains uncertain, with limited evidence suggesting potential improvements when combined with clomiphene. Additionally, there is a lack of data on adverse effects, highlighting the need for well-designed randomized controlled trials in the future.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Obstetrics & Gynecology
Chunyi Yang, Mingrong Xi, Hongwei Liu, Huai Bai, Chenyu Jiang, Qingqing Liu, Ping Fan
Summary: This study found that the T allele of SNP GCLC C-129 T and its combination with the CC genotype of SNP GCLM C-588 T are associated with decreased risk of HA-PCOS in Chinese women, showing lower waist circumference, waist-to-hip ratio, and BMI. Additionally, the study suggests that this gene combination may play a protective role in the pathogenesis of PCOS.
REPRODUCTIVE SCIENCES
(2022)
Review
Endocrinology & Metabolism
Siyu Zhou, Shu Wen, Yongcheng Sheng, Meina Yang, Xiaoyang Shen, Yan Chen, Deying Kang, Liangzhi Xu
Summary: The study found no significant associations between ESR1 and ESR2 gene polymorphisms and PCOS susceptibility, even after considering ethnicity as a major source of heterogeneity.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Jiangyan Zhou, Faying Liu, Lifeng Tian, Ming Yang, Jun Tan, Xianxian Liu, Peishuang Li, Jia Chen, Ge Chen, Lixian Xu, Lisha Peng, Qiongfang Wu, Yang Zou
Summary: This study investigated whether mutations in the minichromosome maintenance complex component (MCM) family genes were present in Chinese patients with polycystic ovary syndrome (PCOS). Through PCR and Sanger sequencing, genomic DNA was obtained from 365 PCOS patients for analysis. The results identified 29 missense or nonsense mutations/rare variants in the MCM genes, suggesting a high frequency of potential pathogenic mutations in Chinese women with PCOS.
GYNECOLOGICAL ENDOCRINOLOGY
(2023)
Article
Genetics & Heredity
Baoping Hu, Yuhe Wang, Zhongtao Wang, Xue He, Li Wang, Dongya Yuan, Yongjun He, Tianbo Jin, Shumei He
Summary: By studying the northwest Chinese Han population, this research identified the relationships between polymorphisms in or near the SLC11A1 gene and age- and sex-specific tuberculosis risk.
FRONTIERS IN GENETICS
(2022)
Article
Endocrinology & Metabolism
B. N. Prabhu, S. H. Kanchamreddy, A. R. Sharma, S. K. Bhat, P. V. Bhat, S. P. Kabekkodu, K. Satyamoorthy, P. S. Rai
Summary: By mapping GWAS genes and conducting computational analysis, insights into the impact of genetic variations in PCOS pathophysiology can be gained. The study identified several SNPs potentially involved in miRNA binding site, transcription factor binding site, and enhancer site in PCOS genes.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Article
Genetics & Heredity
Yamei Li, Ting Han, Yingxia Wang, Jie Gao, Jianglin Zhang, Yinglan Wu, Jiayou Luo
Summary: This study conducted a systematic review and meta-analysis to assess the association between common variants of the CAPN10 gene and susceptibility to PCOS. The results suggested a possible involvement of UCSNP-19, UCSNP-43, and UCSNP-44 in PCOS susceptibility, but further studies are needed to confirm these findings.
FRONTIERS IN GENETICS
(2023)
Article
Medical Laboratory Technology
Meng Li, Xinxin Zhang, Jiabin Liu, Chunlei Zhou, Lei Miao, Jing He, Haiyan Wu, Ruizhong Zhang
Summary: This study investigated the association between two GPC2 polymorphisms (rs1918353 G>A and rs7799441 C>T) and neuroblastoma risk in Chinese children. The results showed no significant association between these polymorphisms and susceptibility to neuroblastoma.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2023)
Article
Cell Biology
Hongji Dai, Xinlei Chu, Qian Liang, Mengyun Wang, Lian Li, Yao Zhou, Zhanye Zheng, Wei Wang, Zhao Wang, Haixin Li, Jianhua Wang, Hong Zheng, Yanrui Zhao, Luyang Liu, Hongcheng Yao, Menghan Luo, Qiong Wang, Shan Kang, Yan Li, Ke Wang, Fengju Song, Ruoxin Zhang, Xiaohua Wu, Xi Cheng, Wei Zhang, Qingyi Wei, Mulin Jun Li, Kexin Chen
Summary: Survival rates for ovarian cancer patients can vary significantly, with a study in 2130 Chinese patients identifying a new genetic locus associated with overall survival. Through further analysis, researchers pinpointed a potentially causal SNP and a lncRNA that may regulate tumor growth.
Article
Endocrinology & Metabolism
Na-Na Wang, Min Tang, Han-Yu Zhang, Qiao-Zhen Yang, Gong-Li Yang
Summary: This meta-analysis suggests that LEPR gene polymorphisms may be associated with PCOS susceptibility. However, more well-designed studies from different races are needed to verify these results due to the limited number of studies and small sample size.
GYNECOLOGICAL ENDOCRINOLOGY
(2023)
Article
Medicine, Research & Experimental
Manuel R. Garcia-Saenz, Miry Lobaton-Ginsberg, Claudia Ramirez-Renteria, Nitzia Lopez-Juarez, Renata Saucedo, Jorge Valencia-Ortega, Aldo Ferreira-Hermosillo
Summary: This study evaluated the clinical and biochemical characteristics of patients with type 1 diabetes (T1D) with and without polycystic ovarian syndrome (PCOS). The results showed a prevalence of 39% for PCOS in T1D patients, and significant differences were found between patients with and without PCOS in terms of insulin usage, glucose levels, ovarian volume, and Ferriman-Gallwey scores. Additionally, PCOS women had a higher incidence of insulin resistance and metabolic syndrome.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Article
Clinical Neurology
Jiaxing Pan, Qingqing Zhuo, Xu Chen, Xuehong Huang, Shiqiang Shen, Qiu Yang, Jiawen Luo, Suiyan Wang, Tianbo Jin
Summary: This study investigated the association between LIPC SNPs and the risk of stroke in the Chinese population. The results showed that rs690 and rs6074 in LIPC were significantly associated with an increased risk of stroke, possibly by regulating the levels of PDW, HCT, and LDL-C.
FRONTIERS IN NEUROLOGY
(2023)
Review
Endocrinology & Metabolism
Nasira Munawar Lone, Sana Babar, Sikandar Sultan, Saira Malik, Kiran Nazeer, Saba Riaz
Summary: The study showed that certain polymorphisms in CYP17 and CYP19 genes are significantly associated with susceptibility to PCOS in Pakistani women, particularly those with traits of infertility and family history of hypertension.
GYNECOLOGICAL ENDOCRINOLOGY
(2021)
Article
Oncology
Fenfen Fu, Dongjie Zhang, Li Hu, Senthil Sundaram, Dingge Ying, Ying Zhang, Shuna Fu, Juan Zhang, Lu Yao, Ye Xu, Yuntao Xie
Summary: The study identified high-risk and moderate-risk breast cancer susceptibility genes in Chinese women, providing valuable data for genetic testing and clinical management of hereditary breast cancer in China. Patients with pathogenic variants in TP53, BRCA1, BRCA2, and PALB2 were more likely to have early onset and family history of breast cancer. Pathogenic variants of NBN, RAD50, BRIP1, and RAD51C did not show increased risk of breast cancer in Chinese women.
CANCER BIOLOGY & MEDICINE
(2022)
Article
Obstetrics & Gynecology
Chen-Ming Xu, Si-Jia Lu, Song-Chang Chen, Jing-Lan Zhang, Cong-Jian Xu, Yuan Gao, Yi-Ping Shen, Yun-Xia Cao, Ling-Qian Wu, Fan Jin, Ge Lin, Ping Liu, Yi-Min Zhu, Yan-Ting Wu, Dan Zhang, Bill Yee, Vitaly A. Kushnir, Zhi-Hong Yang, Jia-Yin Liu, Zi-Jiang Chen, Alan Thornhill, Angie N. Beltsos, Johan Smitz, John Frattarelli, Alan Handyside, Jie Qiao, He-Feng Huang
Summary: The International Society of Reproductive Genetics (ISRG) formed a workgroup comprised of clinicians, clinical laboratory directors, and scientists to develop guidelines for preimplantation genetic testing (PGT). These guidelines incorporate the latest information and clinical insights to provide optimal PGT practice. Recommendations are given to embryologists, medical geneticists, clinical laboratorians, and other healthcare providers to enhance the well-being of patients seeking assisted reproductive treatment and their offspring.
REPRODUCTIVE AND DEVELOPMENTAL MEDICINE
(2023)
Article
Environmental Sciences
Lihong Pang, Wenhao Yu, Jiale Lv, Yunde Dou, Han Zhao, Shanshan Li, Yuming Guo, Gongbo Chen, Linlin Cui, Jingmei Hu, Yueran Zhao, Qi Zhao, Zi-Jiang Chen
Summary: This study investigates the association between exposure to different air pollutants and ovarian reserve in Shandong Province, China. The findings show a negative association between air pollution and ovarian reserve, particularly during the primary to secondary follicle stage. This association varies among different population sub-groups.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Qi Jiang, Ruolan Miao, Yuhuan Wang, Wenqi Wang, Dingying Zhao, Yue Niu, Qiaoqiao Ding, Yan Li, Peter C. K. Leung, Daimin Wei, Zi-Jiang Chen
Summary: Polycystic ovary syndrome (PCOS) is a common and heterogeneous endocrine disorder, which is the main cause of ovulatory obstacle associated with abnormal folliculogenesis. Dysfunction of ovarian granulosa cells (GCs) is recognized as a major factor that underlies abnormal follicle maturation. The expression of angiopoietin-like 4 (ANGPTL4) in GCs differs between patients with and without PCOS. In this study, ANGPTL4 was found to be upregulated in patients with PCOS and its overexpression inhibited the proliferation of GCs through the EGFR/JAK1/STAT3-mediated induction of p21, providing a novel epigenetic mechanism for the pathogenesis of PCOS.
Article
Obstetrics & Gynecology
Zheng Liu, Yukun Zheng, Bingyu Wang, Jialin Li, Lang Qin, Xiao Li, Xin Liu, Yuehong Bian, Zijiang Chen, Han Zhao, Shigang Zhao
Summary: This study examined the association between sleep quality before embryo transfer and pregnancy outcomes. The results showed that good sleep quality was associated with higher clinical pregnancy and live birth rates. Treating sleep disorders and providing sleep behavior guidance may improve pregnancy outcomes in IVF-ET.
FERTILITY AND STERILITY
(2023)
Article
Biochemistry & Molecular Biology
Simin Zhao, Chengzi Huang, Yajuan Yang, Weiwei Xu, Yongze Yu, Canxin Wen, Lili Cao, Fei Gao, Yingying Qin, Zi-Jiang Chen, Ting Guo, Shidou Zhao
Summary: When DNA interstrand crosslink lesions occur, a core complex of Fanconi anemia proteins promotes the ubiquitination of FANCD2 and FANCI, which recruit downstream factors to repair the lesion. FANCD2 maintains genome stability through both its ubiquitination-dependent and ubiquitination-independent functions. This study analyzed germ cell development in Fancd2 KO and ubiquitination-deficient mutant mice, and found that the ubiquitination-dependent and ubiquitination-independent functions of FANCD2 were required for different aspects of germ cell development.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Jiahui Wang, Wei Zhou, Zhiyi Song, Tianxiang Ni, Qian Zhang, Zi-Jiang Chen, Junhao Yan
Summary: This study aimed to evaluate the association between polycystic ovary syndrome (PCOS) and embryo ploidy. The results showed that the rate of embryonic aneuploidy and embryonic mosaic in PCOS women was comparable to non-PCOS women. Therefore, it is suggested that the miscarriage rate arising from abnormal embryonic chromosomes may be similar between PCOS and non-PCOS women.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Yiting Zhang, Xiao Fu, Shuli Gao, Shuzhe Gao, Shanshan Gao, Jinlong Ma, Zi-Jiang Chen
Summary: In the past decade, the use of frozen-thawed embryo transfer treatment has significantly increased. Hormone replacement therapy and the natural cycle are two popular methods for preparing the endometrium. While hormone replacement therapy offers convenience for timing coordination, there are potential risks associated with achieving pregnancy without a corpus luteum. Therefore, there is growing interest in expanding the use of natural cycle FET in ovulatory women to address these concerns and improve outcomes.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Letter
Biology
Xiaolei Chen, Huangcong Shi, Cheng Li, Wanxia Zhong, Linlin Cui, Wenjun Zhang, Ling Geng, Kuona Hu, Mei Fang, Daimin Wei, Junhao Yan, Yun Sun, Keliang Wu, Han Zhao, Zi-Jiang Chen
SCIENCE CHINA-LIFE SCIENCES
(2023)
Article
Multidisciplinary Sciences
Dan Liang, Aleksei Mikhalchenko, Hong Ma, Nuria Marti Gutierrez, Tailai Chen, Yeonmi Lee, Sang-Wook Park, Rebecca Tippner-Hedges, Amy Koski, Hayley Darby, Ying Li, Crystal Van Dyken, Han Zhao, Keliang Wu, Jingye Zhang, Zhenzhen Hou, Seongjun So, Jongsuk Han, Jumi Park, Chong-Jai Kim, Kai Zong, Jianhui Gong, Yilin Yuan, Ying Gu, Yue Shen, Susan B. Olson, Hui Yang, David Battaglia, Thomas O'Leary, Sacha A. Krieg, David M. Lee, Diana H. Wu, P. Barton Duell, Sanjiv Kaul, Jin-Soo Kim, Stephen B. Heitner, Eunju Kang, Zi-Jiang Chen, Paula Amato, Shoukhrat Mitalipov
Summary: The range of DNA repair in response to double-strand breaks induced in human preimplantation embryos is uncertain due to the complexity of analyzing single- or few-cell samples. Whole genome amplification, which is necessary for sequencing such minute DNA input, can introduce artifacts that restrict genotyping accuracy. This study shows that allelic dropouts occur in over 25% of pre-existing heterozygous loci in control single blastomere samples after whole genome amplification. To overcome these limitations, the authors validate gene editing seen in human embryos by studying embryonic stem cells.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Yanling Wan, Shuang Yang, Tongtong Li, Yuling Cai, Xinyue Wu, Mingyu Zhang, Tahir Muhammad, Tao Huang, Yue Lv, Wai-Yee Chan, Gang Lu, Jingxin Li, Qian-Qian Sha, Zi-Jiang Chen, Hongbin Liu
Summary: LSM14B knockout disrupts the assembly of MARDO, leading to improper mRNA storage and clearance, ultimately resulting in female infertility.
NUCLEIC ACIDS RESEARCH
(2023)
Correction
Cell Biology
Xiaoyu Merlin Zhang, Keliang Wu, Yuxuan Zheng, Han Zhao, Junpeng Gao, Zhenzhen Hou, Meiling Zhang, Jiaoyang Liao, Jingye Zhang, Yuan Gao, Yuanyuan Li, Lin Li, Fuchou Tang, Zi-Jiang Chen, Jinsong Li
Letter
Cell Biology
Yuan Gao, Lizhi Yi, Jianhong Zhan, Lijuan Wang, Xuelong Yao, Junhao Yan, Sijing Jian, Lei Gao, Mamadboqirova Farangez, Ming Gao, Yang Zou, Xuan Gao, Keliang Wu, Jiang Liu, Zi-Jiang Chen
Article
Medicine, Research & Experimental
Chengzi Huang, Simin Zhao, Yajuan Yang, Ting Guo, Hanni Ke, Din Mi, Yingying Qin, Zi-Jiang Chen, Shidou Zhao
Summary: Mutations in TP63 gene impair the TID of TAp63 alpha protein, leading to constitutive activation and oocyte apoptosis, resulting in POI. These findings provide insight into the genetic diagnosis of POI and potential therapeutic targets for preserving female fertility.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Obstetrics & Gynecology
Daimin Wei, Yaxin Su, Peter C. K. Leung, Yan Li, Zi-Jiang Chen
Summary: This review summarizes the current knowledge on the pathophysiological roles of BMPs and their underlying molecular mechanisms in regulating human endometrial proliferation and decidualization, aiming to promote the development of innovative strategies for diagnosing, treating, and preventing infertility and adverse pregnancy complications associated with dysregulated human endometrial remodeling.
HUMAN REPRODUCTION UPDATE
(2023)
Article
Obstetrics & Gynecology
Na Chen, Jingyu Li, Yexing Li, Yiyuan Zhang, Jiarong Li, Jie Gao, Jingmei Hu, Linlin Cui, Zi-Jiang Chen
Summary: This study explores the risk factors for monozygotic twinning in offspring conceived by assisted reproductive technology (ART). The factors influencing MZ twinning include parental ages, the transfer of fresh versus frozen embryos, and the grade of blastocysts.
HUMAN REPRODUCTION OPEN
(2023)