Article
Endocrinology & Metabolism
Yuetao Zhang, Yue Wang
Summary: The study found that the HDL-C/ApoA-I ratio can more stably predict fasting glucose levels, guiding better in predicting blood sugar levels, and the negative correlation between HDL-C/ApoA-I ratio and FBG levels gradually strengthens as blood glucose levels increase.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Pharmacology & Pharmacy
Stanislas Faguer, Arnaud Del Bello, Chloe Danet, Yves Renaudineau, Jacques Izopet, Nassim Kamar
Summary: Viral infections can cause cytokine storms and multiorgan failure in individuals with immunosuppression or specific genetic background. This study examined the use of an ApoA-I-containing HDL mimetic in four severe COVID-19 patients with cytokine storms. The treatment resulted in early clinical improvement in three patients and provides initial safety and proof-of-concept data for further evaluation.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Hematology
Thomas W. King, Blake J. Cochran, Kerry-Anne Rye
Summary: ApoA-I, the main component of HDL, has multiple cardioprotective and antidiabetic functions. This review summarizes the current knowledge of apoA-I's antidiabetic effects, the mechanism behind these effects, and the potential of small peptides that mimic apoA-I to be used as innovative treatments for diabetes.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Alexander D. Dergunov, Dmitry Y. Litvinov, Artem A. Malkov, Veronika B. Baserova, Elena Nosova, Liudmila Dergunova
Summary: The study investigated the denaturation of HDL and the dissociation of apoA-I in relation to cholesterol efflux from macrophages. Factors influencing apoA-I dissociation from HDL include phospholipid concentration, compositional and structural heterogeneity, and partition between aqueous and lipid phases. The release of apoA-I enhances ABCA1-mediated cholesterol efflux, suggesting apoA-I dissociation as a new functional property of HDL.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Biochemistry & Molecular Biology
Katerina Dalakoura-Karagkouni, Ioanna Tiniakou, Vassilis Zannis, Dimitris Kardassis
Summary: The overexpression of myeloperoxidase (MPO) in mice increased plasma levels of apoA-I and HDL without affecting the expression of genes involved in HDL synthesis or degradation. MPO overexpression in the liver reduced the expression of pro-inflammatory genes and increased or had no effect on the expression of anti-inflammatory genes. The size and electrophoretic mobility of HDL particles in mice overexpressing MPO did not change significantly, except in mice expressing apoA-I (M148A) which showed an enriched pre-B HDL particles. MPO overexpression was associated with reduced antioxidant capacity of HDL particles in all mice.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Nutrition & Dietetics
Christian Caceres, Mi-Bo Kim, Minkyung Bae, Tho X. Pham, Yoojin Lee, Siqi Hu, Edward N. O'Neill, Bohkyung Kim, Young-Ki Park, Ji-Young Lee
Summary: Consumption of cranberries had minor effects on HDL metabolism but reduced inflammation in white adipose tissue and altered gene expression related to lipid metabolism in the liver, leading to improved energy metabolism in muscle tissues.
BRITISH JOURNAL OF NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Binxing Li, Preejith Vachali, Fu-Yen Chang, Aruna Gorusupudi, Ranganathan Arunkumar, Linjia Shi, Gregory T. Rognon, Jeanne M. Frederick, Paul S. Bernstein
Summary: This study found that HDL serves as the primary transporter for macular carotenoids, and ApoA-I may be involved in the selective delivery of these carotenoids to the retinal pigment epithelium.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Oncology
Samuel C. Delk, Arnab Chattopadhyay, Joan Carles Escola-Gil, Alan M. Fogelman, Srinivasa T. Reddy
Summary: Peptides have advantages over traditional therapeutics due to low toxicity and immunogenicity and have shown efficacy in treating various cancers. Apolipoprotein mimetic peptides, such as oral apoA-I mimetic peptides, can remodel HDL and improve cancer progression.
SEMINARS IN CANCER BIOLOGY
(2021)
Review
Cell Biology
Blake J. Cochran, Kwok-Leung Ong, Bikash Manandhar, Kerry-Anne Rye
Summary: Epidemiological studies have shown a link between high plasma high density lipoprotein cholesterol (HDL-C) levels and reduced cardiovascular risk, but recent clinical trials of interventions to increase HDL-C levels have not established a causal basis for this relationship. This has shifted research towards enhancing the cardioprotective functions of HDLs, with a focus on discovering novel functions like the antidiabetic properties of HDLs. There is a growing need to explore the potential role of HDLs in diabetes and develop new approaches to complement existing therapies.
Article
Nanoscience & Nanotechnology
Junwei Gao, Ziyun Li, Jing Li, Ping Song, Jinsheng Yang, Wei Xiao, Ning Li, Ruodan Xu
Summary: This study utilized pHDL as a carrier to efficiently load lipophilic components from natural plants, resulting in improved bioavailability and reduction of atherosclerosis lesions. The findings suggest that pHDL-based drug delivery system has the potential to be applied in both imaging and therapy for atherosclerosis, while extending the application of bioactive chemicals from natural plants and facilitating the clinical translation of synthetic HDL therapies.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Dennis Pedersbaek, Louise Krogager, Camilla Hald Albertsen, Lars Ringgaard, Anders E. Hansen, Katrine Jonsson, Jannik B. Larsen, Andreas Kjaer, Thomas L. Andresen, Jens B. Simonsen
Summary: The study found that PEGylation of the b-HDL scaffold had minimal effect on the biological fate of the lipids, with both b-HDL and PEG b-HDL sharing similar biological fates including cellular uptake and tumor accumulation. This highlights the dynamic nature of b-HDL particles, where the biological fate of the components (lipids and scaffold) can differ. A phenomenon that may also apply to other multicomponent nanoparticles.
Review
Physiology
Juno Van Valkenburgh, Cristiana Meuret, Ashley E. Martinez, Vibha Kodancha, Victoria Solomon, Kai Chen, Hussein N. Yassine
Summary: High-density lipoproteins (HDL) play a crucial role in the pathology of Alzheimer's disease and vascular dementia, exchanging their protein and lipid components between the brain, cerebrospinal fluid, and vascular cells to impact brain amyloid metabolism and atherosclerosis. Modifications of HDL particles have potential diagnostic and therapeutic implications for brain vascular and neurodegenerative diseases.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rita Del Giudice, Paola Imbimbo, Federico Pietrocola, Isabelle Martins, Fatima Domenica Elisa De Palma, Jose Manuel Bravo-San Pedro, Guido Kroemer, Maria Chiara Maiuri, Daria Maria Monti
Summary: Amyloidoses are characterized by the accumulation and aggregation of misfolded proteins. In this study, a specific variant of Apolipoprotein A-I protein sequence, L75P-ApoA-I, was found to inhibit autophagy and induce excessive mitochondrial stress and cell death. Induction of autophagy or overexpression of the pro-autophagic transcription factor (TFEB) can alleviate the amyloidosis and reduce oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Christina Gkolfinopoulou, Faye Soukou, Ioannis Dafnis, Tahsin F. Kellici, Despina Sanoudou, Thomas Mavromoustakos, Efstratios Stratikos, Angeliki Chroni
Summary: Our study showed that mutations in apoA-I can lead to structural and thermodynamic aberrations, as well as functional defects that impair cholesterol efflux capacity and endothelial cell functions. Mutants in reconstituted HDL were more thermodynamically destabilized and exhibited reduced cholesterol efflux capacity, as well as defects in promoting endothelial cell migration and Akt kinase activation. These findings provide insights into how these mutations affect HDL-cholesterol levels and cardiovascular risk.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jehad Z. Tayyeb, Herman E. Popeijus, Janna van de Sanden, Willem Zwaan, Ronald P. Mensink, Jogchum Plat
Summary: Individual amino acids have different effects on ApoA-I mRNA expression and pro-ApoA-I protein production. Leucine, glutamic acid, and tryptophan can increase ApoA-I and CPT1 mRNA expression, while tryptophan also enhances PPAR alpha transactivation. Glutamine, proline, and histidine can increase pro-ApoA-I protein concentrations, but mTORC1 phosphorylation remains unchanged regardless of the amino acid provided.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
