Article
Medicine, General & Internal
Vincenzo Tarzia, Matteo Ponzoni, Giuseppe Evangelista, Chiara Tessari, Emanuele Bertaglia, Manuel De Lazzari, Fabio Zanella, Demetrio Pittarello, Federico Migliore, Gino Gerosa
Summary: This study retrospectively reviewed the experience of using the AngioVac system for removing infected leads and found it to be an effective and safe alternative for debulking large CDRIE vegetations. Planning the extracorporeal circuit design may be the optimal strategy to enhance surgical tolerability and minimize complications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Ziad F. Issa, Tariq Z. Issa
Summary: This study assessed the management approach and outcome of subacute and delayed cardiac perforation by pacemaker or ICD leads. Percutaneous repositioning or replacement of the perforating lead was found to be a safe and effective management approach in this study.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Carina Blomstrom-Lundqvist, Bozena Ostrowska
Summary: CIED infections are a significant concern despite recommended prevention strategies, with infection rates continuing to rise and leading to increased healthcare costs. Recent trials aim to provide important steps for better prevention of device infections, emphasizing the importance of adherence to recommendations.
Article
Cardiac & Cardiovascular Systems
Fozia Z. Ahmed, Carina Blomstrom-Lundqvist, Heather Bloom, Christopher Cooper, Christopher Ellis, Andreas Goette, Arnold J. Greenspon, Charles J. Love, Jens Brock Johansen, Francois Philippon, Khaldoun G. Tarakji, Reece Holbrook, Lou Sherfesee, Ying Xia, Swathi Seshadri, Daniel R. Lexcen, Andrew D. Krahn
Summary: The PADIT infection risk score, developed from a large dataset, identified five independent predictors of CIED infection. A validation study using U.S. healthcare claims data confirmed the predictive value of the risk score, especially when combined with prior CIED infection history, in identifying high-risk patients for targeted interventions to reduce CIED infection risk.
Review
Cardiac & Cardiovascular Systems
Charles D. Swerdlow, Sylvain Ploux, Jeanne E. Poole, Sandeep G. Nair, Adam Himes, Kenneth A. Ellenbogen
Summary: Implantable cardioverter-defibrillators (ICDs) incorporate automated alerts and diagnostics to detect defibrillation lead failure (LF) and minimize its adverse clinical consequences. These alerts and diagnostics can analyze the state of the leads, provide diagnostic information, and assess defibrillation effectiveness through impedance measurements.
Article
Cardiac & Cardiovascular Systems
Moris Topaz, Ehud Chorin, Arie Lorin Schwartz, Aviram Hochstadt, Avraham Shotan, Itamar Ashkenazi, Mark Kazatsker, Narin-Nard Carmel, Guy Topaz, Yoram Oron, Gilad Margolis, Eyal Nof, Roy Beinart, Michael Glikson, Anna Mazo, Anat Milman, Michal Dekel, Shmuel Banai, Raphael Rosso, Sami Viskin
Summary: This study evaluated the efficacy of delivering continuous, in situ-targeted, ultrahigh concentration of antibiotics (CITA) into the infected device pocket as an alternative to device extraction. It was found that CITA is a safe and effective treatment for patients with pocket infections who are unable or unwilling to undergo extraction.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Biology
Igor Diemberger, Luca Segreti, Christopher A. Rinaldi, Jesper Hastrup Svendsen, Andrzej Kutarski, Arwa Younis, Cecile Laroche, Christophe Leclercq, Barbara Malecka, Przemyslaw Mitkowski, Maria Grazia Bongiorni
Summary: According to the analysis of patients with infection of implantable pacemakers/defibrillators, about one-third of the cases showed systemic infection, which is associated with increased complications and mortality during hospitalization. Patients with systemic infection have different characteristics compared to those with local infection, suggesting that some infections may be systemic from the beginning. These findings have important implications for further research and treatment.
Review
Cardiac & Cardiovascular Systems
Grzegorz Slawinski, Maciej Kempa, Andrzej Przybylski
Summary: The importance of CIEDs in treating cardiac rhythm disturbances, heart failure, and preventing sudden cardiac death is undeniable. However, CIED therapy is associated with complications, particularly infections, which have a significant impact on prognosis. This review summarizes current knowledge on diagnosing and managing CIED infections and also discusses alternative methods like subcutaneous defibrillators, leadless pacemakers, and wearable cardioverter defibrillators.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Simon Pecha, Heiko Burger, Da-Un Chung, Viviane Moeller, Tomas Madej, Alaa Maali, Brigitte Osswald, Raffaele De Simone, Nadeja Monsefi, Virgilijus Ziaukas, Stefan Erler, Hamdi Elfarra, Mathias Perthel, Mahmoud S. Wehbe, Naser Ghaffari, Tim Sandhaus, Henning Busk, Jan D. Schmitto, Volker Baersch, Jerry Easo, Marc Albert, Hendrik Treede, Herbert Naegele, Dieter Zenker, Yasser Hegazy, Donja Ahmadi, Nele Gessler, Wolfgang Ehrlich, Gabriele Romano, Michael Knaut, Hermann Reichenspurner, Stephan Willems, Christian Butter, Samer Hakmi
Summary: The GALLERY study investigates the safety and effectiveness of laser lead extraction procedures in Germany. The results show high success rate and low complication rate. Predictors for complications include female sex and the presence of abandoned leads, while predictors for all-cause mortality include systemic infection, age ≥ 75 years, and chronic kidney disease.
Article
Infectious Diseases
Lucia Boix-Palop, Beatriz Dietl, Esther Calbo, Andrea Di Marco, Mariona Xercavins, Pedro Maria Martinez Perez-Crespo, Adrian Sousa, Miguel Montejo Baranda, Jesus Rodriguez-Bano, Luis Eduardo Lopez-Cortes
Summary: Cardiac device-related infection is common during late-onset bloodstream infection, with Gram-positive pathogens being the main cause.
JOURNAL OF INFECTION
(2022)
Article
Cardiac & Cardiovascular Systems
Thomas F. Deering, John N. Catanzaro, David A. Woodard
Summary: This study found that the use of antibiotics, especially gentamicin, in biologic envelope hydration solution may reduce infection risk in CIED procedures. Additionally, utilizing antibacterial envelopes without adjunct IV ABX may not be sufficient to reduce infection rates.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Khaldoun G. Tarakji, Panagiotis Korantzopoulos, Francois Philippon, Mauro Biffi, Suneet Mittal, Jeanne E. Poole, Charles Kennergren, Daniel R. Lexcen, Jeff D. Lande, Swathi Seshadri, Bruce L. Wilkoff
Summary: Among WRAP-IT patients, the risk of hematoma was 2.2%. Control patients with hematoma had a significantly higher risk of developing major CIED infection, which was effectively reduced by 82% with antibacterial envelope use compared to control patients.
Article
Multidisciplinary Sciences
Sameer Al-Maisary, Gabriele Romano, Matthias Karck, Raffaele De Simone, Jamila Kremer, Rawa Arif
Summary: This study evaluated the safety and efficacy of transvenous laser lead extraction in octogenarian patients. The results showed that it is a safe and effective procedure in this age group, with no increase in morbidity, mortality or perioperative complication.
Article
Cardiac & Cardiovascular Systems
Michele Malagu, Francesco Vitali, Alessandro Brieda, Paolo Cimaglia, Martina De Raffele, Enea Tazzari, Cristina Musolino, Cristina Balla, Matteo Serenelli, Rosario Cultrera, Claudio Rapezzi, Matteo Bertini
Summary: In a study involving patients undergoing CIED surgery, stratification of infective risk guided antibiotic prophylaxis with similar infection rates observed between high and low-risk groups after 250 days of follow-up. Active neoplasia, haematoma, and reintervention were identified as independent risk factors for CIED-related infection.
Article
Cardiac & Cardiovascular Systems
Luca Bontempi, Gianmarco Arabia, Francesca Salghetti, Manuel Cerini, Andrea Dell'Aquila, Antonino Milidoni, Ashraf Ahmed, Angelica Cersosimo, Daniele Giacopelli, Gianfranco Mitacchione, Abdallah Raweh, Claudio Muneretto, Antonio Curnis
Summary: The study found that subclinical PE detected by CT was common in patients undergoing TLE with lead-related infective endocarditis and vegetations, but it was not associated with the complexity of the procedure or adverse outcomes.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2022)