Biochemical Characterization of Human Anti-Hepatitis B Monoclonal Antibody Produced in the Microalgae Phaeodactylum tricornutum

Therapeutic monoclonal antibodies and consistent ends: terminal heterogeneity, detection, and impact on quality

(2014) Kurt Brorson et al.   CURRENT OPINION IN BIOTECHNOLOGY

Genes Involved in the Endoplasmic Reticulum N-Glycosylation Pathway of the Red Microalga Porphyridium sp.: A Bioinformatic Study

(2014) Oshrat Levy-Ontman et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of nutrient levels and average culture pH on the glycosylation pattern of camelid-humanized monoclonal antibody

(2014) Hengameh Aghamohseni et al.   JOURNAL OF BIOTECHNOLOGY

Evaluating the impact of cell culture process parameters on monoclonal antibody N-glycosylation

(2014) Marija Ivarsson et al.   JOURNAL OF BIOTECHNOLOGY

Mechanism, specificity, and physiology of signal peptide peptidase (SPP) and SPP-like proteases

(2013) Matthias Voss et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The availability of glucose to CHO cells affects the intracellular lipid-linked oligosaccharide distribution, site occupancy and the N-glycosylation profile of a monoclonal antibody

(2013) Bo Liu et al.   JOURNAL OF BIOTECHNOLOGY

Conformational characterization of the charge variants of a human IgG1 monoclonal antibody using H/D exchange mass spectrometry

(2013) Liangjie Tang et al.   mAbs

Exploring theN-glycosylation Pathway inChlamydomonas reinhardtiiUnravels Novel Complex Structures

(2013) Elodie Mathieu-Rivet et al.   MOLECULAR & CELLULAR PROTEOMICS

Plant species and organ influence the structure and subcellular localization of recombinant glycoproteins

(2013) Elsa Arcalis et al.   PLANT MOLECULAR BIOLOGY

Probing of C-terminal lysine variation in a recombinant monoclonal antibody production using Chinese hamster ovary cells with chemically defined media

(2012) Jun Luo et al.   BIOTECHNOLOGY AND BIOENGINEERING

Optimized signal peptides for the development of high expressing CHO cell lines

(2012) Lars Kober et al.   BIOTECHNOLOGY AND BIOENGINEERING

The sweet tooth of biopharmaceuticals: Importance of recombinant protein glycosylation analysis

(2012) Nico Lingg et al.   Biotechnology Journal

Marketing approval of mogamulizumab

(2012) Alain Beck et al.   mAbs

Increased serum clearance of oligomannose species present on a human IgG1 molecule

(2012) Leslie Alessandri et al.   mAbs

An engineered diatom acting like a plasma cell secreting human IgG antibodies with high efficiency

(2012) Franziska Hempel et al.   Microbial Cell Factories

Production of active human glucocerebrosidase in seeds of Arabidopsis thaliana complex-glycan-deficient (cgl) plants

(2011) Xu He et al.   GLYCOBIOLOGY

High-mannose glycans on the Fc region of therapeutic IgG antibodies increase serum clearance in humans

(2011) A. M. Goetze et al.   GLYCOBIOLOGY

Therapeutic antibodies: Market considerations, disease targets and bioprocessing

(2011) John G. Elvin et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

UniqueN-Glycan Moieties of the 66-kDa Cell Wall Glycoprotein from the Red MicroalgaPorphyridiumsp.

(2011) Oshrat Levy-Ontman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chlamydomonas reinhardtii as a viable platform for the production of recombinant proteins: current status and perspectives

(2011) Sergio Rosales-Mendoza et al.   PLANT CELL REPORTS

Algae as Protein Factories: Expression of a Human Antibody and the Respective Antigen in the Diatom Phaeodactylum tricornutum

(2011) Franziska Hempel et al.   PLoS One

Chemical and enzymatic N-glycan release comparison for N-glycan profiling of monoclonal antibodies expressed in plants

(2010) Ada Triguero et al.   ANALYTICAL BIOCHEMISTRY

Protein translocation across the ER membrane

(2010) Richard Zimmermann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Optimal nitrogen supply as a key to increased and sustained production of a monoclonal full-size antibody in BY-2 suspension culture

(2010) T. Holland et al.   BIOTECHNOLOGY AND BIOENGINEERING

N-Glycans ofPhaeodactylum tricornutumDiatom and Functional Characterization of ItsN-Acetylglucosaminyltransferase I Enzyme

(2010) Bérengère Baïet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biopharmaceutical benchmarks 2010

(2010) Gary Walsh   NATURE BIOTECHNOLOGY

Production of therapeutic proteins in algae, analysis of expression of seven human proteins in the chloroplast of Chlamydomonas reinhardtii

(2010) Beth A. Rasala et al.   PLANT BIOTECHNOLOGY JOURNAL

Identification and characterization of asparagine deamidation in the light chain CDR1 of a humanized IgG1 antibody

(2009) Josef Vlasak et al.   ANALYTICAL BIOCHEMISTRY

Optimal and consistent protein glycosylation in mammalian cell culture

(2009) P. Hossler et al.   GLYCOBIOLOGY

Strategies to facilitate transgene expression in Chlamydomonas reinhardtii

(2009) Alke Eichler-Stahlberg et al.   PLANTA

Symbol nomenclature for glycan representation

(2009) Ajit Varki et al.   PROTEOMICS

The Phaeodactylum genome reveals the evolutionary history of diatom genomes

(2008) Chris Bowler et al.   NATURE

Heterogeneity of Monoclonal Antibodies

(2007) Hongcheng Liu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Glycosylation of Recombinant Antibody Therapeutics

(2005) Royston Jefferis   BIOTECHNOLOGY PROGRESS