Review
Immunology
Mireia Medrano-Bosch, Blanca Simon-Codina, Wladimiro Jimenez, Elazer R. Edelman, Pedro Melgar-Lesmes
Summary: Monocytes are circulating leukocytes that interact with endothelial cells to regulate inflammation, angiogenesis, and tissue remodeling under physiological and pathophysiological conditions. They transdifferentiate into macrophages and release various substances that induce vascular and tissue remodeling or propagate inflammatory responses. The interactions between infiltrating monocytes and endothelial cells contribute to pathophysiological conditions such as cardiovascular and chronic liver diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Sylvain Raimbault, Guillaume Monneret, Morgane Gossez, Fabienne Venet, Alexandre Belot, Franck Zekre, Solene Remy, Etienne Javouhey
Summary: In this study, the researchers examined the use of monocyte human leucocyte antigen (mHLA)-DR as a potential diagnostic marker for secondary HLH (sHLH). They found that levels of mHLA-DR were significantly higher in patients with sHLH compared to healthy children and those with septic shock. Additionally, mHLA-DR levels decreased after treatment initiation. The findings suggest that elevated mHLA-DR could aid in the diagnosis of sHLH and distinguish it from septic shock.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Qiuhua Yang, Qian Ma, Jiean Xu, Zhiping Liu, Jianqiu Zou, Jian Shen, Yaqi Zhou, Qingen Da, Xiaoxiao Mao, Sarah Lu, David J. Fulton, Neal L. Weintraub, Zsolt Bagi, Mei Hong, Yuqing Huo
Summary: The deficiency of Prkaa1 in myeloid cells impacts the expression of genes involved in glucose and lipid metabolism, compromises macrophages' metabolic abilities, reduces their recruitment in various tissues, and ultimately leads to a deceleration in the development of related metabolic disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
X. Y. Fang, Y. X. Zhan, X. M. Zhou, L. N. Wu, J. Lin, Y. T. Yi, C. M. Jiang, J. Wang, J. Liu
Summary: Mechanical force-induced CXCL12/CXCR4 axis is involved in promoting orthodontic root resorption (ORR) by attracting Ly6C(hi) inflammatory monocytes and modulating macrophage polarization, leading to an increased M1/M2 ratio in periodontal tissues. Blockage of the CXCL12/CXCR4 axis using AMD3100 may potentially inhibit root resorption.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Julie Rondeaux, Deborah Groussard, Sylvanie Renet, Virginie Tardif, Anais Dumesnil, Alphonse Chu, Lea Di Maria, Theo Lemarcis, Manon Valet, Jean-Paul Henry, Zina Badji, Claire Vezier, Delphine Beziau-Gasnier, Annette E. Neele, Menno P. J. de Winther, Dominique Guerrot, Marjorie Brand, Vincent Richard, Eric Durand, Ebba Brakenhielm, Sylvain Fraineau
Summary: Epigenetic regulation of histone H3K27 methylation plays a key role in cardiac repair after myocardial infarction. The authors demonstrate the ectopic EZH2 and cytoplasmic inactive localization of EZH2 during monocyte differentiation and in immunomodulatory cardiac macrophages. Pharmacological inhibition of EZH2 resolves H3K27 methylation, enhances gene expression, and accelerates cardiac inflammatory resolution, preventing infarct expansion and cardiac dysfunction.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Yi-Ping Jin, Jessica Nevarez-Mejia, Allyson Q. Terry, Rebecca A. Sosa, Sebastiaan Heidt, Nicole M. Valenzuela, Enrique Rozengurt, Elaine F. Reed
Summary: Donor-specific HLA antibodies stimulate the formation of complexes between TLR4 and HLA I on ECs, leading to EC activation and recruitment of monocytes. Knockdown of TLR4 or MyD88 inhibits P-selectin expression, von Willebrand factor release, and monocyte recruitment on ECs stimulated by HLA I antibodies.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Victor D. Cuevas, Miriam Simon-Fuentes, Emmanuel Orta-Zavalza, Rafael Samaniego, Paloma Sanchez-Mateos, Maria Escribese, Francisco J. Cimas, Matilde Bustos, Mario Perez-Diego, Alberto Ocana, Angeles Dominguez-Soto, Miguel A. Vega, Angel L. Corbi
Summary: During inflammatory responses, monocytes can differentiate into monocyte-derived macrophages with distinct transcriptional profiles, which are partially regulated by IL-10. This specific gene expression signature may provide potential targets for macrophage-centered therapeutic strategies.
JOURNAL OF INNATE IMMUNITY
(2022)
Article
Chemistry, Physical
Kyle H. Vining, Anna E. Marneth, Kwasi Adu-Berchie, Joshua M. Grolman, Christina M. Tringides, Yutong Liu, Waihay J. Wong, Olga Pozdnyakova, Mariano Severgnini, Alexander Stafford, Georg N. Duda, F. Stephen Hodi, Ann Mullally, Kai W. Wucherpfennig, David J. Mooney
Summary: Myelofibrosis causes pathological remodelling of the bone marrow, leading to increased stiffness and elasticity, thereby promoting the proliferation of proinflammatory monocytes and their differentiation into dendritic cells.
Article
Cell Biology
Brian J. McHugh, Jillian Stephen, Calum T. Robb, Sarah Fox, Tiina Kipari, Jennifer A. Cartwright, Christopher Haslett, Rodger Duffin, Christopher D. Lucas, Adriano G. Rossi
Summary: Cyclin-dependent kinase inhibitor drugs can induce neutrophil apoptosis and enhance inflammation resolution. In this study, CDKi showed significant effects on macrophage pro-inflammatory mediator production and viability. Targeting CDK9 inhibited an inflammatory phenotype in human MDMs, suggesting its importance in therapeutically targeting pro-inflammatory macrophage functions during chronic inflammation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Critical Care Medicine
Philipp A. Reuken, Jonathan F. Brozat, Stefanie Quickert, Oluwatomi Ibidapo-obe, Johanna Reissing, Anika Franz, Sven Stengel, Ulf K-M Teichgraeber, Michael Kiehntopf, Christian Trautwein, Andreas Stallmach, Alexander Koch, Tony Bruns
Summary: In acute pancreatitis (AP), macrophage activation and endothelial dysfunction play a role in organ damage, inflammation, and mortality. This study examined the macrophage activation marker sCD206 and the endothelial function marker vWF in AP patients. The results showed that sCD206 can identify high-risk patients for severe AP at an earlier stage, and vWF antigen levels are elevated upon admission. Further prospective studies are needed to determine the role of these markers in assessing the risk of AP complications.
JOURNAL OF INTENSIVE CARE
(2022)
Article
Cell Biology
Xuejiao Chen, Ziyi Wang, Sheng Han, Zeng Wang, Yu Zhang, Xiangdong Li, Nan Xia, Wenjie Yu, Chenyang Jia, Yong Ni, Liyong Pu
Summary: Liver fibrosis is a danger signal for liver cancer, but there is no effective clinical means to regulate its progress. It has been found that inhibiting SYK in monocyte-derived macrophages may help alleviate chronic liver fibrosis.
CELL DEATH & DISEASE
(2021)
Article
Immunology
Jingbo Pang, Mark Maienschein-Cline, Timothy J. Koh
Summary: In this study, we used single-cell RNA sequencing to explore the heterogeneity and state transitions of Mos/M phi during skin wound healing in mice. We identified eight distinctive clusters of Mos/M phi populations and categorized them into early-stage/proinflammatory, late-stage/prohealing, and Ag-presenting phenotypes. Further analysis revealed the functions of different Mos/M phi subsets, including inflammation, chemotaxis, biosynthesis, angiogenesis, proliferation, and cell death. Our data also showed state transitions between early- and late-stage Mos/M phi as healing progressed.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Eleonore Maury, Benoit Navez, Sonia M. Brichard
Summary: The study demonstrates that circadian clock function is disrupted in adipose tissue of individuals with obesity, and inhibition of NFkB can improve clock function. Investigating the interplay between circadian clocks and the NF-kappa B pathway in human adipose tissue reveals a relationship between NF-kappa B and the molecular clock, which may contribute to obesity-related complications.
NATURE COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Hui Quan, Mei Yin, Joungmin Kim, Eun-A Jang, Si-Ho Yang, Hong-Beom Bae, Seongtae Jeong
Summary: Resveratrol has beneficial effects on sepsis by regulating the inflammatory response, but its role in the development of endotoxin tolerance remains unclear. It has been found that resveratrol inhibits the expression of IRAK-M and SHIP1 through AMPK activation, suppressing the development of endotoxin tolerance.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Yun Wu, Ziping Qi, Beilei Wang, Junjie Wang, Qingwang Liu, Aoli Wang, Chenliang Shi, Bin Zhou, Qianmao Liang, Wenliang Wang, Fengming Zou, Shuang Qi, Zuowei Wang, Li Wang, Wenchao Wang, Jing Liu, Qingsong Liu
Summary: A novel, potent, and selective MST1 inhibitor 19 was discovered, which protected ss cells from inflammatory cytokines in vitro and showed potential in treating diabetes in animal models.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Emergency Medicine
T. Gruebl, D. Nauheimer, H. Wolff, G. Gehret, N. Rott, W. Schmidbauer, B. Schieffer, B. Gliwitzky
Summary: The treatment of patients with cardiac arrest is complex, and establishing cardiac arrest centers can improve patient outcomes. The certification and re-certification process for these centers is multi-stage and takes about a year. These centers require infrastructure, evidence-based treatment algorithms, structured training, and regular evaluations for process optimization. The goal is to provide focused and standardized care for patients with cardiac arrest. Multidisciplinary cooperation, accurate procedures, high standards for patient safety, and detailed documentation are necessary. These measures optimize treatment and improve outcomes for cardiac arrest patients. The updated international resuscitation guidelines strongly recommend the establishment of cardiac arrest centers.
NOTFALL & RETTUNGSMEDIZIN
(2023)
Article
Cardiac & Cardiovascular Systems
Julian Kreutz, Amar Mardini, Ann-Christin Schaefer, Bernhard Schieffer, Birgit Markus
Summary: This article presents a case of severe cardiogenic-septic shock and introduces a method of treating accompanying complications using an experimental arterio-venous shunt, which achieved good therapeutic effects.
Editorial Material
Cell Biology
Manoj B. Menon, Matthias Gaestel
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Peripheral Vascular Disease
Christian Beger, Astrid Mayerboeck, Konrad Klein, Theresa Karg, Kai M. Schmidt-Ott, Olaf Randerath, Florian P. Limbourg
Summary: This study assessed the current practice of blood pressure measurement and associated values in German medical practices. The findings suggest that blood pressure control is insufficient and measurements are often not performed according to guideline recommendations.
Article
Engineering, Biomedical
Julian Kreutz, Maryana Choukeir, Georgios Chatzis, Bernhard Schieffer, Birgit Markus
Summary: This case report highlights the recognition of severe Capnocytophaga infection in immunocompetent patients, which can lead to critical conditions. Combined therapeutic measures, including broad spectrum antibiotic therapy, mass transfusions, continuous renal replacement therapy, and hemoadsorption therapy, resulted in control of the critical situation.
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
(2023)
Article
Hematology
Nadia Meyer, Katja Richter, Lars Brodowski, Constantin von Kaisenberg, Anette Melk, Bernhard Schmidt, Florian P. Limbourg, Bianca Schroeder-Heurich, Frauke Von Versen-Hoeynck
Summary: Kidney transplantation affects endothelial progenitor cells in women, leading to increased cardiovascular risk.
Editorial Material
Oncology
Fadia Boudghene-Stambouli, Mathilde Soulez, Natalia Ronkina, Anneke Doerrie, Alexey Kotlyarov, Ole-Morten Seternes, Matthias Gaestel, Sylvain Meloche
Summary: Patients with triple-negative breast cancer face poor outcomes due to the aggressive nature of the disease and the lack of effective treatments. Identifying new therapeutic targets is essential, and recent research suggests that the protein kinase ERK4 may be a promising candidate. However, there are concerns about the experimental methods used to validate the oncogenic function of ERK4 in breast cancer.
Article
Cell Biology
Chanchal Chauhan, Ana Martinez-Val, Rainer Niedenthal, Jesper Velgaard Olsen, Alexey Kotlyarov, Simon Bekker-Jensen, Matthias Gaestel, Manoj B. Menon
Summary: The TNF receptor-interacting protein kinases (RIPK)-1 and 3 regulate cell death response pathways. RIPK1 determines cell survival or death by associating with distinct complexes, while RIPK3 is a target of PRMT5-mediated arginine dimethylation. This study uncovers PRMT5-mediated RIPK3 methylation as a novel modulator of RIPK1-dependent signaling.
CELL DEATH DISCOVERY
(2023)
Article
Peripheral Vascular Disease
Christian Beger, Theresa Karg, Jan B. Hinrichs, Bastian Ringe, Hermann Haller, Bernhard C. Meyer, Florian P. Limbourg
Summary: This study analyzed patients with treatment-resistant hypertension and inadequate low renin in the presence of renin-angiotensin system inhibition (RASi), indicating a risk for primary aldosteronism (PA). The study found that low renin in the presence of RASi is a strong indicator of autonomous aldosterone secretion in patients with resistant hypertension, suggesting it as an on-medication screening test for PA.
Article
Pharmacology & Pharmacy
Adam Olaitan Abdulkareem, Priya Tiwari, Zahid Rasool Lone, Hina Iqbal, Satish Gupta, Rajesh Kumar Jha, Debabrata Chanda, Kumaravelu Jagavelu, Kashif Hanif
Summary: This study investigated the ameliorative effects of ormeloxifene, a selective estrogen receptor modulator, in pulmonary hypertension. The results showed that ormeloxifene promoted the synthesis of 17β-estradiol, alleviated inflammation, and improved the NOX4/HO1/Nrf/PPAR gamma/PGC-1 alpha axis, thereby attenuating pulmonary hypertension.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Immunology
Abhiram Charan Tej Mallu, Sivapriya Sivagurunathan, Debasish Paul, Hobby Aggarwal, Abel Arul Nathan, Amrutha Manikandan, Mahalakshmi M. Ravi, Ramanamurthy Boppana, Kumaravelu Jagavelu, Manas Kumar Santra, Madhulika Dixit
Summary: Nutritional availability during fasting and refeeding affects immune cell redistribution. Nutritional imbalance and impaired glucose metabolism are associated with chronic inflammation and abnormal leukocyte trafficking. The physiological effects of hormonal changes on immune cell function and trafficking are underexplored.
Article
Virology
Mark Windheim, Thomas F. Reubold, Khadija Aichane, Matthias Gaestel, Hans-Gerhard Burgert
Summary: Human adenoviruses (HAdVs) are widespread pathogens that can cause mild infections in immunocompetent individuals but severe or fatal diseases in immunocompromised patients. They have developed immunomodulatory proteins to counteract the host immune defenses.
JOURNAL OF VIROLOGY
(2023)
Article
Pharmacology & Pharmacy
Mohammad Shafiq, Zahid Rasool Lone, Adam Olaitan Abdulkareem, Gurpreet Kaur, Sai Navya, Himalaya Singh, Kumaravelu Jagavelu, Kashif Hanif
Summary: Endothelial dysfunction is critical in pulmonary hypertension. Inhibiting PARP-1 can protect against pulmonary hypertension and associated right ventricular hypertrophy. The current study investigates the role of PARP-1 in endothelial dysfunction. Results show that PARP-1 inhibition reduces proliferation and inflammation, improves mitochondrial dysfunction, and promotes apoptosis through DNA damage. Inhibition of PARP-1 also reduces cell migration, VEGF expression, and tubule formation.
PULMONARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Cardiac & Cardiovascular Systems
Christian Beger, Dominik Rueegger, Anna Lenz, Steffen Wagner, Herrmann Haller, Kai Martin Schmidt-Ott, Dirk Volland, Florian P. Limbourg
Summary: Self-monitoring of blood pressure at home is recommended in hypertension guidelines. This study found that the initial blood pressure category and measurement schedule influenced blood pressure values during home blood pressure monitoring (HBPM). BP classification tracking revealed that the time to reach the final BP category depended on the baseline category, with users in higher categories requiring more time to reach their definitive BP class. Overall, >90% of users maintained their category by day 5. Completing at least two HBPM periods resulted in a decrease in average blood pressure and improved hypertension control.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Correction
Pharmacology & Pharmacy
Adam Olaitan Abdulkareem, Priya Tiwari, Zahid Rasool Lone, Hina Iqbal, Satish Gupta, Rajesh Kumar Jha, Debabrata Chanda, Kumaravelu Jagavelu, Kashif Hanif
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)