Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 136, Issue 40, Pages 14128-14135Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja506278z
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Funding
- Department of Science and Technology (DST), New Delhi, India [SR/S1/OC-65/2012, SB/S1/PC-39/2012, SR/NM/NS-42/2009]
- UGC (University Grant Commission), India
- Department of Science and Technology (DST), New Delhi, India
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Artificial anion selective ion channels with single-file multiple anion-recognition sites are rare. Here, we have designed, by hypothesis, a small molecule that self-organizes to form a barrel rosette ion channel in the lipid membrane environment. Being amphiphilic in nature, this molecule forms nanotubes through intermolecular hydrogen bond formation, while its hydrophobic counterpart is stabilized by hydrophobic interactions in the membrane. The anion selectivity of the channel was investigated by fluorescence-based vesicle assay and planar bilayer conductance measurements. The ion transport by a modified hopping mechanism was demonstrated by molecular dynamics simulation studies
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