Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 136, Issue 17, Pages 6255-6258Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja5029028
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Funding
- MEXT [24106721, 25107002]
- JSPS [25220802, 24685007, 23655037]
- Grants-in-Aid for Scientific Research [23655037, 25620031, 25107002] Funding Source: KAKEN
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Tuning the reactivity of arylpalladium intermediates enables control of catalytic arylative 5-exo and 6-endo cyclizations of alkynols. The two modes of cyclizations represent a rare example of controllable, regioselective difunctionalization of alkynes. The cyclizations are useful in offering a divergent synthesis of oxygen-containing heterocycles, which is of synthetic use for further derivatization. Formal synthesis of an hNK-1 receptor antagonist also showcases the utility of our arylative cyclization.
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