Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 136, Issue 45, Pages 15837-15840Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja5075745
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Funding
- National Natural Science Foundation of China [21032003, 21125208]
- National Basic Research Program of China [2010CB833300]
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An efficient palladium-catalyzed asymmetric hydrogenation via capture of an active intermediate generated in situ from acid-catalyzed aza-Pinacol rearrangement has been successfully developed, providing efficient access to chiral exocyclic amines with up to 98% ee. Three-, four-, and five-membered cyclic N-sulfonyl amino alcohols are viable substrates. This study opens a new window to the application of asymmetric hydrogenation.
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