Article
Multidisciplinary Sciences
Joseph d'Alessandro, Alex Barbier--Chebbah, Victor Cellerin, Olivier Benichou, Rene Marc Mege, Raphael Voituriez, Benoit Ladoux
Summary: Cells actively migrate in their environment and leave physicochemical footprints that can determine their future path. The impact of self-induced environmental perturbations on cell trajectories at different scales remains unexplored. The general coupling between motile cells and their environment can result in spatial memory of their path and change their space exploration significantly.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Elisabetta Catalani, Simona Del Quondam, Kashi Brunetti, Agnese Cherubini, Silvia Bongiorni, Anna Rita Taddei, Silvia Zecchini, Matteo Giovarelli, Clara De Palma, Cristiana Perrotta, Emilio Clementi, Giorgio Prantera, Davide Cervia
Summary: This study evaluated the effects of plumbagin on retina homeostasis in a hyperglycemic fruit fly model. The results showed that plumbagin improved visual performance, repaired damaged eye structures, and reduced neuronal impairment and eye damage induced by high glucose through various mechanisms, such as Nrf2 signaling activation and inhibition of mitochondrial-endoplasmic reticulum stress and unfolded protein response pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Sudhakar Krittika, Pankaj Yadav
Summary: This study investigated the effects of long-term protein restriction diet on body size, weight, and wing length in fruit flies. The results showed that flies on a protein-restricted diet had lower body weight and relative water content, unchanged or higher relative fat content, and smaller normal and dry wing length. Furthermore, protein restriction also significantly affected wing size and pupal size, and these effects were influenced by diet and generation.
ROYAL SOCIETY OPEN SCIENCE
(2022)
Article
Biology
Marina E. Wosniack, Dylan Festa, Nan Hu, Julijana Gjorgjieva, Jimena Berni
Summary: This study investigates the foraging adaptation of Drosophila larvae to different food conditions and the influence of genetic background. The findings reveal the specific modulation of motor programs by food quality and distribution, as well as the role of the foraging gene in adjusting the behavioral response to food conditions.
Article
Microbiology
Runhang Shu, Daniel A. Hahn, Edouard Jurkevitch, Oscar E. Liburd, Boaz Yuval, Adam Chun-Nin Wong
Summary: The study demonstrates a clear sex-specific effect of the microbiome on foraging and locomotion behaviors in fruit flies, with female flies deprived of their microbiome showing reduced activity in foraging on fruits compared to their male counterparts. This highlights the importance of specific mechanisms driving the modulation of insect behavior by interactions between the host, the microbiome, and food.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Behavioral Sciences
Calvin W. Daack, Derek Yeh, Marc Busch, Christopher L. Kliethermes
Summary: The results suggest that ethanol-induced locomotor stimulation in fruit flies may be mediated by ionotropic GABA receptors. Knockdown of the ionotropic GABA receptor subunit RDL increased ethanol-induced locomotor stimulant response, and feeding the GABAA antagonist picrotoxin had a similar effect. However, the observed increase in ethanol-stimulated locomotion was primarily due to decreased baseline activity in the experiments.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Multidisciplinary Sciences
Weipang Chang, Andrea Pedroni, Reinhard W. Koster, Stefania Giacomello, Konstantinos Ampatzis
Summary: This study demonstrates experimentally that Purkinje cells in the valvular part of the cerebellum in adult zebrafish exhibit variable firing patterns and functional responses, categorizing into three classes. Compared to Purkinje cells in the corpus cerebelli, valvular Purkinje cells receive weak and occasional input from the inferior olive and are inactive during locomotion. These findings expand the understanding of regional functional differences among Purkinje cells and highlight their non-locomotor functionalities.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Hwa-Jin Lee, Shin-Hae Lee, Ji-Hyeon Lee, Yongjoong Kim, Ki Moon Seong, Young Woo Jin, Kyung-Jin Min
Summary: This study found that axenic flies are more sensitive to mitochondrial responses to radiation compared to conventional flies. This increased sensitivity leads to a reduced lifespan and other physiological changes in axenic flies.
Article
Biology
Yuji Matsuo, Akinao Nose, Hiroshi Kohsaka
Summary: The study revealed that the locomotion kinetics of Drosophila larvae diverge among species and are correlated with habitat temperature rather than body length. Phylogenetic analyses using Bayesian inference indicated diverse evolutionary rates of kinematics in different phylogenetic branches.
Article
Entomology
Mikaela M. Ceder, Frida A. Lindberg, Emelie Perland, Michael J. Williams, Robert Fredriksson
Summary: The body relies on transporters to function properly, including the orphan transporter MFSD11. By studying its orthologue in fruit flies, researchers discovered its expression in the brain and its possible involvement in metabolism and locomotion. This study sheds light on the importance of characterizing orphan transporters for understanding normal conditions and diseases.
Article
Environmental Sciences
Sergei Redondo-Lopez, Enrique Gonzalez-Ortegon, Freylan Mena, Cristiano V. M. Araujo
Summary: Behavioral changes in two shrimp species, P. vannamei and P. varians, exposed to copper were studied. The locomotion of the shrimps showed opposite trends, with P. varians reducing movements above 50 mu g/L and P. vannamei exhibiting hyperactivity. Both species significantly avoided the highest concentrations of copper in a non-forced exposure scenario, but the repellence of copper was stronger for P. vannamei.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Shao-Kuei Huang, Peter H. Whitney, Sayantan Dutta, Stanislav Y. Shvartsman, Christine A. Rushlow
Summary: Studying early Drosophila embryos revealed that RNA polymerase II accumulates at histone locus bodies during early genome activation. Co-regulated genes do not cluster into nuclear sub-domains, but transcribing genes in close 3D proximity have distinct RNA polymerase II speckles. This challenges the emerging model of clustered active genes in gene regulation.
Article
Chemistry, Multidisciplinary
Jie Wang, Fu Tang, Chuang Yao, Lidong Li
Summary: A new spatial confinement gelation strategy is proposed for fabricating hysteresis-free polymer hydrogels, avoiding stress concentration and achieving ultra-tough hydrogels with fatigue resistance. This strategy is based on the difference in hydratability between salts and polymer chains. The prepared hydrogels show excellent properties, including low hysteresis, good fatigue resistance, water retention, antifreeze ability, water-assisted healing, and bionic muscle capability for driving bionic fish.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Multidisciplinary Sciences
Keisuke Inoue, Meiko Asaka, Sachiko Lee, Kinya Ishikawa, Dai Yanagihara
Summary: The study found that cerebellar stroke has adverse effects on the locomotor kinematics of mice, including gait ataxia and increased hindlimb duty ratio. These findings contribute to the evaluation of treatment options for cerebellar stroke.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Rachel A. Short, Jenny L. McGuire, P. David Polly, A. Michelle Lawing
Summary: We are currently experiencing a modern biodiversity crisis that will reshape global community compositions and ecological functions. This study examines the relationship between vegetation cover and locomotor traits for artiodactyl and carnivoran communities using ecometrics. The results show that combining the locomotor traits of primary consumers (artiodactyls) and secondary consumers (carnivorans) into one trophically integrated ecometric model strengthens the ability to detect a functional relationship. Furthermore, applying this integrated model to paleontological sites reveals mismatches in the past and today, demonstrating the utility of the model for understanding community traits and their associated vegetations over time.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biology
Mads Kuhlmann Andersen, Nikolaj Johannes Skole Jensen, R. Meldrum Robertson, Johannes Overgaard
JOURNAL OF EXPERIMENTAL BIOLOGY
(2018)
Article
Psychology, Biological
Shuang Qiu, Chengfeng Xiao
PHYSIOLOGY & BEHAVIOR
(2018)
Article
Biochemistry & Molecular Biology
R. Meldrum Robertson, Arianne J. Cease, Stephen J. Simpson
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2019)
Article
Neurosciences
Chengfeng Xiao, Shuang Qiu
NEUROSCIENCE LETTERS
(2019)
Article
Biology
Chengfeng Xiao, Niki Bayat Fard, Kaylen Brzezinski, R. Meldrum Robertson, Adam K. Chippindale
JOURNAL OF EXPERIMENTAL BIOLOGY
(2019)
Editorial Material
Biology
Kathryn Knight
JOURNAL OF EXPERIMENTAL BIOLOGY
(2019)
Article
Neurosciences
Chengfeng Xiao, Shuang Qiu, Xiao Li, Dan-Ju Luo, Gong-Ping Liu
NEUROSCIENCE LETTERS
(2019)
Article
Environmental Sciences
Shuang Qiu, Shuying Wang, Chengfeng Xiao, Shijian Ge
SCIENCE OF THE TOTAL ENVIRONMENT
(2019)
Article
Genetics & Heredity
Chengfeng Xiao, Danna Hull, Shuang Qiu, Joanna Yeung, Jie Zheng, Taylor Barwell, R. Meldrum Robertson, Laurent Seroude
G3-GENES GENOMES GENETICS
(2019)
Article
Behavioral Sciences
Chengfeng Xiao, Shuang Qiu
Summary: Mutation of the classic eye-color gene white (w) in fruit flies results in selectively increasing high-frequency locomotor components, leading to altered behavior patterns. This is associated with reduced transcripts of the w(+) gene in neurons, showing a link between genetic mutation and locomotion changes in adult fruit flies.
GENES BRAIN AND BEHAVIOR
(2021)
Article
Zoology
Shuang Qiu, Chenxi Li, Guihua Cao, Chengfeng Xiao
Summary: This study found that mating experience in male fruit flies promoted fast and consistent locomotor activities and increased the power of episodic motor activities.
Article
Physiology
Ting Wang, Xiaohui Du, Zhihua Wang, Yiya Gu, Qian Huang, Jixing Wu, Yuan Zhan, Jinkun Chen, Chengfeng Xiao, Jungang Xie
Summary: Chronic obstructive pulmonary disease (COPD) is a combination of chronic airway inflammation and emphysema. Recent studies have found that Class IA phosphatidylinositol 3-kinases (PI3Ks) play a crucial role in controlling inflammation and emphysema. This study focuses on the regulatory subunit p55PIK of Class IA PI3Ks and its specific NH2-terminal, showing that p55PIK deficiency or TAT-N15 can inhibit cigarette smoke induced inflammation and prevent emphysema. The findings suggest that p55PIK is involved in the pathogenesis of COPD and TAT-N15 could be a potential drug for COPD treatment by inhibiting the Akt and NF-kappa B pathways.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Cell Biology
Yiya Gu, Jinkun Chen, Qian Huang, Yuan Zhan, Ting Wang, Jixing Wu, Jianping Zhao, Zhilin Zeng, Yongman Lv, Chengfeng Xiao, Jungang Xie
Summary: MTMR14 expression was reduced in COPD patients' lungs. Overexpression of MTMR14 inhibited inflammation and apoptosis induced by cigarette smoke extract, and improved mitochondrial function and mitophagy. Further verification in COPD model mice showed that MTMR14 overexpression inhibited lung inflammation, reduced levels of inflammatory factors, prevented emphysema and a decline in lung function. Furthermore, MTMR14 overexpression improved mitochondrial function and mitophagy to a certain extent.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Behavioral Sciences
Chengfeng Xiao, Shuang Qiu, R. Meldrum Robertson