Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 133, Issue 32, Pages 12451-12453Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja206138d
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- National Institutes of Health [GM28553]
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A concise, diastereoselective total synthesis of (+/-)-cortistatin J has been completed in 20 steps from furan. Key steps include an intramolecular [4 + 3] cyclization of a disubstituted furan with a (Z)-2-(trialkylsilyloxy)-2-enal to construct the tetracyclic core and a (Z)-vinylsilane/iminium ion cyclization to form the A ring.
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