Article
Urology & Nephrology
Patrick J. Hensley, Kelly K. Bree, Charles C. Guo, Niyati Lobo, Matthew T. Campbell, Curtis A. Pettaway, Ashish M. Kamat
Summary: The study described the clinical characteristics of inflammatory myofibroblastic tumor (IMT) of the urinary bladder and provided initial management and surveillance recommendations. It was found that no recurrences occurred beyond 6 months in patients with IMT treated with aggressive endoscopic management, and no recurrences were noted after partial or radical cystectomy.
Article
Medicine, General & Internal
Christina S. Lee, Jason S. Kim, Rosemarie Rodriguez, Robert W. Krell
Summary: Inflammatory myofibroblastic tumors (IMTs) are rare neoplasms with unclear biological behavior. This case report demonstrates successful treatment of an IMT through surgery.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Review
Pediatrics
Ethan Craig, Laura M. Wiltsie, Lynda K. Beaupin, Ayesha Baig, Rafal Kozielski, David H. Rothstein, Veetai Li, Clare J. Twist, Matthew Barth
Summary: Inflammatory myofibroblastic tumors (IMTs) are rare and often associated with ALK gene rearrangement. Recent studies suggest that ALK inhibitors can improve outcomes. A systematic literature review revealed promising treatment outcomes for ALK-positive IMTs in children, highlighting the importance of further genetic characterization for precise treatment strategies.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Multidisciplinary Sciences
Tongqing Li, Steven E. Stayrook, Yuko Tsutsui, Jianan Zhang, Yueyue Wang, Hengyi Li, Andrew Proffitt, Stefan G. Krimmer, Mansoor Ahmed, Olivia Belliveau, Ian X. Walker, Krishna C. Mudumbi, Yoshihisa Suzuki, Irit Lax, Diego Alvarado, Mark A. Lemmon, Joseph Schlessinger, Daryl E. Klein
Summary: The proto-oncogene ALK encodes anaplastic lymphoma kinase, which is primarily expressed in the developing nervous system. Its activity is associated with learning and memory, energy expenditure, and obesity prevention. Aberrant ALK signaling causes various cancers, including being a driver in pediatric neuroblastoma. The study reveals the crystal structures of ALK's extracellular glycine-rich domain (GRD) and how it regulates receptor activity, providing insights into potential therapeutics for ALK-expressing cancers.
Article
Multidisciplinary Sciences
Andrey V. Reshetnyak, Paolo Rossi, Alexander G. Myasnikov, Munia Sowaileh, Jyotidarsini Mohanty, Amanda Nourse, Darcie J. Miller, Irit Lax, Joseph Schlessinger, Charalampos G. Kalodimos
Summary: ALK is a receptor tyrosine kinase that regulates important functions in the central nervous system, and mutations in this gene may lead to neuroblastoma. Research has revealed a mechanism of RTK activation that allows dimerization by different ligands, with the complex architecture of the receptor-ligand complex playing a key role in this process.
Review
Immunology
Ye Guo, Hanfei Guo, Yongfei Zhang, Jiuwei Cui
Summary: Alterations in the ALK gene are crucial in the development of various tumors, and targeted therapy has transformed the treatment approach. However, resistance remains a challenge. ALK gene variants have a significant impact on the tumor immune microenvironment, suggesting potential clinical applications for immunotherapy targeting ALK-altered tumors.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Ting Zhao, Xiaowei Zhang, Xin Liu, Min Ren, Yufan Cheng, Jian Wang, Zhiguo Luo
Summary: This article describes a case in which a 57-year-old woman initially diagnosed with uterine leiomyosarcoma (LMS) was later re-diagnosed with uterine inflammatory myofibroblastic tumor (IMT) based on ALK expression and gene fusion. The patient achieved complete response and at least 18 months of progression-free survival after receiving ALK tyrosine kinase inhibitor (TKI) treatment.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Louisre Gros, Angelo Paolo Dei Tos, Robin L. Jones, Antonia Digklia
Summary: Inflammatory myofibroblastic tumor (IMT) is an extremely rare subtype of sarcoma with specific oncogene-driven mechanisms. Early identification of gene rearrangement is important for accurate treatment in advanced stages. Surgery is the preferred treatment for localized tumors, while the treatment for advanced disease is still unclear. Targeted therapy, particularly with tyrosine kinase inhibitors, plays a significant role in the management of IMT.
Article
Pathology
Jung-Woo Choi, Youngseok Lee, Hyunchul Kim, Hyun Yee Cho, Soo Kee Min, Young-Sik Kim
Summary: In solid tumors and malignant lymphomas, lactate transport is regulated by different monocarboxylate transporters. Malignant lymphomas with ALK(+) ALCL show a unique metabolic phenotype characterized by high coexpression of MCT1 and MCT4 in tumor cells. Immunostaining for MCT4, together with ALK, can be useful for the differential diagnosis of ALK(-) ALCL and peripheral T-cell lymphoma. Dual targeting of MCT1 and MCT4 may be an appropriate therapeutic approach for ALK(+) ALCL.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)
Article
Medicine, General & Internal
Shih-Lung Chen, Kai-Chieh Chan
Summary: ALCL is a rare form of non-Hodgkin's lymphoma, especially when it occurs in the external auditory canal (EAC). Diagnosis of ALCL in the EAC region can be challenging, but a combination of imaging, histopathological examination and IHC staining can confirm the presence of the disease. Treatment options include radiotherapy, chemoradiotherapy, and targeted therapies like Brentuximab vedotin for ALK-positive ALCL.
Article
Immunology
Annkristin Heine, Stefanie Andrea Erika Held, Solveig Nora Daecke, Chrystel Flores, Peter Brossart
Summary: This study investigates the immunosuppressive effects of two different ALK inhibitors on dendritic cells. The results show that crizotinib significantly suppresses the activation, migration, and cytokine production of dendritic cells, while alectinib has lesser immunosuppressive effects.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Luca Mologni, Sebastien Tardy, Alfonso Zambon, Alexandre Orsato, William H. Bisson, Monica Ceccon, Michela Viltadi, Joseph D'Attoma, Sara Pannilunghi, Vito Vece, Jerome Bertho, Peter Goekjian, Leonardo Scapozza, Carlo Gambacorti-Passerini
Summary: A series of azacarbazole inhibitors were designed, synthesized, and evaluated, with compound 149 showing selective inhibition of both native and drug-resistant mutants of the ALK kinase. The three-dimensional structure of a 149:ALK-KD cocrystal revealed extensive interaction through the hinge region and the catalytic lysine 1150, demonstrating its potential as a promising therapeutic candidate.
Article
Nutrition & Dietetics
Simona Dedoni, Maria Scherma, Chiara Camoglio, Carlotta Siddi, Walter Fratta, Paola Fadda
Summary: The expression of ALK receptor is reduced in rats with activity-based anorexia, indicating a potential involvement of ALK receptor in the pathophysiology of anorexia nervosa.
Article
Pathology
Kyle M. Devins, Wesley Samore, G. Petur Nielsen, Vikram Deshpande, Esther Oliva
Summary: This study reports 3 cases of uterine inflammatory myofibroblastic tumors (IMTs) that appeared similar to leiomyoma in their recurrence. These tumors are rare and often have ALK gene rearrangements, but a low risk of metastasis. ALK immunohistochemistry was positive in all tumors, and all showed ALK rearrangements. Two typical IMTs recurred in the lung and abdomen, while the third patient experienced multiple recurrences. Performing ALK immunohistochemistry on recurrent uterine tumors can help identify patients who may benefit from tyrosine kinase inhibitors.
Article
Medicine, Research & Experimental
Erna-Zulaikha Dayang, Matthijs Luxen, Timara Kuiper, Rui Yan, Savithri Rangarajan, Matijs van Meurs, Jill Moser, Grietje Molema
Summary: Sepsis is a life-threatening condition with no pharmacological treatment available, where endothelial cells play a key role in inflammatory response. Kinases such as FAK1 and ALK are potential targets for inhibiting LPS-induced endothelial activation, with FAK1 inhibition showing promising results in attenuating inflammatory response. ALK inhibition, on the other hand, acts through a pathway independent of NF-kappa B signaling to attenuate LPS-induced inflammation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Mechanics
Hongyi Jiang
Summary: This study identifies and explains the formation mechanisms of secondary vortex street in the far wake of a circular cylinder for different Reynolds numbers. It demonstrates that both hydrodynamic instability of the mean flow and merging of layered vortices play a role in the formation, with their dominance depending on the Reynolds number. The variation in streamwise locations for the emergence of secondary vortices with Reynolds number is quantified and explained.
JOURNAL OF FLUID MECHANICS
(2021)
Article
Mechanics
Hongyi Jiang
Summary: The study investigates the three-dimensional wake transition for flow past a diamond cylinder at different Reynolds numbers, revealing variations in wake characteristics such as mode swapping between modes A and B, as well as the gradual disorganization of mode B. It is found that there are major differences in wake properties between a diamond and a circular cylinder, with the decomposition of flow properties aiding in the understanding of these differences. The complex interactions between streamwise and spanwise vortices, as well as the wake transition and base-flow transition, are identified as factors that excite mode B and suppress the subharmonic mode.
JOURNAL OF FLUID MECHANICS
(2021)
Article
Mechanics
Hongyi Jiang, Liang Cheng
Summary: In this study, mesh convergence for Re=3900 was demonstrated using the Nektar++ model, comparing the computational efficiencies of Nektar++ and OpenFOAM. The computations were then generalized to a range of Re=400-3900, exploring the physical mechanisms behind the variations in wake recirculation length and hydrodynamic forces.
Article
Thermodynamics
Xiaoying Ju, Hongyi Jiang
Summary: The transition from primary and two-layered vortex streets to secondary vortex streets of a rectangular cylinder is examined using direct numerical simulations, revealing two formation mechanisms and the influence of free-stream perturbation.
INTERNATIONAL JOURNAL OF HEAT AND FLUID FLOW
(2022)
Article
Engineering, Manufacturing
Wanbin Pan, Shufang Wang, Xinying Zhang, Wen Feng Lu, Yigang Wang, Hongyi Jiang
Summary: This paper proposes a smart and kinematics-aware part decomposition approach to improve the surface quality and kinematic performance of CAD parts in Additive Manufacturing. The approach defines new criteria and uses a heuristic method to determine the fabrication orientation for each assembly interface. Experimental results demonstrate the effectiveness of the proposed approach.
ADDITIVE MANUFACTURING
(2022)
Article
Mechanics
Hongyi Jiang, Xiaoyuan Hu, Liang Cheng, Tongming Zhou
Summary: This study examines the turbulent kinetic energy and energy dissipation rate in the wake of a circular cylinder at a Reynolds number of 1000. The results from direct numerical simulation reveal the dominance of the remainder component in the dissipations, highlighting the importance of considering the regions of vortices in the analysis of turbulent wakes. The study also evaluates the validity and performance of different surrogates to the true dissipation rate.
JOURNAL OF FLUID MECHANICS
(2022)
Article
Engineering, Marine
Xiaofan Lou, Chenlin Sun, Hongyi Jiang, Hongjun Zhu, Hongwei An, Tongming Zhou
Summary: The effects of yaw angle on wake characteristics of a stationary square cylinder were investigated using direct numerical simulations. The results showed that the drag and lift coefficients deviated from a certain principle as the yaw angle increased, indicating the impairment of the two-dimensionality of the wake flow.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2022)
Article
Immunology
Shida Lin, Jiajie Lua, Qiaoxue Chen, Hongyi Jiang, Chao Lou, Chihao Lin, Weidan Wang, Jian Lin, Xiaoyun Pan, Xinghe Xue
Summary: Plantamajoside has potential as an anti-OA therapeutic candidate by inhibiting inflammatory factors and slowing the progression of cartilage and joint degeneration.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Mechanics
Zhanbiao Zhang, Ahsan Kareem, Fuyou Xu, Hongyi Jiang
Summary: Large-eddy simulations investigate the unsteady flows around rectangular prisms with different chord-to-depth ratios at a Reynolds number of 1000. The study focuses on understanding the physical mechanisms governing the global instability of the flow. It is found that large-scale leading-edge vortices are formed by the coalescence of Kelvin-Helmholtz rollers. The interaction between the leading-edge vortex and the trailing-edge vortex at different chord-to-depth ratios is revealed, and the phase difference between them plays a critical role in increasing the Strouhal number. Pressure feedback-loop mechanisms are identified to maintain the self-sustained oscillations in different flow conditions.
JOURNAL OF FLUID MECHANICS
(2023)
Article
Biotechnology & Applied Microbiology
Yanping Feng, Mingzhen Wu, Haidong Zhang, He Xu, Huili Li, Dongmin Chen, Hongyi Jiang, Jiang Chang, Zhihong Dong, Chen Yang
Summary: In clinical practice, the use of antibiotics for wound contamination lacks the ability to accelerate wound healing and has brought about concerns regarding antimicrobial resistance. CuO/SiO2 nanowires, with good near-infrared photothermal conversion ability, are synthesized and shown to have excellent antibacterial properties against both E. coli and S. aureus. In addition, CuSi NWs at suitable concentrations can promote proliferation, migration, and angiogenic gene expression, demonstrating a remarkable ability for pro-vascularization.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Changkun Huang, Ran Xu, Xuan Zhu, Hongyi Jiang
Summary: The highly expressed circABCC4 in prostate cancer tissues and cells is associated with poor overall survival of patients. METTL3 overexpression increases circABCC4 expression through m6A modification. CircABCC4 interacts with IGF2BP2, enhancing CCAR1 mRNA stability and activation of the Wnt/β-catenin pathway, promoting PCa cell stemness and metastasis.
CANCER GENE THERAPY
(2023)
Article
Mechanics
Dan Pang, Liang Cheng, Hongyi Jiang, Feifei Tong, Hongwei An
Summary: This paper presents a new flow control approach to suppress vortex shedding in the wake of a circular cylinder through high-frequency oscillation. The numerical results show that the wake characteristics of the cylinder experience transitions from vortex shedding to suppression and finally to symmetry breaking with increasing Keulegan-Carpenter number. The cylinder oscillation delays the wake transition to three-dimensional flow.
Correction
Mechanics
Dan Pang, Liang Cheng, Hongyi Jiang, Feifei Tong, Hongwei An
Proceedings Paper
Computer Science, Interdisciplinary Applications
Hongyi Jiang, Samitha Samaranayake
Summary: This paper studies the capacitated assignment problem under a budget constraint, proposes a randomized rounding algorithm, and presents a hardness result. It also shows how to apply this framework to solve assignment problems related to transportation systems, conducts numerical experiments based on real-world data, and makes improvements on previous work.
COMPUTING AND COMBINATORICS, COCOON 2022
(2022)
Article
Oncology
Huanghao Deng, Bin Zhu, Zhitao Dong, Hongyi Jiang, Xiaokun Zhao, Shuiqing Wu
Summary: The study revealed the crucial regulatory role of the DANCR-miR-214-5p-TGF-beta axis in the progression of prostate carcinoma, offering novel strategies for patient screening and treatment.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
