Article
Multidisciplinary Sciences
Wen-yu Yin, Jiao Yuan, Zhi-min Zhang, Cheng Mei, Wei Xu, Yong-xiang Tang, Fang Peng, Ning Li
Summary: Stressed red blood cells showed differences in various indicators compared to untreated red blood cells, being more prone to phagocytosis by macrophages and mainly trapped in the spleen as shown by F-18-FDG PET/CT imaging, while the untreated red blood cells continued to circulate in the system.
SCIENTIFIC REPORTS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Moath Said Alfawara, Ahmed Ibrahim Ahmed, Jean Michel Saad, Yushui Han, Fares Alahdab, Mahmoud Al Rifai, Mahwash Kassi, Talal Alnabelsi, William A. Zoghbi, Mouaz H. Al-Mallah
Summary: This study evaluated the use of serum beta-hydroxybutyrate (BHB) to identify adequate suppression of the left ventricle (LV) in patients undergoing cardiac inflammatory/infectious studies. The results showed that serum BHB level can be used to determine sufficient LV suppression.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Medicine, General & Internal
Cecile Tissot, Joseph Therriault, Peter Kunach, Andrea L. Benedet, Tharick A. Pascoal, Nicholas J. Ashton, Thomas K. Karikari, Stijn Servaes, Firoza Z. Lussier, Mira Chamoun, Dana L. Tudorascu, Jenna Stevenson, Nesrine Rahmouni, Nina Margherita Poltronetti, Vanessa Pallen, Gleb Bezgin, Min Su Kang, Sulantha S. Mathotaarachchi, Yi-Ting Wang, Jaime Fernandez Arias, Pamela Cristina Lukasewicz Ferreira, Joao Pedro Ferrari-Souza, Eugeen Vanmechelen, Kaj Blennow, Henrik Zetterberg, Serge Gauthier, Pedro Rosa-Neto
Summary: This study investigated the agreement between [F-18]MK6240 tau-PET, plasma pTau181, and pTau231 in Alzheimer's disease. The findings suggest that these biomarkers reflect different stages of tau progression and can be useful in diagnosing and evaluating the disease stage.
Article
Rheumatology
Kaitlin A. Quinn, Hugh Alessi, Cristina Ponte, Emily Rose, Mark A. Ahlman, Christopher Redmond, Yiming Luo, Ertugrul Cagri Bolek, Carol A. Langford, Peter A. Merkel, Peter C. Grayson
Summary: This study assessed the importance of incorporating FDG-PET data into eligibility criteria for clinical trials in TAK. The results showed that FDG-PET data can influence physicians' decisions about enrollment in trials and improve the accuracy and consistency of clinical assessment. Therefore, future trials in TAK should consider including FDG-PET data in eligibility criteria.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yun Hye Song, Jung Won Moon, Yoo Na Kim, Ji Young Woo, Hye Joo Son, Suk Hyun Lee
Summary: This study aimed to investigate the reduction of [F-18]FDG uptake in dependent lungs by performing [F-18]FDG PET/CT in the prone position. The results showed that dependent lungs had significantly higher SUVmean and HU compared to nondependent lungs on both supine and prone position PET/CT. The study concluded that prone position PET/CT can effectively reduce gravity-dependent opacity-related [F-18]FDG uptake.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Virginia Liberini, Michael Messerli, Lars Husmann, Ken Kudura, Hannes Grunig, Alexander Maurer, Stephan Skawran, Erika Orita, Daniele A. Pizzuto, Desiree Deandreis, Reinhard Dummer, Joanna Mangana, Daniela Mihic-Probst, Niels Rupp, Martin W. Huellner
Summary: BSREM detects significantly more ITM than OSEM, with higher SUVmax, higher TBR, and less blurring. BSREM is particularly helpful in small and less avid lesions, which are more often missed with OSEM.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kailin Qiao, Xueting Qin, Shuai Fu, Jiazhong Ren, Jing Jia, Xinying Hu, Yuanyuan Tao, Shuanghu Yuan, Yuchun Wei
Summary: The uptake of [F-18]AlF-NOTA-FAPI-04 and [F-18]FDG imaging tracers varies in malignant and inflammatory lung lesions, with lower uptake observed in inflammatory lesions. This difference in uptake can be valuable for distinguishing between malignancy and various inflammatory findings.
EUROPEAN RADIOLOGY
(2023)
Article
Clinical Neurology
Kai Wang, Xiaobin Zhao, Leilei Yuan, Qian Chen, Qun Wang, Lin Ai
Summary: An asymmetric F-18-FDG metabolic pattern exists in patients with anti-LGI1 encephalitis, and varied regional metabolic differences were revealed bilaterally in specific cerebral areas.
FRONTIERS IN NEUROLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Benjamin Koa, Austin J. Borja, Mahmoud Aly, Sayuri Padmanabhan, Joseph Tran, Vincent Zhang, Chaitanya Rojulpote, Sheila K. Pierson, Mark-Avery Tamakloe, Johnson S. Khor, Thomas J. Werner, David C. Fajgenbaum, Abass Alavi, Mona-Elisabeth Revheim
Summary: Castleman disease is a rare hematologic condition involving lymphadenopathy and clinical abnormalities, classified into UCD and MCD; MCD is further divided based on etiological driver; FDG-PET/CT plays an important role in differential diagnosis and monitoring treatment responses.
INSIGHTS INTO IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Joao Borges-Rosa, Manuel Oliveira-Santos, Rodolfo Silva, Andreia Gomes, Jose de Almeida, Gracinda Costa, Lino Goncalves, Maria Joao Ferreira
Summary: In patients with biopsy-proven sarcoidosis, cardiac involvement detected by [18F]FDG-PET or CMR is associated with a higher risk of cardiovascular events, regardless of symptoms. Patients with probable CS had a higher prevalence of heart failure, atrial fibrillation, coronary disease, and valvular disease compared to those without cardiac involvement. Probable CS patients had significantly higher rates of heart failure hospitalizations, uncontrolled arrhythmias, and pacemaker implantation during follow-up, with a trend towards increased all-cause mortality.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Clinical Neurology
Jeong-Min Kim, Eun Seong Lee, Kwang-Yeol Park, Ju Won Seok
Summary: Stroke patients with carotid atherosclerosis had decreased FDG uptake in the lumbar vertebrae compared to control subjects. Further studies are needed to evaluate the pathophysiological link between cerebral atherosclerosis and FDG uptake in the spine and organs.
JOURNAL OF CLINICAL NEUROLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
K. S. M. van der Geest, G. Treglia, A. W. J. M. Glaudemans, E. Brouwer, F. Jamar, R. H. J. A. Slart, O. Gheysens
Summary: [18F]FDG-PET/CT scanning can effectively diagnose polymyalgia rheumatica by identifying significant uptake of FDG at specific anatomic sites. The technique shows promise as an important diagnostic tool for patients with suspected PMR, but standardized interpretation criteria and procedural recommendations are necessary for its use.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Oncology
Chao Lu, Kailiang Wang, Fei Meng, Yihe Wang, Yongzhi Shan, Penghu Wei, Guoguang Zhao
Summary: Patients with epileptogenic hypothalamic hamartoma exhibit reduced glucose metabolism and gray matter volume predominantly in the ipsilateral neocortex, as well as overall metabolic reduction in the cerebellum. Hypometabolism in the neocortex is more distributed ipsilaterally than contralaterally to the hamartoma. The characteristics of glucose hypometabolism differ based on seizure type and sex, suggesting potential involvement of specific brain pathways in seizure propagation in these patients.
FRONTIERS OF MEDICINE
(2021)
Review
Oncology
Sungmin Woo, Anton S. Becker, Richard K. G. Do, Heiko Schoder, Hedvig Hricak, H. Alberto Vargas
Summary: FDG-PET or PET/CT had a meaningful impact on the management of patients with CUP, with approximately a third of patients having their management changed as a result, mainly due to detection of the primary site. This finding was consistent across numerous subgroups.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dan Shao, Qiang Gao, You Cheng, Dong-Yang Du, Si-Yun Wang, Shu-Xia Wang
Summary: The study demonstrates that F-18-FDG PET/CT can predict the survival of patients with primary tracheal malignant tumors. Patients with higher metabolic tumor volume (MTV) and total lesion glycolysis (TLG) on PET/CT scans, squamous cell carcinoma, and non-E1 surgeries are more likely to have reduced overall survival.
KOREAN JOURNAL OF RADIOLOGY
(2021)
Article
Psychology, Clinical
Franziska Maier, Andrea Greuel, Marius Hoock, Rajbir Kaur, Masoud Tahmasian, Frank Schwartz, Ilona Csoti, Frank Jessen, Alexander Drzezga, Thilo van Eimeren, Lars Timmermann, Carsten Eggers
Summary: This study investigated impaired self-awareness of cognitive deficits in Parkinson's disease (PD) and its associations with clinical-behavioral and neuroimaging markers. The results showed that PD patients with mild cognitive impairment (PD-MCI) had significantly higher impaired self-awareness than healthy controls and PD patients without MCI. Neuroimaging analysis revealed that glucose metabolism in the cingulate cortex was negatively correlated with impaired self-awareness. In PD-MCI patients, impaired self-awareness was associated with decreased metabolism in the right temporal lobe, insula, and midcingulate cortex. These findings suggest that impaired self-awareness of cognitive deficits in PD may be related to disruptions in the cognitive network and metabolic changes in specific brain regions.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
Zachary Winder, Tiffany L. Sudduth, Sonya Anderson, Ela Patel, Janna Neltner, Barbara J. Martin, Katherine E. Snyder, Erin L. Abner, Gregory A. Jicha, Peter T. Nelson, Donna M. Wilcock
Summary: The study evaluated the relationship between plasma biomarkers and neuropathology associated with Alzheimer's disease (AD) and vascular contributions to cognitive impairment and dementia (VCID). The results showed certain plasma biomarkers were associated with AD and VCID pathology, providing support for further research in using plasma biomarkers as a clinical screening tool.
ALZHEIMERS & DEMENTIA
(2023)
Article
Biochemistry & Molecular Biology
Carolin Kurz, Laura Stoeckl, Isabelle Schrurs, Ivonne Suridjan, Selim Uestuen Guersel, Tobias Bittner, Alexander Jethwa, Robert Perneczky
Summary: An investigation was conducted on the impact of different pre-analytical sample handling procedures on plasma biomarkers for Alzheimer's disease (AD). The effects of storage time, freeze/thaw cycles, anticoagulants, tube transfer, and tube types were evaluated. The results provide recommendations for an optimal sample handling protocol to improve the reproducibility of future studies on plasma biomarkers assays for AD.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Constantinos Constantinides, Laura K. M. Han, Clara Alloza, Linda Antonella Antonucci, Celso Arango, Rosa Ayesa-Arriola, Nerisa Banaj, Alessandro Bertolino, Stefan Borgwardt, Jason Bruggemann, Juan Bustillo, Oleg Bykhovski, Vince Calhoun, Vaughan Carr, Stanley Catts, Young-Chul Chung, Benedicto Crespo-Facorro, Covadonga M. Diaz-Caneja, Gary Donohoe, Stefan Du Plessis, Jesse Edmond, Stefan Ehrlich, Robin Emsley, Lisa T. Eyler, Paola Fuentes-Claramonte, Foivos Georgiadis, Melissa Green, Amalia Guerrero-Pedraza, Minji Ha, Tim Hahn, Frans A. Henskens, Laurena Holleran, Stephanie Homan, Philipp Homan, Neda Jahanshad, Joost Janssen, Ellen Ji, Stefan Kaiser, Vasily Kaleda, Minah Kim, Woo-Sung Kim, Matthias Kirschner, Peter Kochunov, Yoo Bin Kwak, Jun Soo Kwon, Irina Lebedeva, Jingyu Liu, Patricia Mitchie, Stijn Michielse, David Mothersill, Bryan Mowry, Victor Ortiz-Garcia de la Foz, Christos Pantelis, Giulio Pergola, Fabrizio Piras, Edith Pomarol-Clotet, Adrian Preda, Yann Quide, Paul E. Rasser, Kelly Rootes-Murdy, Raymond Salvador, Marina Sangiuliano, Salvador Sarro, Ulrich Schall, Andre Schmidt, Rodney J. Scott, Pierluigi Selvaggi, Kang Sim, Antonin Skoch, Gianfranco Spalletta, Filip Spaniel, Sophia Thomopoulos, David Tomecek, Alexander S. Tomyshev, Diana Tordesillas-Gutierrez, Therese van Amelsvoort, Javier Vazquez-Bourgon, Daniela Vecchio, Aristotle Voineskos, Cynthia S. Weickert, Thomas Weickert, Paul M. Thompson, Lianne Schmaal, Theo G. M. van Erp, Jessica Turner, James H. Cole, Danai Dima, Esther Walton
Summary: Schizophrenia patients show evidence of advanced brain ageing, which is not associated with clinical characteristics.
MOLECULAR PSYCHIATRY
(2023)
Article
Biology
Nirmal Verma, Gopal Viswanathan Velmurugan, Edric Winford, Han Coburn, Deepak Kotiya, Noah Leibold, Laura Radulescu, Sanda Despa, Kuey C. Chen, Linda J. Van Eldik, Peter T. Nelson, Donna M. Wilcock, Gregory A. Jicha, Ann M. Stowe, Larry B. Goldstein, David K. Powel, Jeffrey H. Walton, Manuel F. Navedo, Matthew A. Nystoriak, Andrew J. Murray, Geert Jan Biessels, Claire Troakes, Henrik Zetterberg, John Hardy, Tammaryn Lashley, Florin Despa
Summary: Impairment of vascular pathways contributes to Alzheimer's disease. Blood amylin secreted from the pancreas perturbs cerebral A beta clearance, leading to amylin and A beta co-deposits in the brain microvasculature. Altering bloodborne amylin could potentially reduce cerebrovascular amylin deposits and A beta pathology.
COMMUNICATIONS BIOLOGY
(2023)
Article
Neurosciences
Marlena Duda, Armin Iraji, Judith M. Ford, Kelvin O. Lim, Daniel H. Mathalon, Bryon A. Mueller, Steven G. Potkin, Adrian Preda, Theo G. M. Van Erp, Vince D. Calhoun
Summary: By using spatially constrained independent component analysis (scICA), this study found that rsfMRI scans of just 2-5 minutes can provide good clinical utility without significant loss of individual functional network connectivity (FNC) information from longer scan lengths.
HUMAN BRAIN MAPPING
(2023)
Article
Pharmacology & Pharmacy
Bryan Shapiro, Eric Kramer, Dina Khoury, Adrian Preda
Summary: This study investigated the prevalence and severity of common withdrawal symptoms after chronic antidepressant treatment. The symptoms of dizziness, brain zaps, irritability/agitation, and anxiety/nervousness showed the largest increase in severity during withdrawal. Almost all participants reported worsening of at least one of these four symptoms. Incorporating these four core symptoms into a screening test may be useful in ruling out antidepressant withdrawal.
PHARMACOPSYCHIATRY
(2023)
Article
Clinical Neurology
Eun-jin Cheon, Alie G. Male, Bingchen Gao, Bhim M. Adhikari, Jesse T. Edmond, Stephanie M. Hare, Aysenil Belger, Steven G. Potkin, Juan R. Bustillo, Daniel H. Mathalon, Judith M. Ford, Kelvin O. Lim, Bryon A. Mueller, Adrian Preda, Daniel O'Leary, Gregory P. Strauss, Anthony O. Ahmed, Paul M. Thompson, Neda Jahanshad, Peter Kochunov, Vince D. Calhoun, Jessica A. Turner, Theo G. M. van Erpa
Summary: This study examined the association between resting-state amplitude of low frequency fluctuations (ALFF) and negative symptoms in schizophrenia. It found positive associations between total negative symptom scores and ALFF in temporal and frontal brain regions. Additionally, it found that negative symptom domain scores had stronger associations with regional ALFF compared to total scores, suggesting that domain scores may be better indicators of neural signatures.
PSYCHIATRY RESEARCH-NEUROIMAGING
(2023)
Article
Neurosciences
Deniz Alacam, Robyn Miller, Oktay Agcaoglu, Adrian Preda, Judith Ford, Vince Calhoun
Summary: In this study, a framework was proposed to analyze time-resolved spectral coupling among different brain circuits using independent component analysis. The results showed significant differences in visual network connectivity and spectral power profiles between people with schizophrenia and healthy controls. This approach can be useful in understanding the underlying causes of impaired visual processing in schizophrenia.
FRONTIERS IN NEUROSCIENCE
(2023)
Editorial Material
Pharmacology & Pharmacy
Adrian Preda
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Neurosciences
Justin R. Deters, Alexandra C. Fietsam, Phillip E. Gander, Laura L. Boles L. Ponto, Thorsten Rudroff
Summary: Combining MRI and PET imaging with FDG can provide a comprehensive overview of the effects of PCS on brain volumes and metabolism. This study found differences in MRI/PET outcomes between individuals <6 months and >6 months post-COVID-19, as well as associations between these outcomes and fatigue symptoms.
Review
Clinical Neurology
Atri Chatterjee, Veronica Hirsch-Reinshagen, Imogene Scott, Neil Cashman, Ging-Yuek Robin Hsiung
Summary: This study conducted a systematic review and found that the frequency of psychosis in FTD patients was 24.2%. Among the genetic mutation carriers, C9orf72 mutation carriers had the highest frequency of psychosis (31.4%), while GRN and MAPT mutation carriers had lower frequencies of psychosis. Among the pathological subtypes, patients with FUS pathology, TDP-43 pathology, and tau pathology had a prevalence of psychosis at 30%, 25.3%, and 16.4% respectively.
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2023)
Review
Clinical Neurology
Robert Perneczky, Geert Dom, Andrew Chan, Peter Falkai, Claudio Bassetti
Summary: This article summarizes the latest evidence on novel antibody therapies for Alzheimer's disease targeting amyloid-β, indicating significant breakthroughs in slowing disease progression, improving clinical outcomes, and reducing amyloid-β levels.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
A. Iraji, Z. Fu, A. Faghiri, M. Duda, J. Chen, S. Rachakonda, T. DeRamus, P. Kochunov, B. M. Adhikari, A. Belger, J. M. Ford, D. H. Mathalon, G. D. Pearlson, S. G. Potkin, A. Preda, J. A. Turner, T. G. M. van Erp, J. R. Bustillo, K. Yang, K. Ishizuka, A. Faria, A. Sawa, K. Hutchison, E. A. Osuch, J. Theberge, C. Abbott, B. A. Mueller, D. Zhi, C. Zhuo, S. Liu, Y. Xu, M. Salman, J. Liu, Y. Du, J. Sui, T. Adali, V. D. Calhoun
Summary: This study identifies replicable multi-spatial-scale canonical intrinsic connectivity network (ICN) templates using rsfMRI data from over 100k individuals through multi-model-order independent component analysis (ICA). The feasibility of estimating subject-specific ICNs via spatially constrained ICA is also studied. The results show that subject-level ICN estimations vary as a function of the ICN itself, the data length, and the spatial resolution. Longer scans may not always be desirable and spatial smoothness should be considered in optimizing data length.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
Soichiro Nakahara, Alie G. Male, Jessica A. Turner, Vince D. Calhoun, Kelvin O. Lim, Bryon A. Mueller, Juan R. Bustillo, Daniel S. O'Leary, James Voyvodic, Aysenil Belger, Adrian Preda, Daniel H. Mathalon, Judith M. Ford, Guia Guffanti, Fabio Macciardi, Steven G. Potkin, Theo G. M. Van Erp
Summary: Individuals with schizophrenia show abnormal brain activation during auditory oddball tasks, which is associated with cognitive performance and genetic contributions. This study compares individuals with schizophrenia to healthy volunteers and identifies novel relationships between regional brain activity, cognitive performance, and genetic loci. The findings highlight the importance of continued data sharing and collaborative efforts in schizophrenia research.
PSYCHIATRY RESEARCH-NEUROIMAGING
(2023)