Article
Biotechnology & Applied Microbiology
Mustafa Ozkan, Nurullah Gunay, Elif Funda Sener, Ozgur Karcioglu, Reyhan Tahtasakal, Fatma Dal, Nahide Ekici Gunay, Abdullah Tuncay Demiryurek
Summary: The study revealed significant associations between TNF gene (-308G/A, rs1800629) and NOS3 gene -786T/C (rs2070744) polymorphisms with susceptibility to sepsis in the Turkish population. No significant associations were found with other polymorphisms studied in this research.
JOURNAL OF GENE MEDICINE
(2021)
Article
Multidisciplinary Sciences
Camylla Vilas Boas Figueiredo, Rayra Pereira Santiago, Caroline Conceicao Guarda, Rodrigo Mota Oliveira, Luciana Magalhaes Fiuza, Setondji Cocou Modeste Alexandre Yahouedehou, Suellen Pinheiro Carvalho, Joelma Santana dos Santos Neres, Antonio Mateus de Jesus Oliveira, Cleverson Alves Fonseca, Valma Maria Lopes Nascimento, Isa Menezes Lyra, Milena Magalhaes Aleluia, Marilda Souza Goncalves
Summary: Priapism, a urologic emergency often associated with sickle cell disease, was found to be linked with alterations in laboratory biomarkers and lower levels of HbF. Patients with sickle cell anemia using hydroxyurea and those who received blood products seemed to have a lower risk of priapism. Multivariate analysis showed that low HbF and NOm were independently associated with priapism.
Article
Allergy
Younes Aftabi, Amir Amiri-Sadeghan, Neda Gilani, Tahereh Zahedi, Mohamad Taghi Khodayari, Elnaz Faramarzi, Ensiyeh Seyedrezazadeh, Khalil Ansarin
Summary: The NOS3-c.894G/T gene is associated with asthma risk and severity, with a stronger effect in males.
Review
Biochemistry & Molecular Biology
Rajaa Ejghal, Hicham Charoute, Hasnaa Talimi, Sara Rhazlane, Meryem Lemrani
Summary: The clinical spectrum of leishmaniasis depends on various factors, including Leishmania species and immunogenetic factors. A meta-analysis showed no significant association between allele G and allele A of TNF alpha-308G > A polymorphism and leishmaniasis, suggesting that TNF alpha may not be the sole determinant factor for Leishmania infection outcome.
Article
Biochemistry & Molecular Biology
Karolina A. P. Wijnands, Dennis M. Meesters, Benjamin Vandendriessche, Jacob J. Briede, Hans M. H. van Eijk, Peter Brouckaert, Anje Cauwels, Wouter H. Lamers, Martijn Poeze
Summary: Competition between NOS3 and NOS2 for arginine during endotoxemia appears crucial in the derangement of microcirculatory flow. This study found that L-citrulline supplementation enhances de novo arginine synthesis and NO production in mice during endotoxemia, especially in mice with functional NOS3-enzyme.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Polina V. Moskaleva, Natalya A. Shnayder, Marina M. Petrova, Daria S. Kaskaeva, Oksana A. Gavrilyuk, Sergey V. Radostev, Natalia P. Garganeeva, Victoria B. Sharavii, Elena E. Vaiman, Regina F. Nasyrova
Summary: Migraine and arterial hypertension are common diseases with comorbidity. Research on single nucleotide variants of NOS genes related to their development shows contradictory results, possibly due to study designs, sample sizes, and environmental factors. Further studies are needed to explore genetic markers and predictors for better diagnostics and treatment.
Article
Infectious Diseases
Angelica Menezes Santiago, Ednelza da Silva Graca Amoras, Maria Alice Freitas Queiroz, Simone Regina Souza da Silva Conde, Izaura Maria Vieira Cayres-Vallinoto, Ricardo Ishak, Antonio Carlos Rosario Vallinoto
Summary: The study found that the TNFA -308G>A genotype is protective against chronic HCV infection, while the IL10 -1082A>G genotype is associated with higher HCV viral load. Further studies are needed to confirm these associations.
BMC INFECTIOUS DISEASES
(2021)
Review
Obstetrics & Gynecology
Hossein Golestanpour, Reza Bahrami, Seyed Alireza Dastgheib, Razieh Sadat Tabatabaei, Atiyeh Javaheri, Mojgan Karimi-Zarchi, Seyed Reza Mirjalili, Hossein Neamatzadeh
Summary: The study evaluated the association of eNOS VNTR 4b/a and + 894G > T polymorphisms with the risk of recurrent pregnancy loss and found that these two polymorphisms are significantly associated with an increased risk of RPL, while the -786C > T polymorphism is not significantly associated.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Article
Biochemistry & Molecular Biology
Elisa Rubino, Andrea Marcinno, Alberto Grassini, Elisa Maria Piella, Fabio Ferrandes, Fausto Roveta, Silvia Boschi, Aurora Cermelli, Salvatore Gallone, Lidia Savi, Innocenzo Rainero
Summary: Migraine is a common disorder with unsatisfactory response to acute pain-relieving therapies. Functional polymorphism in the TNF-alpha gene is associated with the efficacy of NSAID administration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Dong Wang, Liqun He, Xiaotian Zhang
Summary: The meta-analysis found a significant association between -308G/A polymorphism of TNF-alpha gene and metabolic syndrome. The A allele was associated with an increased risk of MS in the Asia group, but a decreased risk in the Europe group. Different ethnic groups may play different roles in the association between TNF-alpha gene polymorphism and MS.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Jennifer C. Hill, Marie Billaud, Tara D. Richards, Mary P. Kotlarczyk, Sruti Shiva, Julie A. Phillippi, Thomas G. Gleason
Summary: This study found differential expression of Nos3 related to valve morphology and aneurysm, providing new insights into the pathophysiology of aneurysms and supporting the idea that mechanisms of ascending aortopathy in BAV and TAV patients are distinct.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Clinical Neurology
Amrit Sudershan, Srishty Sudershan, Mohd Younis, Meenakshi Bhagat, Agar Chander Pushap, Hardeep Kumar, Parvinder Kumar
Summary: This meta-analysis found that the TNF-alpha 308G > A mutation is associated with an increased risk of migraine only in the Asian population.
Article
Genetics & Heredity
Maria Trapali, Dimitra Houhoula, Anthimia Batrinou, Anastasia Kanellou, Irini F. Strati, Argyris Siatelis, Panagiotis Halvatsiotis
Summary: The present study found that the TNF-alpha- 308G/A and leptin receptor (LEPR) Gln223Arg polymorphisms are associated with the risk of developing type 2 diabetes mellitus (T2DM).
Article
Rheumatology
Mariana Ivanova, Irena Manolova, Rumen Stoilov, Spaska Stanilova
Summary: The A-allele at TNFA-308 site plays a crucial role in reducing susceptibility to AS, with a significant synergistic protective effect when combined with IL-10-1082AA genotypes. Moreover, the presence of this variant allele is associated with a more benign clinical phenotype of the disease.
RHEUMATOLOGY INTERNATIONAL
(2021)
Review
Oncology
Christina M. Alymatiri, Georgia T. Gkegka, Maria Gavriatopoulou, Evangelos Terpos, Meletios A. Dimopoulos, Theodoros N. Sergentanis, Theodora Psaltopoulou
Summary: This study investigated the association between two TNF-alpha gene polymorphisms and the risk and survival of multiple myeloma (MM). The results showed no association between the two polymorphisms and MM susceptibility or survival.
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2022)
Article
Clinical Neurology
Yinglu Liu, Zhao Dong, Rongfei Wang, Ran Ao, Xun Han, Wenjing Tang, Shengyuan Yu
Article
Neurosciences
Xun Han, Ye Ran, Min Su, Yinglu Liu, Wenjing Tang, Zhao Dong, Shengyuan Yu
Article
Neurosciences
Zhihua Jia, Wenjing Tang, Dengfa Zhao, Guanqun Hu, Ruisheng Li, Shengyuan Yu
Article
Multidisciplinary Sciences
Zhihua Jia, Wenjing Tang, Dengfa Zhao, Shengyuan Yu
SCIENTIFIC REPORTS
(2017)
Article
Neurosciences
Zhihua Jia, Xiaoyan Chen, Wenjing Tang, Dengfa Zhao, Shengyuan Yu
Article
Clinical Neurology
Wenjing Tang, Meichen Zhang, Enchao Qiu, Shanshan Kong, Yingji Li, Huanxian Liu, Zhao Dong, Shengyuan Yu
Article
Integrative & Complementary Medicine
Shengyuan Yu, Ye Ran, Wei Xiao, Wenjing Tang, Jianjun Zhao, Wei Chen, Huikui Zhuang, Cun Ouyang, Hai Lin, Dequan Liu, Tongjun Chen, Hui Huang, Baoshen Wang, Yanlei Hao, Zhongrui Yan, Shike Zhao, Yanling Wang, Jinjun Ni, Chaodong Wang, Wentao Ding, Guoqian Li, Jianhua Cao, Shujuan Tian
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2019)
Article
Clinical Neurology
Yingji Li, Wenjing Tang, Li Kang, Shanshan Kong, Zhao Dong, Dengfa Zhao, Ruozhuo Liu, Shengyuan Yu
Summary: Mutations in ATP1A2 gene can lead to phenotypes ranging from pure FHM to FHM with epilepsy and intellectual disability due to varying degrees of deficits in the biochemical and electrophysiological properties of Na+/K+-ATPase. Mutations associated with intellectual disability result in severe impairment of Na+/K+-ATPase, while the presence of epilepsy or the type of epilepsy does not seem to affect the degree of pump function impairment.
JOURNAL OF HEADACHE AND PAIN
(2021)
Article
Clinical Neurology
Li Kang, Wenjing Tang, Yaofen Zhang, Mingjie Zhang, Jing Liu, Yingji Li, Shanshan Kong, Dengfa Zhao, Shengyuan Yu
Summary: The study reveals the involvement of gut microbiome in normal mechanical pain sensation and pathogenesis of migraine, with mice transplanted with gut microbiota from a migraine patient showing exacerbated hyperalgesia.
Article
Clinical Neurology
Leyi Zhang, Chenglong Lu, Li Kang, Yingji Li, Wenjing Tang, Dengfa Zhao, Shengyuan Yu, Ruozhuo Liu
Summary: This study found that recurrent infusion of inflammatory soup in mice resulted in mechanical allodynia in both the periorbital and hind paw regions, with increased and sustained levels of GFAP protein and mRNA in the TNC. Furthermore, the levels of cytokines CCL7, CCL12, and IL-10 may be modulated by astrocytic activation, contributing to the pathology of chronic migraine.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Chemistry, Multidisciplinary
Shiyao Song, Wenjing Tang, Shengyuan Yu, Huwei Liu, Yu Bai
Summary: In this study, the levels of bile acid metabolites were compared in the serum of migraine patients and healthy controls, and it was found that there were differences between male patients and male controls, suggesting a gender-related variation in bile acids. This highlights the importance of gender-stratified analysis in studying diseases with varying morbidity in males and females. Five differential metabolites may serve as potential serum biomarkers for male migraine patients.
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
(2022)
Article
Cell & Tissue Engineering
Tao Wang, Wenjing Tang, Quan Zeng, Shuai Miao, Chenghui Pi, Yingji Li, Wen Yue, Shengyuan Yu
Summary: In this study, peripheral blood mononuclear cells from a healthy 25-year-old Han Chinese man were reprogrammed into induced pluripotent stem cells (iPSCs) using transcription factors. The pluripotency of these iPSC lines was confirmed and they were able to differentiate into all three germ layers, making them suitable for use as control cells in drug development and pathological mechanism studies.
STEM CELL RESEARCH
(2022)
Article
Neurosciences
Zhe Yu, Bozhi Li, Wenjing Tang, Zhao Dong, Ruozhuo Liu, Shengyuan Yu
Summary: Sleep deprivation can significantly prolong the duration of hyperalgesia induced by nitroglycerin and increase the expression of Fos in the brain. This study highlights the importance of sleep disorders for migraine.
Article
Clinical Neurology
Wei Xie, Ruibing Li, Wenjing Tang, Zhenjie Ma, Shuai Miao, Chenhao Li, Chunxiao Yang, Bozhi Li, Tao Wang, Zihua Gong, Yue Zhou, Shengyuan Yu
Summary: This study investigated the role of mitochondria in migraine using a mouse model of chronic migraine. The proteomics profiling revealed mitochondrial dysfunction in key brain regions associated with migraine pathogenesis. Furthermore, the intervention of Urolithin A partially alleviated mitochondrial damage and migraine symptoms.
JOURNAL OF HEADACHE AND PAIN
(2023)
Article
Medicine, General & Internal
Chunlin Li, Shengyuan Yu, Huiying Li, Jin Zhou, Jieqiong Liu, Wenjing Tang, Lei Zhang
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2017)