Article
Multidisciplinary Sciences
Dan Ye, Hong Lu, Yi He, Zhaojing Zheng, Jinghao Wu, Hao Wei
Summary: This study presents an acyl transfer-annulation reaction to convert heteroaryl ketones to N-fused heterocycles. By driven via aromatisation, the acyl group of a heteroaryl ketone can be transferred from the carbon atom to the nitrogen atom of the corresponding heterocycle. The reaction conditions are optimized and demonstrate a wide range of substrates, showing potential application in the synthesis of complex natural products and drug derivatives.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Juanjuan Wang, Hong Lu, Yi He, Chunxiu Jing, Hao Wei
Summary: This study describes a simple protocol for late-stage diversification of bioactive molecules. The use of an inexpensive cobalt catalyst under aqueous and open-air conditions makes this method very practical. Examples demonstrate the broad applicability of this method in the modification of pharmaceutical compounds and complex fused ring compounds.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Engineering, Environmental
Chongchong Wang, Yuanyuan Xia, Gang Wu, Lin Zhou, Shaohua Wei
Summary: This study presents a reliable, general, and facile method for the synthesis of various 2D TMOs through a cascade reaction strategy involving the cleavage of oxide bonds in the presence of H2O2. The fabricated 2D CuO2, CuO, and Mn3O4 show potential applications in cancer treatment, with enhanced biodegradability, reactivity, and drug loading efficiency compared to CuO2 nanoparticles.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Inorganic & Nuclear
Milan Kumar Bisai, V. S. V. S. N. Swamy, K. Vipin Raj, Kumar Vanka, Sakya S. Sen
Summary: The reactivity of a newly reported silylene compound was investigated, resulting in a series of reactions with borane compounds and other molecules, demonstrating the ability of silylene to activate multiple small molecules and form novel coupling products.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Xiaoming Jie, Chaohuang Chen, Constantin G. Daniliuc, Gerald Kehr, Gerhard Erker
Summary: The hydroboration of styrene or vinylcyclohexane with the IMes(C6F5)BH+ cation followed by deprotonation provides a convenient synthetic route to boraalkenes [B]=CHCH2R. The in-situ generated IMes(SCN)BH+ system reacts similarly with 1,1-diphenylethene, resulting in the formation of isothiocyanato-substituted boraalkene. The boraalkenes participate in [2+2] cycloaddition reactions with heterocumulenes, yielding respective four-membered heterocycles. The addition of borane HB(C6F5)(2) to [B]=CHCH2R+CO2 cycloadducts leads to cleavage of the central B-C sigma-bond.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Organic
Zhen-Yu Wang, Biao Ma, Hui Xu, Xing Wang, Xu Zhang, Hui-Xiong Dai
Summary: In this study, a novel method for the arylation, alkylation, and alkenylation of aryl ketones via a palladium-catalyzed Suzuki-Miyaura cross-coupling reaction was reported, with the key of using a pyridine-oxazoline ligand. The late-stage arylation of aryl ketones derived from drugs and natural products demonstrated the synthetic utility of this protocol.
Article
Chemistry, Multidisciplinary
Zeming Xia, Sai Ho Pun, Han Chen, Qian Miao
Summary: New strategies for designing and synthesizing unprecedented zigzag carbon nanobelts have been reported, demonstrating their structure and binding properties with C60 in solution. The formation of multiple carbon-carbon bonds through Scholl reactions, as well as the increase in strain during the ladderization process of these nanobelts through Scholl reactions, were successfully validated in this study.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Organic
Akira Shiozuka, Kohei Sekine, Yoichiro Kuninobu
Summary: Direct unreactive C-N borylation of aromatic amines was achieved using a photocatalyst, with improved yield of borylated products under a CO2 atmosphere, suggesting a possible mechanism involving C-N bond cleavage and C-B bond formation via a concerted pathway.
Article
Chemistry, Multidisciplinary
Zhigao Shen, Isaac Maksso, Rositha Kuniyil, Torben Rogge, Lutz Ackermann
Summary: This study demonstrates the selective control of C-H activations using alkylidenecyclopropanes (ACPs) for assembling cyclopropanes or dienes. Unprecedented rhodaelectro-catalyzed C-H activations were achieved with a wide range of substrates and electricity as the sole oxidant.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Tim Goelich, Daniel S. Frost, Nico Boback, Nathan T. Coles, Birger Dittrich, Peter Mueler, William D. Jones, Christian Mueler
Summary: The photochemical activation selectively leads to the formation of coordination compounds of the type LnPt(aryl)(C P) in Pt(0)-eta(2)-aryl-phosphaalkyne complexes, and the subsequent oxidative addition reaction is a novel and clean route for the synthesis of reactive terminal Pt(II)-cyaphido complexes. The thermodynamically uphill C-C bond cleavage reaction can be reversed upon heating, leading to quantitative reductive elimination towards the Pt(0)-phosphaalkyne-pi-complex.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Construction & Building Technology
Jack Gillham, Richard Sturm, Neil A. Hoult, Evan C. Bentz
Summary: This paper explores the potential of using distributed fiber optic sensing (DFOS) to assess load distribution and support reactions in statically indeterminate structures. A multibeam two-span composite model bridge was built and equipped with DFOS instrumentation. Different loading scenarios and slab thicknesses were used to examine their effects on load distribution and reaction forces. The challenge of measuring shear forces and reactions near the supports was overcome by developing and evaluating extrapolation techniques. The study demonstrates the accuracy and applicability of DFOS technology for estimating reactions in real-life structures.
JOURNAL OF STRUCTURAL ENGINEERING
(2023)
Review
Chemistry, Applied
Keiichi Hirano, Masanobu Uchiyama
Summary: This review discusses recent advancements in transition-metal-free inter-element boration reactions, focusing on activation of various boron reagents via Lewis-basic mechanism. Specifically, the review highlights boration reactions of carbon-carbon multiple bonds without electron-withdrawing (activating) groups and those with electron-withdrawing groups displaying inverse polarity in the addition reaction.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Organic
Yuhang Wang, Peng Ma, Ning Ma, Jianhui Wang
Summary: Ligand-controlled nickel-catalyzed selective cleavage of the C1-C2 or C1-C8 bond of benzocyclobutenones (BCBs) is reported. The delicate selection of dpppe or PMe3 as the ligand led to the predictable synthesis of a wide range of 1-naphthols and 2-naphthols without C2 and C3 substituents, respectively, from BCBs and potassium alkynyltrifluoroborate, and the increase in the amount of PMe3 resulted in tandem reaction of 2 equiv of BCB with the borate to afford 3,4,5-trisubstituted 2-naphthols. The fabulous ligand effect resulted in the facile and unique construction of multisubstituted naphthols with well-controlled regioselectivity and a high degree of structural diversity.
Article
Chemistry, Organic
Shuohan Ji, Shengxiang Qin, Chunyu Yin, Lu Luo, Hua Zhang
Summary: In this study, unreactive C-N bonds in anilines were successfully activated through photoinduced aerobic borylation, leading to the conversion of a variety of tertiary and secondary anilines to aryl boronate esters in moderate to good yields with wide functional group tolerance. This transformation provides a direct and convenient route for converting readily available anilines into useful aryl boronate esters.
Article
Chemistry, Physical
Jan Patrick Calupitan, Tao Wang, Alejandro Perez Paz, Berta Alvarez, Alejandro Berdonces-Layunta, Paula Angulo-Portugal, Rodrigo Castrillo-Bodero, Frederik Schiller, Diego Pena, Martina Corso, Dolores Perez, Dimas G. de Oteyza
Summary: This paper reports the activation of a C-C sigma bond at room temperature on Cu(111). A biphenylene derivative's C-C sigma bond is broken, followed by the insertion of Cu from the substrate. The study offers new synthetic routes that can be used for in situ generation of activated species for the on-surface synthesis of novel C-based nanostructures. Overall significance of the article is rated 7.5 out of 10.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Y. A. N. N. I. K. APPIARIUS, A. N. N. E. STAUBITZ
Summary: 1,2-azaborinines, formed by replacing two neighboring carbon atoms in benzene with boron and nitrogen atoms, exhibit increased aromaticity compared to borazine. Experimental analysis of bond lengths, resonance stabilization energies, NMR shifts, and reactivities against electrophiles confirms this. Azaborinines, both monocyclic and polycyclic, have potential applications in materials science, pharmacology, and analytics due to their unique chemical, physical, and optical properties introduced by the polar B-N-unit.
CHEMIE IN UNSERER ZEIT
(2023)
Article
Chemistry, Multidisciplinary
Pablo Ramos-Sanchez, Jeremy N. Harvey, Jose A. Gamez
Summary: A novel algorithm is proposed to explore the chemical space by generating reaction networks using heuristics based on chemical theory. The algorithm improves performance by considering only transformations that break two chemical bonds and form two new ones. It estimates energy barriers using quantum chemical calculations and can also identify missed species during the previous step to further define the reaction network. The algorithm has successfully identified the most important reaction pathways in five different chemical reactions.
JOURNAL OF COMPUTATIONAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
David E. Herbert
Summary: The C-N bond is crucial for the properties and reactivity of coordination complexes. This paper presents an overview of our work investigating the impact of site-selective benzannulation on the chemistry and properties of phenanthridine as a molecule and ligand.
CANADIAN JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Dion B. Nemez, Baldeep K. Sidhu, Kevin Carlin, Albert Friesen, David E. Herbert
Summary: The synthesis of novel analogues of the antimalarial (hydroxy)chloroquine was achieved through the substitution of the chloro group at the 4-position of 4,7-dichloroquinolines with amino alcohols. Short-chain and long-chain coupling partners were used, with electron-donating amino and dimethylamino substituents being tolerated. The compounds were characterized using various techniques and crystal structures of selected products were obtained.
CANADIAN JOURNAL OF CHEMISTRY
(2023)
News Item
Chemistry, Multidisciplinary
Robert J. Ortiz, David E. Herbert
Summary: Charge-transfer emission, which is rare for iron coordination complexes, has been observed in an Fe(iii) complex. The emission arises from both metal-to-ligand and ligand-to-metal charge transfer.
Article
Polymer Science
Shuo Li, Katrin Bamberg, Yuzhou Lu, Frank D. Soennichsen, Anne Staubitz
Summary: In this study, linear photoresponsive poly(thioether)s containing diazocine moieties in the polymer backbone were synthesized and their photoisomerization behavior was investigated. The resulting polymers showed reversible photoswitchability between the (Z)- and (E)-configurations. The study highlights the potential use of diazocine as an elongating actuator in macromolecular systems and smart materials.
Article
Chemistry, Inorganic & Nuclear
Robert J. Ortiz, Michael Shepit, Johan van Lierop, J. Krzystek, Joshua Telser, David E. Herbert
Summary: The ligand fields of Ni(II) complexes supported by diarylamido pincer-type amido ligands were investigated. The ligand field parameters were determined using HFEPR, SQUID magnetometry, and electronic absorption spectroscopy. The ability to electrochemically address ligand-based oxidations and the presence of electronic communication between N-amido moieties were also studied.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Sven Schultzke, Nikolai Scheuring, Pim Puylaert, Matthias Lehmann, Anne Staubitz
Summary: A liquid crystalline polymer is designed to be bendable under visible light, allowing for safer and more efficient use in soft robotics, engineering, and biology.
Article
Chemistry, Inorganic & Nuclear
Yannik Appiarius, Pim Puylaert, Julius Werthschuetz, Tim Neudecker, Anne Staubitz
Summary: The isoelectronic relationship between 1,2-azaborinine and benzene is well known. By deprotonating 1,2-azaborinine, the anionic 1,2-azaboratabenzene is obtained, which has similar properties to pyridine. The study demonstrates the influence of formal boron substitution on the structure and electronic properties.
Article
Chemistry, Multidisciplinary
Melanie Walther, Waldemar Kipke, Raul Renken, Anne Staubitz
Summary: This study presents a novel method for stannylation and borylation of different positions of diazocines, which are azobenzene derived macrocyclic photoswitches with well resolved photostationary states. The results demonstrate their successful use in Stille cross-coupling and Suzuki cross-coupling reactions with organic bromides, achieving high yields.
Article
Chemistry, Multidisciplinary
Ester Maria Di Tommaso, Melanie Walther, Anne Staubitz, Berit Olofsson
Summary: This study developed a synthetic route to access ortho-substituted azobenzenes via novel ortho-substituted azobenzene-functionalized diaryliodonium salts. The selective transfer of the azobenzene moiety to various nucleophiles enables the synthesis of a wide range of ortho-substituted azobenzenes. The photoswitching properties and crystal structure of the reagents were investigated.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Organic
Souvik Ghosh, Christoph Eschen, Nadi Eleya, Anne Staubitz
Summary: This study presents the synthesis and versatile functionalization of 12-membered azobenzene macrocycles (AzMs). By introducing different substituents at different positions in the periphery, the thermal half-lives of the less-stable Z isomers can be significantly influenced. Meta-substitution leads to slower thermal relaxation compared to para-substitution, and electron-withdrawing groups result in slower relaxation than electron-donating groups.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Polymer Science
Ruchira Colaco, Clement Appiah, Anne Staubitz
Summary: In this study, Poly(N-isopropylacrylamide) PNIPAAm hydrogels were modified with a new azobenzene-containing co-monomer to achieve light responsiveness and two phase transitions controlled by light. The lower critical solution transition temperature (LCST) of the hydrogel was reduced by 12 degrees C through the incorporation of 2.5 mol% of the co-monomer. The LCST and structure of the hydrogel can be tuned by the hydrophobicity-hydrophilicity of the (E) and (Z) isomeric state of azobenzene. The large light-driven modulation of the LCST may have diverse applications in the field of soft robotics actuators.
Article
Chemistry, Physical
Tamara Rinkovec, Demian Kalebic, Mark Van der Auweraer, Wim Dehaen, Jeremy N. Harvey, Steven De Feyter
Summary: This study investigates the effect of concentration on the self-assembly process of molecular networks using scanning tunneling microscopy. The research aims to improve the understanding of 2D supramolecular chemistry by obtaining quantitative data. The results show highly cooperative behavior and the significant impact of molecular structure on the critical concentration.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Chemistry, Multidisciplinary
Yannik Appiarius, Sandra Miguez-Lago, Pim Puylaert, Noah Wolf, Sourabh Kumar, Martin Molkenthin, Delia Miguel, Tim Neudecker, Michal Juriek, Araceli G. Campana, Anne Staubitz
Summary: The incorporation of boron-nitrogen units into polycyclic aromatic hydrocarbons improves their optical properties while retaining their geometries. The study found that helicenes with boron-nitrogen groups exhibited higher fluorescence quantum yield and outstanding luminescence dissymmetry, making them suitable candidates for circularly polarized luminescence emitters in materials science.
